Monitoring Over Time of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Through an Ensemble Vision Transformers‐Based Model by Maria Colomba Comes, Annarita Fanizzi, Samantha Bove, Luca Boldrini, Agnese Latorre, Deniz Can Guven, Serena Iacovelli, Tiziana Talienti, Alessandro Rizzo, Francesco Alfredo Zito, Raffaella Massafra

“…We further validated our model using a subset of 20 patients selected from the publicly available I‐SPY2 trial dataset (independent test). …”
Get full text

PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands by Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko

“…Here we show that monotherapy with selective PRMT5 inhibitors induced a potent anti-tumor activity across several cellular and animal models of ACC, which was paralleled by downregulation of genes associated with ACC tumorigenesis, including MYB and MYC (the recognized drivers of ACC progression). Furthermore, as a subset of genes targeted by lenvatinib is upregulated in ACC, we demonstrate that addition of lenvatinib enhanced the growth inhibitory effect of PRMT5 blockade in vitro, suggesting a potential clinical benefit for patients expressing lenvatinib favorable molecular profile. …”
Get full text

Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

“…Median overall survival was 12.9 months (95% CI 18.7–19.3). In a subset analysis excluding patients who had prior OLU exposure (N = 51), CR/CRh was achieved in 19/51 (37%; 95% CI 24–52) patients, CR was achieved in 16/51 (31%; 95% CI 19–46), and overall response was achieved in 30/51 (59%; 95% CI 44–72). …”
Get full text

Evaluation of CORDEX ERA5-forced NARCliM2.0 regional climate models over Australia using the Weather Research and Forecasting (WRF) model version 4.1.2 by G. Di Virgilio, G. Di Virgilio, F. Ji, F. Ji, E. Tam, J. P. Evans, J. P. Evans, J. Kala, J. Andrys, C. Thomas, D. Choudhury, C. Rocha, Y. Li, M. L. Riley

“…This evaluation shows that NARCliM2.0 ERA5 RCMs provide valuable reference simulations for upcoming CMIP6-forced downscaling over CORDEX-Australasia and are informative datasets for climate impact studies. Using a subset of these RCMs for simulating CMIP6-forced climate projections over CORDEX-Australasia and/or at convection-permitting scales could yield tangible benefits in simulating regional climate.…”
Get full text

Hyperglycemia and Correlated High Levels of Inflammation Have a Positive Relationship with the Severity of Coronavirus Disease 2019 by Wen Zhang, Chuanwei Li, Yu Xu, Binfeng He, Mingdong Hu, Guoqiang Cao, Li Li, Shuang Wu, Xia Wang, Chun Zhang, Jianping Zhao, Jungang Xie, Zihui Xu, Qi Li, Guansong Wang

“…The initial measurement of plasma glucose levels after hospitalization may help identify a subset of patients who are predisposed to a worse clinical course.…”
Get full text

A Wideband Chemical Survey of Massive Star-forming Regions at Subarcsecond Resolution with the Submillimeter Array by Charles J. Law, Qizhou Zhang, Arielle C. Frommer, Karin I. Öberg, Roberto Galván-Madrid, Eric Keto, Hauyu Baobab Liu, Paul T. P. Ho, Andrés F. Izquierdo, L. Ilsedore Cleeves

“…Thus, to establish an interpretative framework for these efforts, detailed observations that simultaneously provide high sensitivity, spatial resolution, and large bandwidths for a subset of diverse sources are needed. Here, we present wide-band (≈32 GHz) Submillimeter Array (SMA) observations of four high-mass star-forming regions (G28.20-0.05, G20.08-0.14 N, G35.58-0.03, and W33 Main) at subarcsecond resolution, where we detect and spatially resolve hundreds of lines from over 60 molecules, including many complex organic molecules (COMs). …”
Get full text

Identification of Clusters in a Population With Obesity Using Machine Learning: Secondary Analysis of The Maastricht Study by Maik JM Beuken, Melanie Kleynen, Susy Braun, Kees Van Berkel, Carla van der Kallen, Annemarie Koster, Hans Bosma, Tos TJM Berendschot, Alfons JHM Houben, Nicole Dukers-Muijrers, Joop P van den Bergh, Abraham A Kroon, Iris M Kanera

“…The factor probabilistic distance clustering algorithm was applied in order to detect clusters within this high-dimensional data. To identify a subset of distinct, minimally redundant, predictive variables, we used the statistically equivalent signature algorithm. …”
Get full text

Identification of Southeast Asian Anopheles mosquito species with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a cross-correlation approach by Victor Chaumeau, Sunisa Sawasdichai, Thu Zar Ma Ma Moe Min, Thithiwarada Kularbkeeree, Naw Jaruwan, Naw Gloria, Naw Yu Lee, Muesuwa Trackoolchengkaew, Monticha Phanaphadungtham, Patcharamai Rongthong, Aritsara Inta, Wanitda Watthanaworawit, François Nosten

