Validity, reliability and clinical utility of ASSIST-Y in assessing risk of substance-related harm and dependence in Spanish male adolescents by Núria Ibáñez-Martínez, Matthew William Richard Stevens, Núria Civit-Bel, Noemí Moreno-Ferrer, Sandra Lopez-Ferré, Ana Olivares-Casado, Juame Claramunt-Mendoza, Chris Holmwood, Robert Ali

“…Abstract Background Substance use among adolescents is strongly associated with adverse physical, mental health, and social outcomes. …”
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Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis by Zhe Chen, Mingyang Tang, Nan Wang, Jiangjiang Liu, Xiaoyan Tan, Haitao Ma, Jing Luo, Kai Xie

“…Conclusions BRSK2 is identified as a critical pathogenic factor in IPF, with strong potential as a therapeutic target. Future studies should focus on its translational implications and the development of targeted therapies to improve patient outcomes.…”
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Fecal microbiota transplantation modulates jejunal host-microbiota interface in weanling piglets by Shankumar Mooyottu, Muhammed Shafeekh Muyyarikkandy, Farnaz Yousefi, Ganwu Li, Orhan Sahin, Eric Burrough, Joy Scaria, Brett Sponseller, Alejandro Ramirez

“…FMT significantly enriched the jejunal microbiota composition, while multiple bacterial genera were specifically lacking in control weanling piglets. FMT was strongly associated with the enrichment of the genus Pseudoscardovia of the Bifidobacteriaceae family, which was found lacking in the jejunum of weanling control piglets and inversely associated with the abundance of the genus Bifidobacterium within the same family. …”
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The development of modern-day competences in education, in the context of an agile approach by János Varga, Ágnes Csiszárik-Kocsir, Mónika Garai-Fodor

“…Generations Y and Z, although they have a positive view of agility, are willing and able to identify with it, but in their case there is still a strong lack of concrete knowledge and understanding. …”
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Significance of KLK7 expression, polymorphisms, and function in sheep horn growth by Mingzhu Shan, Hao Li, Xinyue Li, Guoqing Zhang, Jianxin Shi, Pingjie Feng, Lisheng Zhou, Zhangyuan Pan, Mingxing Chu

“…Our findings suggest a strong association between KLK7 and sheep horn length, indicating the potential role of KLK7 in inhibiting horn growth and providing novel insights into the functionality of KLK7.…”
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Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study by Yuhui Chen, Li Chen, Liang Xian, Haibing Liu, Jiaxing Wang, Shaohuai Xia, Liangfeng Wei, Xuewei Xia, Shousen Wang

“…The calibration curve closely approximated the ideal curve, indicating strong predictive performance of the model. Conclusions The implementation of our proposed OTBI classification system and its use alongside the other prognostic factors identified here may improve the prediction of patient prognosis and aid in the selection of the most suitable treatment strategies.…”
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Identifying Who Benefits the Most from a Community Health Worker-Led Multicomponent Intervention for Hypertension by Meng Pan, Andrea Beratarrechea, Rosana Poggio, Hua He, Chung-Shiuan Chen, Jing Chen, Vilma Irazola, Adolfo Rubinstein, Jiang He, Katherine T. Mills

“…The effect of the intervention was consistent across many subgroups with some key groups showing a particularly strong intervention effect. These findings could be useful for planning future hypertension control programs in low- and middle-income countries.…”
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Assessing caregiver stress and resource needs in pediatric cancer care by Shaimaa Mohamed Amin, Mahmoud Abdelwahab Khedr, Azza Medhat Aziz Mansy, Ahmed Hashem El-Monshed, Mohamed Gamal Noaman Malek, Ayman Mohamed El-Ashry

“…Data were collected using the Caregiver Needs and Resources Assessment (CNRA) and the King Stone Caregiver Stress Scale (KCSS), both of which demonstrated strong reliability and validity. Descriptive statistics, t-tests, ANOVA, and Pearson correlation coefficients were employed for data analysis using SPSS version 29, with a significance level set at p < 0.05. …”
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Predictive value of the perivascular fat attenuation index for MACE in young people suspected of CAD by Yani Yu, Dongkai Shan, Xi Wang, Zinuan Liu, Guanhua Dou, Junjie Yang, Yuqi Liu, Yundai Chen

“…Abstract Objective The perivascular fat attenuation index (FAI) evaluated by coronary computed tomographic angiography (CCTA) has been reported to have strong prognostic value, but few studies have focused on young people. …”
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Cognitive behavior therapy for academic burnout, procrastination, self-handicapping behavior, and test anxiety among adolescents: a randomized control trial by Khizra Khurshid, Rabia Mushtaq, Umara Rauf, Nida Anwar, Qasir Abbas, Sumayah Aljhani, Zoobia Ramzan, Mafia Shahzadi

