Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling by Qian Xing, Wendi Cheng, Wei Wang, Chunlin Jin, Haiyin Wang

“…Sensitivity analysis highlights that factors like combination therapies, faster mechanisms of action, and novel therapeutic parts notably influence the value dimension. …”
Get full text

A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease by Qingdong Guan

“…In this review, we have systemically reviewed the pathogenesis of IBD and highlighted recent advances in host genetic factors, gut microbiota, and environmental factors and, especially, in abnormal innate and adaptive immune responses and their interactions, which may hold the keys to identify novel predictive or prognostic biomarkers and develop new therapies.…”
Get full text

ACADEMIC PERSONNEL MANAGEMENT AT CLASSICAL UNIVERSITY by Yuriy A. Bubnov

“…The causes of the negative trends in the staffing of universities are explored and ways to overcome them are also suggested. The use of empirical data allows the author to trace the influence of innovative activity on decrease in the outflow of young scholars and professors and on the rejuvenation of the teaching staff. …”
Get full text

PROTAC technology for prostate cancer treatment by Zhen Wang, Dingpeng Zhang, Hiroyuki Inuzuka, Wenyi Wei

“…Although androgen deprivation therapy remains the mainstay for early-stage PrCa treatment, efficacy is temporary because many cases advance to castration-resistant PrCa (CRPC), presenting a significant therapeutic hurdle. …”
Get full text

Optimal Fleet Policy of Rental Vehicles with Relocation: A Simulation Study by John-Carlo Favier, Subhamoy Ganguly, Timofey Shalpegin

“…To answer this conundrum, we develop two simulation models and compare them in terms of fleet utilisation, branch service level, relocations, and operating profit. …”
Get full text

Nonsurgical Treatment of a Massive Substance Loss by Pasquale Fino, Fioramonti Paolo, Diego Massera, Vittoria Amorosi, Maria Giuseppina Onesti

“…But in this case, considering the young age and the regenerative capacity of the patient, a quick and targeted antibiotic therapy was chosen, combined with debridement and worked with collagenase ointment.…”
Get full text

Drug-Induced Liver Injuries (Clinical Guidelines for Physicians) by Vladimir T. Ivashkin, Andrey Yu. Baranovsky, Karina L. Raikhelson, Lyudmila K. Palgova, Marina V. Maevskaya, Elina A. Kondrashina, Natalya V. Marchenko, Tatyana P. Nekrasova, Igor G. Nikitin

“…A section on the assessment of causal relationships in the diagnosis of DILI is presented; the practical value of using the CIOMS-RUCAM scale is shown. All possible therapeutic measures and pharmacological approaches to the treatment of patients with various DILI phenotypes are investigated in detail. …”
Get full text

TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B by Dvison de Melo Pacífico, Deiziane Viana da Silva Costa, Maria Lucianny Lima Barbosa, Conceição Silva Martins Rebouças, Simone de Goes Simonato, Cirle Alcantara Warren, Maria Luana Gaudencio dos Santos Morais, Renata Ferreira de Carvalho Leitao, Gerly Anne de Castro Brito

“…These results highlight TRPV4’s significant role in CDI pathogenesis and its potential as a therapeutic target to counteract the detrimental effects of C. difficile toxins on enteric glia.…”
Get full text

The Mustachioed Woman, or The Problem of Androgyny in Victoria Cross’ Six Chapters of a Man’s Life by Ana Raquel Rojas

“…The male narrator, Cecil, finds himself first attracted to and then frustrated by the ever-shifting gender identity of his female lover, Theodora, who secretly cross-dresses as a man, Theodore, so that they may travel together unmarried. …”
Get full text

Resource-based View and Contingent Perspective on the Relationship between Geographic Diversification of Businesses and Organizational Performance by Aloisio Pereira Júnior, Vinícius Silva Pereira

