The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways by Ju Ang Kim, Soomin Im, Jiwon Lim, Jung Min Hong, Hye Jung Ihn, Jong-Sup Bae, Jung-Eun Kim, Yong Chul Bae, Eui Kyun Park

“…The mechanism responsible for enhanced bone formation induced by DOCK5 inhibition may involve the suppression of Rac1 under TAK1, accompanied by the activation of MKK3/6 and p38 induced by BMP2. These findings strongly suggest that DOCK5 negatively regulates osteoblast differentiation and bone regeneration through signaling pathways involving TAK1, MKK3/6, and p38, providing new insights into potential therapeutic strategies for bone regeneration.…”
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An Analysis of Urban Livability for Children with Scenario Planning Approach (Case Study: District 3 of Tabriz) by Shahrivar Rostaei, Fariba Kouhi Gholghasem

“…By using the Delphi method, has taken scenarios for these seven forces and 27 scenarios were written for forces and analyzed in the Scenario wizard software, and 3 strong scenarios, 7 believable scenarios and 309 poor scenarios were extracted. …”
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Synthesis, Characterization, Optical and Dielectric Properties of NiO and Zn-Doped NiO Nanostructures: Toward Advanced Applications by Atizaz Ali, Sohail Ahmad, Muhammad Usman, Nangyaley Khan, Muhammad Hashim, Yasir Ali, Rasool Shah, Naveed Ur Rahman

“…Photoluminescence analysis unveiled a strong peak at 470 nm (near band edge) and another at 665 nm (indicative of defects), exhibiting intensified signals in doped and nanocomposite samples due to a higher defect density. …”
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Results from an Australopithecus africanus dental enamel fragment confirm the potential of palaeoproteomics for South African Plio-Pleistocene fossil sites by Palesa P. Madupe, Fazeelah Munir, Marc Dickinson, Alberto J. Taurozzi, Meaghan Mackie, Mirriam Tawane, Catherine Mollereau, Nomawethu Hlazo, Kirsty Penkman, Lauren Schroeder, Clément Zanolli, Jesper V. Olsen, Rebecca R. Ackermann, Enrico Cappellini

“…Although it is still in its infancy for Plio-Pleistocene hominin fossils, palaeoproteomics has the potential to help unravel the causes of observed morphological variation. Lastly, we strongly believe that the involvement of African researchers at all levels of this research, including leadership, is of great importance. …”
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Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults by Junping Liu, Zhaoyue Liu, Xinru Liu, Nan Wang, Lin Wu, Xiaoxue Xu, Wei Liu, Yajie Feng, Huanyu Zhang, Yue Zhou, Xinle Yin, Yaping Liu, Qunhong Wu, Ning Ning, Libo Liang

“…Additionally, RCS regression model also verified the strong non-linear relationship that existed between OSAS risk and PBB153. …”
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Are Ancient Durum Wheats Less Toxic to Celiac Patients? A Study of α-Gliadin from Graziella Ra and Kamut by M. Stella Colomba, Armando Gregorini

“…Although some DQ2-Glia-α1 and DQ2-Glia-α2 variants evidenced herein were previously reported to have a diminished or abolished T cell stimulatory capacity, present results cannot confirm that ancient durum wheats would be less CD-toxic. In conclusion, we strongly advice celiac patients from consuming ancient wheats including Graziella Ra or Kamut.…”
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Accounting for retarded weathering products in comparing methods for quantifying carbon dioxide removal in a short-term enhanced weathering study by Emily E. E. M. te Pas, Elliot Chang, Elliot Chang, Alison R. Marklein, Rob N. J. Comans, Mathilde Hagens

“…Hence, a large portion of weathering products may be retained in the soil due to strong adsorption and/or further mineral precipitation reactions (31.6–92.7%), with potentially important implications for the quantification of CDR across time. …”
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Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach by Ronghua Bei, Justin Thomas, Shiven Kapur, Mahlet Woldeyes, Adam Rauk, Jason Robarge, Jiangyan Feng, Kaoutar Abbou Oucherif

“…Compared with intravenous delivery, subcutaneous injections reduce administration costs, shorten the administration time, and are strongly preferred from a patient experience point of view. …”
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Spatio-temporal Distribution of Aboveground Forest Biomass and Carbon in Tropical Dry Forest under Anthropogenic Pressure, Brazil by Gabriela Salami, Rinaldo Luiz Caraciolo Ferreira, José Antônio Aleixo da Silva, Fernando José Freire, Emanuel Araújo Silva, Marco Antonio Diodato, Dhonatan Diego Pessi

“…The results showed a strong spatial dependence of biomass and carbon stocks in both studied areas, indicating the influence of the areas’ use history. …”
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Command, Control and Co-Creation: Drivers and Barriers Faced by Professionals Co-Creating in the Slovenian Public Sector by Sanja Vrbek, Marlot Kuiper

