Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…The data show an increased activity of DAC in high stromal cell cocultures and suggest the potential of the tumor-stroma ratio in predicting the outcome of DNA-demethylating epigenetic cancer therapy.…”
Get full text

Association between elevated cystatin C levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis by Nianying Fu, Xiaotao Tan, Jie He

“…Moreover, the increase in cystatin C levels may serve as a risk factor for stroke and MACC in patients with OSAHS. Serum/plasma cystatin C levels exhibited a positive correlation with AHI scores and ODI. …”
Get full text

Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…Elevated CHI3L1 levels have been observed in neurological conditions such as traumatic brain injury (TBI), Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease (CJD), multiple sclerosis (MS), Neuromyelitis optica (NMO), HIV-associated dementia (HAD), Cerebral ischemic stroke (CIS), and brain tumors. This review explores the role of CHI3L1 in the pathogenesis of these disorders, with a focus on its contributions to neuroinflammation, immune cell infiltration, and neuronal degeneration. …”
Get full text

Comparison of Two Preparation Methods for Platelet-Rich Plasma Eye Drops for Release of Growth Factors and De-Epithelization Rabbit Model by Tatsuhiko Kobayashi, Takashi Suzuki, Tomohiko Saito, Takashi Itokawa, Yuichi Hori

“…There was no corneal damage with inflammation in corneal stroma and epithelium of all tested groups. Electron microscopy revealed strong adhesion between cell junctions in T-PRP-treated eyes. …”
Get full text

Pengembangan Knowledge Management System Ukiran Kayu Khas Bali Berbasis Artificial Intelligence by I Putu Restu Indrawan Prabawa, Ariq Cahya Wardhana

Get full text

Influence of bleaching gels containing 45S5 Bioglass on enamel color, surface roughness, and microhardness by Rafael Dascanio, Camila Siqueira Silva Coelho, Marina Trevelin Souza, Edgar Dutra Zanotto, Vanessa Cavalli

Get full text

Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men by Carla Basualto-Alarcón, Paola Llanos, Gerardo García-Rivas, Mayarling Francisca Troncoso, Daniel Lagos, Genaro Barrientos, Manuel Estrada

“…Importantly, plasma SHBG levels are strongly correlated with testosterone concentrations, and in men, low testosterone levels are associated with an adverse cardiometabolic profile. …”
Get full text

Antioxidant Stability of Moringa Leaves Extract Powders Obtained by Cocrystallization, Vacuum Drying, and Plating by Bambang Nurhadi, Fatsyarien Citra Angiputri, Robi Andoyo, Riksfardini Annisa Ermawar, Rudy Adi Saputra

“…The results indicated that the high temperature used in the process was likely to impact crystalline structure through the pore formation, which entrapped bioactive compounds and resulted in strong antioxidant activity. While, vacuum drying resulted in powders with a lower but increased antioxidant activity (84.06%–86.43%). …”
Get full text

Comparisons of risk factors and outcomes between abdominal aortic aneurysm and peripheral arterial disease: a case-control study by Ian Beeton, Jay Acharya, Bengisu Kesin Meric, James Hobden, Tahir Ali, Thang S. Han

“…Myocardial infarct was more prevalent in AAA, and diabetes more in PAD, whilst atrial fibrillation, stroke, congestive heart failure and hypertension did not differ between groups. …”
Get full text

Timed Bromocriptine-QR Therapy Reduces Progression of Cardiovascular Disease and Dysglycemia in Subjects with Well-Controlled Type 2 Diabetes Mellitus by Bindu Chamarthi, J. Michael Gaziano, Lawrence Blonde, Aaron Vinik, Richard E. Scranton, Michael Ezrokhi, Dean Rutty, Anthony H. Cincotta

“…Treatment impact upon a prespecified composite CVD endpoint (first myocardial infarction, stroke, coronary revascularization, or hospitalization for angina/congestive heart failure) and the odds of losing glycemic control (HbA1c >7.0% after 52 weeks of therapy) were determined. …”
Get full text

Small Magnets, Big Future: Low-Field MRI Technology and Clinical Utility by Mohamamdreza Elhaie, Abolfazl Koozari, Iraj Abedi, Mahmoud Mohammadi-Sadr, Abbas Monsef

“…One study found that 0.55T MRI had an accuracy similar to 1.5T for microbleed detection, suggesting its potential as an efficient alternative for stroke diagnosis. The literature has demonstrated the utility of low-field MRI in applications such as musculoskeletal, breast, and abdominal imaging. …”
Get full text

