Inhibition of Kv1.3 channel restrains macrophage M2 polarization and ameliorates renal fibrosis via regulating STAT6 phosphorylation by Yanshan Chen, Yuanxing Zhi, Hailin Zhong, Liang Ma, Xinpei Gu, Yijing Cai, Jingjing Huang, Xin Yi, Xiaoyan Wu, Ken Kin Lam Yung, Pingzheng Zhou

“…Macrophages play crucial roles in regulating both homeostatic and inflammatory responses, with classical activated (M1) and alternatively activated (M2) subsets defined by the surrounding micro-environment. …”
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Effects of Telbivudine Treatment on the Circulating CD4+ T-Cell Subpopulations in Chronic Hepatitis B Patients by Yanhua Zheng, Zemin Huang, Xianhua Chen, Yi Tian, Jun Tang, Yi Zhang, Xiaomin Zhang, Jijun Zhou, Qing Mao, Bing Ni, Qinghong Wang, Yuzhang Wu

“…However, CD4+ T-cell subsets are heterogeneous, and it remains unknown how the antiviral agents affect the different CD4+ T cell subtypes. …”
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The Frequency and the Significance of TNF-α+CD19+ B-cell Population in Lymph Nodes of Patients with Squamous Cell Carcinoma of Head and Neck by Marzieh Norouzian, Fereshteh Mehdipour, Mohammad Javad Ashraf, Bijan Khademi, Abbas Ghaderi

“…Materials and Methods: Thirty-six draining lymph nodes from untreated patients with tongue and larynx SCC were stimulated with CpG, recombinant CD40L and phorbol-12-myristate-13-acetate/ionomycin and analyzed by flow cytometry for the frequency of B-cell subsets based on interleukin (IL)-10 and tumor necrosis factor-alpha (TNF-α) cytokine production. …”
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Alkylresorcinols as a New Type of Gut Microbiota Regulators Influencing Immune Therapy Efficiency in Lung Cancer Treatment by Aleksandr V. Shestopalov, Oleg I. Kit, Anastasia A. Zabolotneva, Elena Y. Zlatnik, Aleksey Yu Maksimov, Inna A. Novikova, Alexander B. Sagakyants, Sofya V. Timofeeva, Anna S. Goncharova, Anastasia V. Galina, Svetlana A. Appolonova, Pavel A. Markin, Valentin V. Makarov, Sergey M. Yudin, Anton A. Keskinov, Sergei A. Roumiantsev, Oleg I. Meshkov

“…Quantitative analysis of AR levels, as well as other microbial metabolites in blood serum and faeces, was performed using gas chromatography with mass spectrometric detection; estimation of lymphocyte subsets was performed by flow cytometry; faecal microbiota transplantation (FMT) from lung cancer patients after ICI therapy to germ-free mice was performed to explore whether the intestinal microbiota could produce AR molecules. …”
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Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group by Guadalupe Oñate, Ana Garrido, Montserrat Arnan, Helena Pomares, Ester Alonso, Mar Tormo, Marina Diaz-Beya, Susana Vives, Lurdes Zamora, Antonia Sampol, Rosa Coll, Olga Salamero, Marta Cervera, Antoni Garcia, Ferran Vall-Llovera, Sara Garcia-Avila, Joan Bargay, Xavier Ortin, Eva Iranzo, Francisca Guijarro, Marta Pratcorona, Josep F. Nomdedeu, Jordi Esteve, Jorge Sierra

“…Remission and survival outcomes varied among different genetic subsets. An especially adverse genetic group included complex, monosomal karyotype, TP53 alterations (deleted/mutated), and MECOMr. …”
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Intermittent fasting boosts antitumor immunity by restricting CD11b+Ly6Clow Ly6Glow cell viability through glucose metabolism in murine breast tumor model by Chenghao Fu, Zhehao Liang, Zemiao Niu, Ning Chen, Yuemin Li, Zhenhua Liang, Yanwei Huo, Hao Xi, Rong Wang, Yonghuan Yan, Xiaoru Gano, Mengtian Wang, Yun Huang, Yan Zhang, Mingming Gao, Pin Lü

“…On the other hand, glucose metabolism restriction can directly induce the apoptosis of Ly6Glow G-MDSC, but not Ly6Ghigh subsets. In summary, these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3+ T cells, providing potential solutions for enhancing immune-based cancer interventions.…”
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Differences in the intrahepatic expression of immune checkpoint molecules on T cells and natural killer cells in chronic HBV patients by Lucile Dumolard, Marie-Noelle Hilleret, Marie-Noelle Hilleret, Charlotte Costentin, Charlotte Costentin, Marion Mercey-Ressejac, Marion Mercey-Ressejac, Nathalie Sturm, Nathalie Sturm, Theophile Gerster, Thomas Decaens, Thomas Decaens, Evelyne Jouvin-Marche, Patrice N. Marche, Zuzana Macek Jilkova, Zuzana Macek Jilkova

“…Immune checkpoint molecules (ICMs) control the amplitude of the activation and function of immune cells, which makes them the key regulators of immune response.MethodsWe performed a multiparametric flow cytometry analysis of ICMs and determined their expression on intrahepatic lymphocyte subsets in untreated and treated patients with HBV in comparison with non-pathological liver tissue.ResultsThe liver of untreated HBV patients exhibited a high accumulation of PD-1+CD8+ T cells, while the frequencies of 4-1BB+ T cells, 4-1BB+ natural killer (NK) cells, and TIM-3+CD8+ T cells were the highest in the chronic hepatitis phase. …”
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Induction of Tolerance via the Sublingual Route: Mechanisms and Applications by Philippe Moingeon, Laurent Mascarell

