Factors affecting patient satisfaction during endoscopic procedures by Maryam Ghazala, E-Hinna Rashk, Sardar Saman, Khan Jahangir, Isram Javaria, Hassan Fayyaz

“…The questionnaire demonstrated strong internal consistency with a Cronbach's Alpha value of 0.917. …”
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Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents by Dhiraj A. Jamdade, Dishantsingh Rajpali, Komal A. Joshi, Rohini Kitture, Anuja S. Kulkarni, Vaishali S. Shinde, Jayesh Bellare, Kaushik R. Babiya, Sougata Ghosh

“…This is the first study of its kind that provides a strong scientific rationale that phytogenic CuNPs synthesized using G. glauca and P. zeylanica can be considered to develop candidate antidiabetic nanomedicine.…”
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Ddx21 mutant peptide is an effective neoantigen in prophylactic lung cancer vaccines and activates long-term anti-tumor immunity by Zhe Zhang, Yimeng Xia, Yimeng Xia, Zhihong Wang, Yaxing Sun, Dan Pu, Yijia He, Ruixian Liu, Yanru Zhang, Yan Liu, Junzhi Yu, Shiyang Ning, Baisui Feng, Yaohe Wang, Na Wang

“…Our previous studies indicated that mice immunized with a prophylactic vaccine based on lung cancer cell lines KPL 160302S, derived from early-stage murine lung cancer tissues, exhibited a significantly extended survival period, with a strong anti-tumor immune response. While the vaccine based on KPL 160424S, derived from advanced-stage murine lung cancer tissues, failed to extend survival time and demonstrated limited capacity to stimulate anti-tumor immunity. …”
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p97 Inhibitors Possessing Antiviral Activity Against SARS-CoV-2 and Low Cytotoxicity by Rui Ding, Tiffany C. Edwards, Prithwish Goswami, Daniel J. Wilson, Christine D. Dreis, Yihong Ye, Robert J. Geraghty, Liqiang Chen

“…More significantly, these two inhibitors exhibit strong antiviral activity against SARS-CoV-2 at doses with no significant cytotoxicity. …”
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An EPQ inventory model with Weibull distribution, dynamic time-dependent holding cost under various demand pattern using Maclaurin series approximations by Gopal Kumar Gupta, Atma Nand, N. S. Chauhan, Shivanand

“…Abstract In this research study we present an advanced adaption of the economic and efficient optimized production model by integrating Weibull-distributed progressive degradation, dynamic holding costs, fluctuating demand, and strong strategies for effectively managing shortages and backlogs. …”
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Habitat fragmentation increases the risk of local extinction of small reptiles: A case study on Phrynocephalus przewalskii by Cui Yang, Yue Qi, Jiayuan Guo, Liangfei Peng, Neng Xiong, Wenya Zhang, Wei Zhao

“…Genomic analyses revealed significantly fewer SNPs, INDELs, and SVs in the highly fragmented area compared to others, with the slowest linkage disequilibrium decay rate, indicating strong environmental pressure. Furthermore, individuals in the highly fragmented area had significantly higher fluctuating asymmetry, serve as an important ecological and biological indicator reflecting habitat fragmentation. …”
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Human blood cell transcriptomics unveils dynamic systemic immune modulation along colorectal cancer progression by Pedro J Romero, Mauro Delorenzi, Amaia Martínez-Usatorre, Laura Ciarloni, Noushin Hadadi, Eric Durandau, Sylvain Monnier-Benoit, Paolo Angelino, Victoria Wosika, Alessandra Jordano Conforte, Sara S Fonseca Costa, Hector Fabio Satizabal, Jérémie Despraz, Andres Perez-Uribe, Stephan Morgenthaler, Brian Hashemi, Sahar Hosseinian-Ehrensberger

“…Moreover, some biomarkers show similar dysregulation in tumors and are implicated in known pathways of CRC pathophysiology.Conclusions The strong systemic immune modulation triggered during CRC progression leads to previously unnoticed alterations detectable in PBMCs, paving the way for the development of an early CRC screening blood test, incorporating 226 validated biomarkers identified through immunotranscriptomics.…”
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What was Killing Babies in Rostock? An Investigation of Infant Mortality Using Individual-Level Cause-of-Death Data, 1800–1904 by Michael Mühlichen, Laura Ann Cilek

“…This suboptimal development from 1840 was strongly related to post-neonatal mortality and causes of death that are related to unfavourable sanitary conditions and/or poor nutrition, which possibly hints at worsening housing and living conditions following accelerated population growth. …”
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The Effect of Rural Guide Plan on Objective Quality of Life among Rural Communities in Fariman County by Aliakbar Anabestani, Hamdollah Sojasi Qeidari, Fahime Jafari

