Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…BpAbs bind two independent epitopes on the same antigen, which allows fine-tuning of mechanisms of action, including enhancement of on-target specificity and induction of strong antigen clustering due to the unique binding mode. …”
Get full text

Histological and immune response in the fish Centropomus viridis elicited by the parasite Rhabdosynochus viridisi by Dania López-Moreno, Zeinab Yazdi, Francisco N. Morales-Serna, Juan M. Martínez-Brown, Leonardo Ibarra-Castro, Alejandra García-Gasca, Selene M. Abad-Rosales, Rodolfo Lozano-Olvera, Emma J. Fajer-Ávila, Esteban Soto

“…As showed by the decrease of the intensity of infection from Time 1 to Time 2, it seems that the PWS is able to combat R. viridisi; however, our immunological analysis did not reveal strong evidence of a possible mechanism. …”
Get full text

Optimization of Preparation Process and Antioxidant Activity of Kidney Bean-Haskap Composite Fermentation Liquid by Jia WANG, Fangli DING, Yu AN, Xueying ZENG, Zhihui ZHANG, Sinan LI, Kaiyuan XU, Fang ZHOU, Ying WANG, Lu ZHANG, Bingzheng XU, Zekun SUN

“…The optimal process parameters resulted in a strong antioxidant capacity in the composite fermentation liquid of kidney bean and haskap.…”
Get full text

Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of (<i>Z</i>)-5-Benzylidene-2-(naphthalen-1-ylamino)thiazol-4(5<i>H</i>)-one Analogs: In Vitro and In Vivo Insight... by Hee Jin Jung, Hye Jin Kim, Hyeon Seo Park, Hye Soo Park, Jeongin Ko, Dahye Yoon, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon

“…Compounds <b>8</b> and <b>10</b> exhibited strong antioxidant capacities, scavenging 2,2-diphenyl-1-picrylhydrazyl, (2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid)⁺ radicals, and reactive oxygen species. …”
Get full text

Retrospectively understanding the multifaceted interplay of COVID-19 outbreak, air pollution, and sociodemographic factors through explainable AI by Mohmmed Talib, Kripabandhu Ghosh, Gopala Krishna Darbha

“…The study concluded distinct COVID-19 transmission patterns across regions and pandemic phases, highlighting the influence of non-pharmaceutical interventions, viral strains, and socio-demographics in driving the pandemic.The findings highlight the need for strong pollution controls to mitigate air pollution's impact on health. …”
Get full text

Assessing the dynamics of  Mycobacterium bovis infection in three French badger populations by Calenge, Clément, Payne, Ariane, Réveillaud, Édouard, Richomme, Céline, Girard, Sébastien, Desvaux, Stéphanie

“…In all the clusters, the infection was strongly spatially structured, whereas the mean correlation between the infection status of the animals trapped in the same commune was negligible. …”
Get full text

Clostridium Difficile and COVID-19: Novel Risk Factors for Acute Portal Vein Thrombosis by Venkata Ram Pradeep Rokkam, Gurusaravanan Kutti Sridharan, Rathnamitreyee Vegunta, Radhakrishna Vegunta, Umesha Boregowda, Babu P. Mohan

“…During the current pandemic, clinicians should strongly consider abdominal imaging in patients presenting with abdominal pain due to clostridium difficile infection in the setting of COVID-19 to rule out complications such as portal vein thrombosis. …”
Get full text

Autoencoder Reconstruction of Cosmological Microlensing Magnification Maps by Somayeh Khakpash, Federica B. Bianco, Georgios Vernardos, Gregory Dobler, Charles Keeton

“…Enhanced modeling of microlensing variations in light curves of strongly lensed quasars improves measurements of cosmological time delays, the Hubble Constant, and quasar structure. …”
Get full text

Wireless Sensor Network Optimization for Constrained Environments With Limited a Priori Target Information by Joseph Mockler, Sarah Wielgosz, Huan Xu

“…Because estimation performance is strongly dependent on sensor-target relative positions, many analytically optimal expressions for sensor positions have been constructed as a function of target locations under ideal circumstance. …”
Get full text

Phenotypic Variation in Fruit Morphology among Provenances of Sclerocarya birrea (A. Rich.) Hochst. by Idah Mkwezalamba, Chimuleke R. Y. Munthali, Edward Missanjo

“…However, there were significant (P<0.05) and strong positive relationships between fruit weight and pulp weight (r=0.987) and fruit length and diameter (r=0.775). …”
Get full text

Converting the sociotechnical convergence hazards into the risks of digitalisation by V. V. Zotov, I. A. Aseeva, V. G. Budanov, V. A. Belkina

“…The authors come to the conclusion that not all hazards are converted into risks in the same way. Strongly expressed explicit risks are observed as a result of converting the hazard of unauthorized use of personal data. …”
Get full text