“…Abstract Objective Academic stressors among adolescents, strongly associated with emotional disturbance, increase the chance of psychiatric problems, and their severity increases over time when emotional and educational issues remain unresolved. …”
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Role of outer membrane vesicles of hypervirulent Klebsiella pneumoniae isolated from bovine uterine discharge in pro-inflammatory dysregulation by A. F. Daham, A. H. Jaber, A. Neamah, H. Al-Karagoly

“…These bands included OmpX, flagellin, MipA, OmpA, OmpC, and OmpF (4244 kDa), a strong OmpA band at 45 KDa, and a faint band at 60 kDa of GroEL as an oligomer of OmpA. …”

Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer by Biying Wang, Lunmin Bao, Xiaoduo Li, Guang Sun, Wu Yang, Nanzi Xie, Ling Lei, Wei Chen, Hailong Zhang, Man Chen, Xing Zhao, Xiufang Wan, Rui Yuan, Hongmei Jiang

“…Conclusion Our study demonstrated that KIF11 was upregulated in EC and was strongly associated with a poor prognosis. Notably, we found that reduced KIF11 expression inhibited EC cell proliferation, migration and invasion. …”
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An outbreak within an outbreak: The impact of Infection Prevention and Control strategies on hospital-acquired infections and the occurrence of multi-drug resistant organisms durin... by B Mashigo, A Parker, U Lalla, B W Allwood, M S Moolla, T Lovelock, C F N Koegelenberg

“…The outbreak of both CRE and A. baumannii, and the fact that many patients cultured the same CRE organism and A. baumannii, strongly suggests that a critical breakdown in IPC measures had occurred. …”
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From fear to food: predation risk shapes deer behaviour, their resources and forest vegetation by Martin, Jean-Louis, Chamaillé-Jammes, Simon, Salomon, Anne, Gomez Pourroy, Devana Veronica, Schlaeflin, Mathilde, Le Saout, Soizic, Lucas, Annick, Bentaleb, Ilham, Chollet, Simon, Pattison, Jake, Martin-Blangy, Soline, Gaston, Anthony James

“…In the absence of risk, deer had a strong negative effect on understory vegetation cover and plant composition. …”
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RUSSIA'S RELATIONS WITH THE EUROPEAN UNION AND CHINA: COMPARATIVE ANALYSIS OF MUTUAL PERCEPTION IN THE BORDER REGIONS by R. H. Simonyan, T. M. Kochegarova

“…Today, therefore, Russia should not deifying the West, than succeeded ones and not the deification of exclusivity, what more you want to succeed others, but strong awareness of the reality and the pursuit of maximum expediency, pragmatism in the development of the achievements of Western civilization. …”
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based rand... by Natalie Walker, Amanda Calder, Joanne Barnes, George Laking, Varsha Parag, Chris Bullen

“…The trial will provide some of the first evidence on the effectiveness of combining nicotine salt e-cigarettes with cytisine for smoking cessation, in a country with strong tobacco control policy. Findings will be incorporated into relevant systematic reviews, informing practice and policy. …”
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“Kyrie paschale” in Polish Organ Tablatures from the First Half of the 16th Century – Problems of Style and Attribution by Grzegorz Kos

“…Based on analysis of the sources, examination of the contrapuntal and formal structure of the segments and comparisons with analogous repertoire from other organ tablatures and with vocal arrangements of the ‘Kyrie paschale’ (as ordinaries both independent and part of a Mass cycle) by identified and anonymous composers, the author of the article has identified new affinities between intabulations and redefined the roles played in their writing by individuals whose names or monograms were partly inscribed in the tablatures. Having found strong arguments to exclude Josquin (an attribution that has often been challenged), the author now attributes crucial roles to two authors of Masses that were in all probability the material basis or inspiration for the organ intabulations: Heinrich Finck and the newly identified Heinrich Isaac. …”
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Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…Experimental validation showed vitamin A’s role in suppressing endoplasmic reticulum stress and altering mitochondrial dynamics, as well as metabolic reprogramming influencing inflammation via the STAT3 pathway in RAW 264.7 cells.ResultsThe study identified 13 differentially expressed ATGs in periodontitis, showing strong correlations with inflammation, particularly in plasma cells, macrophages, dendritic cells, neutrophils, and mast cells. …”
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The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice by Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu

“…These findings indicate that ΔmcpC provides effective immune protection in mice.ConclusionThis study demonstrates that deletion of the mcpC gene attenuates the virulence of SE. The ΔmcpC offers strong immune protection in mice, providing a solid foundation for the development of genetically engineered attenuated live vaccines against SE.…”
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Factors that influence the adoption of a school-based eHealth alcohol prevention program among Spanish personnel: a mixed methods study by Ester Alejandra Rosado-Pulido, Pablo Fernández-León, Marta Lima-Serrano, Hein de Vries

“…Results School personnel with a strong intention to adopt the program (intenders) perceived significantly more advantages and positive innovation attributes, than those participants with a weaker intention to adopt (non-intenders). …”
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