“…In the absence of danger signals, all these DC subsets are tolerogenic in that they support the differentiation of Th1- and IL10-producing regulatory CD4+ T cells. …”
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Pluripotency Factors on Their Lineage Move by Clair E. Weidgang, Thomas Seufferlein, Alexander Kleger, Martin Mueller

“…Moreover, recent studies reveal different facets of these core factors in balancing a controlled and directed exit from pluripotency. Thereby, subsets of pluripotency-maintaining factors have been shown to adopt new roles during lineage specification and have been globally defined towards neuroectodermal and mesendodermal sets of embryonic stem cell genes. …”
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Le bois du Baradat, deux siècles et deux révolutions d’une superbe chênaie de l’Adour by Michel Bartoli, Gilberte Doly

“…Du milieu du XVIIe siècle à celui du XIXe, se succèdent des coupes suivant les pratiques de l’Ancien Régime puis, à partir de 1797, des coupes avec éclaircies. …”
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Recent Advances in Sharding Techniques for Scalable Blockchain Networks: A Review by Brandon Liew Yi Quan, Nur Haliza Abdul Wahab, Arafat Al-Dhaqm, Ahmad Alshammari, Ali Aqarni, Shukor Abd Razak, Koh Tieng Wei

“…The general definition of sharding is the partitioning of the network into subsets known as shards, which allows them to validate transactions in parallel, resulting in performance and scalability improvements of the existing network. …”
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In Memoriam: † ACAD. ALEXANDRU UNGUREANU (1941 - 2024) by George-Bogdan TOFAN

“…Păcurar, căruia și pe această cale îi mulțumim din suflet încă o dată. …”
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Incorporating Environmental Education in English Language Teaching through Bloom’s Revised Taxonomy by Defne Erdem Mete

“…Our Iceberg is Melting: Changing and Succeding Under Any Conditions (2005), written by John Kotter and Holger Rathgeber as a fable, has been chosen as the sample authentic text. …”
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Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis by Aldo Bonaventura, François Mach, Aline Roth, Sébastien Lenglet, Fabienne Burger, Karim J. Brandt, Aldo Pende, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Franco Dallegri, Michele Cea, Nicolas Vuilleumier, Fabrizio Montecucco, Federico Carbone

“…The association between CRP and intraplaque lipids, collagen, neutrophils, smooth muscle cells (SMC), and macrophage subsets was determined. No correlation between serum CRP and intraplaque biomarkers was observed. …”
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Geometry and dynamics of representations in a precisely balanced memory network related to olfactory cortex by Claire Meissner-Bernard, Friedemann Zenke, Rainer W Friedrich

“…The covariance structure of these manifolds supported pattern classification when information was retrieved from selected neuronal subsets. Networks with E/I assemblies therefore transformed the geometry of neuronal coding space, resulting in continuous representations that reflected both relatedness of inputs and an individual’s experience. …”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…By analyzing interactions and broader cellular networks, we interrogate the tumour microenvironment to understand how immune cells are spatially organized in clinically matched adenocarcinoma and squamous cell carcinoma subsets. This spatial analysis revealed distinct patterns of immune cell aggregation, particularly among macrophage populations, that correlated with patient prognosis differentially in adenocarcinoma and squamous cell carcinoma, suggesting potential new strategies for therapeutic intervention. …”
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População em situação de rua na pandemia: desdobramentos da crise do capital by Elaine Teixeira Alves dos Santos, Fernanda Oliveira Sarreta

“…Utilizamos o materialismo histórico-dialético como método de pesquisa e, por meio de uma abordagem qualitativa, realizamos um estudo bibliográfico para apresentar as bases históricas do capitalismo, que é o que produz esse fenômeno social e submete uma parcela da população a condições de vida e trabalho extremamente precárias. …”
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A comunidade científica de analistas lusófonos de redes sociais: qual o potencial para a ação coletiva? by Marta Pedro Varanda, Breno Augusto Souto Maior Fontes, Raquel Rego, Klaus Eichner

“… O crescimento dos estudos de redes sociais na comunidade lusófona tem experimentado um crescimento importante na última década, fato que constatamos nos encontros que realizamos com a comunidade acadêmica no Congresso Luso-Afro-Brasileiro (realizado em 2010, Salvador, Brasil) e SUNBELT (realizado em 2011, no Riva Del Garda, Itália).   …”
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EEG Source Imaging Guided by Spatiotemporal Specific fMRI: Toward an Understanding of Dynamic Cognitive Processes by Thinh Nguyen, Thomas Potter, Trac Nguyen, Christof Karmonik, Robert Grossman, Yingchun Zhang

“…A novel multimodal EEG/fMRI integration method was developed in this study to achieve high spatiotemporal accuracy by employing the most probable fMRI spatial subsets to guide EEG source localization in a time-variant fashion. …”
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Rule-Based Knowledge Acquisition Method for Promoter Prediction in Human and Drosophila Species by Wen-Lin Huang, Chun-Wei Tung, Chyn Liaw, Hui-Ling Huang, Shinn-Ying Ho

“…PromHD identifies two feature subsets with 99 and 74 DNASDs and yields test accuracies of 96.4% and 97.5% in human and Drosophila species, respectively. …”
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