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    Adenomas from individuals with pathogenic biallelic variants in the MUTYH and NTHL1 genes demonstrate base excision repair tumour mutational signature profiles similar to colorecta... by Romy Walker, Jihoon E. Joo, Khalid Mahmood, Mark Clendenning, Julia Como, Susan G. Preston, Sharelle Joseland, Bernard J. Pope, Ana B.D. Medeiros, Brenely V. Murillo, Nicholas Pachter, Kevin Sweet, Allan D. Spigelman, Alexandra Groves, Margaret Gleeson, Krzysztof Bernatowicz, Nicola Poplawski, Lesley Andrews, Emma Healey, Steven Gallinger, Robert C. Grant, Aung K. Win, John L. Hopper, Mark A. Jenkins, Giovana T. Torrezan, Christophe Rosty, Finlay A. Macrae, Ingrid M. Winship, Daniel D. Buchanan, Peter Georgeson

    Published 2025-02-01
    “…Background: Colorectal cancers (CRCs) from people with biallelic germline likely pathogenic/pathogenic variants in MUTYH or NTHL1 exhibit specific single base substitution (SBS) mutational signatures, namely combined SBS18 and SBS36 (SBS18+SBS36), and SBS30, respectively. The aim was to determine if adenomas from biallelic cases demonstrated these mutational signatures at diagnostic levels. …”
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    Factors influencing changes in the quality of life of the Hainan migratory population with hypertension: a survey of the Chengmai mangrove bay community by Qiaochun Chen, Jing Zhou, Na Li, Luming Liu, Yixuan Li, Wenfang Long, Ziyue Luo, Yunru Liu, Sha Xiao

    Published 2025-01-01
    “…After obtaining informed consent, we investigated the demographic characteristics of the participants and evaluated their QoL with the SF-36 twice; one round of the SF-36 was about their hometown, and the other round was about living in Hainan for 1 month. …”
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    Detection and Classification of Sporadic E Using Convolutional Neural Networks by J. A. Ellis, D. J. Emmons, M. B. Cohen

    Published 2024-01-01
    “…After corresponding the two data sets, a total of 36,521 samples are available for training and testing the models. …”
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    Autoinflammatory diseases. Part 1: concept, classification, immunobiology, diagnosis by O.V. Shvaratska, M.V. Kalichevska, O.V. Klymenko, O.M. Taran, O.V. Klimova, Y.V. Vilenskyi, T.M. Plekhanova, T.K. Mavropulo

    Published 2024-11-01
    “…In particular, we review how the innate immune system triggers inflammation within the inflammasome, interferon and nuclear factor kappa B ­(NF-κB) signaling pathways, highlighting the role of intracellular sensor proteins, inflammasomes, gasdermin D, IL-1β, IL-18 and IL-36, ­NF-κB, tumor necrosis factor, type 1 interferons, and others. …”
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    Alzheimer's disease image classification based on enhanced residual attention network. by Xiaoli Li, Bairui Gong, Xinfang Chen, Hui Li, Guoming Yuan

    Published 2025-01-01
    “…By combining residual learning, attention mechanism, and soft thresholding, the feature representation ability and classification accuracy of the model have been improved. …”
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