“…Methods Anopheles mosquitoes were captured in 33 villages in Karen (Kayin) state in Myanmar. A subset of 403 specimens was selected for inclusion in either the reference or the test panel (270 and 133 specimens, respectively). …”
Get full text

Chronic limb-threatening ischemia under the age of 50 – a single-center 12-year retrospective study by Inês Gueifão, Anita Quintas, Rita Soares Ferreira, Fábio Pais, Tiago Ribeiro, Joana Cardoso, Helena Fidalgo, Maria Emília Ferreira

“… INTRODUCTION: Premature peripheral artery disease (PAD), defined as occurring before or at the age of 50, is a poorly studied subset of PAD due to its low incidence. It has been associated with a higher risk of progression to chronic limb-threatening ischemia (CLTI), major adverse limb events and mortality. …”
Get full text

Regional-scale precision mapping of cotton suitability using UAV and satellite data in arid environments by Jianqiang He, Yonglin Jia, Yi Li, Asim Biswas, Hao Feng, Qiang Yu, Shufang Wu, Guang Yang, Kadambot.H.M. Siddique

“…An optimized set of vegetation indices was identified through multicollinearity analysis and full subset selection. Six advanced machine learning methods, including Random Forest (RF), were used alongside the ratio mean method to effectively upscale soil water and salt content models from the field to the regional level. …”
Get full text

A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

“…Immature neutrophils promote excessive inflammation and suppress T cell activation, while a specific macrophage subset (Macro_03_M1) displaying features akin to myeloid-derived suppressor cells (M-MDSCs) suppress T cells and promote inflammation. …”
Get full text

The Existence and Uniqueness of Nonlinear Elliptic Equations with General Growth in the Gradient by Angelo Alvino, Vincenzo Ferone, Anna Mercaldo

“…In this paper, we prove the existence and uniqueness results for a weak solution to a class of Dirichlet boundary value problems whose prototype is <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>−</mo><msub><mo>Δ</mo><mi>p</mi></msub><mi>u</mi><mo>=</mo><mi>β</mi><msup><mrow><mo>|</mo><mo>∇</mo><mi>u</mi><mo>|</mo></mrow><mi>q</mi></msup><mo>+</mo><mi>f</mi><mo> </mo><mrow><mi mathvariant="normal">i</mi><mi mathvariant="normal">n</mi><mo> </mo><mo>Ω</mo></mrow><mspace width="0.166667em"></mspace><mo>,</mo><mo> </mo><mi>u</mi><mo>=</mo><mn>0</mn><mo> </mo><mrow><mi mathvariant="normal">o</mi><mi mathvariant="normal">n</mi><mo> </mo><mo>∂</mo><mo>Ω</mo></mrow><mspace width="0.166667em"></mspace><mo>,</mo><mspace width="4pt"></mspace></mrow></semantics></math></inline-formula> where <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mo>Ω</mo></semantics></math></inline-formula> is a bounded open subset of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mrow><mi mathvariant="double-struck">R</mi></mrow><mi>N</mi></msup></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>N</mi><mo>≥</mo><mn>2</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1</mn><mo><</mo><mi>p</mi><mo><</mo><mi>N</mi></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mo>Δ</mo><mi>p</mi></msub><mi>u</mi><mo>=</mo><mi>div</mi><mfenced separators="" open="(" close=")"><msup><mrow><mo>|</mo><mo>∇</mo><mi>u</mi><mo>|</mo></mrow><mrow><mi>p</mi><mo>−</mo><mn>2</mn></mrow></msup><mo>∇</mo><mi>u</mi></mfenced></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>p</mi><mo>−</mo><mn>1</mn><mo><</mo><mi>q</mi><mo><</mo><mi>p</mi></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>β</mi></semantics></math></inline-formula> is a positive constant and <i>f</i> is a measurable function satisfying suitable summability conditions depending on <i>q</i> and a smallness condition.…”
Get full text

Nonthermal atmospheric pressure plasma (NTAPP) effectively eliminates skin tumors in a mouse model of UV-induced carcinogenesis with a short-term treatment regimen by Szabolcs Bozsányi, Ruby Acquah, Rhea Carmel Glen Rodrigues, Erin C. Tracy, Sean P. Murphy, Gregory Fridman, Wendy J. Huss, Peter C. Friedman, Gyorgy Paragh

“…., nearby tumors on the same mouse) in UV-exposed, NTAPP-treated mice were evaluated for tumor size at 0 and 28 days after the beginning of the treatment by using ImageJ on standardized photographs. A subset of the tumors was also assessed with a 33 MHz high-frequency ultrasound (HFUS) to measure vertical tumor thickness. …”
Get full text

