Accurate identification of snoRNA targets using variational graph autoencoder to advance the redevelopment of traditional medicines by Zhina Wang, Zhina Wang, Yangyuan Chen, Hongming Ma, Hongming Ma, Hong Gao, Hong Gao, Yangbin Zhu, Hongwu Wang, Nan Zhang, Nan Zhang

“…Case studies revealed that snoRNA SNORA21 and SNORD33 are abnormally expressed in lung cancer patients and are strong candidates for potential therapeutic targets. …”
Get full text

Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain by Darine Villela, Claudia K. Suemoto, Renata Leite, Carlos Augusto Pasqualucci, Lea T. Grinberg, Peter Pearson, Carla Rosenberg

“…Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs). …”
Get full text

Re-Structuring Evaluation Findings into Useful Knowledge by Danielle Houston, Bernadette Wright, Steven E. Wallis

“…Building on that research, the authors applied Integrative Proposition Analysis to visualize, integrate, and assess the quality and usefulness of knowledge gained from the NMAC (formerly National Minority AIDS Council) Strong Communities evaluation. Purpose: Demonstrate an innovative method to rigorously integrate and strengthen knowledge gained from evaluation and to encourage discussion of future directions for developing stronger theories for more effective evaluation and more effective action. …”
Get full text

Numerical modelling of erosional landforms driven by offshore groundwater flow on siliciclastic continental margins: a conceptual approach by Shubhangi Gupta, Shubhangi Gupta, Aaron Micallef

“…Field observations from siliciclastic margins suggest strong causal links between sub-seafloor OFG flow and seafloor depressions, canyons and landslide scars. …”
Get full text

G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells by Chiao-Chun Liao, Yuqing Long, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Chia-Hwa Lee

“…Notably, the G-cleave LC3B biosensor exhibited strong concordance with established autophagy metrics, encompassing LC3B lipidation, SQSTM1 degradation, and puncta accumulation analysis. …”
Get full text

The relationship between principals’ pedagogical leadership practices and teachers’ job performance: the role of sociodemographic characteristics by Kelemu Zelalem Berhanu

“…Findings Consequently, there were strong and moderate correlations between teachers’ job performance and pedagogical leadership. …”
Get full text

Predicting turbidity dynamics in small reservoirs in central Kenya using remote sensing and machine learning by Stefanie Steinbach, Anna Bartels, Andreas Rienow, Bartholomew Thiong’o Kuria, Sander Jaap Zwart, Andrew Nelson

“…Random forest and gradient boosting models showed that annual turbidity outcomes depend on meteorological variables, topography, and land cover (R2 = 0.46 and 0.43 respectively), while longer-term turbidity was influenced more strongly by land management and land cover (R2 = 0.88 and 0.72 respectively). …”
Get full text

Comparative Evaluation of Salt Tolerance in Four Self-Rooted Hazelnut (<i>Corylus avellana</i> L. and <i>Corylus americana</i> Walter) Cultivars by Xavier Rius-Garcia, María Videgain-Marco, José Casanova-Gascón, Luis Acuña-Rello, Pablo Martín-Ramos

“…Barcelona showed moderate tolerance at lower salinity levels but declined sharply under higher stress. Yamhill exhibited a strong survival capacity despite its poor photosynthetic performance, while Tonda Gentile Romana proved most sensitive to salinity stress. …”
Get full text

Case report: 10-year follow-up of a patient with neuronal intranuclear inclusion disease and a literature review by Kenji Yoshida, Tomotsugu Kaga, Sachiko Hosoyama, Jun-ichi Niwa, Jun Sone, Naoki Mabuchi

“…Our report highlights that DWI signal changes are strongly correlated with the clinical manifestations of NIID.…”
Get full text

Core-genome guided novel therapeutic targets identification and chimeric vaccine designing against Rickettsia rickettsii by Fizza Arshad, Asifa Sarfraz, Muhammad Shehroz, Umar Nishan, Asia Perveen, Riaz Ullah, Mohamed A. Ibrahim, Mohibullah Shah

“…Their capacity to trigger strong humoral and cellular immunological responses was further demonstrated by in silico immune simulations. …”
Get full text

Characteristics of Traffic Accidents on Highways: An Analysis Based on Patients Treated at a Regional Trauma Center by Sung Yong Lee, Kyung Hoon Sun, Chan Yong Park, Tae Hoon Kim

“…The incidence of traffic accidents was strongly influenced by meteorological conditions (rain, snow/ice, and fog).…”
Get full text

