Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. by Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David Pulford, Carlos Cruchaga

“…Polygenic risk scores for AD risk did not reliably stratify fast from slow progressors; however, a deeper investigation found that APOE ε4 status predicts amyloid-β and tau positive versus negative patients (odds ratio for an additional APOE ε4 allele = 5.78 [95% confidence interval: 3.76-8.89], P<0.001) when restricting to a subset of patients with available CSF biomarker data. …”
Get full text

The influence of complexity: a bibliometric analysis of complexity science in healthcare by Jeffrey Braithwaite, Kate Churruca, Louise A Ellis, Chiara Pomare, Janet C Long

“…We also analysed the influence of this body of work through citation and network analyses.Results Articles on complexity science in healthcare were published in 268 journals, though a much smaller subset was responsible for a substantial proportion of this literature. …”
Get full text

A Framework for Coxeter Spectral Classification of Finite Posets and Their Mesh Geometries of Roots by Daniel Simson, Katarzyna Zając

“…In this case, the Coxeter spectrum speccJ is a subset of the unit circle and consists of roots of unity. …”
Get full text

Multiple large language models versus experienced physicians in diagnosing challenging cases with gastrointestinal symptoms by Xintian Yang, Tongxin Li, Han Wang, Rongchun Zhang, Zhi Ni, Na Liu, Huihong Zhai, Jianghai Zhao, Fandong Meng, Zhongyin Zhou, Shanhong Tang, Limei Wang, Xiangping Wang, Hui Luo, Gui Ren, Linhui Zhang, Xiaoyu Kang, Jun Wang, Ning Bo, Xiaoning Yang, Weijie Xue, Xiaoyin Zhang, Ning Chen, Rui Guo, Baiwen Li, Yajun Li, Yaling Liu, Tiantian Zhang, Shuhui Liang, Yong Lv, Yongzhan Nie, Daiming Fan, Lina Zhao, Yanglin Pan

“…The diagnoses by Claude 3.5 Sonnet covered the highest proportion (95% confidence interval [CI]) of instructive diagnoses (76.1%, [70.6%–80.9%]), significantly surpassing all the gastroenterologists (p < 0.05 for all). …”
Get full text

Machine Learning Models for Predicting the Compressive Strength of Concrete with Shredded PET Bottles and M-Sand as Fine Aggregate by Altamashuddinkhan Nadimalla, Siti Aliyyah Masjuki, Abdullah Gubbi, Anjum Khan, Imran Mokashi

“…Machine learning is a critical subset of AI that deliberates the development of self-trained algorithms that use previous databases and analysis for result predictions. …”
Get full text

Yaygın Din Eğitiminde İslam İçi Çoğulculuğun İmkânı: Şırnak Örneği by Mustafa Cabir Altıntaş

“…Böylelikle Kur’an ve sünnet merkezli dini bilgiyi esas alan bir din eğitimi gerçekleştirmek hedeflenmiştir. …”
Get full text

İmâmu’l-Haremeyn el-Cüveynî’nin Bilgi Tanımlarına Yaklaşımı by Muhammed Selim Kaya, Sabri Yılmaz

“…Onun söz konusu eleştirileri incelendiğinde öne çıkan ilk husus, Ehl-i Sünnet âlimlerinin birçoğunda da görüldüğü üzere bilginin tanımına Allah Teâlâ’nın bilgisini dâhil edebilme çabasıdır. …”
Get full text

Inhibiting HnRNP L-mediated alternative splicing of EIF4G1 counteracts immune checkpoint blockade resistance in Castration-resistant prostate Cancer by Xumin Zhou, Shilong Cheng, Zhongjie Chen, Jinming Zhang, Jiaqi Wang, Qiang Li, Xumin Zhou

“…Immunotherapy with checkpoint inhibitors produced significant clinical responses in a subset of cancer patients who were resistant to prior therapies. …”
Get full text

Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART by William Worodria, Marguerite Massinga-Loembe, Harriet Mayanja-Kizza, Jane Namaganda, Andrew Kambugu, Yukari C. Manabe, Luc Kestens, Robert Colebunders

“…Commencement of antiretroviral treatment (ART) in severely immunosuppressed HIV-infected persons is associated with unmasking of subclinical disease. The subset of patients that are diagnosed with tuberculosis (TB) disease while on ART have been classified as ART-associated TB. …”
Get full text

Identification of mitophagy-related key genes and their correlation with immune cell infiltration in acute myocardial infarction via bioinformatics analysis by Zulong Sheng, Rui Zhang, Zhenjun Ji, Zhuyuan Liu, Yaqing Zhou

“…BackgroundAcute myocardial infarction (AMI), a subset of acute coronary syndrome, remains the major cause of mortality worldwide. …”
Get full text

