Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH by Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero

“…Using purified plasma proteins and recombinant mutants, FHR-B was found to form dimers and bind strongly to C3, C3b, iC3b, and C3dg. It also competes with mouse Factor H (mFH) for binding to C3b-coated surfaces and disrupts mFH regulation in hemolysis assays with sheep and guinea pig erythrocytes. …”
Get full text

Evaluation of Rivaroxaban Exposure via Anti-Xa Levels During VTE Prophylaxis in Hospitalized Patients by Kaitlin Blotske PharmD, Toral Patel PharmD, BCPS, Toby Trujillo PharmD, FCCP, FAHA, BCPS, Matthew Marlar MLS (ASCP), Stuart Lind MD, Henry Kramer MD, Kathryn Hassell MD, Tyree H. Kiser PharmD, FCCM, FCCP, BCCCP, BCPS

“…The LMWH calibrated anti-Xa assays were strongly correlated to rivaroxaban concentrations ranging from (1-59 ng/ml) in patients receiving rivaroxaban 10 mg daily, r 2  = 0.99 ( P  < .00001). …”
Get full text

Reliability, Objectivity, Validity and Reference Levels of the Austrian Balance Check (ABC)—A Novel Balance Field Test for Children, Adolescents and Young Adults to Assess Static B... by Gerald Jarnig, Reinhold Kerbl, Mireille N. M. van Poppel

“…A gold standard comparison using an electronic force plate showed a strong negative correlation: participants with high overall ABC scores showed less movement on the force plate (parameters of the center of pressure: surface area (ρ = −0.61), mean velocity (ρ = −0.65) and path length (ρ = −0.65). …”
Get full text

Empirical Analysis for Improving Food Quality Using Artificial Intelligence Technology for Enhancing Healthcare Sector by S. K. UmaMaheswaran, Gaganpreet Kaur, A. Pankajam, A. Firos, Piyush Vashistha, Vikas Tripathi, Hussien Sobahi Mohammed

“…Further analysis has shown that independent variables ML, DL, NLP, and RES have a strong positive correlation with improving SQ. These results have been justified by secondary journals, and it is proved that AI technologies enhance the service quality in healthcare and food sectors.…”
Get full text

BMI gain and dietary characteristics are risk factors of MASLD in non-obese individuals by Hirokazu Taniguchi, Miho Ueda, Yukiko Kobayashi, Takatomo Shima

“…Multivariable-adjusted logistic regression analyses using the rate of change per year with standardized values found that BMI gain was strongly associated with the onset of MASLD for both men (OR: 1.90, 95% CI: 1.64–2.19) and women (OR: 1.95, 95% CI: 1.72–2.21). …”
Get full text

Effects of Different Intertillage Practices on Soil Biochemical Properties and Soybean Yield in Soybean Fields by Mingcong Zhang, Yanhong Zhou, Chenglin Li, Cheng Yuan, Mingfen Shan, Yuxin Fan, Zhongxia Yu, Linfeng Ren, Liu Cui, Chen Wang

“…Intertillage time and depth had a strong influence on the soil microbial characteristics. …”
Get full text

Assessing cross-country inequalities in global burden of gastrointestinal cancers: slope and concentration index approach by Haoyun Zhou, Yongbo Wang, Fang Wang, Runtang Meng, Yong Yu, Su Han, Yu Zhang, Yu Wu, Xiaoxue Liu

“…Conclusion This study suggests strong heterogeneity in global DALYs for gastrointestinal cancers across different SDI regions. …”
Get full text

Chromosome Numbers and Reproductive Life Cycles in Green Plants: A Phylotranscriptomic Perspective by Rijan R. Dhakal, Alex Harkess, Paul G. Wolf

“…ABSTRACT The strong correlation between reproductive life cycle type and chromosome numbers in green plants has been a long‐standing mystery in evolutionary biology. …”
Get full text

Continuous Patient-Independent Estimation of Respiratory Rate and Blood Pressure Using Robust Spectro-Temporal Features Derived From Photoplethysmogram Only by Muhammad Ahmad Sultan, Wala Saadeh

“…In addition, we derived a set of novel spectral and statistical features strongly correlated to BP. We proposed robust correlation-based feature selection methods for accurate RR estimates. …”
Get full text

Intraspecific classification of durum wheat: new botanical varieties and forms by O. A. Lyapunova

“…The subspecies also has liguleless forms and those with strongly pubescent leaves. The subsp. durum is represented by 6 groups of botanical varieties (convarieties): durum, durocompactum, aglossicon, villosum, falcatum, and caucasicum. …”
Get full text

A semantic strength and neural correlates in developmental dyslexia by Sladjana Lukic, Sladjana Lukic, Sladjana Lukic, Fei Jiang, Maria Luisa Mandelli, Maria Luisa Mandelli, Ting Qi, Sarah M. Inkelis, Sarah M. Inkelis, Emily Rosenthal, Emily Rosenthal, Zachary Miller, Zachary Miller, Emma Wellman, Emma Wellman, Silvia A. Bunge, Silvia A. Bunge, Silvia A. Bunge, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Christa Watson Pereira, Christa Watson Pereira

