Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids by Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka

“…On the other hand, amide-type harmicens 10, 12, and 14 exhibited strong, but non-selective activity, in the low micro-molar range. …”
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Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics by Lihe Jiang, Lihe Jiang, Lihe Jiang, Peili Wang, Peili Wang, Yixuan Hou, Jingying Chen, Hua Li, Hua Li

“…Our approach involves a multi-omics analysis of IFI30 tumor immunological profile in the macrophage-mediated Tumor Microenvironment (TME), spanning various cancers and bolstered by rigorous co-culture laboratory work.ResultsIFI30 predominantly localizes in monocyte/macrophage populations, correlating strongly with immune cell infiltration. Substantiated by single-cell analysis, IFI30 exhibits significant functional enrichment in immune-related pathways. …”
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Stress and Strain: Differentiating the Responses to High and Moderate Heat Loads and Subsequent Recovery in Grain-Fed Feedlot Steers—Metabolic Hormones by Gene Wijffels, Megan L. Sullivan, Sally Stockwell, Suzie Briscoe, Roger Pearson, Stephen T. Anderson, Yutao Li, Cintia C. de Melo Costa, Russell McCulloch, John B. Gaughan

“…The Challenge simulated a strong heatwave. Finally, the steers were maintained in outdoor pens for 38 d. …”
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MicroRNA-3145 as a potential therapeutic target for hepatitis B virus: inhibition of viral replication via downregulation of HBS and HBX by Amrizal Muchtar, Amrizal Muchtar, Daichi Onomura, Daichi Onomura, Dan Ding, Dan Ding, Hironori Nishitsuji, Kunitada Shimotohno, Shunpei Okada, Keiji Ueda, Koichi Watashi, Takaji Wakita, Kei Iida, Kei Iida, Hironori Yoshiyama, Hisashi Iizasa

“…The expression of pri-miR-3145 showed a strong correlation with the Nance–Horan syndrome-like 1 (NHSL1) gene, as it is encoded within an intron of NHSL1, and higher NHSL1 expression in hepatocellular carcinoma patients with HBV infection was associated with better prognosis. …”
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Pervasive glacier retreats across Svalbard from 1985 to 2023 by Tian Li, Stefan Hofer, Geir Moholdt, Adam Igneczi, Konrad Heidler, Xiao Xiang Zhu, Jonathan Bamber

“…The interannual variability of calving front retreat shows a strong sensitivity to both atmospheric and oceanic warming, with immediate responses to large air and ocean temperature anomalies in 2016 and 2019, likely driven by atmospheric blocking that can influence extreme temperature variability. …”
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The Plasma Membrane Ca2+-ATPase2 (PMCA2) Is Involved in the Regulation of Purkinje Cell Dendritic Growth in Cerebellar Organotypic Slice Cultures by Pradeep Sherkhane, Josef P. Kapfhammer

“…We found that PMCA2 is strongly expressed in the plasma membrane and dendritic spines of Purkinje cells in organotypic slice cultures compatible with a role for controlling the local dendritic calcium equilibrium. …”
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Searching for elusive journalism values in the era of fake news by Stanley Tsarwe

“…Secondly, in Zimbabwe, there are strong relationships between the type of falsified and misleading news and the sociopolitical and economic context. …”
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The Exile Experience Reconsidered: a Comparative Perspective in European Cultural Migration during the Interwar Period by Renato Camurri

“…The first phase of studies into intellectual exile was strongly conditioned by two classic interpretative paradigms: the acculturation paradigm and the paradigm of the impact refugee scholars had on American culture. …”
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Assessment of Tear Film Quality among Smokers Using Tear Ferning Patterns by Ali M. Masmali, Adil Al-Shehri, Saud A. Alanazi, Ali Abusharaha, Raied Fagehi, Gamal A. El-Hiti

“…The mean values obtained from PRT and TBUT tests were 22.23±6.35 mm and 12.17±3.81 s for smokers and 22.16±5.63 mm and 14.13±2.62 s for nonsmokers, respectively. Strong correlations were found between MacMonnies scores and both PRT (r=0.596) and TF (r=0.516). …”
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Sliding Mode Backstepping Control of Excavator Bucket Trajectory Synovial in Particle Swarm Optimization Algorithm and Neural Network Disturbance Observer by Xiangfei Tao, Kailei Liu, Jing Yang, Yu Chen, Jiayuan Chen, Haoran Zhu

“…As proven by the experimental results, PSO-NNDO-SMBC possessed strong anti-interference ability. In contrast to the sliding mode backstepping control based on the particle swarm optimization algorithm (PSO-SMBC), the maximum displacement tracking error was lowered by 50.5%. …”
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Targeting C-Reactive Protein in Inflammatory Disease by Preventing Conformational Changes by J. R. Thiele, J. Zeller, H. Bannasch, G. B. Stark, K. Peter, S. U. Eisenhardt

