Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids by Suya Shen, Bing Liu, Wenyan Guan, Ziyao Liu, Yuqing Han, Yingzhe Hu, Yiqiang Chen, Siyuan Liu, Jian He, Zhiwen Li, Weifeng Tang, Pengju Zhang, Wei Ren, Yudong Qiu, Hongping Zheng, Jingjing Li

“…Results A total of 34 PDOs were successfully established with a 61.8% success rate. The classification method based on chemotherapy sensitivity closely corresponded to clinical responses. …”
Get full text

Arthralgia and Extraintestinal Manifestations in Crohn’s Disease Elevate the Risk of IBD-Related Arthritis over Sacroiliitis by Ivan Giovannini, Nicola Cabas, Marco Marino, Annarita Tullio, Ilaria Tinazzi, Angela Variola, Carmelo Cicciò, Fabro Cinzia, Berretti Debora, Chiara Zuiani, Rossano Girometti, Luca Quartuccio, Alen Zabotti, Lorenzo Cereser

“…Sacroiliitis detected on MRE was not associated with an increased risk of IBD-related arthritis (odds ratio [OR] = 2.12 [95% confidence interval (CI) 0.36, 12.53, p = 0.408]). …”
Get full text

Random resistive memory-based deep extreme point learning machine for unified visual processing by Shaocong Wang, Yizhao Gao, Yi Li, Woyu Zhang, Yifei Yu, Bo Wang, Ning Lin, Hegan Chen, Yue Zhang, Yang Jiang, Dingchen Wang, Jia Chen, Peng Dai, Hao Jiang, Peng Lin, Xumeng Zhang, Xiaojuan Qi, Xiaoxin Xu, Hayden So, Zhongrui Wang, Dashan Shang, Qi Liu, Kwang-Ting Cheng, Ming Liu

“…The co-design system is validated on 3D segmentation (ShapeNet), event recognition (DVS128 Gesture), and image classification (Fashion-MNIST) tasks, achieving accuracy comparable to conventional systems while delivering 6.78 × /21.04 × /15.79 × energy efficiency improvements and 70.12%/89.46%/85.61% training cost reductions.…”
Get full text

Retrospective cohort study on diseases and risk factors associated with death in hospitalized neonatal foals by Donatienne L. Castelain, Alexander Dufourni, Mathilde L. Pas, Jade Bokma, Eva deBruijn, Ellen Paulussen, Laurence Lefère, Gunther vanLoon, Bart Pardon

“…Neonatal sepsis significantly increased the risk of death (hazard ratio [HR] = 1.9; 95% confidence interval [CI] = 1.2‐3.0; P = .009). Multivariable Cox regression in foals ≤7 days old revealed comatose mental state (HR = 2.9; 95% CI = 1.1‐8.1; P = .04), L‐lactatemia (≥373.8 mg/L [4.2 mmol/L]; HR = 4.4; 95% CI = 1.7‐11.7; P = .003) and increased serum amyloid A (SAA; ≥2054 μg/mL; HR = 3.9; 95% CI = 1.2‐12.7; P = .02) as risk factors for death, with a sensitivity and specificity of 7.5% and 95.7%, respectively. …”
Get full text

Establishment and evaluation of a method for measuring ornithine transcarbamylase activity in micro blood of neonates by Zhilei Zhang, Xin Wang, Jingjing Zhang, Xianwei Guan, Yanyun Wang, Dongyang Hong, Yahong Li, Peiying Yang, Yun Sun, Tao Jiang

“…The intra-coefficient variation and inter-coefficient variation were 11% and 12.5% with a 1-h reaction time, and 6.77% and 9.58% with a 3-h reaction time, respectively. …”
Get full text

Modified minimally invasive chevron osteotomy versus traditional incision chevron osteotomy by Run Tang, Jie Yang, Xiao Jun Liang, Yi Li, JunHu Wang, MiaoLuo Jin, Yang Du, Tong Lu, YiXiang Hao

“…The AOFAS scores, VAS, HVA, 1-2IMA, and DMAA in the MIC group improved from 54.61 ± 7.60, 4.50 ± 0.79, 28.38° ± 5.02°, 12.88° ± 1.50°, 12.03° ± 1.88°preoperatively to 89.93 ± 4.96, 2.04 ± 1.10, 10.27° ± 1.68°, 7.49° ± 0.95° and 7.83° ± 1.33° at the last follow-up, the difference was statistically significant (P < 0.05); the AOFAS score, VAS, HVA, 1-2IMA, and DMAA of the TIC group improved from 57.31 ± 7.59, 4.34 ± 0.70, 28.45° ± 4.47°, 12.88° ± 1.50°, 12.16° ± 1.81° preoperatively to 87.97 ± 5.96, 2.00 ± 1.11, 10.99° ± 2.25°, 7.49° ± 0.95°, and 8.25° ± 1.12° at the last follow-up, the difference was statistically significant (P < 0.05), but there was no significant difference in AOFAS score, VAS, HVA, 1-2IMA, and DMAA between the two groups (P > 0.05). …”
Get full text

