Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Molecular dynamics simulations indicated that millettone, uzarigenin, and dihydrobiochanin A demonstrated strong binding affinities and stable interactions with AKT2, suggesting their potential as therapeutic agents for cancers that involve AKT2 hyperactivation. …”
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Automated Breast Cancer Detection in Mammograms using Transfer Learningbased Deep Learning Models by Preeti Katiyar, Krishna Singh

“…Patients’ chances of survival increase when BC is detected early and treated with the appropriate treatment at the right time. There is strong evidence that mammography, when used as a screening tool, can detect BC at an early stage. …”
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Risk factors for malignancy in pediatric subacute/chronic focal craniocervical lymphadenopathy by Yishai Haimi-Cohen, Yishai Haimi-Cohen, Yishai Haimi-Cohen, Eyal Elron, Eyal Elron, Lital Oz-Alcalay, Lama Hejly, Roy Hod, Roy Hod, Liat Ashkenazi-Hoffnung, Liat Ashkenazi-Hoffnung, Liat Ashkenazi-Hoffnung

“…Multivariate analysis showed associations with malignancy of older age and larger lymph nodes; the respective odds ratios were 1.649 (95%CI: 1.197–2.349, p = 0.004) for every 3 years and 2.080 (95%CI: 1.292–3.330, p = 0.002) for every one centimeter.ConclusionsOlder age and increased nodal size can help identify children with focal craniocervical lymphadenopathy who are at increased risk for malignancy and for whom surgical intervention should be strongly considered.…”
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Monocytes serve as Shiga toxin carriers during the development of hemolytic uremic syndrome by Xinlei Sun, Shuang Qu, Fenglian Zhou, Fujie Shi, Yunfei Wu, Lin Gu, Minghui Liu, Zhen Bian, Lei Shi, Zhihong Liu, Yuan Liu, Ke Zen

“…Through single-cell sequencing analysis of Stx2-B-bound peripheral white blood cells sorted by flow cytometry, we observe that nearly all monocytes exhibit strong Stx2-B binding, whereas less than 10% of neutrophils are associated with Stx2-B, albeit with a lower affinity. …”
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Fuzzy Approach in Rail Track Degradation Prediction by Mostafa Karimpour, Lalith Hitihamillage, Najwa Elkhoury, Sara Moridpour, Reyhaneh Hesami

“…The expectation from such a method is to develop models to minimise the human error that is strongly related to manual prediction. Such models will help rail transport authorities in understanding how the track degradation occurs at different conditions (e.g., rail type, rail profile) over time. …”
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THE IMPACT OF RUSSIAN-CHINESE INTER-REGIONAL AND CROSS-BORDER COOPERATION ON ENTREPRENEURSHIP DURING THE GLOBAL ECONOMIC CRISIS by Xin Ran

“…The active level of the business not only strongly influences the development of cross-border and inter-regional cooperation, but also for the development of the border areas. …”
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The Prediction of Metro Shield Construction Cost Based on a Backpropagation Neural Network Improved by Quantum Particle Swarm Optimization by Lanjun Liu, Denghui Liu, Han Wu, Xinyu Wang

“…This method combined the strong nonlinear analysis capabilities of the BP and the global search capabilities of the QPSO. …”
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ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Cancer stem cells (CSCs) accelerate the progression ESCC via their strong self‐renewal and tumourigenic capabilities, presenting significant clinical challenges due to increased risks of recurrence and drug resistance. …”
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Development and validation of a nomogram for predicting perioperative transfusion in children undergoing cardiac surgery with CPB by Wenting Wang, He Wang, Jia Liu, Yu Jin, Bingyang Ji, Jinping Liu

“…The predictive model incorporating these variables demonstrated strong performance, with an area under the curve (AUC) of 0.886 (95% CI: 0.880–0.891) in the training cohort and 0.883 (95% CI: 0.875–0.892) in the testing cohort. …”
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A scoping review of the residual barriers to skilled birth attendance in Ghana: A conceptual framework and a fish bone analysis. by Juliet Abredu, Catherine K Dwumfour, Boo Alipitio, Mawusi Alordey, Veronica Millicent Dzomeku, Sophie Witter

“…The achievement of the Sustainable Development Goals (SDGs) targets 3.1, 3.2 and 3.3.1 is strongly dependent on the effective utilization of skilled birth services. …”
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Probability Error Bounds for Approximation of Functions in Reproducing Kernel Hilbert Spaces by Ata Deniz Aydın, Aurelian Gheondea

