Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect by Xiyuan Wang, Zhengsheng Zhan, Zhen Wang, Yan Zhang, Kaiyan Zhao, Han Li, Xiaoqian Zhou, Yuting Guo, Fengying Fan, Jian Ding, Meiyu Geng, Xuekui Yu, Wenhu Duan, Zuoquan Xie

“…Finally, DW18343 was shown to be an activator of both the innate and adaptive antitumor immunity in tumor tissue, potentially explaining its strong antitumor effects in vivo. In conclusion, DW18343 serves as a novel non‐nucleotide STING agonist with systemic antitumor effect through the activation of antitumor immunity.…”
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Costa cantábrica (Santillana del Mar, España) (2019) by Alberto Cabrerizo

“…Costa cantábrica (Santillana del Mar, Spain) (2019) This picture was taken on December 9, 2019 in the beach Santa Justa, that belongs to Santillana del Mar municipality, on the coast of Cantabria. The sea beats strongly against the coastal relief made of dipped strata and erodes the coast, making vertical forms. …”
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Phase II Study of Personalized Peptide Vaccination with Both a Hepatitis C Virus-Derived Peptide and Peptides from Tumor-Associated Antigens for the Treatment of HCV-Positive Advan... by Shigeru Yutani, Kazuomi Ueshima, Kazumichi Abe, Atsushi Ishiguro, Junichi Eguchi, Satoko Matsueda, Nobukazu Komatsu, Shigeki Shichijo, Akira Yamada, Kyogo Itoh, Tetsuro Sasada, Masatoshi Kudo, Masanori Noguchi

“…Further clinical study of PPV would be warranted for HCV-positive advanced HCC, based on the safety and strong immune induction.…”
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Critical Analysis on the Structural and Magnetic Properties of Bulk and Nanocrystalline Cu-Fe-O by D. Paul Joseph, C. Venkateswaran, R. Selva Vennila

“…From the absence of any strong new peaks at high pressure, it is evident that the secondary phases if present could be less than the level of detection. …”
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Exposure to Volatile Organic Compounds in Relation to Visceral Adiposity Index and Lipid Accumulation Product Among U.S. Adults: NHANES 2011–2018 by Ziyi Qian, Chenxu Dai, Siyan Chen, Linjie Yang, Xia Huo

“…Our findings suggest that VOC exposure is strongly associated with visceral obesity indicators. …”
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A simulation study to quantitatively assess the performance of electronic prescribing systems in English NHS Hospital Trusts by Stephanie Klein, Athanasios Tsanas, Jamie Coleman, Rebecca Osselton, Jude Heed, Ann Slee, Neil Watson

“…Moreover, we found that mitigation performance varied considerably across NHS Trusts using the same EP system, strongly suggesting there are opportunities to optimise performance within systems. …”
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The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients by Li Wang, Yingjun Kong, Yao Zhang, Chuanyong Mu

“…Results: In ALK positive patients, the PD-L1 positivity rate was 59.8 %, with 19.2 % showing strong positivity. PD-L1 positive patients were predominantly male, over 55 years old, and presented more clinical symptoms, higher Ki-67 expression, larger tumor sizes, and more advanced disease stages. …”
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Interrogating the global application of e-certification of seafarers by Margie Mendoza Mataac, Michael Ekow Manuel, Anne Pazaver

“…It also identified various challenges to global application along with potential solutions. Despite the strong industry support for the entire replacement of seafarers’ traditional printed certificates with e-certificates, the study concludes that the coexistence of both formats will persist until crucial challenges are effectively addressed. …”
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Strengthening and toughening an ultra-high strength medium Mn steel by fibrous ferrite bridging mechanism by Chao Zhang, Qian Cheng, Bo Yang, Wuli Su, Xue Chen, Qingyuan Wang, Wenquan Cao, Chongxiang Huang

“…In this work, an ultra-strong medium Mn steel with hard martensite as the matrix and a large number of uniformly distributed long and coarse soft fibrous ferrites embedded within it had been designed. …”
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Hydrogeochemical characterization and water quality assessment of mountain springs: Insights for strategizing water management in the lesser Indian Himalayas by Bhargabnanda Dass, M. Someshwar Rao, Sumit Sen

