Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…Finally, DW18343 was shown to be an activator of both the innate and adaptive antitumor immunity in tumor tissue, potentially explaining its strong antitumor effects in vivo. In conclusion, DW18343 serves as a novel non‐nucleotide STING agonist with systemic antitumor effect through the activation of antitumor immunity.…”
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Adapting amidst adversity: investigating medical educators’ attitudes towards change and resilience in the face of educational barriers during COVID-19 pandemic by Laleh Khojasteh, Zahra Karimian, Elham Nasiri, Reza Kafipour

“…A researcher-made questionnaire, including 36 items in eight components, was designed to assess the teachers’ resilience to educational barriers.ResultsBased on findings, teachers’ attitudes towards change were moderate in the affective and behavioral aspects but strongly positive in the cognitive aspect (p < 0.001). …”
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Fast anomalous traffic detection system for secure vehicular communications by Qasem Abu Al-Haija, Abdulaziz A. Alsulami

“…These assaults might confuse original electronic control units (ECUs) or cause system failures, emphasizing the need for strong cybersecurity solutions in automobile networks. …”
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Costa cantábrica (Santillana del Mar, España) (2019) by Alberto Cabrerizo

“…Costa cantábrica (Santillana del Mar, Spain) (2019) This picture was taken on December 9, 2019 in the beach Santa Justa, that belongs to Santillana del Mar municipality, on the coast of Cantabria. The sea beats strongly against the coastal relief made of dipped strata and erodes the coast, making vertical forms. …”
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Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advan... by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…Further clinical study of PPV would be warranted for HCV-positive advanced HCC, based on the safety and strong immune induction.…”
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Critical Analysis on the Structural and Magnetic Properties of Bulk and Nanocrystalline Cu-Fe-O by D. Paul Joseph, C. Venkateswaran, R. Selva Vennila

“…From the absence of any strong new peaks at high pressure, it is evident that the secondary phases if present could be less than the level of detection. …”
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Exposure to Volatile Organic Compounds in Relation to Visceral Adiposity Index and Lipid Accumulation Product Among U.S. Adults: NHANES 2011–2018 by Ziyi Qian, Chenxu Dai, Siyan Chen, Linjie Yang, Xia Huo

“…Our findings suggest that VOC exposure is strongly associated with visceral obesity indicators. …”
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A simulation study to quantitatively assess the performance of electronic prescribing systems in English NHS Hospital Trusts by Stephanie Klein, Athanasios Tsanas, Jamie Coleman, Rebecca Osselton, Jude Heed, Ann Slee, Neil Watson

“…Moreover, we found that mitigation performance varied considerably across NHS Trusts using the same EP system, strongly suggesting there are opportunities to optimise performance within systems. …”
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The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients by Li Wang, Yingjun Kong, Yao Zhang, Chuanyong Mu

“…Results: In ALK positive patients, the PD-L1 positivity rate was 59.8 %, with 19.2 % showing strong positivity. PD-L1 positive patients were predominantly male, over 55 years old, and presented more clinical symptoms, higher Ki-67 expression, larger tumor sizes, and more advanced disease stages. …”
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Interrogating the global application of e-certification of seafarers by Margie Mendoza Mataac, Michael Ekow Manuel, Anne Pazaver

“…It also identified various challenges to global application along with potential solutions. Despite the strong industry support for the entire replacement of seafarers’ traditional printed certificates with e-certificates, the study concludes that the coexistence of both formats will persist until crucial challenges are effectively addressed. …”
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Strengthening and toughening an ultra-high strength medium Mn steel by fibrous ferrite bridging mechanism by Chao Zhang, Qian Cheng, Bo Yang, Wuli Su, Xue Chen, Qingyuan Wang, Wenquan Cao, Chongxiang Huang