“…For sequences of points xii=1∞ constituting a so-called uniqueness set, the orthogonal projections πxn to spanKxii=1n converge in the strong operator topology to the identity operator. …”
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miR-129-5p Regulates the Immunomodulatory Functions of Adipose-Derived Stem Cells via Targeting Stat1 Signaling by He-Yang Zhang, Yu-Han Wang, Yan Wang, Yan-Nv Qu, Xiao-Hui Huang, Hui-Xin Yang, Chang-Ming Zhao, Youdi He, Si-Wei Li, Jin Zhou, Changyong Wang, Xiao-Xia Jiang

“…These novel insights into the mechanisms of ASC immunoregulation may lead to the consistent production of ASCs with strong immunosuppressive functions and thus better clinical utility of these cells.…”
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Isolation and characterization of cadmium-resistant Bacillus cereus strains from Cd-contaminated mining areas for potential bioremediation applications by Bixia Liang, Yimeng Feng, Xiyue Ji, Chune Li, Qian Li, Zhenshun Zeng, Yuqi Wang

“…Additionally, they exhibited strong salt tolerance, starch hydrolysis, citrate utilization, and ammonia production capabilities. …”
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Optimal Proportion of Similar Materials and Rockburst Tendency of White Sandstone by Chaoyi Ma, Zhengguo Zhu, Zhichun Fang, Zhaobin Li, Liu Liu

“…By judging the rockburst propensity and verifying the index, it is concluded that the similar materials can effectively simulate the characteristics of white sandstone, which is an ideal similar material of rockburst, and they all show strong rockburst propensity. The rock specimens with optimal proportions were produced, and the internal energy changes and rockburst mechanisms of the model at different temperatures were discussed. …”
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Diversity of Rhizophydiales (Chytridiomycota) in Thailand: unveiling the hidden gems of the Kingdom by Vedprakash G. Hurdeal, Joyce E. Longcore, E. B. Gareth Jones, Kevin D. Hyde, Eleni Gentekaki

“…The results provided strong support for the presence of eight distinct lineages within the Rhizophydiales, representing our newly discovered species. …”
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Novel MOF-based vanadium and 2,2 -bipyridine-4,4 -dicarboxylic acid as phenomenal dye adsorbent and antimicrobial agent by Baraa Mohammed Yaseen, Farag M. A. Altalbawy, Farag M. A. Altalbawy, Rafid Jihad Albadr, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad, Hiba Mushtaq, Khursheed Muzammil, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel, Ahmed Hussein Zwamel

“…Synthesized V/BP-MOF was introduced as a strong adsorbent of Congo Red (CR) and an effective agent in eliminating microbial species. …”
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Release Profile and Antibacterial Activity of <i>Thymus sibthorpii</i> Essential Oil-Incorporated, Optimally Stabilized Type I Collagen Hydrogels by Caglar Ersanli, Ioannis Skoufos, Konstantina Fotou, Athina Tzora, Yves Bayon, Despoina Mari, Eleftheria Sarafi, Konstantina Nikolaou, Dimitrios I. Zeugolis

“…Antimicrobial resistance is one of the drastically increasing major global health threats due to the misuse and overuse of antibiotics as traditional antimicrobial agents, which render urgent the need for alternative and safer antimicrobial agents, such as essential oils (EOs). Although the strong antimicrobial activity of various EOs has already been studied and revealed, their characteristic high sensitivity and volatility drives the need towards a more efficient drug administration method via a biomaterial system. …”
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Self-Centered Function of Adaptive Immunity in Regulation of Immune Responses and in Tolerance by Silvana Balzar

“…Transplantation represents an extreme setting of strong systemic compartment-level adaptive/MHC-restricted immune responses. …”
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Comprehensive multispectral and computational study of isoxazolidine derivative ‘ISoXD3’: Synthesis, spectral characteristics, DNA binding, and comparative effects of allyl and pro... by Ibrahim A. Alhagri, Siwar Ghannay, Norah A. Al-Suwailem, Rania Hussien Al-Ashwal, Sadeq M. AlHazmy, Sabri Messaoudi, Kaiss Aouadi

“…In this article, we have synthesized and examined the spectral properties of the isoxazolidine derivative ISoXD3, particularly its UV–Visible and fluorescence spectra. ISoXD3 shows a strong absorbance peak at 228 nm (S₀ → S₂ transition) and another at 290 nm (S₀ → S₁ transition). …”
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Regularizing Effects for a Singular Elliptic Problem by Ida de Bonis, Maria Michaela Porzio

“…We show that, despite the lack of regularity of the data, for suitable choices of the function <i>b</i> in the lower order term, a strong regularizing effect appears. In particular we exhibit the existence of bounded solutions. …”
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