The Complete Blood Count Sepsis Index Using Monocyte Distribution Width for Early Detection of Sepsis in Patients Without Obvious Signs by Scott Levin, PhD, Nima Sarani, MD, Jeremiah Hinson, MD, PhD, Melissa Naiman, PhD, Chad Cannon, MD, Aria Smith, MS, Benjamin Steinhart, MS, Arnaud DeBraine, BS, Sarah Kehoe, PhD, Bryan Immhoff, MD, Yasir Taribichi, MD, Alexandra Malinovska, MD, Kemi Badaki-Makun, MD

“…The CBC-SI demonstrated strong performance for early sepsis detection. Its performance was best for nonobvious presentations, suggesting highest utility in a subgroup that is most susceptible to delayed interventions and poorer outcomes.…”
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NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model by Ismail M Meraz, Mourad Majidi, Renduo Song, Feng Meng, Lihui Gao, Qi Wang, Jing Wang, Elizabeth J Shpall, Jack A Roth

“…IFNγ, CD8b, and TBX21 associated with T-cell functions were significantly increased, whereas FOXP3, TGFB1/B2, and IL-10RA were strongly inhibited by NPRL2. A list of T-cell co-inhibitory molecules was also downregulated. …”
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The position of Lithuanian parties towards Poland in 1920-1926: from modus vivendi to permanent confrontation by Andrius Grodis

“…As the Copenhagen negotiations in the autumn of 1925 illustrated, the Christian Democrats' attempt to reduce the tension between the two small countries by starting economic relations of a narrow nature was met with strong hostility by the opposing Union of Peasants and National Union Parties, as well as by the majority of society supporting them. …”
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Effectiveness of Single-Tablet Combination Therapy in Improving Adherence and Persistence and the Relation to Clinical and Economic Outcomes by Carly J. Paoli, Jörg Linder, Khushboo Gurjar, Deepika Thakur, Julie Wyckmans, Stacy Grieve

“…**Discussion:** Evidence from RWE and economic studies strongly favored STCT use, while clinical trials and HRQoL studies primarily reported similarity between STCTs and LDCs. …”
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Accuracy Assessment of Nonlinear Seismic Displacement Demand Predicted by Simplified Methods for the Plateau Range of Design Response Spectra by Pierino Lestuzzi, Lorenzo Diana

“…However, the accuracy of displacement demand prediction strongly depends on the shape of the response spectrum after the plateau. …”
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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Especially, SCFAs were strongly associated with Bifidobacterium, Alistipes, Ruminococcus, Anaerotruncus, and Allobaculum.Conclusion: These findings suggest that collagen immunization leads to disruption of gut microbiome and induces changes of fecal metabolites in mice, which may play a key role in early development of RA in CIA mice.Keywords: gut microbiota, fecal metabolites, short-chain fatty acids, preclinical stage, collagen-induced arthritis…”
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A common mechanism of detoxification for lambda-cyhalothrin and abamectin in Cydia pomonella by Di Ju, Chao Hu, Peirong Li, Ping Gao, Yuting Li, Xueqing Yang

“…We observed that PBO had a strong synergistic effect on LCT and AM, while DEM on LCT. …”
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Assessing the development of health technology assessment in Iran: a policy analysis using Kingdon’s Multiple streams framework: a qualitative study by Meysam Behzadifar, Saeed Shahabi, Ahad Bakhtiari, Samad Azari, Seyed Jafar Ehsanzadeh, Mohammad Yarahmadi, Masoud Behzadifar

“…The experiences of other countries, especially those with strong institutional leadership in HTA, provide useful models for Iran to follow in its HTA development journey.…”
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Meta-analysis on the chronic effects of exercise on depression in older adults by Melanie Mack, Claudia Voelcker-Rehage, Pinelopi S. Stavrinou, Iuliia Pavlova, Yaël Netz, Burcu Kömürcü Akik, Antonia Kaltsatou, Sandra Haider, Christoforos D. Giannaki, Arzu Erden, Andreea Badache, Michel Audiffren

“…Regarding exercise characteristics, effects were particularly strong for interventions that included exergames, had a long duration, and involved high cognitive demand. …”
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A methodical approach for evaluating the variability of productivity and fruit quality in the genetic collections of strawberry (Fragaria × ananassa Duch.) by V. I. Lapshin, V. V. Yakovenko, S. N. Shcheglov, V. N. Podorojny

“…A complicated genomic composition, the  diversity of genetic control systems, and a strong modifying effect of growing conditions on the implementation of quantitative traits make it necessary to improve  methods for analysis of the  genotypic variability of economically  valuable  traits with the  aim of identifying genotypes that  are characterized by stability and adaptive qualities in a wide ecological  range  of growing  conditions. …”
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Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype by I. A. Goncharova, E. Yu. Bragina, I. Zh. Zhalsanova, M. B. Freidin, M. S. Nazarenko