Blue light irradiation combined with low-temperature storage further enhances postharvest quality of strawberries through improving antioxidant defense and cell wall metabolic acti... by Wei Lu, Wanqing Li, Keke Zhao, Xiaofeng Bai, Yuchang Zhang, Qingyun Li, Zhanjun Xue, Xin-Xin Wang

Get full text

PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling by Koji Hashimoto, Yuji Kamijo, Takero Nakajima, Makoto Harada, Makoto Higuchi, Takashi Ehara, Hidekazu Shigematsu, Toshifumi Aoyama

“…Peroxisome proliferator-activated receptor α (PPARα), a member of the steroid/nuclear receptor superfamily, is known to perform various physiological functions. …”
Get full text

A Complementary Low Schottky Barrier Nonvolatile Bidirectional Reconfigurable Field Effect Transistor Based on Dual Metal Silicide S/D Contacts by Liu Xi, Ya Wang, Meile Wu, Lin Qi, Mengmeng Li, Shouqiang Zhang, Xiaoshi Jin

Get full text

Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer by Dominika Wróbel-Dudzińska, Jorge Alio, Alejandra Rodriguez, Ewa Suchodoła-Ratajewicz, Ewa Kosior-Jarecka, Beata Rymgayłło-Jankowska, Agnieszka Ćwiklińska-Haszcz, Tomasz Żarnowski

“…The study group consists of 25 patients with nonhealing corneal ulcers due to herpes simplex or herpes zoster infection and facial nerve or trigeminal nerve paralysis as a result of a neurosurgical operation caused by a tumour or stroke. The patients were given autologous platelet-rich plasma drops five times a day and additionally preservative-free artificial tears and a vitamin A ointment at night for maximum 3 months. …”
Get full text

ADvAnced PhysioTherapy in MuSculosKeletal Triage: Investigating prognostic factors, healthcare utilisation and clinical outcomes (ADAPT MSK) - a cohort study protocol. [version 2;... by Louise Keating, Fiona Callan, Helen P. French, Sarah Casserley-Feeney

“…The STrengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines will be adhered to for future reporting. …”
Get full text

Elevation of High-Mobility Group Protein Box-1 in Serum Correlates with Severity of Acute Intracerebral Hemorrhage by Yu Zhou, Kun-Lin Xiong, Sen Lin, Qi Zhong, Feng-Lin Lu, Hong Liang, Jing-Cheng Li, Jing-Zhou Wang, Qing-Wu Yang

“…The purpose of this study was to examine the correlation between changes in serum levels of HMGB1 following acute ICH and the severity of stroke as well as the underlying mechanism. Changes in serum levels of HMGB1 in 60 consecutive patients with primary hemispheric ICH within 12 hours of onset of symptoms were determined. …”
Get full text

Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides by Soumitra Pathak, Nguyen Bui Thao Le, Taiji Oyama, Yusuke Odahara, Atsuya Momotake, Kazunori Ikebukuro, Chiho Kataoka-Hamai, Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki

“…G4 structures can form in parallel, anti-parallel, or hybrid topologies, depending on strand orientation, but the effects of these topologies on CpG ODNs have not yet been explored. …”
Get full text

A new score for predicting intracranial hemorrhage in patients using anticoagulant drugs by Fuxin Ma, Zhiwei Zeng, Jiana Chen, Chengfu Guan, Wenlin Xu, Chunhua Wang, Jinhua Zhang

“…Our aim was to identify factors associated with cerebral hemorrhage in patients using anticoagulants and to develop a predictive model that would provide an effective tool for the clinical assessment of cerebral hemorrhage.MethodsIn our study, indications for patients receiving anticoagulation included AF, VTE, stroke/TIA, arteriosclerosis, peripheral vascular diseases (PVD), prosthetic mechanical valve replacement, etc. …”
Get full text

Exploring the functional diversity and metabolic activities of the human gut microbiome in Thai adults in response to a prebiotic diet by Amornthep Kingkaw, Preecha Patumcharoenpol, Narissara Suratannon, Massalin Nakphaichit, Sittiruk Roytrakul, Wanwipa Vongsangnak

“…Further identification of cooperative metabolic routes promisingly highlighted the importance of glycolysis/gluconeogenesis, tricarboxylic acid (TCA) cycle, inositol phosphate metabolism, steroid hormone biosynthesis, O-antigen repeat unit biosynthesis, and chloroalkane and chloroalkene degradation. …”
Get full text