Long-term Clinical Outcomes After Syndesmosis Fixation With K-wires in Ankle Fractures With Syndesmotic Instability by Diogo Vieira Cardoso MD, Filippo Pierobon MD, Anne Lübbeke-Wolff DSc, Victor Dubois-Ferrière MD

“…Conclusion: We report long-term (10.6 ± 3 years) functional outcomes using a validated patient-reported questionnaire in patients who underwent syndesmosis fixation with 2 K-wires for unstable ankle fractures. In the subset of patients we were able to find in follow-up, we found low rates of syndesmosis fixation failure, low pain scores, and excellent functional outcomes. …”
Get full text

A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder (WAD): Part 4 – Noninvasive Interventions for Chronic WAD by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

“…While the majority of a subset of nine studies supported the effectiveness of interdisciplinary interventions, the two randomized controlled trials provided conflicting results. …”
Get full text

Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or witho... by Andrew E. Potter, Christopher Baker, Stephen Shumack, Robert Sinclair, Walter J. Curran, David Christie, Bradley Wong, Peter Foley, Peter O’Brien, Lynda Spelman

“…This analysis included 12-month follow-up data on 89 treated fields from a subset of 83 patients.Results Clinical success (>90% field clearance) was 96% (ESFC, n = 63) and 88% (ESFC with KC, n = 26). …”
Get full text

Rare Cell Population Analysis in Early-Stage Breast Cancer Patients by Stefan Schreier, Prapaphan Budchart, Suparerk Borwornpinyo, Lakkana Adireklarpwong, Prakasit Chirappapha, Wannapong Triampo, Panuwat Lertsithichai

“…Circulating epithelial and endothelial-like cell subsets have been demonstrated to be associated with or independent of cancer with tumor presence. …”
Get full text

Identifying the Minimal Clinically Important Difference in Emotion Regulation Among Youth Using the JoyPop App: Survey Study by Jaidyn Charlton, Ishaq Malik, Angela M Ashley, Amanda Newton, Elaine Toombs, Fred Schmidt, Janine V Olthuis, Kristine Stasiuk, Tina Bobinski, Aislin Mushquash

“…ObjectiveThis study aims to calculate the MCID for youth using the JoyPop app and to explore how the MCID may differ for a subset of Indigenous youth. MethodsYouth (N=36; aged 12-18 years) were recruited to use the JoyPop app for up to 4 weeks as part of a larger pilot evaluation. …”
Get full text

Definition of Triangular Norms and Triangular Conorms on Subfamilies of Type-2 Fuzzy Sets by Pablo Hernández-Varela, Francisco Javier Talavera, Susana Cubillo, Carmen Torres-Blanc, Jorge Elorza

“…In particular, we define these new operators on the subsets of the functions that are convex, normal, and normal and convex, as well as the functions taking only the values 0 or 1 and the subset of functions whose support is a finite union of closed intervals. …”
Get full text

Epigenetic Biomarkers and the Wnt/β-Catenin Pathway in Opisthorchis viverrini-associated Cholangiocarcinoma: A Scoping Review on Therapeutic Opportunities. by Alok Kafle, Sutas Suttiprapa, Mubarak Muhammad, Jan Clyden B Tenorio, Roshan Kumar Mahato, Norhidayu Sahimin, Shih Keng Loong

“…Within these, 11 studies specifically explored Ov-CCA tissues to investigate potential epigenetic biomarkers and therapeutic targets. This subset of 11 articles provided a foundation for exploring the applications of epigenetics-based therapies and biomarkers for Ov-CCA. …”
Get full text

New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite by Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar, Abeer S. Elsherbiny

“…Recent research indicates that malignant tumors are highly variable and consist of a tiny subset of unique cancer cells, known as cancer stem cells (CSCs), which are responsible for the beginning and spread of tumors. …”
Get full text

Stem Cells in Solid Tumors: Accumulated Evidence and Future Directions by Deepthi Venkatachalapathy, Parveen Doddamani, Aradya V Hirriyannaiah, Prashant Vishwanath, Suma Nataraj, Akila Prashant

“…These represent a minority subset of cells within a tumor, believed to orchestrate the relentless growth of the entire tumor. …”
Get full text

LUCY MAUD MONTGOMERY’NİN “YEŞİL’İN KIZI” ADLI KİTABININ YAZIN ÇEVİRİSİ VE MAKİNE ÇEVİRİSİ ÇERÇEVESİNDE KARŞILAŞTIRMALI İNCELENMESİ by Rabia Aksoy Arıkan

“…Ayrıca bu ça¬lışma makine çevirisine yönelik güncel teknolojik çalışmalarda yazın çevirilerinin nasıl daha iyi yapılabileceği sorusuna cevap bulma amacı da taşımaktadır. …”
Get full text