“…Native, pentameric CRP (pCRP) is considered to be the circulating precursor form of monomeric CRP (mCRP) that has been identified to be strongly proinflammatory. Recently, a dissociation mechanism of pCRP has been identified on activated platelets and activated/apoptotic cells associated with the amplification of the proinflammatory potential. …”
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Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases by Ami B. Shah, Katarzyna A. Rejniak, Jana L. Gevertz

“…Simulations reveal a small number of fractionated-dose protocols that are at least as effective as metronomic therapy in eradicating micrometastases with acquired resistance (weak or strong), while also being at least as effective on those that harbor weakly pre-existing resistant cells. …”
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Damage Assessment of an SRC Frame-Core Tube Structure under the Action of a Main Aftershock Sequence by Peng Wang, Qingxuan Shi, Feng Wang, Siusiu Guo

“…Historical seismic damage data show that most strong earthquakes are accompanied by multiple intense aftershocks. …”
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Effect of Macrocapsule Geometry on PCM Performance for Thermal Regulation in Buildings by Margarida Gonçalves, António Figueiredo, German Vela, Filipe Rebelo, Ricardo M. S. F. Almeida, Mónica S. A. Oliveira, Romeu Vicente

“…Nevertheless, the performance of PCM-based systems is strongly influenced by the container geometry. Among the various forms of incorporating PCMs into building applications, macroencapsulation is the most versatile and is, therefore, widely used. …”
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Fiber-tip photonic crystal for real-time referenced biosensing in serum by Mathias Dolci, Paco Dreverman, Mildred S. Cano-Velázquez, Arthur L. Hendriks, Emiel Veth, P.J. van Veldhoven, Andrea Fiore, Peter Zijlstra

“…The coupling of light with a transducer at the tip of the optical fiber enables the detection of physical and biological parameters. 2D photonic crystals (PhC) can be designed to feature guided-mode resonances (GMR) characterized by a strong electric field at the PhC surface, providing a suitable tool for the detection of local refractive index variations (e.g. biomolecule adsorption). …”
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Electroacupuncture Treatment Alleviates Central Poststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant Astrocyte Activation by Gui-Hua Tian, Shan-Shan Tao, Man-Tang Chen, Yu-Sang Li, You-Ping Li, Hong-Cai Shang, Xiao-Yi Tang, Jian-Xin Chen, He-Bin Tang

“…Meanwhile, the high-frequency EA treatment induced a greater inhibition of the aberrant astrocyte activation, accompanied by the downregulation of the expressions of COX-2, β-catenin, and subsequently NK-1R, thereby alleviating inflammation and producing strong analgesic effects. Together, these findings suggest that CPSP is closely related to pathological changes of the neocortex and hippocampus. …”
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Experimental and Numerical Study of Rock Stratum Movement Characteristics in Longwall Mining by Wan-rong Liu

“…As the coal seam continues to advance, the maximum subsidence displacement remains basically constant, and the subsidence displacement curves present an asymmetric flat-bottomed distribution. (2) After the coal seam is mined, the overburden forms an arched shape force chain, and the arched strong chain is the path of the overburden transmission force. …”
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A Novel Prognostic Stratified System Based on Tumor Budding and the Cell Nest Size in Ureter Urothelial Carcinoma by Jialin Li, Xinyue Li, Jing Yang

“…The results showed that higher tumor budding, cell nest size, and TBNS grading system were strongly related to shorter overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). …”
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Association between erectile dysfunction and the severity of obstruction to airflow in patients with chronic obstructive pulmonary disease by María J. Pareja-Zabala, Carlos Aguirre, Abraham Alí-Munive, María C. Pareja-Zabala, Luis F. Guerrero, Sandra Huertas, Leidy P. Prada, Luis F. Giraldo-Cadavid

“…Therefore, ED screening in COPD patients using the IIEF could be justified. The strong association between beta-blockers and ED had not been previously described in patients with COPD but must be considered in their clinical management. …”
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Extraocular Surgical Approach for Placement of Subretinal Implants in Blind Patients: Lessons from Cochlear-Implants by Assen Koitschev, Katarina Stingl, Karl Ulrich Bartz-Schmidt, Angelika Braun, Florian Gekeler, Udo Greppmaier, Helmut Sachs, Tobias Peters, Barbara Wilhelm, Eberhart Zrenner, Dorothea Besch

“…Retina implant extraocular surgical technique relies strongly on cochlear-implant know-how. However, a completely new surgical approach providing safe handling of the photosensor array had to be developed. …”
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