Impact and optimization of vehicle charging scheduling on regional clean energy power supply network management by Penghui Xu, Xiaobo Wang, Zhichao Li

“…In particular, the demand forecasting model based on machine learning effectively solves the dilemma of matching the charging load with a clean energy supply. Experimental data strongly confirms that the optimization strategy has led to a 15% reduction in peak load on the grid, a 23% increase in the proportion of clean energy consumption, and a 10% reduction in total electricity consumption. …”
Get full text

EXPERIENCES OF CONDUCTING ONLINE EXAM PROCTORING IN LOW-RESOURCE SETTINGS: A SRI LANKAN CASE STUDY by Dilky N. Felsinger, Thilina Halloluwa, C. L. Ishani Fonseka

“…This paper presents evidence of the experiment that strongly recommends that online exam proctoring solutions be developed after a careful examination of the constraints such as internet connection speed, stability, and affordability, as well as sudden power outages of the environment in which they will be utilised, in order to unlock the true potential of e-learning technologies. …”
Get full text

Association between prognostic nutritional index and all-cause mortality and cardiovascular disease mortality in American adults with non-alcoholic fatty liver disease by Yuqing Lei, Shaohong Tao, Yubo Yang, Fang Xie, Weining Xie

“…Time-dependent ROC analysis highlighted the strong predictive performance of PNI across various time points.ConclusionPNI played a significant role as an effective predictor of prognosis in individuals diagnosed with NAFLD.…”
Get full text

D-dimer as a predictor of severity and outcome in acute pancreatitis by Joseph A, Harikrishnan CP, Oommen AN, Nair A

“…Specifically, D-dimer levels ≥2528 ng/L were strongly associated with severe acute pancreatitis (SAP), while levels ≤1871 ng/L were primarily linked to mild cases. …”
Get full text

Probiotic Potential and Enhanced Adhesion of Fermented Foods-Isolated Lactic Acid Bacteria to Intestinal Epithelial Caco-2 and HT-29 Cells by Eun Ah Sim, Seon-Young Kim, SangNam Kim, Eun-Gyung Mun

“…Their combination (JAMI_LB_02 + JAMI_LB_05) significantly enhanced adhesion to 18.57 ± 5.49% on Caco-2 and 21.67 ± 8.19% on HT-29 cells, demonstrating strong synergy. These findings highlight the probiotic potential of the isolated LAB strains, particularly in mixed formulations, which may improve intestinal survival, adaptability, and efficacy. …”
Get full text

Imaging the large‐scale and cellular response to focal traumatic brain injury in mouse neocortex by Yelena Bibineyshvili, Thomas J. Vajtay, Shiva Salsabilian, Nicholas Fliss, Aastha Suvarnakar, Jennifer Fang, Shavonne Teng, Janet Alder, Laleh Najafizadeh, David J. Margolis

“…Correspondingly, two‐photon calcium imaging in the primary somatosensory cortex (S1) found strong activation of neuropil and neuronal populations during the CCI‐induced travelling wave. …”
Get full text

An Evidence-Based Update on the Impact of Local Antimicrobials as Adjunct to Periodontal Therapy by Nabaz Yahya Hussein, Sadat Abdulla Aziz, Twana Mohammed M. Ways, Omed Amiri, Hisham Al-Obaidi, Dianne Ford

“…CHX demonstrated the greatest clinical improvement due to its broad-spectrum antimicrobial activity, strong substantivity, and its application in sustained-release formulations. …”
Get full text

Goal-Setting of Modern Students: Inverse Analysis by D. A. Sevostyanov, A. R. Gainanova

“…In particular, it was found that narrow social motives related to personal and / or family well-being strongly prevail in the goal-setting of students over broad social motives, as well as over cognitive and research motives. …”
Get full text

Identification of phytophthora blight resistance of different pepper inbred lines and correlation analysis of plant functional traits by YANG Kaiwei, ZHOU Yingying, DU Jiao, JIANG Pan, LUO Gongwen, OU Lijun

“…[Conclusions] The results demonstrate that eight inbred lines (‘RT19-248’, ‘RC17-555’, ‘YJ-24’, ‘NJ- 07’, ‘702’, ‘298a’, ‘CF19’, and ‘CF20’) possess the potential to serve as parental sources for developing highly blight-resistant pepper varieties. Strong stalks, vigorous growth, and low nitrogen tolerance are the preliminary identification criteria of pepper varieties with high blight-resistance.…”
Get full text