An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants by Bruce Nmezi, Guillermo Rodriguez Bey, Talia DeFrancesco Oranburg, Kseniia Dudnyk, Santana M. Lardo, Nathan Herdman, Anastasia Jacko, Sandy Rubio, Emanuel Loeza-Alcocer, Julia Kofler, Dongkyeong Kim, Julia Rankin, Emma Kivuva, Nicholas Gutowski, Katherine Schon, Jelle van den Ameele, Patrick F. Chinnery, Sérgio B. Sousa, Filipe Palavra, Camilo Toro, Filippo Pinto e Vairo, Jonas Saute, Lisa Pan, Murad Alturkustani, Robert Hammond, Francois Gros-Louis, Michael S. Gold, Yungki Park, Geneviève Bernard, Raili Raininko, Jian Zhou, Sarah J. Hainer, Quasar S. Padiath

“…Most cases of ADLD are caused by tandem genomic duplications involving the lamin B1 gene (LMNB1) while a small subset are caused by genomic deletions upstream of the gene. …”
Get full text

Transurethral Water Vapor Ablation: Potential for a Novel Prostate Cancer Management Strategy by Warlick CA, Spilseth BD, Dixon CM

“…The study also includes results from a subset of patients that received additional treatments of newly identified cancer in previously untreated areas on the other side of the prostate, or retreatment of residual (missed) cancer after the initial procedure. …”
Get full text

Geospatial Access to Emergency Obstetric Surgery in Indonesia: Is Travel Time for Access Too Long? by Brahmana Askandar Tjokroprawiro, Hanif Ardiansyah Sulistya, Farizal Rizky Muharram, Renata Alya Ulhaq, Alifina Izza, Budi Prasetyo, Khoirunnisa Novitasari, Budi Wiweko, Pandu Hanindito Habibie, Arya Ananda Indrajaya Lukmana, Muhammad Muhibuddin Hilmy Asari

“…Background: Ensuring timely access to safe and affordable surgery within a travel time of a 2-h drive or 30-min walk is crucial for achieving universal health coverage, as endorsed by the Lancet Commission on Global Surgery (LCoGS). In this study, we aimed to quantify the percentage of Indonesian women of reproductive age (WRA) who can access a hospital with emergency obstetric and gynecological services within this time frame. …”
Get full text

Lethal clinical outcome and chemotherapy and immunotherapy resistance in patients with urothelial carcinoma with MDM2 amplification or overexpression by Weijuan Zhang, Jiejie Xu, Hailong Liu, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Yuan Chang, Le Xu, Kaifeng Jin, Jingtong Xu, Xiaohe Su, Yawei Ding, Lingkai Zhang, Jiaxing Sun, Yuzhen Wu

“…In addition, UC with MDM2 amplification or overexpression was associated with an immuno-evasive contexture characterized by lower proportion of tertiary lymphoid structure infiltration, lower abundance of CD8+ T cells, IFN-γ+ cells, GZMB+ cells, and decreased expression of immune checkpoint molecules including programmed death-ligand 1 (PD-L1), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).Conclusions MDM2 amplification or overexpression defines a lethal subset of patients with UC with inferior prognosis and resistance to both platinum-based chemotherapy and immunotherapy irrespective of TP53/p53 status. …”
Get full text

Preventing sensory and motor dysfunctions in children receiving neurotoxic chemotherapy: PrepAir study - an update by Céline Hammadou, Bianca Celine Schmidli, Christina Schindera, Nicolas von der Weid, Uta Tacke, Oliver Faude, Sarah Koch, Fiona Streckmann

“…Peripheral neuropathy in children and adolescents treated for cancer. The Lancet Child & Adolescent Health, 2(10), 744–754. https://doi.org/10.1016/S2352-4642(18)30236-0 Kandula, T., Park, S. …”
Get full text

Reduction in <i>Aedes aegypti</i> Population After a Year-Long Application of Targeted Sterile Insect Releases in the West Valley Region of Southern California by Solomon Kibret Birhanie, Jacob Hans, Jennifer Thieme Castellon, Ale Macias, Rubi Casas, Huy Hoang, Deanna Mormile, Kecia Pitts-Love, Michelle Q. Brown

“…Data from weekly BG Sentinel-2 traps were utilized to compare the mosquito densities between the pre-intervention (2023) and intervention (2024) periods for both cohorts. In addition, a subset of samples (<i>n</i> = 50) of irradiated male mosquitoes were placed in a separate cage with freshly emerged unirradiated female mosquitoes to evaluate the level of sterility of the eggs from these mosquitoes. …”
Get full text

Characterization of cellular immune system at different ages in water buffalo (Bubalus bubalis) by Maria C. Scata’, Giovanna De Matteis, Francesco Grandoni, Gabriele Di Vuolo, Giovanna Cappelli, Domenico Vecchio

“…The calves showed differences in total monocytes (p=0.0010), cM and ncM subsets (p=0.0335 and p=0.0065), respectively. The heifers showed differences only in the CD21+ B lymphocyte subset (p=0.0439). …”
Get full text