CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair by Luc Provencher, Wilson Nartey, Peter M. Brownlee, Austin W. Atkins, Jean-Philippe Gagné, Lou Baudrier, Nicholas S. Y. Ting, Cortt G. Piett, Shujuan Fang, Dustin D. Pearson, Shaun Moore, Pierre Billon, Zachary D. Nagel, Guy G. Poirier, Gareth J. Williams, Aaron A. Goodarzi

“…While CHD6 loss does not impair RAD51 foci formation or DNA double-strand break repair, it causes sensitivity to replication stress, and PARP1/2-trapping or Pol ζ inhibitor-induced γH2AX foci accumulation in S-phase. …”
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Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammat... by Wen Zhang, Junke Song, Wan Li, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du

“…Inflammatory response participates in the overall pathophysiological process of stroke. It is a promising strategy to develop antistroke drugs targeting inflammation. …”
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The First 24 h Hemodynamic Management in NICU after Revascularization Surgery in Moyamoya Disease by Jie Song, Yu Lei, Long Chen, Chao Gao, Wei Ni, Xing Wu, Gang Wu, Ying Mao, Jin Hu, Yuxiang Gu

“…The retrospective study reviewed a single-center MMD cohort in Huashan Hospital from August 2017 to January 2020. Stroke events in 30 days and follow-up modified Rankin Scale (mRS) grade were recorded. …”
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PATHOLOGICAL CHANGES IN MICE TREATED WITH CYCLOPHOSPHAMIDE AND EXOGENOUS DNA by E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov

“…This suggestion is proven by structural equivalents of functional involution of lymphoid organs, such as thymus, spleen, and lymph nodes.We speculate that the death of treated animals resulted from multiple organ dysfunctions caused by accidental involution of lymphoid organs and the systemic inflammatory response syndrome, both associated with injections of fragmented exogenous DNA into experimental animals within the «death window», which corresponds to the final step in the repair of the majority of CP-induced double-strand breaks.…”
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Investigating Falls Risk Awareness in Hospitals Using the Self‐Awareness of Falls Risk Measure (SAFRM): Empirical Research Quantitative by Elissa Dabkowski, Simon J. Cooper, Jhodie Duncan, Karen Missen

“…Impact: Registered nurses, health professionals, inpatients. Reporting Method: STROBE checklist for cross‐sectional studies. Patient or Public Contribution: This study involved the collection of data from patient participants and registered nurses.…”
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Ovarian development of female mud crab, Scylla serrata supplemented with cholesterol and injected with serotonin by Betsy J. Pattiasina, M. Zairin Junior, I. Mokoginta, R. Affandi, W. Manalu

“… Cholesterol is known to play an important role in nutrition of crustacean and function as a precursor for steroids synthesis, while neurohormone of serotonin could induce ovarian maturation in crustacean. …”
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank by Ting Li, Jing Chen, Yan Zheng, Klodian Dhana, Geng Zong, Yuan Ma, Trudy Voortman, Wei Gan, Yaying Cao, Yonghua Hu, Changzheng Yuan, Jie Shen, Gaohong Zhu, Chengwu Feng

“…Comparing the high versus low tertile of FGCRS, the odds ratios (ORs) and 95% confidence intervals (CIs) were 1.26 (1.12 to 1.41) for all-cause dementia, 1.67 (1.33 to 2.09) for Alzheimer’s disease and 1.53 (1.07 to 2.16) for vascular dementia (all ptrend<0.05). Incident stroke and coronary heart disease accounted for 14% (95% CI: 9% to 21%) of the association between FGCRS and all-cause dementia. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…In this prospective study, we investigated the prognostic significance of urinary Marinobufagenin (uMBG), a cardiotonic steroid with acknowledged pro-fibrotic activity, for stratifying the risk of CKD progression in individuals with non-advanced renal disease.MethodsAfter baseline uMBG measurements, 108 CKD patients (eGFR 40.54 ± 17 mL/min/1.73 m2) were prospectively followed up to 24 months. …”
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Germline Single-Nucleotide Polymorphism <i>GFI1-36N</i> Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acu... by Jan Vorwerk, Longlong Liu, Theresa Helene Stadler, Daria Frank, Helal Mohammed Mohammed Ahmed, Pradeep Kumar Patnana, Maxim Kebenko, Eva Dazert, Bertram Opalka, Nikolas von Bubnoff, Cyrus Khandanpour

