Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer’s disease by Hua-xiong Zhang, Dilmurat Hamit, Qing Li, Xiao Hu, San-feng Li, Fu Xu, Ming-yuan Wang, Guo-qing Bao, Hong-yan Li

“…Finally, we discovered that all biomarkers could bind to MLT with a strong binding energy. Conclusion: Our study identified three novel biomarkers related to MLT for AD, namely, GPRC5B, NFKBIA and RASSF4, providing a novel approach for the investigation and treatment of AD patients.…”
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Novel models based on machine learning to predict the prognosis of metaplastic breast cancer by Yinghui Zhang, Wenxin An, Cong Wang, Xiaolei Liu, Qihong Zhang, Yue Zhang, Shaoqiang Cheng

“…Furthermore, the CatBoost model maintains strong performance in an external independent dataset, with AUC values of 0.937 for 1-year survival, 0.907 for 3-year survival, and 0.890 for 5-year survival, respectively. …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…Ccr8 is also expressed by dysfunctional CD4+ and CD8+ T cells, but the CCR8 protein was only prominent on the highly activated and strongly T-cell suppressive ti-Treg subpopulation of mouse and human tumors, with no major CCR8-positivity found on peripheral Tregs. …”
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Insights into the effects of biomass feedstock and pyrolysis conditions on the energy storage capacity and durability of standard biochar-based phase-change composites by Dimberu G. Atinafu, Ji Yong Choi, Jihee Nam, Yujin Kang, Sumin Kim

“…The composites demonstrated strong leakage resistance at high heating temperatures (60 °C, above the melting temperature of HXD), good chemical compatibility between the biochar and HXD, and high durability after 500 thermal cycles. …”
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A Local Adversarial Attack with a Maximum Aggregated Region Sparseness Strategy for 3D Objects by Ling Zhao, Xun Lv, Lili Zhu, Binyan Luo, Hang Cao, Jiahao Cui, Haifeng Li, Jian Peng

“…The results indicate that our method can be effectively combined with different texture optimization methods, with the average precision decreasing by 0.488 and 0.662 across different networks, which indicates a strong attack effectiveness.…”
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Factors affecting cadmium toxicity to rice germinated in soils collected from downstream areas of abandoned zinc mines by P. Chanpiwat, A. Numprasanthai

“…The concentrations of plant-available, exchangeable, carbonate-bound, and total cadmium strongly affected the accumulation of cadmium in germinated roots. …”
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Exploring the multifaceted roles of Sonneratia apetala and Nipa fruticans in coastal habitat restoration and bioactive properties discovery by Sabina Yasmine, Rezwana Zaman Proma, Md. Ripaj Uddin, Mohammad Saydur Rahman, Md. Hamedul Islam, Muhammad Abdullah Al Mansur, AHM Shofiul Islam Molla Jamal, Abu Yousuf, Md. Hasnain Mustak, Sarker Kamruzzaman, M. Mahboob Ali Siddiqi

“…The seeds are particularly rich in polyphenols (300.1 mg GAE/g), flavonoids (30.6 mg CE/g), anthocyanins (2.3 μmol/g), and vitamin C (4.0 mg/g), showcasing their strong antioxidant properties. The pericarp, though lower in these compounds, still presents significant nutritional value, containing 55.4 mg GAE/g polyphenols and 14.6 mg CE/g flavonoids. …”
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PLCG2 and IFNAR1: The Potential Biomarkers Mediated by Immune Infiltration and Osteoclast Differentiation of Ankylosing Spondylitis in the Peripheral Blood by Bo Han, Qiaobo Xie, Weishi Liang, Peng Yin, Xianjun Qu, Yong Hai

“…In the WGCNA, modules of MCODE with different algorithms were used to find 33 key genes that were related to each other in a strong way. Immune infiltration analysis found that naive CD4+ T cells and monocytes may be involved in the process of AS. …”
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Individual- and Community-Level Risk Factors Associated with Childhood Diarrhea in Ethiopia: A Multilevel Analysis of 2016 Ethiopia Demographic and Health Survey by Setegn Muche Fenta, Teshager Zerihun Nigussie

“…Therefore, integrated child health intervention programs including provisions of toilet facility, access to a clean source of drinking water, educate parents about the importance of breastfeeding, and vaccination have to be strongly implemented in order to reduce the high incidence of childhood diarrhea among children in Ethiopia.…”
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Predictive Factors for Access-Site Pain Chronicity after Percutaneous Coronary Intervention via Radial Artery Access by Liuda Brogiene, Giedre Baksyte, Agne Klimaite, Martynas Paliokas, Andrius Macas

“…Pain control was performed with Ketoprofen and Ibuprofen as most used NSAIDs. 10 mg of Morphine intravenously was the choice from strong opioids if necessary. Conclusions. The prevalence of chronic A-S pain is 3.7%. …”
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Serum PCSK9 Correlates with PTX3 and Apolipoproteins B, A1, and C3 Concentrations in Patients with Type 2 Diabetes by Małgorzata Waluś-Miarka, Maria Kapusta, Przemysław Miarka, Ewa Kawalec, Barbara Idzior-Waluś