“…According to the results of Pearson's correlation tests, the findings of present study showed a significant and strong correlation between implementation of rural guide plan and the mental facet of life quality by a 0.75 correlation coefficient, so that rural guide plan explained 57% of the variation of dependent variable, and among guide plan dimensions the changing environmental rural affected the objective improvement of life quality of villagers by 29 percent. …”
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Comparative Analysis of the Influence of Selected Physical Factors on the Level of Pain in the Course of Temporomandibular Joint Disorders by Łukasz Kopacz, Żaneta Ciosek, Helena Gronwald, Piotr Skomro, Roman Ardan, Danuta Lietz-Kijak

“…The treatment of a patient’s discomfort associated with masticatory system dysfunctions strongly depends on their cause. Aim of the Study. …”
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La forteresse de Sadr, une lecture géo-historique au temps des croisés by Corinne Feïss-Jehel, Jean-Michel Mouton, Claudine Piaton, Pierre-Jérôme Jehel, Jeannine Le Rhun

“…Firstly, construction on a high butte gave the fortress a strong defensive position with a commanding view of the lower areas, which were the only way an army could approach. …”
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Teenagers with type 2 diabetes mellitus as a hidden population: A qualitative study of the representations and experiences related to the disease in Mazatlán, Mexico by Nathaly Llanes-Díaz, Dewi Hernández-Montoya

“…Identity construction is strongly affected by the disease; indeed, diabetes implied a reconstruction of male identity, while for females the disease was associated with overweight that affects their self-esteem. …”
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Large-Scale Mapping and Predictive Modeling of Submerged Aquatic Vegetation in a Shallow Eutrophic Lake by Karl E. Havens, Matthew C. Harwell, Mark A. Brady, Bruce Sharfstein, Therese L. East, Andrew J. Rodusky, Daniel Anson, Ryan P. Maki

“…Occurrence of Chara was strongly associated with peat sediments, and maximal depths of occurrence varied between sediment types (mud, sand, rock, and peat). …”
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Prediction of the axial compression capacity of ECC-CES columns using adaptive sampling and machine learning techniques by Khaled Megahed

“…The FE model was validated against experimental data and demonstrated strong predictive accuracy. An adaptive sampling process is employed for efficient exploration of the design space to generate a database of 840 FE models. …”
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TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders by Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht

“…After immunization with Spike/CpG-motifs, mRNA vaccination or SARS-CoV-2 infection, CORSET8 T cells strongly proliferated and showed signs of T cell activation. …”
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Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…Owing to their ultra-small size, LNT-UsSeNPs exhibited strong spinal barrier penetration and potent antioxidative and anti-inflammatory effects without compromising immune function. …”
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Streptomyces sp. MUM 195J: A Promising Probiotic for Controlling Vibrio parahaemolyticus Infection in Aquaculture by Joanna Xuan Hui Goh, Loh Teng-Hern Tan, Jodi Woan-Fei Law, Giva Kuppusamy, Janaranjani M, Kooi-Yeong Khaw, Wei Hsum Yap, Kok-Gan Chan, Vengadesh Letchumanan, Learn-Han Lee, Bey-Hing Goh

“…MUM 195J emerges as a promising probiotic strain that demonstrates a strong inhibitory effect against V. parahaemolyticus. …”
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Supplementation with Complex Phytonutrients Enhances Rumen Barrier Function and Growth Performance of Lambs by Regulating Rumen Microbiome and Metabolome by Juan Du, Yuan Wang, Shaohui Su, Wenwen Wang, Tao Guo, Yuchao Hu, Na Yin, Xiaoping An, Jingwei Qi, Xuan Xu

“…Notably, CPS5.0 could optimize the composition of rumen microbiota and increase the levels of Ursolic acid and other metabolites. The strong associations between rumen bacteria and health-related indicators and differential metabolites were further highlighted. …”
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H. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition by Nabil M. Selim PhD, Seham S. El-Hawary PhD, Soheir M. El Zalabani PhD, Rehab Nabil Shamma PhD, Nariman El Sayed Mahdy PhD, Noheir H. Sherif PhD, Khayrya A. Youssif PhD, Usama Ramadan Abdelmohsen PhD, Mai H. Mekkawy PhD, Hanan A. Fahmy PhD

“…Furthermore, the histological investigations strongly confirmed the combined effect of NE and IRR in fighting DEN-induced HCC. …”
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Observational Study on the Characteristics of the Boundary Layer during Changes in the Intensity of Tropical Cyclones Landing in Guangdong, China by Fei Liao, Ran Su, Pak-Wai Chan, Yanbin Qi, Kai-Kwong Hon

“…At this time, the maximum radial inflow, maximum tangential wind, and maximum angular momentum are in the same height range in the vertical direction. When a strong radial outflow occurs in the boundary layer of a tropical cyclone or the area with maximum wind velocity is located in the air outflow, the angular momentum cannot easily be transported towards the centre of the typhoon. …”
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