Cutaneous Effects of Notch Inhibitor Therapy: A Report of Two Cases by Claire J. Wiggins, Susan Y. Chon

“…As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. …”
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Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity by Brian M Ortmann

“…HIF’s dysregulation is frequently observed in various cancer types and correlates with increased aggressiveness, metastasis, resistance to therapy and poor patient prognosis. Consequently, understanding the cellular mechanisms underlying HIF activation and its downstream effects has become crucial to developing targeted cancer therapies for improving cancer patient outcomes and represents a key step towards precision medicine.Recent advancements in drug development have led to the emergence of HIF inhibitors, which aim to disrupt HIF-driven processes in cancer providing therapeutic benefit. …”
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Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Additionally, de novo DNA methylation programs promote T cell exhaustion, which poses a significant limitation for CAR-T cell therapy applications.MethodsHigh-throughput liquid protein chip and CBA analyses were utilized to determine the expression levels of inflammatory factors. …”
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TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…Journal for ImmunoTherapy of Cancer…”
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Impacts of Thermal Inertia Factor on Adiabatic Decomposition of 40% Mass Content DCP in Ethyl Benzene by Xiaojuan Wu, Liping Chen, Guoning Rao, Wanghua Chen, Ruili Yin

“…DSC experiment showed that ethyl benzene has no effect on the characteristic parameters of thermal decomposition of DCP, such as the temperature of the exothermic peak (Tpeak) and the decomposition energy (Ea), and the thermal decomposition reaction of 40% DCP followed the one-step reaction principle. …”
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<i>Klebsiella pneumoniae</i> Phage M198 and Its Therapeutic Potential by Lika Leshkasheli, Ia Kusradze, Darejan Bolkvadze, Lia Askilashvili, Maria Chichashvili, Giorgi Tsertsvadze, Elisabed Zaldastanishvili

“…This prospect highlights the need for well-characterized therapeutic phages. In this work, we describe a <i>K. pneumoniae</i> phage, which also infects strains of <i>Klebsiella oxytoca</i>. …”
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Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

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Simulating Study on Mechanical Properties of Rock Wool Board for Thermal Insulation on External Walls by Xiaoguang Li, Jinjin Liu, Xin Fan, Jinyi Qin, Rui Zhang, Ren Cao, Panqi Wang, Xiaoliang Huo

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Comparative Thermal Analysis of Different Cool Roof Materials for Minimizing Building Energy Consumption by Y. Anand, A. Gupta, A. Maini, Avi Gupta, A. Sharma, A. Khajuria, S. Gupta, S. Sharma, S. Anand, S. K. Tyagi

“…The impact of using cool roof technologies on the thermal comfort of the office buildings has been estimated. …”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

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Comparison of Ignition Control Techniques in HCCI Engines from Theoretical and Practical Perspectives by Yang Jiaqi

“…This paper aims to delve into the theoretical and practical aspects of ignition control methods in HCCI engines, highlighting the differences and challenges between theoretical models and real-world applications.…”
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Defending Against Advanced Persistent Threats Using Game-Theory. by Stefan Rass, Sandra König, Stefan Schauer

“…Theoretically, these models come with different properties than classical game theoretic models, whose technical solution presented in this work may be of independent interest.…”
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Influence of cooling intensity on the structure formation in stripe steel by thermomechanical treatment by Goryany V., Khlyntseva T., Mamuzić I., Radsinsky V.

Subjects: “…thermal srtengthening…”
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Bubble Flow Analysis of High Speed Cylindrical Roller Bearing under Fluid-Solid Thermal Coupling by Li Cui, Wenxia Wang, Zhang Yanlei

“…Bubble flow calculation model of roller bearing considering fluid-solid thermal coupling is constructed based on two-body fluid model and k-ε turbulent model, in which diameter and size of bubbles, breakup, and coalescence model of bubbles are considered. …”
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A shared value network model based on synergy theory in intelligent manufacturing by Pingping Gu, Jiahui Yu, Xianzhong Zhou, Hengrong Ju

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Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres by Felipe Nasser, Joaquim Maurício Motta Leal Filho, Breno Boueri Affonso, Francisco Leonardo Galastri, Rafael Noronha Cavalcante, Diego Lima Nava Martins, Vanderlei Segatelli, Lilian Yuri Itaya Yamaga, Rene Claudio Gansl, Bernardino Tranchesi Junior, Antônio Luiz de Vasconcellos Macedo

“…In conjunction with systemic therapy, SIRT can achieve sustained disease control.…”
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Digital economy: theory, practice and perspective by I. D. Matskulyak, V. D. Kuligin, D. I. Matskulyak, N. N.Z.-O. Nagdaliev

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Taking decision general theory and its application in the medical assistance field (I). by Luis Alberto Corona Martínez

“…This paper analyses the classic (rational) and behavioural theories in decision making.…”
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An Analytical Solution for Effect of Magnetic Field and Initial Stress on an Infinite Generalized Thermoelastic Rotating Nonhomogeneous Diffusion Medium by S. R. Mahmoud

“…The problem of generalized magneto-thermoelastic diffusion in an infinite rotating nonhomogeneity medium subjected to certain boundary conditions is studied. …”
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Theoretical Model of Engagement in the Context of Brand Communities by Flávia D\u2019albergaria Freitas, Victor Manoel Cunha de Almeida

“…This paper follows the tradition of Marketing Research and Consumer Behavior, more specifically the perspective of cognitive psychology. The main theoretical foundation of the study is the Social Identity Theory (SIT), also incorporating relevant contributions from the perspective of Consumer Culture Theory (CCT). …”
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