An Injectable Hydrogel Bioimplant Loaded with Engineered Exosomes and Triple Anti-Tuberculosis Drugs with Potential for Treating Bone and Joint Tuberculosis by Huang J, Li H, Mei Y, Yi P, Ren Y, Wang Y, Han L, Tang Q, Liu D, Chen W, An Y, Hu C

“…In addition, drug-loaded liposomes equipped with an aldehyde group on the surface are cross-linked with the amine group of the hydrogel skeleton to participate in the Schiff base reaction.Results: The designed scaffold has characteristics of self-healing and injectability exhibit excellent anti-tuberculosis and promoting bone repair activities. Exoeng strongly stimulates cellular angiogenesis and osteogenic differentiation. …”
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The Modulation of Laser Refractive Surgery on Sensory Eye Dominance of Anisometropia by Hongting Liu, Qi Chen, Fangfang Lan, Yan Luo, Enwei Lin, Wuqiang Luo, Ming Kong, Jiangxia Wang, Fengju Zhang

“…Stronger sensory eye dominance is seen in the subjects with anisometropic myopia compared to subjects with nonanisometropic myopia. The strong sensory dominance of anisometropia becomes more balanced at one week of postoperation but returns to the preoperative level after one month. …”
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An ensemble machine learning-based performance evaluation identifies top In-Silico pathogenicity prediction methods that best classify driver mutations in cancer by Subrata Das, Vatsal Patel, Shouvik Chakravarty, Arnab Ghosh, Anirban Mukhopadhyay, Nidhan K. Biswas

“…The top PCSAs demonstrated strong performance on a validation cohort including independent HNSC and other cancer types: breast, lung, and colorectal - reflecting its consistency, robustness and generalizability. …”
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Analysis of Adverse Pregnancy Outcomes of Pregnant Women with Syphilis and Maternal-Infant Serological Association in Changzhou, China, 2015–2019 by Chaorong Bian, Zhiqiang Qin, Jieying Zhang, Mengtao Sun, Manman Gu, Kejin Chen

“…The adaptation of standardized treatment protocols for pregnant women with syphilis in China is a strong proof of the progress of precision medicine.…”
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Assessment of Chaves Low-Temperature CO2-Rich Geothermal System (N-Portugal) Using an Interdisciplinary Geosciences Approach by J. M. Marques, P. M. Carreira, L. A. Aires-Barros, F. A. Monteiro Santos, M. Antunes da Silva, P. Represas

“…The Chaves low-temperature CO2-rich geothermal waters present similar 87Sr/86Sr ratios (between 0.728035 and 0.716713) to those of the plagioclases from granitic rocks (between 0.72087 and 0.71261) suggesting that water mineralization is strongly ascribed to Na-plagioclase hydrolysis. Geophysical methods (e.g., resistivity and AMT soundings) detected conductive zones concentrated in the central part of the Chaves graben as a result of temperature combined with the salinity of the Chaves low-temperature CO2-rich geothermal waters in fractured and permeable rock formations. …”
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Magnitude of opportunistic infections and associated factors among HIV-infected individuals attending care and treatment clinics in Dar es Salaam, Tanzania: a hospital-based cross-... by Agricola Joachim, Doreen Kamori, Mtebe Majigo, Doris Andrew Njelekela, Rogath Kishimba, Mololo Noah

“…Promptly implementing the test-and-treat protocol while an individual’s immunity is still strong and timely screening for OI are critical.…”
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Multivariate Statistical Analysis Reveals the Heterogeneity of Lacustrine Tight Oil Accumulation in the Middle Permian Jimusar Sag, Junggar Basin, NW China by Yuce Wang, Jian Cao, Keyu Tao, Xiuwei Gao, Erting Li, Chunhua Shi

“…From base to top, the accumulation mechanisms in the Lucaogou Formation were NA, VLMA (vertical and lateral migration and accumulation), NA and VLMA, thereby showing strong heterogeneities. Our data suggest that these processes might be typical of tight oil accumulations universally, and are important for future exploration and exploitation in the region to consider the heterogeneities rather than a closed system. …”
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Theoretical Study of CO, NO, NO₂, Cl₂, and H₂S Adsorption Interactions with PdO–Graphene Composites for Gas Sensor Applications by Piumantha Samaranayake, Azeez Ahamed, Visal de Silva, Nadeesha Manohari Wickramage, Muhammad Raziq Rahimi Kooh, Roshan Thotagamuge

“…The findings show that CO exhibited the highest adsorption energy (−6.5513 eV) and adsorbed with a noticeable tilt toward the PdO–graphene plane, indicating a strong interaction, and H₂S exhibited the lowest adsorption energy, calculated as −2.0110 eV. …”
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“Use 19 Metal Pieces of Approximately the Same Timbre”. An Analysis of Twelve Recorded Performances of Xenakis’s Métaux (Pléïades) by Diederik Mark de Ceuster

“…In the preface to the score of Pléïades, Xenakis describes that the primordial element of the work is rhythm; strong periodic elements are repeated, and then superposed to form “arhythmic clouds of sound.” …”
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The plight of Ukrainian refugees staying in Sweden under EU:s mass refugee directive: a brief trauma-focused, participatory, online intervention as a pilot feasibility study by Solvig Ekblad, Oksana Gramatik, Yuliia Suprun

“…Four out of ten needed individual psychosocial support online.The participants' open questions were analyzed with qualitative content analysis, giving five general categories and 25 sub-categories and the theme “Strong efforts to cope with Swedish system”.ConclusionTrust and reduced anxiety level changed after the intervention and a combination online of small, closed group meetings with the possibility of personal acquaintance, trust and individual follow-up psychosocial support for those in need to be paid attention to for future refugee support services, particular an online format.…”
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Rural–urban and age differences in association between depression and suicidal attempt: a large retrospective clinical sample study in China by Yong Xia, Dandan Ge, Zhonghua Zhang