“…Differential dynamic rs-fMRI connectivity (shorter average dwell time and greater brain state switches) was observed between the high and average groups in a large-scale bilateral frontal-temporal-occipital network.DiscussionThese data demonstrate that a subgroup of children with dyslexia perform above average on semantic fluency tasks and their performance is strongly linked to distinct psycholinguistic patterns and differences in a task-free resting-state brain network, which includes regions previously implicated in semantic processing. …”
Get full text

Cerebrospinal fluid metabolites as potential biomarkers for epilepsy: Insights from genome‐wide association studies by Zhenxiang Zhao, Na Xing, Lin Hou

“…Two of these chemicals were strongly linked to epilepsy, suggesting they could be important for creating specific treatments or prevention strategies.…”
Get full text

Examining Prenylated Xanthones as Potential Inhibitors Against Ketohexokinase C Isoform for the Treatment of Fructose-Driven Metabolic Disorders: An Integrated Computational Approa... by Tilal Elsaman, Magdi Awadalla Mohamed

“…Hits <b>7</b>, <b>8</b>, <b>9</b>, <b>13</b>, and <b>15</b> not only surpassed these benchmarks in binding affinity, but also exhibited superior pharmacokinetic properties compared to α-Mangostin, LY-3522348, and marine-derived inhibitors, indicating strong in vivo potential. Among these, hit <b>8</b> emerged as the best performer, achieving a binding free energy of −61.30 kcal/mol, 100% predicted oral absorption, enhanced metabolic stability, and stable molecular dynamics. …”
Get full text

Insights into the contribution of multiple factors on Ixodes ricinus abundance across Europe spanning 20 years using different machine learning algorithms by Samantha Lansdell, Abin Zorto, Misaki Seto, Edessa Negera, Saeed Sharif, Sally Cutler

“…We provide a summary of the factors most strongly linked to I. ricinus abundance, which can be used to guide interventions to aid the control of ticks and tick-borne disease across Europe.…”
Get full text

Prognostic value and clinicopathological significance of pre-and post-treatment systemic immune-inflammation index in colorectal cancer patients: a meta-analysis by Yueting Tan, Bei’er Hu, Qian Li, Wen Cao

“…High SII levels were strongly correlated with inferior OS, PFS, DFS, and RFS. …”
Get full text

Determinants of well-being and their interconnections in Australian general practitioners: a qualitative study by Nick Glozier, Ian B Hickie, Christiane Klinner, Alyssa Milton, Diana Naehrig, Louise Acland, Brendan Goodger

“…Determinants of well-being were underpinned by GPs’ sense of identity. This was strongly influenced by GPs seeing themselves as a distinct but often undervalued profession working in small organisations within a broader health system. …”
Get full text

The Ka’ulayawaa festivals among the Wayùu. Exploring continuities and variations in forms, meanings and contexts through ethnographic sources by Alessandro Mancuso

“…However, there are very strong and complex relationships between this “festive” and “playful” character of the ka’ulayawaa festivals and a series of fundamental cosmological oppositions of the Wayùu worldview, as described in the ethnographic literature. …”
Get full text

Similar Material Simulation Study on Protection Effect of Steeply Inclined Upper Protective Layer Mining with Varying Interlayer Distances by Zhigang Yuan, Yaohua Shao, Zhuohui Zhu

“…The results show the following. (1) The proportioning parameters of similar material have strong linear relations with its mechanical properties, and mechanical behaviors of such similar material denote that it can simulate most coal-rock lithologies in coal mine. (2) Both pressure-relief curves and swelling strain curves for protected layer present convex shapes; protection angles at lower excavation boundary are greater than those of upper excavation boundary; with the increase of interlayer distance, the pressure-relief curve evolves from pattern “∩” to pattern “∧” and corresponding pressure-relief region becomes narrower, the center of pressure-relief region tends to transfer to the corresponding center of upper protective layer excavation region, the stress concentration coefficient decreases, the protection angles change little, and the length of the protection region reduces dramatically. (3) The protection region and protection angle calculated based on swelling strain of 3‰ are less than the empirical values based on the dip angle in Provisions, denoting that the method proposed in this study is safer than that in Provisions. …”
Get full text

Estimating the Potential Modal Split of Any Future Mode Using Revealed Preference Data by Gijsbert Koen de Clercq, Arjan van Binsbergen, Bart van Arem, Maaike Snelder

“…Mode choice behaviour is often modelled by discrete choice models, in which the utility of each mode is characterized by mode-specific parameters reflecting how strongly the utility of that mode depends on attributes such as travel speed and cost, and a mode-specific constant value. …”
Get full text

Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation by Kabita Pradhan, Balram Neupane, Paul Niehues, Martin Kirschner, Fabian Beier, Chao‐Chung Kuo, Erika Anneliese Hilbold, Christian Bär, Oana‐Maria Thoma, Maximilian Waldner, Margherita Vieri, Tim H. Brümmendorf, Vithurithra Tharmapalan, Wolfgang Wagner, Michael Kleines, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich

“…Furthermore, there was a strong correlation between the extent of left atrial low voltage areas, TL, and outcome after catheter ablation of AF. 24 months after ablation, only 26.5% of patients with advanced fibrosis and short TL were in sinus rhythm compared with 62.5% of patients with no/low fibrosis and long TL. …”
Get full text