Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies by Lidia Ślusarczyk, Klaudia Rząd, Grzegorz Niedzielski, Mikołaj Gurba, Jose Chavez, Luca Ceresa, Joe Kimball, Ignacy Gryczyński, Zygmunt Gryczyński, Mariusz Gagoś, James Hooper, Arkadiusz Matwijczuk

“…We previously reported the strong synergism of this molecular system and now wish to present related stationary measurements of UV-Vis absorption, fluorescence, and fluorescence anisotropy in a polar, aprotic solvent (DMSO and a PBS buffer), followed by time-resolved fluorescence intensity and anisotropy decay studies using different ratios of the selected 1,3,4-thiadiazole derivative to Amphotericin B. …”
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Streamflow and sediment simulation in the Song River basin using the SWAT model by Shams Quamar, Pradeep Kumar, Harendra Prasad Singh

“…The calibration results indicated a strong fit, with R2 values of 0.77, NSE of 0.70, and PBIAS of 17.06, demonstrating good agreement between observed and simulated streamflow. …”
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Impact investments opportunities and limitations by N. V. Aksakova

“…The paper has also confirmed that the identified perspectives and limitations show a strong interconnection and influence on each other, which is important for a full and deep understanding of the role and significance of impact investing in the contemporary context.…”
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Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults by Gilberto Santos Morais Junior, Diego Ignacio Valenzuela Perez, Audrey Cecília Tonet-Furioso, Lucy Gomes, Karla Helena Coelho Vilaça, Vicente Paulo Alves, Clayton Franco Moraes, Otávio Toledo Nóbrega

“…Conclusions. Our study shows a strong negative correlation of IL-6 levels with Fried’s frailty components of grip strength and walk speed in very old adults, regardless of confounding factors.…”
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Effects of therapeutic alliance on patients with major depressive disorder: a literature review by Giovanni Videtta, Silvia Busilacchi, Giulia Bartoccioni, Luisa Cirella, Ylenia Barone, Giuseppe Delvecchio

“…Seven of the reviewed studies highlighted that therapeutic alliance is a strong predictor of clinical outcomes, contributing to symptom improvement, relapse prevention, and more adaptive functioning in patients with MDD. …”
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Multi-faceted examination of a deepwater seamount reveals ecological patterns among coral and sponge communities in the equatorial Pacific by Brian RC Kennedy, Steven Auscavitch, Timothy M. Shank, Constance Sartor, Anameere Tennaba, Alexis M. Weinnig, Randi D. Rotjan

“…Waters below 500 m hosted communities predominantly composed of octocorals, however, several coral taxa showed seamount flank preference (higher abundance on one or more flanks than the others) even though strong vertical (depth) zonation of corals and sponges was observed on all flanks. …”
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Intelligent Prediction of Flood Disaster Risk Levels Based on Knowledge Graph and Graph Neural Networks by Peisheng Yang, Xiaohua Xu, Meilan Shao, Yewei Liu

“…Additionally, statistical analysis of flood disaster warning levels and flash flood risk zoning across cities in Jiangxi Province provides a visual representation of flood risk distribution and risk level proportions in different cities, offering strong reference for flood prevention, disaster mitigation, and urban planning. …”
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Kinematic Rupture Process of Manyas (Mw=4.7) and Gemlik (Mw=4.8) Earthquakes Occurred in The Southern Marmara Region by Feyza Nur Bekler, Nurcan Meral Özel, Gülüm Tanırcan

“…Multi time-window linear waveform inversion technique (MTWIT) was applied to strong ground motion (SGM) data. Theoretical Green’s functions between subfaults and stations were calculated by a Discrete Wave Number Method (DWNM) using one-dimensional (1-D) velocity structure. …”
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FARMERS RELUCTANCE TO USING PROTECTED CULTIVATION IN BAGHDAD PROVINCE AND WAYS TO ADDRESS IT by A. H. Ali, S. O. Fayyadh

“…To measure these reasons and treatments, a four-level scale was developed, consisting of four levels according to the importance (strongly agree, agree, somewhat agree and disagree). …”
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MACEDONIAN NATIONAL INNOVATION SYSTEM – MAIN CHALLENGES by Radmil Polenakovik, Ivana Stankovska, Bojan R. Jovanovski

“…This process was accompanied by disintegration of many large industrial complexes, leading to a large number of bankruptcies and lay-offs. The existing strong governmental support for the scientific and research projects in the Federation was disrupted and disabled by these rapid changes, which was also reflected in the breakdown of direct links between academia and industry. …”
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Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking by Maheswata Sahoo, Lingaraja Jena, Surya Narayan Rath, Satish Kumar