“…In subgroup analyses, we further found that depression was strongly associated with SA in juveniles (OR 2.84, 95% CI 1.19 to 6.76, p=0.018) and urban patients (OR 1.67, 95% CI 1.15 to 2.40, p=0.006). …”
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Probabilistic nested model selection in pharmacokinetic analysis of DCE-MRI data in animal model of cerebral tumor by Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Prabhu C. Acharya, Indrin J. Chetty, Benjamin Movsas, James R. Ewing, Kundan Thind

“…The K-SOM PNMS’s estimation for the leaky tumor regions were strongly similar (Dice-Similarity-Coefficient, DSC = 0.774 [CI: 0.731–0.823], and 0.866 [CI: 0.828–0.912] for Models 2 and 3, respectively) to their respective NMS regions. …”
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Effects of Salt Field Waste-Generated Bio-Organic Fertilizer Application on Bacterial Community Structure in Tea Plantations Rhizosphere Soil by Chengran Yu, Liuting Zhou, Xiaoyun Huang, Xiaofeng You, Jiali Lin, Haidong Han, Xiusheng Huang

“…Network association analyses showed a strong positive correlation between <i>g_Candidatus_Solibacter</i> and <i>g_Bryobacter</i> and a significant negative correlation between <i>g_AD3</i> and <i>g_ADurb.Bin063_1</i>. …”
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A novel minimally invasive neurosurgical cranial fixation device for improved accuracy of intraventricular catheter placement: an experimental animal study by Atai Daniel, Matan Coronel, Segev Peer, Ben Grinshpan, Soner Duru, Jose L. Peiro, James L. Leach, Elena Abellán, Carolyn M. Doerning, David Zarrouk, Francesco T. Mangano

“…Herein, we introduce a new concept of a cranial fixation device for insertion of EVDs, that reduces reliance on freehand placement and drilling techniques and provides a simple, minimally invasive approach that provides strong fixation to minimal thickness skulls. Methods An experimental device for catheter insertion and fixation was designed and tested in both ex-vivo and in-vivo conditions to assess accurate cannulation of the ventricle and to test the strength of fixation to the skull. …”
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Toxicity of nickel oxide nanoparticles in Capoeta fusca, using bioaccumulation, depuration, and histopathological changes by J. Kharkan, M.H. Sayadi, M. Hajiani, M.R. Rezaei, M. Savabieasfahani

“…These anomalies were fusion of lamellae, lamellar synechiae, curvature and oedema in the gill; increased number of goblet cells and cell swelling; and degradation of villi structure and expansion of villi structure in the intestine.CONCLUSION: The study conclusively demonstrated that nickel oxide nanoparticles were eco-toxic and harmful to aquatic organisms. Strong global nickel oxide nanoparticles regulations must be enforced to prevent further environmental contamination with nanoparticles.…”
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Evaluation of CORDEX ERA5-forced NARCliM2.0 regional climate models over Australia using the Weather Research and Forecasting (WRF) model version 4.1.2 by G. Di Virgilio, G. Di Virgilio, F. Ji, F. Ji, E. Tam, J. P. Evans, J. P. Evans, J. Kala, J. Andrys, C. Thomas, D. Choudhury, C. Rocha, Y. Li, M. L. Riley

“…At 20 km resolution, improvements in mean and extreme precipitation for ERA5 RCMs versus ERA-Interim RCMs are principally evident over southeastern Australia, whereas strong biases remain over northern Australia. At convection-permitting scale over southeastern Australia, mean absolute biases for mean precipitation for the ERA5 RCM ensemble are around 79 % smaller versus the ERA-Interim RCMs that simulate for this region. …”
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Impact of PCSK9 Immunization on Glycemic Indices in Diabetic Rats by Amir Abbas Momtazi-Borojeni, Mahmoud Reza Jaafari, Elham Abdollahi, Maciej Banach, Amirhossein Sahebkar

“…The prepared nanoliposomal vaccine could strongly induce anti-PCSK9 antibodies in the vaccinated rats. …”
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A 32-year trend analysis of lower respiratory infections in children under 5: insights from the global burden of disease study 2021 by Yan Wang, Ruiyang Han, Xiao Ding, Junli Chen, Wenjia Feng, Chunping Wang, Runguo Gao, Anning Ma, Anning Ma

“…Additionally, there was a strong negative correlation between the burden of lower respiratory infections in children under 5 and the socio-demographic index. …”
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Interactions between NAD+ metabolism and immune cell infiltration in ulcerative colitis: subtype identification and development of novel diagnostic models by Linglin Tian, Huiyang Gao, Tian Yao, Tian Yao, Yuhao Chen, Linna Gao, Jingxiang Han, Lanqi Zhu, He Huang, He Huang, He Huang

“…These biomarkers are closely linked to various immune cells within the UC microenvironment, particularly NAMPT and PTGS2, which were strongly associated with neutrophil infiltration. Nomograms developed for subtyping and diagnosis demonstrated high predictive accuracy, achieving area under curve (AUC) values up to 0.989 and 0.997 in the training set and up to 0.998 and 0.988 in validation sets. …”
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Acceptability and feasibility of pre-exposure prophylaxis for bacterial STIs: a systematic review. by Julie-Anne Carroll, Amy B Mullens, Sarah Warzywoda, Philip R A Baker, Meika Stafford, Faye McMillan, Jacintha Manton, Daniel Demant

“…<h4>Conclusion</h4>Further research into acceptability, feasibility and knowledge transfer among diverse high-risk groups, healthcare professionals, and policymakers is necessary to create a strong foundation for implementing STI PrEP.…”
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