Multidrug Resistance and Plasmid Profiles of Escherichia coli Isolated from Lebanese Broiler Farms by Houssam Shaib, Paul Aoun, Ahmad Ghaddar, Hamza Al Labadi, Youssef Obeid

“…Nevertheless, the presence of specific plasmids, namely, the 2.2 or 7.7 kbp sized ones, was strongly correlated to Quinolones or Trimethoprim resistance, respectively. …”
Get full text

Thermospheric Neutral Density Variation During the “SpaceX” Storm: Implications From Physics‐Based Whole Geospace Modeling by Dong Lin, Wenbin Wang, Katherine Garcia‐Sage, Jia Yue, Viacheslav Merkin, Joseph M. McInerney, Kevin Pham, Kareem Sorathia

“…Thermospheric mass density strongly depends on the strength, timing, and location of high‐latitude energy input, which cannot be fully reproduced with empirical models. …”
Get full text

Implications for cost and access of site-of-service referrals for ancillary medical services in a US Medicaid population: analysis of claims data from Maryland, USA by Maqbool Dada, Simrita Singh, Kelsey J Rydland, Chester Chambers, Vishal Mundlye, Edward Kumian, Kayode Ayodele Williams

“…We used location-allocation optimisation models to find the optimal sites to minimise net costs.Setting Coverage area included Medicaid patients throughout the state of Maryland.Participants All rural and urban members of this Medicaid cohort.Primary and secondary outcome measures Change in payer costs and member travel times on shifting ancillary bundles from regulated to unregulated sites.Results Procedure cost and travel time differentials between regulated and unregulated sites strongly correlated with the percentage of procedures referred to regulated sites. …”
Get full text

Layered Babinet complementary patterns acting as asymmetric negative index metamaterial by Emese Tóth, Olivér A. Fekete, Balázs Bánhelyi, Maxim Durach, Zsolt Szabó, Mária Csete

“…The negative index material (NIM) phenomenon is accompanied by electric multipoles that add up non-radiatively and correlates with the strong, pronouncedly-tilted, rotating magnetic dipoles characteristic on the nano-entities, where the outgoing waves are linearly (slightly elliptically) polarized. …”
Get full text

The Impact of Astaxanthin Supplementation on the Lipid Profile by Filip Arczewski, Michalina Wójcikiewicz, Witold Czyż, Julia Kacperczyk, Karol Dziedzic, Marta Chuncia, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Ryniecka, Wiktor Czaja, Michał Krzciuk

“… Astaxanthin (AST) is a carotenoid renowned for its strong antioxidant properties and its role as a pigment in various aquatic organisms. …”
Get full text

MXenes in biosensing: Enhancing sensitivity and flexibility – A review of properties, applications, and future directions by Ali Mohammad Amani, Lobat Tayebi, Ehsan Vafa, Alireza Jahanbin, Milad Abbasi, Ahmad Vaez, Hesam Kamyab, Lalitha Gnanasekaran, Shreeshivadasan Chelliapan

“…These materials, made from transition metal nitrides, carbides, or carbonitrides, have a number of advantages, including high hydrophilicity, a large surface area, strong metallic conductivity, superior ion transport capabilities, biocompatibility, and low diffusion barriers. …”
Get full text

The Importance of Upper Body Strength Testing and Training For Performance of High-Intensity Actions in Professional Soccer Players: A Survey Exploring Perceptions and Current Prac... by Ivan Curovic, David Grecic, David Rhodes, Jill Alexander, Damian James Harper

“…Relative to “not important” options, UB strength was perceived as important for all HIA, especially for jumping (89%) and acceleration (87%). Coaches strongly supported the idea that UB strength plays a role in enhancing HIA, with particular influence on jumping (100%), acceleration (97%) and COD (93%). …”
Get full text

A Novel Multi-Attribute Decision-Making Method for Supplier Selection in the Health Care Industry Using Cosine Similarity Measures of Single-Valued Neutrosophic Cubic Hypersoft Set... by Muhammad Sajid, Khuram Ali Khan, Jaroslav Frnda, Atiqe Ur Rahman

“…The results of the ranking technique are strongly influenced by the weights given to the attributes. …”
Get full text

First density estimates of the Endangered Claire's mouse lemur Microcebus mamiratra and recommendations for its conservation by Luke D. Martin, Herison Razafimanantsoa, Eva S. Nomenjanahary, Sylviane Volampeno, Alison M. Behie

“…We present recommendations for the conservation of M. mamiratra and highlight the potential for lemur watching, sustained by the strong tourism industry on Nosy Be, to help protect lemur habitat and generate economic opportunities for local communities.…”
Get full text