“…This work contributes to the theory by proposing the theoretical aspects integration of different theories in the analysis of the relationship between international diversification and performance and allowing the outlining of opportunities for future research.…”
Get full text

Fragility Assesment of Mid-Rise RC Building using HAZUS Method in High Seismic Zone by M. Hasbi Zuher, Ade Prayoga Nasution, Zairah Nabila Sidiq, Masrilayanti Masrilayanti, Jafril Tanjung

“…This paper addresses the performance based design method to consider the building capacity due to Padang ground motion. Therefore, the damage probability was calculated by using the lognormal distribution with the probabilistic parameter was acquired by HAZUS engineering building module. …”
Get full text

African Activism Through Pugwash by Nola Dippenaar, Joelien Pretorius

“…The history and role of Pugwash has been the subject of many publications, but none of them pay adequate attention to Africans’ participation in Pugwash, if at all. …”
Get full text

Trapezoidal Type Fejér Inequalities Related to Harmonically Convex Functions and Application by Sercan Turhan

“…By using a mapping M(t), the new theorems and corollaries are obtained. Taking advantage of these, applications were given for some real number averages.…”
Get full text

The Dialectics of Political Ideology and Power Relations in African Literature: A Reading of Adébáyọ̀ Fálétí’s Baṣọ̀run Gáà by Sola Owonibi

“…It is the underlying theory that governs every organized movement, institution, and government. …”
Get full text

Modified Fermions Tunneling Radiation from Nonstationary, Axially Symmetric Kerr Black Hole by Jin Pu, Kai Lin, Xiao-Tao Zu, Shu-Zheng Yang

“…In this paper, by applying the deformed dispersion relation in quantum gravity theory, we study the correction of fermions’ tunneling radiation from nonstationary symmetric black holes. …”
Get full text

SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…Thus, a combination therapy is required to enhance the OXA’s therapeutic effectiveness and improve patient outcomes. …”
Get full text

FUNCTIONS AND PECULIARITIES OF MANAGEMENT OF ELECTRICAL POWER ENGINEERING COMPLEX IN THE TRANSITION PERIOD by S. B Belyi, T. G. Pospelova, P. V. Yakoubovich

“…The principles and peculiarities of the corporate changes in power industry on the basis of «organizational development» theory have been considered in the paper. Special attention has been given to the functions of top-management in the transition period.…”
Get full text

‘God Gave us Legs to Walk!’ by Marizanne Grundlingh

“…This is done by exploring the coping strategies that the participants employ to support themselves and their families. Networks and family ties form an essential component of the financial and emotional survival of this group of women. …”
Get full text

An Experimental Study on the Reinforcement of Silt with Permeable Polyurethane by Penetration Grouting by Chaojie Wang, Qi Liu, Chengchao Guo, Yangyang Xia, Yanjie Hao, Mingsheng Shi, Peng Zhao

“…The results of SEM-EDS and mercury intrusion test proved that the polyurethane had a significant filling effect on the soil structure, which could effectively reduce the porosity of the soil and cement the soil particles through wrapping, complexing, and hydrogen bonding, thereby improving the soil properties. Moreover, the results revealed from a microscopic perspective that the grouting altered the pore structure of the soil structure through the seepage-erosion-splitting coupling effect, but when the grouting pressure exceeded 0.4 MPa, the soil particle and grout would be partially remixed and arranged closely, showing a phenomenon of jet grouting. …”
Get full text

Implementation strategies to increase human papillomavirus vaccination uptake for adolescent girls in sub-Saharan Africa: A scoping review protocol. by Mwansa Ketty Lubeya, Mulindi Mwanahamuntu, Carla Chibwesha, Moses Mukosha, Mercy Monde Wamunyima, Mary Kawonga

“…Achieving success for HPV vaccination in real-world settings requires strategies to overcome implementation bottlenecks. Therefore, a better understanding and mapping of the implementation strategies used in sub-Saharan Africa to increase HPV vaccination uptake is critical. …”
Get full text