“…A key driver for them to co-create in such a context is strong political support at the highest level. However, a more profound internalisation of co-creation depends on the redefinition of their professional identity, as well as on the (personal or collective/organisational) interest in co-creation. …”
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Wild pea (<i>Pisum sativum</i>Pisum sativum L. subsp. <i>elatius</i> (Bieb.) Aschers. et Graebn. s.l.) at the periphery of its range: Zagros Mountains by O. E. Kosterin, V. S. Bogdanova, A. V. Mglinets

“…In such regions, wild pea populations are rare, small in size and suffer from climatic change and land exploitation, hence their focused search is strongly desirable. A two-week-long expedition to Iran in May 2017 revealed two small populations of the wild pea (Pisum sativum subsp. elatius) in the Zagros Mts, in Aligudarz and Khorramabad Districts of Lorestan Province, Iran, at elevations of 1841 and 1971 m a.s.l., respectively. …”
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DA 362: A Gamma-Ray-emitting Compact Symmetric Object by Subhashree Swain, Vaidehi S. Paliya, D. J. Saikia, C. S. Stalin

“…Swift X-Ray Telescope observation of DA 362 reveals an extremely hard X-ray spectrum, though a strong claim cannot be made due to large uncertainties. …”
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AMERICAN POLONIA’S RESOURCES OF IFLUENCE AND US FOREIGN POLICY by I. D. Loshkariov

“…Firstly, the foreign policy agenda of the Polish diaspora in the United States faces no strong opponents. This fact means the diaspora has sufficiently developed structural resource. …”
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Parathyroid carcinoma: impact of preoperative diagnosis on the choice of surgical procedure by Yoshitaka Kawai, Yo Kishimoto, Hisanobu Tamaki, Takashi Fujiwara, Ryo Asato, Koji Ushiro, Shogo Shinohara, Shinpei Kada, Shinji Takebayashi, Tsuyoshi Kojima, Shuya Otsuki, Masakazu Miyazaki, Yohei Kumabe, Koichi Omori

“…In conclusion, the surgical procedure for parathyroid carcinoma strongly depends on the preoperative diagnosis. The presence of excessive iPTH levels might contribute to improved preoperative diagnostic sensitivity for parathyroid carcinoma.…”
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Cloud-Based Transaction Fraud Detection: An In-depth Analysis of ML Algorithms by Ali Alhchaimi

“…Conclusion: ML, especially ensemble and boosting models like XGBoost and Random Forest, offers a strong approach to detecting transaction fraud in cloud-based financial systems. …”
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Experimental case study for optimizing heat sink performance using ZnO nanocarriers integrated with phase change materials for environmental sustainability by Muhammad Farooq, Imran Zahid, M. Yasar Javaid, Noreen Sher Akbar, Enio Pedone Bandarra Filho, M. Farrukh Shahzad, M. Imran Khan, Mohammad Ilyas Khan, Mohammad Rehan, Fahid Riaz

“…Hence, the incorporation of nanocarriers into nontoxic environment friendly PCMs is strongly advocated to promote sustainable progress in electronic thermal management, as it offers clean, zero-emission energy storage solution.…”
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Comparison of Fourier-Domain and Time-Domain Optical Coherence Tomography in the Measurement of Thinnest Corneal Thickness in Keratoconus by Chunxiao Wang, Xueying Xia, Bishan Tian, Shiyou Zhou

“…For keratoconus eyes, the TCT was 425.0 ± 58.2 μm and 424.4 ± 55.7 μm (difference being 0.6 ± 10.2 μm, p=0.604). Strong correlation (r = 0.938∼0.985) (ICC = 0.915–0.984) was observed between the two OCTs, and each OCT exhibited excellent repeatability in determining the TCT in all subjects (ICC = 0.984–0.994). …”
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Clinical outcomes and long-term efficacy of high tibial osteotomy in treating knee instability: An updated systematic review by Mustamsir Edi, Aji Aulia Pandu, Adiwangsa Ahmad Abdilla, Akmalizzan Azfar Ahnaf

“…The procedure demonstrates strong mid- to long-term outcomes, high patient satisfaction, and a low rate of complications. …”
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Structural shifts in the Baltic States’ foreign trade by Vladimir G. Varnavskii

“…The first hypothesis, proposing a general increase in the TII between the Baltic states from 2004 to 2023, is partially supported; Lithuania’s exports deviate from the overall trend due to the country’s strong trade links with Poland and Germany. The second hypothesis, asserting the adaptability of Baltic business to geo-economic and geopolitical stresses — including sustained trade with Russia—has been fully confirmed. …”
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Minute-cadence Observations of the LAMOST Fields with the TMTS. VI. Physical Parameters of Contact Binaries by Qiqi Xia, Xiaofeng Wang, Kai Li, Xiang Gao, Fangzhou Guo, Jie Lin, Cheng Liu, Jun Mo, Haowei Peng, Qichun Liu, Gaobo Xi, Shengyu Yan, Xiaojun Jiang, Jicheng Zhang, Cui-Ying Song, Jianrong Shi, Xiaoran Ma, Danfeng Xiang, Wenxiong Li

“…Spectral subtraction analysis revealed that the equivalent width of H α indicates strong magnetic activity in J0047, J0305, J0638, and J1402. …”
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