“…Furthermore, among 13 natural compounds, theaflavin, found in green tea, was observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Hence, it may be of interest to consider theaflavin for further in vitro and in vivo evaluation.…”
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Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock by David A. C. Messerer, Stephanie Denk, Karl J. Föhr, Rebecca Halbgebauer, Christian K. Braun, Felix Hönes, Julia Harant, Michael Fauler, Manfred Frick, Benedikt L. Nußbaum, Peter Radermacher, Sebastian Hafner, Markus S. Huber-Lang

“…PMN showed a significant dose- and time-dependent depolarization in response to C5a with a strong response after one minute. The chemotactic peptide fMLP also evoked a significant shift in the membrane potential of PMN. …”
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Excess Weight and Body Fat Percentage Associated with Waist Circumference as a Cardiometabolic Risk Factor in University Students by Roberto E. Nuñez-Leyva, Tabita E. Lozano-López, Yaquelin E. Calizaya-Milla, Sergio E. Calizaya-Milla, Jacksaint Saintila

“…Also, excess body weight (OR, 17.28; 95% CI, 13.21, 22.59) and a high %BF (OR, 4.55; 95% CI, 3.55, 5.84) were strongly associated with CMR. Conclusion. CMRs are a public health problem among university students. …”
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Short-term growth, movement and response of European eel Anguilla anguilla to re-meandering of a small English chalk stream by Champkin James D., Bašić Tea, Haubrock Phillip J., Balzani Paride, Sayer Carl D., George Laura K., Godard Michael J., Vilizzi Lorenzo, Copp Gordon H.

“…In recent decades, the population of European eel Anguilla anguilla has strongly declined and the stock is outside safe biological limits. …”
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Novel method for classification of prion diseases by detecting PrPres signal patterns from formalin-fixed paraffin-embedded samples by Sachiko Koyama, Kaoru Yagita, Hideomi Hamasaki, Hideko Noguchi, Masahiro Shijo, Kosuke Matsuzono, Kei-Ichiro Takase, Keita Kai, Shin-Ichi Aishima, Kyoko Itoh, Toshiharu Ninomiya, Naokazu Sasagasako, Hiroyuki Honda

“…In sCJD, a pronounced PrPres signal was observed, with antibodies specific for type 1 and type 2 PrPres exhibited a strong or weak signals depending on the case. Histological examination of serial sections revealed that the histological changes were compatible with the biochemical characteristics. …”
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Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways by Ciprian Pușcașu, Corina Andrei, Octavian Tudorel Olaru, Anca Zanfirescu

“…GPR40, activated by long-chain fatty acids, exhibits strong anti-inflammatory effects by reducing cytokine expression. …”
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miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years by Frank Tacke, Martina E. Spehlmann, Mihael Vucur, Fabian Benz, Mark Luedde, David Vargas Cardenas, Sanchari Roy, Sven Loosen, Hans-Joerg Hippe, Norbert Frey, Christian Trautwein, Alexander Koch, Christoph Roderburg, Tom Luedde

“…Intriguingly, when patients were subdivided according to their age upon admission to the ICU into those younger than 65 years, lower levels of miR-155 turned out as a strong marker, indicating patient mortality with a similar accuracy than other markers frequently used to evaluate critically ill patients on a medical ICU. …”
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Lessons from the Virtual Delivery of Building Information Modelling Modules in the COVID-19 Era by Fonbeyin Henry Abanda, Avar Almukhtar, Mark Austin

“…This has been further exacerbated by the outbreak of COVID-19 whereby the adoption of virtual teaching techniques in higher education has been strongly recommended. However, since the outbreak, in December 2019, there has been a paucity of research with regards to experiences with the virtual delivery of BIM. …”
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Identification of Salvia miltiorrhiza germplasm resources based on metabolomics and DNA barcoding by Gaojie He, Jinhui Man, Ying Chen, Xiaoqin Zhang, Xin Wang, Kelu An, Laha Amu, Wenqin Chen, Baowei Wang, Yue Shi, Yue Shi, Xiaohui Wang, Xiaohui Wang, Shengli Wei, Shengli Wei

“…The findings provide strong scientific evidence for the clinical safety of S. miltiorrhiza, emphasizing the importance of proper cultivation, selection, and breeding of varieties.…”
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SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration by Zhen-Zhen Guo, Qun-An Cao, Zong-Zhuang Li, Li-Ping Liu, Zhi Zhang, Ya-Juan Zhu, Guang Chu, Qiu-Yan Dai

“…In vitro, nicotine induced the expression of MCP-1 and RANTES in both RAW264.7 (mouse macrophage) and MOVAS (mouse vascular smooth muscle) cells in a dose-dependent manner; expression was upregulated by 0.5 ng/mL nicotine but strongly downregulated by 500 ng/mL nicotine. SP600125 attenuated the upregulation of MCP-1 and RANTES expression and subsequent macrophage migration. …”
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