Phytogeographic Transition Areas Hide Floristic Diversity in Hyper-Arid Environments (Sharaan Natural Reserve, NW-Saudi Arabia) by Mohamed Djamel Miara, Sami Youssef, Yassine Fendane, Louise Marris, Robin Sallio, Hassan Boukcim, Sami D. Almalki, Shauna K. Rees, Benjamin P. Y.-H. Lee, Abdalsamad Aldabaa, Ahmed H. Mohamed

“…Among the identified plants, 13 taxa were not mentioned in the 44 consulted references and seem more or less exclusive to the reserve/phytogeographic region. Also, 12 taxa are considered of Least Concern according to the IUCN red list while the presence of <i>Calligonum comosum</i> L’Hér. allows the classification of its natural habitat (dunes) as a Critical Habitat according to the PS6 criteria. …”
Get full text

The impact of biological and psychosocial factors on the formation of mental disorders in patients who have experienced COVID-19 and exposed to the stressors of the SARS-COV-2 pand... by N.O. Maruta, V.Y. Fedchenko, I.O. Yavdak, T.V. Panko

Get full text

Exome sequencing in Nigerian children with early‐onset epilepsy syndromes by Ibitayo Abigail Ademuwagun, Yagoub Adam, Solomon Oladapo Rotimi, Steffen Syrbe, Maximilian Radtke, Julia Hentschel, Johannes R. Lemke, Ezekiel Adebiyi

Get full text

Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases by S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

Get full text

Using apparent diffusion coefficient maps and radiomics to predict pathological grade in upper urinary tract urothelial carcinoma by Rile Nai, Kexin Wang, Shuai Ma, Zuqiang Xi, Yaofeng Zhang, Xiaodong Zhang, Xiaoying Wang

Get full text

Development and internal validation of the Edmonton Obesity Staging System-2 Risk screening Tool (EOSS-2 Risk Tool) for weight-related health complications: a case-control study in... by Evan Atlantis, P Fahey, Kathryn Williams, Paul Dugdale, James Rufus John, SL Hocking, Kath Peters

Get full text

Adding salt to foods and risk of incident depression and anxiety by Weiwei Wang, Xiaotian Chang, Feifei Lin, Lei Feng, Mengying Wang, Jie Huang, Tao Wu

“…The outcomes were incidents of diagnosed depression (F32-F33) and anxiety (F40-F48), defined by the International Statistical Classification of Diseases and Related Health Problems, 10th Revision codes. …”
Get full text

Laryngeal cancer diagnosis based on improved YOLOv8 algorithm by Xin Nie, Xueyan Zhang, Di Wang, Yuankun Liu, Lumin Xing, Wenjian Liu

Get full text

The characteristics of dermatology inpatients seen at the quaternary Inkosi Albert Luthuli Central Hospital in Durban, South Africa, over a 5-year period – 2015 - 2020 by L Mthembu, J T Masuka, K Duze, A Mosam

Get full text

Association of ultra-processed food-related metabolites with selected biochemical markers in the UK Biobank by Anthony Kityo, Byeonggeun Choi, Jung-Eun Lee, Chulho Kim, Sang-Ah Lee

“…UPF and UNPF intakes were evaluated using the NOVA classification, and related metabolites were identified using elastic net penalized regression. …”
Get full text

Trends in initial pharmacological COPD treatment in primary care (2010–2021): a population-based study using the PHARMO Data Network by Guilherme Rodrigues, Joana Antão, Qichen Deng, Brenda N. Baak, Alda Marques, Frits M. E. Franssen, Martijn A. Spruit

Get full text

Predictive models and determinants of mortality among T2DM patients in a tertiary hospital in Ghana, how do machine learning techniques perform? by Godsway Edem Kpene, Sylvester Yao Lokpo, Sandra A. Darfour-Oduro

Get full text

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores by Timing Liu, Alagu Sankareswaran, Gordon Paterson, Genes & Health Research Team, Diane P. Fraser, Sam Hodgson, Qin Qin Huang, Teng Hiang Heng, Meera Ladwa, Nick Thomas, David A. van Heel, Michael N. Weedon, Chittaranjan S. Yajnik, Richard A. Oram, Giriraj R. Chandak, Hilary C. Martin, Sarah Finer

Get full text

Risk Assessment of Soil Heavy Metals in the Jiahe River Basin of Yantai City, China by Xizhuo Chen, Pengfei Zhao, Jiaxin Huang, Jun Liu, Xiaoli Cao, Jing Che, Hui Liao, Xiaolong Zhu, Qingjie Gong

“…A total of 213 soils were sampled and analyzed for 12 items: Cr, Hg, As, Pb, Cd, Cu, Ni, Zn, Co, V, Mn, and pH. …”
Get full text