“…<b>Results</b>: Following the isolation of leukemic bone marrow cells, we were able to show that the <i>GFI1-36N</i> SNP in our model is associated with enhanced oxidative phosphorylation (OXPHOS), increased ROS levels, and results in elevated γ-H2AX levels as a marker of DNA double-strand breaks (DSBs). The use of free radical scavengers such as N-acetylcysteine (NAC) and α-tocopherol (αT) reduced ROS-induced DNA damage, particularly in <i>GFI1-36N</i> leukemic cells. …”
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Effects of brown alga, Stoechospermum marginatum extract on growth performance, body chemical compositions and some serum biochemical parameters in grey mullet, Mugil cephalus (Lin... by Nazanin Kiani, Paria Akbary

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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes by Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess

“…Abstract Aims Aptamer BC 007, a 15‐mer single‐strand DNA oligonucleotide (5'‐GGTTGGTGTGGTTGG‐3'), was developed to neutralize functional autoantibodies that bind to the extracellular domains of G protein‐coupled receptors (GPCR‐AAB), leading to the modulation of receptor‐mediated signalling cascades that induce pathophysiological states. …”
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The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohor... by Yan N, Wu P, Zhu B, Ma A, Wang X, Hai X, Ma X, Jiang H, Yang S

“…All patients were clinically followed for 3-year to collect major adverse cardiac and cerebrovascular events (MACCEs), comprising all-cause death, nonfatal myocardial infarction (MI), rehospitalization for angina, rehospitalization for heart failure (RHF), and stroke. Cox regression models were employed to analyze the association between MR and 3-year clinical outcomes after adjusting for various confounding factors.Results: Among the 6940 patients, 2871 (41.35%) exhibited no MR, 3681 (53.04%) had mild MR, and 388 (5.59%) had moderate/severe MR. …”
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Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Accumulating evidence suggests rationales for continuing immunotherapy beyond progression, synergistic effects between immune checkpoint inhibitors and angiogenesis inhibitors, and a preferable combination of steroid-free chemotherapy with immunotherapy. These rationales imply that nanoparticle albumin-bound (nab)-paclitaxel plus ramucirumab in combination with nivolumab (anti-PD-1 antibody) may enhance anti-tumor effects as second-line treatment. …”
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Flowering characteristics and breeding system of Deutzia parviflora by WANG Qi, LI Jinyu, WANG Xinyi, WANG Yixuan, GUO Wei, YUAN Tao

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Identifikasi Dan Pengendalian Hama Tanaman Jambu Air Dengan Pendekatan Case Based Reasoning Berbasiskan Sistem Pakar by Dasril Aldo

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Pengelompokan Hasil Pencarian Skripsi Berbahasa Indonesia Menggunakan Metode DBSCAN dengan Pembobotan BM25 by Rangga Adi Satria, Indriati Indriati, Sutrisno Sutrisno

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Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports by Lee Shepstone, John F Potter, Lee Hooper, Asmaa Abdelhamid, Amy Jennings, Paul R Hunter, W Garry John, Neil P Walsh, Adam Ali, Diane K Bunn, Susan Kerry, Gregor Lindner, Carmen A Pfortmueller, Fredrik Sjöstrand, Susan J Fairweather-Tait

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Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms by Marc Dörner, Malte Pfister, Anthony Tyndall, Roland von Känel, Katja Neumann, Frank Schreiber, Philipp Arndt, Erelle Fuchs, Cornelia Garz, Wenzel Glanz, Michaela Butryn, Anna-Charlotte John, Annkatrin Hildebrand, Sebastian Euler, Andreas B. Hofmann, Lena Machetanz, Johannes Kirchebner, Pawel Tacik, Alexander Grimm, Robin Jansen, Marc Pawlitzki, Solveig Henneicke, Valentina Perosa, Bendix Labeit, Emrah Düzel, Sven G. Meuth, Stefan Vielhaber, Hendrik Mattern, Jose Bernal, Stefanie Schreiber

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Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022 by Yasmim Gabrielly Souza Sousa, Carolina Alcântara Maneschy, Carolina Costa Monteiro, João Victor Souza Rodrigues, Patrícia Santos Lobo, Dielle Monteiro Teixeira, Jones Anderson Monteiro Siqueira, Kenny Costa Pinheiro, Hugo Reis Resque, Luciana Damascena Silva, Sylvia Fátima dos Santos Guerra, Luana Silva Soares

“…HBoV, a non-enveloped virus with a single-strand DNA genome, belongs to the Parvoviridae family. …”
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Effectiveness of Electronic Quality Improvement Activities to Reduce Cardiovascular Disease Risk in People With Chronic Kidney Disease in General Practice: Cluster Randomized Trial... by Jo-Anne Manski-Nankervis, Barbara Hunter, Natalie Lumsden, Adrian Laughlin, Rita McMorrow, Douglas Boyle, Patty Chondros, Shilpanjali Jesudason, Jan Radford, Megan Prictor, Jon Emery, Paul Amores, An Tran-Duy, Craig Nelson

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