Induction Versus Noninduction Antiviral Therapy for Chronic Hepatitis C Virus in Patients with Congenital Coagulation Disorders: A Canadian Multicentre Trial by A Chatterjee, MG Swain, SS Lee, VG Bain, K Peltekian, K Croitoru, PC Adams, K Kaita, J Teitel, EJ Heathcote

“…BACKGROUND: Patients with congenital coagulation disorders and chronic hepatitis C virus (HCV) infection have multiple risk factors (ie, infection predominantly with genotype-1 HCV, long duration of the disease, HIV coinfection and male sex) for poor response to antiviral therapy. The present study compared induction therapy with interferon-alpha (IFN-α)-2b with standard IFN-α2b therapy. …”
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Comparative efficacy and safety of first-line neoadjuvant therapy for early-stage non-small cell lung cancer based on immune checkpoint inhibitor therapy: a systematic review and network meta-analysis by Linfeng Wang, Guangda Zheng, Yue Hu, Ayidana Maolan, Yue Luo, Yue Li, Rui Liu

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The impact of maximum cross-sectional area of lesion on predicting the early therapeutic response of multidrug-resistant tuberculosis by Fuzhen Zhang, Yu Zhang, Zilong Yang, Ruichao Liu, Shanshan Li, Yu Pang, Liang Li

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Implications of a twelve-week aerobic exercise on functional work capacity in HIV positive clients on antiretroviral therapy by Mwebaze Nicholas, Mshilla Maghanga, Edward Ojuka, Constance A.n. Nsibambi

“…The implications of aerobic exercise on functional work capacity of Human Immunodeficiency Virus (HIV) positive clients on antiretroviral therapy (ART) in Uganda have been established. ART and the efforts to scale it up have significantly improved the value of life and life’s hope of among PLHIV. …”
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Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL by Lavinia Arseni, Gianluca Sigismondo, Haniyeh Yazdanparast, Johanne U. Hermansen, Norman Mack, Sibylle Ohl, Verena Kalter, Murat Iskar, Mathias Kalxdorf, Dennis Friedel, Mandy Rettel, Yashna Paul, Ingo Ringshausen, Eric Eldering, Julie Dubois, Arnon P. Kater, Marc Zapatka, Philipp M. Roessner, Eugen Tausch, Stephan Stilgenbauer, Sascha Dietrich, Mikhail M. Savitski, Sigrid S. Skånland, Jeroen Krijgsveld, Peter Lichter, Martina Seiffert

“…To investigate the underlying molecular mechanisms, we generate a mouse model of ibrutinib resistance, in which, after initial treatment response, relapse under therapy occurrs with an aggressive outgrowth of malignant cells, resembling observations in patients. …”
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Event segmentation in ADHD: neglect of social information and deviant theta activity point to a mechanism underlying ADHD by Christian Beste, Veit Roessner, Astrid Prochnow, Xianzhen Zhou, Foroogh Ghorbani, Bernhard Hommel

“…The results call for a novel conceptual view of ADHD, based on event segmentation theory.…”
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Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity by Salome’ V. Ibba, Mohamed A. Ghonim, Kusma Pyakurel, Matthew R. Lammi, Anil Mishra, A. Hamid Boulares

“…Our study suggests that the amount of iNOS and NO are critical determinants in the modulation of AHR by selective iNOS inhibitors and renews the potential of iNOS as a therapeutic target for asthma.…”
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Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis by Bonnie Hei Man Liu, Yuezhen Lin, Xi Long, Sze Wan Hung, Anna Gaponova, Feng Ren, Alex Zhavoronkov, Frank W. Pun, Chi Chiu Wang

“…Abstract Endometriosis affects over 190 million women globally, and effective therapies are urgently needed to address the burden of endometriosis on women's health. …”
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Deconstructing the Gel’fand–Yaglom Method and Vacuum Energy from a Theory Space by Nahomi Kan, Kiyoshi Shiraishi

“…The discrete Gel’fand–Yaglom theorem was studied several years ago. In the present paper, we generalize the discrete Gel’fand–Yaglom method to obtain the determinants of mass matrices which appear in current works in particle physics, such as dimensional deconstruction and clockwork theory. …”
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Dermocosmetics as an integral part of isotretinoin therapy in acne patients: results of an observational study by Dominika Kwiatkowska, Diana Wolańska-Buzalska, Barbara Zegarska, Adam Reich

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Phase Transition of Black Holes in Brans–Dicke Born–Infeld Gravity through Geometrical Thermodynamics by S. H. Hendi, M. S. Talezadeh, Z. Armanfard

“…Using the geometrical thermodynamic approach, we study phase transition of Brans–Dicke Born–Infeld black holes. …”
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New results on system of variational inequalities and fixed point theorem by Ayache Benhadid, Mahmoud Brahimi

“…Benhadid showed by a counterexample that a number of publications in the research on the variational inequalities system contains inaccurate results about applying the Lipschitz continuity concept in relation to both the first and second variables during the proof of the main theorem on the part of authors. In this paper, We suggest to applying fixed point theorem to correct the main results of some publications.…”
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L’éducation à la majorité selon Theodor W. Adorno by Alain-Patrick Olivier

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Covariant Canonical Method for Yang-Mills Theory Expressed as a Constrained BF-Like Theory by Alberto Escalante, Irving García

“…The covariant canonical analysis for Yang-Mills theory expressed as a BF-like action is performed. …”
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Rhodamine B Adsorption- Kinetic, Mechanistic and Thermodynamic Studies by S. Ramuthai, V. Nandhakumar, M. Thiruchelvi, S. Arivoli, V. Vijayakumaran

“…The values of their corresponding constant were determined from the slope and intercepts of their respective plots. Thermodynamic parameters like ΔG0, ΔH0 and ΔS0 were calculated. …”
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The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches by Pankita H. Pandya, Mary E. Murray, Karen E. Pollok, Jamie L. Renbarger

“…Using a personalized approach may have a significant, positive impact on the use of oncolytics to better guide safer and more effective therapies.…”
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Transient disturbances in a relaxing thermoelastic half space due to moving internal heat source by Sarbani Chakravorty, Amitava Chakravorty

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Early Relief of Upper Gastrointestinal Dyspeptic Symptoms: A Survey of Empirical Therapy with Pantoprazole in Canadian Clinical Practice by David Armstrong, Farouk Kazim, Marcel Gervais, Myron Pyzyk

“…BACKGROUND: Upper gastrointestinal symptoms attributable to gastroesophageal reflux disease or peptic ulcer are common, but the outcome of proton pump inhibitor therapy in clinical practice is not well documented.…”
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The Concept of Theoretical-Empirical Dualism in Teaching Math by G. D. Gefan

“…Among the problems of mathematical education, the article highlights: (1) insufficient attention paid to the fundamental, structure-forming role of mathematics; (2) speculative learning, its isolation from practice. The concept of theoretical-empirical dualism in teaching is formulated as the unity of the abstract-theoretical and experimental-empirical cognitive activity of students. …”
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Estimating theoretical stress regime for engineered geothermal energy systems in an arctic community (Kuujjuaq, Canada) by Miranda, Mafalda M., Raymond, Jasmin, Dezayes, Chrystel

“…In remote northern regions, lacking deep geothermal exploratory boreholes, a theoretical approach to provide a first-order estimate of the stress regime seems a useful tool. …”
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