“…Circulating PCSK9 correlated negatively with age (r=−0.21, p<0.05) and HbA1c (r=−0.21, p<0.05) and positively with BMI (r=0.21, p<0.05), total cholesterol (r=0.59), LDL-cholesterol (r=0.50), triglyceride (r=0.35), apo B100 (r=0.43), apo A1 (r=0.43) (p<0.001 for all), apo C3 (r=0.29, p<0.01), and apo B48 (r=0.25, p<0.01) concentration and FLI (r=0.26, p<0.01). Strong correlation between PTX3 and PCSK9 levels was observed (r=0.47, p<0.001). …”
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Mortality and immunological indicators of men who have sex with men living with HIV on antiretroviral therapy: a 10-year retrospective cohort study in Southern China by Huaxiang Lu, Huanhuan Chen, Shujia Liang, Yuhua Ruan, He Jiang, Jinghua Huang, Guangjie Tan, Xiuling Wu, Jianjun Li, Chen Gong, Qiuying Zhu, Guanghua Lan

“…Conclusions Mortality among MSM PLHIV on ART in Guangxi is relatively low, and both high viral loads and low CD4+/CD8+ T cell ratios during treatment and at recent follow-up are strongly predictive of a serious prognosis and should be closely monitored.…”
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Association between the attentional network efficiency and change of direction speed ability in young male Indian footballers by Debabrata Chatterjee, Santi Ranjan Dasgupta, Santi Ranjan Dasgupta, Arkadeb Dutta, Arkadeb Dutta

“…Partial correlation was conducted between the physical (field tests) and cognitive test scores adjusted for age and BMI.ResultsCODS ability measured with IAT was significantly correlated [r = +0.507 (large), p &lt; 0.05] with the executive control network only, nor with alerting [r = −0.039 (trivial), p &gt; 0.05] and orienting [r = + 0.051 (trivial), p &gt; 0.05] networks and neither the CRT task performance [r = −0.011 (trivial), p &gt; 0.05].DiscussionA strong positive association between executive control and preplanned CODS indicates better interference control by the attentional network. …”
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Occurrence and assessment of chronic pain fatigue and sleep disturbance in axial spondyloarthritis patients by Eman Abdel Ghani Sayed, Samer Samy, Faruk Ali Abdi, Anna Abou-Raya

“…Features of axSpA include pain, stiffness, reduced mobility, fatigue, and sleep disturbance. Fatigue has a strong link to sleep disorders, disease determining parameters, and poor psychological status. …”
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Financial Innovations and Financial Inclusion Among Commercial Banks in Uganda: Case Study Of Kabale District. by Mpirirwe, Christine

“…Microsoft EXCEL and SPSS Version 21.0 were used to analyze the data and produce both descriptive and inferential statistics. The study found a strong correlation between product innovation and financial inclusion in rural families. …”
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The Contributions of Mgahinga Gorilla National Park Towards Economic Development of Kisoro District: A Case Study of Gisozi Parish. by Munyambabazi, Danny

“…From the Research findings Recommendations were prescribed for instance if the government of Uganda and Kisoro District local government could make a strong policy governing the contribution of MGNP, and increase the setting up of many campsites, it could help them get more funds from the industry in the form of taxes. …”
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Tea Growing and Social Economic Development of Local Communities in Rubanda: A Case Study of Ikumba Sub-County Rubanda District. by Aharimpisya, Janet

“…It was concluded that the majority of the participants 80 (60%) strongly agreed that tea factories were setting up primary and secondary schools to provide quality education for the children in the area in Ikumba sub-county thus reducing the illiteracy rate and giving jobs to educated people in the area and also with still majority agreeing that local community has got money to pay school fees as indicated with (Mean= 3.41, SD = 0.854). …”
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An Examination of Records Management in Private Sector Agencies in Kabale Municipality: A Case Study of Kigezi Private Sector. by Kakuru, Danis

“…Staff needs suitable working and recreational accommodation, following the standards in effect within the government or organization, there should be the provision of quality leadership to promote the efficient management of organizations' resources correctly, and there should be the provision of quality services to customers based on their needs that is changing the view of management from sole control to service, Enhance customer focus through strong partnerships; Commit to achieving high standards of customer services, there should be a need to provide high-quality information on federal government operations which fully supports financial and performance reporting, establish standards and definitions and all top management should be committed to implementing effective and efficient internal controls. …”
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Types, Magnitude and Factors Associated with Medication Administration Errors Among Nurses in Rubanda East Health Sub District. by Atuhaire, Oliva

“…Underdoses were commonly administered to a moderate extent, while wrong documentation and wrong drug administration to the correct patient occurred to a greater extent. Factors strongly associated with MAEs included age, gender, poor drug administration knowledge, and interruptions during medication administration.…”
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Performance of Sisal Fabre as Natural Geotextile to Reinforce Soil Layers on Unpaved Road. by Kyomugasho, Lilian

“…Natural geotextiles are strong synthetic fabric usually used in civil engineering construction projects such as high way that stabilizes loose soil. …”
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