“…In this work, an ultra-strong medium Mn steel with hard martensite as the matrix and a large number of uniformly distributed long and coarse soft fibrous ferrites embedded within it had been designed. …”
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Hydrogeochemical characterization and water quality assessment of mountain springs: Insights for strategizing water management in the lesser Indian Himalayas by Bhargabnanda Dass, M. Someshwar Rao, Sumit Sen

“…New hydrological insights for the region: Results reveal strong spatio-temporal variations in spring aquifer chemistry, primarily influenced by silica degradation and groundwater mixing, with secondary effects from ion-exchange and anthropogenic activities. …”
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Deciphering the Molecular Mechanism of Peracetic Acid Response in Listeria monocytogenes by Marianna Arvaniti, Ahmed Gaballa, Renato H. Orsi, Panagiotis Skandamis, Martin Wiedmann

“…Peracetic acid (PAA), a strong oxidizing agent, has been widely used as a disinfectant in food processing settings as it does not produce harmful chlorinated by-products. …”
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STUDENTS' PERCEPTIONS AND MOTIVATION TOWARD E-LEARNING AT AKM HIGH SCHOOL DURING THE COVID-19 PANDEMIC by Nur Fitria Anggrisia, M. Fadel Ihza Islami

“…Notably, 44.5% of students felt that e-learning improved their English skills, with 41.7% strongly agreeing that teachers facilitated productive question-and-answer sessions. …”
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Household farms facing barriers in indigenous knowledge-based adaptation to extreme climatic events — Evidence from the Huangshui Basin by Hailin Zhang, Jinyan Zhan, Zheng Yang, Huihui Wang, Naikang Xu, Chunyue Bai, Yufei He, Yuhan Cao

“…Rural households face strong barriers in adaption, and food production is seriously threatened. …”
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The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance by Katharina Otten, J. Christopher Edgar, Heather L. Green, Kylie Mol, Marybeth McNamee, Emily S. Kuschner, Mina Kim, Song Liu, Hao Huang, Marisa Nordt, Kerstin Konrad, Yuhan Chen

“…The N1m-to-P1m amplitude also exhibited a non-linear decrease, with strong responses observed in younger infants (∼2–3 months) and then a gradual decline. …”
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Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice by Hesham Haffez, Rehab Hosni, Shady A. Swidan, Hatem K. Amin

“…Results: BCSO reduced LPS-induced liver injury and exhibited strong anti-inflammatory effects by downregulating the expression of TLR4, IL-1β, IL-6, tumor necrosis factor-α, and heme-oxygenase 1. …”
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Evaluation of Cross-Border Transport Connectivity and Analysis of Spatial Patterns in Latin America by Changqi Miao, Yinbao Zhang, Xinjia Zhang, Jianzhong Liu, Shike Zhang

“…The overall connectivity of Latin America was low, and the overall development was unbalanced, with a strong law of spatial differentiation, which was mainly manifested in the strongest connectivity of the integrated coastal countries, followed by the island countries, and the lowest connectivity of the landlocked countries. …”
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Adaptive compensation for multi-axial real-time hybrid simulation via nonlinear parameter estimation by Santiago Ruiz, Wei Song

“…Extensive simulations on the maRTHS incorporating various earthquake inputs, sensor noise, and model uncertainties, demonstrated an excellent tracking performance and strong robustness across four parameter estimation cases (EKF-TF, UKF-TF, EKF-SS, and UKF-SS). …”
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Intraocular Pressure and Anterior Segment Morphometry Changes after Uneventful Phacoemulsification in Type 2 Diabetic and Nondiabetic Patients by João N. Beato, David Reis, João Esteves-Leandro, Manuel Falcão, Vítor Rosas, Ângela Carneiro, Fernando Falcão Reis

“…Nonglaucomatous eyes with open-angles from both type 2 diabetic and nondiabetic patients experienced similar AS changes and IOP reductions following uneventful phacoemulsification, and this IOP-lowering effect was strongly correlated with preoperative IOP.…”
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