“…Then, the disease-associated SNPs were annotated in silico in relation to their potential regulatory functions. Strong LD was detected between rs1928298 and rs1927914, as well as rs7026297 and rs7038716 in the Slavs of West Siberia. …”
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Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women by Kayla R. Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Haixiang Zhang, Chongliang Luo, Jingqin Luo, Adetunji T. Toriola

“…Abstract Background Mammographic breast density (MBD), a strong predictor of breast cancer, is highly influenced by body mass index (BMI) in childhood and early adulthood, but the mechanisms underlying these associations are not fully understood. …”
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Shortening duration of untreated illness in young people with first episode eating disorders: protocol of a randomised controlled feasibility trial of a smartphone friendly multi-m... by Luiza Grycuk, Dina Monssen, Molly R. Davies, Helen Sharpe, Karina L. Allen, Vibhore Prasad, Rachel Potterton, Priya Popat, Victoria A. Mountford, Sheryllin McNeil, Vanessa Lawrence, Nina Grant, Kimberley A. Goldsmith, Danielle Glennon, Sarah Byford, Amy Brown, Ulrike Schmidt

“…Patient-related factors (e.g. poor mental health literacy and help-seeking difficulties) are strongly associated with DUED. The aims of our study are to co-design and test the feasibility of FREED-Mobile (FREED-M), an online intervention tool for young people with early-stage EDs. …”
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Comparison of Machine Learning Methods and Conventional Logistic Regressions for Predicting Gestational Diabetes Using Routine Clinical Data: A Retrospective Cohort Study by Yunzhen Ye, Yu Xiong, Qiongjie Zhou, Jiangnan Wu, Xiaotian Li, Xirong Xiao

“…Fasting blood glucose, HbA1c, triglycerides, and BMI strongly contributed to GDM. A cutoff point for the predictive value at 0.3 in the GBDT model had a negative predictive value of 74.1% (95% CI 69.5%-78.2%) and a sensitivity of 90% (95% CI 88.0%-91.7%), and the cutoff point at 0.7 had a positive predictive value of 93.2% (95% CI 88.2%-96.1%) and a specificity of 99% (95% CI 98.2%-99.4%). …”
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Korelasi Motivasi Kerja Terhadap Kinerja Pegawai Satuan Polisi Pamong Praja Provinsi Jawa Timur by Windy Nur Ramadhina, Tukiman Tukiman

“…The results show a very strong relationship between work motivation and employee performance in the Satpol PP of East Java Province, with a correlation test result of 0.843. …”
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Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study by Charlotte Boullé, Elodie Lebredonchel, Jérémy T. Campillo, Valentin Dupasquier, Marlhand C. Hemilembolo, Sébastien D. S. Pion, Jean Claude Djontu, Ludovic Rancé, Philippe Souteyrand, François Missamou, Michel Boussinesq, Francine Ntoumi, Cédric B. Chesnais

“…Conclusions This study provides a detailed description of spleen morphology and the factors influencing its size in a rural central African population. It demonstrates a strong association between L. loa MFD and reduced SV, suggesting that loiasis may lead to AH, and potentially to functional hyposplenia, with consequences such as increased susceptibility to bacterial infections. …”
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From Acceptance to Dependence: Exploring Influences of Smart Healthcare on Continuous Use Intention of Mobile Health Services Among Older Adults with Chronic Illnesses in China by Jiacheng Luo, Kewei Zhang, Qianghong Huang, Shan Jiang, Younghwan Pan

“…This study not only provides strong evidence for the effectiveness of the integrated TAM and VAM model in the mHealth field but also offers theoretical insights and practical recommendations for product optimization and promotion to mHealth service providers and designers.…”
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Facial Anthropometry and Self-expressed Behaviours: A Systematic Review by Ankit Srivastava, Vilas Chimurkar, Nisha Mani Pandey, Anand Bihari

“…Aim: To assess the association of facial measurements with self-expressed behaviours and to determine how strongly these behaviours correlate with facial measurements. …”
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Cell-Specific Regulation of Inflammatory Cytokines and Acute-Phase Proteins by the Glucocorticoid Receptor by Rebecca Winkler, Hong Lu

“…In PHH from donor 1, GR strongly inhibited LPS-induced CXCL1 and CXCL8 translation and transcription, whereas CXCL2 transcription tended to increase with DEX treatment. …”
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Trends and opportunities in renewable energy investment in Saudi Arabia: Insights for achieving vision 2030 and enhancing environmental sustainability by Mahmoud Mohamed Selim, Nasser Alshareef

“…Saudi Arabia, driven by its Vision 2030, has strongly committed to shifting from fossil fuels to renewable energy sources such as solar, wind, and hydrogen. …”
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