“…New hydrological insights for the region: Results reveal strong spatio-temporal variations in spring aquifer chemistry, primarily influenced by silica degradation and groundwater mixing, with secondary effects from ion-exchange and anthropogenic activities. …”
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STUDENTS' PERCEPTIONS AND MOTIVATION TOWARD E-LEARNING AT AKM HIGH SCHOOL DURING THE COVID-19 PANDEMIC by Nur Fitria Anggrisia, M. Fadel Ihza Islami

“…Notably, 44.5% of students felt that e-learning improved their English skills, with 41.7% strongly agreeing that teachers facilitated productive question-and-answer sessions. …”
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The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance by Katharina Otten, J. Christopher Edgar, Heather L. Green, Kylie Mol, Marybeth McNamee, Emily S. Kuschner, Mina Kim, Song Liu, Hao Huang, Marisa Nordt, Kerstin Konrad, Yuhan Chen

“…The N1m-to-P1m amplitude also exhibited a non-linear decrease, with strong responses observed in younger infants (∼2–3 months) and then a gradual decline. …”
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Evaluation of Cross-Border Transport Connectivity and Analysis of Spatial Patterns in Latin America by Changqi Miao, Yinbao Zhang, Xinjia Zhang, Jianzhong Liu, Shike Zhang

“…The overall connectivity of Latin America was low, and the overall development was unbalanced, with a strong law of spatial differentiation, which was mainly manifested in the strongest connectivity of the integrated coastal countries, followed by the island countries, and the lowest connectivity of the landlocked countries. …”
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Intraocular Pressure and Anterior Segment Morphometry Changes after Uneventful Phacoemulsification in Type 2 Diabetic and Nondiabetic Patients by João N. Beato, David Reis, João Esteves-Leandro, Manuel Falcão, Vítor Rosas, Ângela Carneiro, Fernando Falcão Reis

“…Nonglaucomatous eyes with open-angles from both type 2 diabetic and nondiabetic patients experienced similar AS changes and IOP reductions following uneventful phacoemulsification, and this IOP-lowering effect was strongly correlated with preoperative IOP.…”
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Recent advances in oblique plane microscopy by Kim Jeongmin

“…This review gives an overview of OPM’s working principle and imaging performance and introduces recent technical developments in OPM methods and applications. OPM has strong potential in a variety of research fields, including cellular and developmental biology, clinical diagnostics in histology and ophthalmology, flow cytometry, microfluidic devices, and soft materials.…”
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Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs by Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes

“…All compounds exhibited strong antiparasitic activity, with Cu-phendione showing the greatest potency (EC50 = 2.3 µM for S. mansoni and 6.4 µM for A. cantonensis). …”
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Pleural Mesothelial Cells-Induced Monocytes to the Pleural Cavity through the Effect of C3 Lytic Products in Tuberculous Pleural Effusion by Lisha Luo, Juntao Feng, Shuanglinzi Deng, Xinyue Hu, Bingrong Zhao, Wei Tang, Xiaozhao Li

“…Complement activates strongly in TPE, and PMCs induced monocytes to the pleural cavity through C3a, C3b, and C3d.…”
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The Human Mesenchymal Stromal Cell-Derived Osteocyte Capacity to Modulate Dendritic Cell Functions Is Strictly Dependent on the Culture System by Sara Trabanelli, Federico La Manna, Marco Romano, Valentina Salvestrini, Michele Cavo, Marilena Ciciarello, Roberto M. Lemoli, Antonio Curti

“…Conversely, Adh-DOC strongly suppress DC functions by a profound downregulation of CD80 and CD86 on DC as well as by the inhibition of TGF-β production. …”
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Meat analogues: The relationship between mechanical anisotropy, macrostructure, and microstructure by Miek Schlangen, Iris van der Doef, Atze Jan van der Goot, Mathias P. Clausen, Thomas E. Kodger

“…Both correlation analyses on the response parameters and parameter variance are studied to distinguish the product sets. Strong correlations are found between anisotropy-related parameters, such as fibre score in macrostructure, air anisotropy in microstructure, and the toughness anisotropy index from mechanical properties. …”
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One-dimensional River Network Hydrodynamic Model Based on HLL Finite Volume Method: A Case Study of Jiaokou–Yinjiang Region by GU Weiwei, CHEN Longzan, ZHANG Jingsi, LI Weizheng, YANG Yanfei, ZHANG Weiguo

“…The model's validity is confirmed by a dam-break model, demonstrating strong capabilities for handling cross-critical flow changes. …”
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