Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

“…Molecular docking studies showed that 4896 − 4038 has a strong binding affinity to the active site of Mpro and forms key interactions, such as hydrogen bonds, carbon-hydrogen bonds, pi-sulfur, and multiple van der Waals and pi-pi stacked bonds. …”
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Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study by Maysam Riyadh Mohammed Hussein Alaasam, Karrar Mohammed Abbas Al-buthabhak, Ahmed Mech, Shamim Riadh Mohammed Hussein

“…In the diabetes group, no statistically significant correlation was noted between RDW and disease duration (p = 0.143). RDW was strongly and directly associated with HbA1c and C-reactive protein levels (p < 0.0001 and р = 0.002, respectively). …”
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A self-assembled nanoparticle vaccine elicits effective neutralizing antibody response against EBV infection by Ping Li, Ping Li, Ziyi Jiang, Jingjing Shi, Haochuan Sha, Zihang Yu, Yan Zhao, Sanyang Han, Lan Ma, Lan Ma, Lan Ma

“…Most importantly, the L350–ferritin nanoparticle induced efficient neutralizing antibodies to block EBV-GFP infection in AKATA cells and also constructed a strong antigen-specific B-cell memory in immunized mice. …”
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Advancing health equity: evaluating AI translations of kidney donor information for Spanish speakers by Oscar A. Garcia Valencia, Charat Thongprayoon, Caroline C. Jadlowiec, Shennen A. Mao, Napat Leeaphorn, Pooja Budhiraja, Nadeen Khoury, Justin H. Pham, Iasmina M. Craici, Maria L. Gonzalez Suarez, Wisit Cheungpasitporn

“…Similarly, excellent-quality translations in cultural sensitivity were achieved in 89% of cases for both versions (p = 1.00).ConclusionChatGPT 4.0 demonstrates strong potential to enhance health equity by improving Spanish-speaking Hispanic patients’ access to LKD information through accurate and culturally sensitive translations. …”
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Deciphering the role of metal ion transport-related genes in T2D pathogenesis and immune cell infiltration via scRNA-seq and machine learning by Zuhui Pu, Zuhui Pu, Tony Bowei Wang, Ying Lu, Ying Lu, Zijing Wu, Zijing Wu, Yuxian Chen, Ziqi Luo, Xinyu Wang, Lisha Mou, Lisha Mou

“…Twelve protein structures were predicted using AlphaFold 3, revealing potential functional conformations. We observed a strong correlation between hub RMITRGs and immune cells, and PPI network analysis revealed key interactions. …”
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Antidepressant- and Anxiolytic-like Effects in Mice of Alkaloids from Aerial Parts of <i>Argemone platyceras</i> Link & Otto by Mayra Beatriz Gómez-Patiño, Rosa Estrada-Reyes, Héctor Hugo Hernández-Mendoza, Ángela Suarez-Rojas, Daniel Arrieta-Baez

“…<b>Conclusions:</b> The easy and standardized AlkExt analyzed in pharmaceuticals assays in this study strongly suggest its therapeutic potential to treat the comorbidity of anxiety and depression disorders and support further investigations in people with these diseases.…”
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Impact of witnessing abuse of their mother and childhood trauma on men's perpetration of intimate partner violence in the cross-sectional UN multi-country study on men and violence... by Rachel Jewkes, Ruchira Tabassum Naved, Naeema Abrahams, Nwabisa Shai, Leane Ramsoomar, Bianca Dekel, Andrew Gibbs, Jani Nöthling, Samantha Willan, Esnat Chirwa

“…Conclusions: Both childhood trauma and witnessing IPV were important in driving IPV perpetration, with independent effects, however, broader childhood trauma exposure was most strongly associated. The effects were mediated by food insecurity, depression and gender inequitable and anti-social masculinities, all recognised risk factors for IPV perpetration. …”
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Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies by Elena Rampanelli, Nadia Romp, Antonio Dario Troise, Jakshana Ananthasabesan, Hao Wu, Ismail Sahin Gül, Sabrina De Pascale, Andrea Scaloni, Fredrik Bäckhed, Vincenzo Fogliano, Max Nieuwdorp, Thi Phuong Nam Bui

“…Abstract Background The human gut microbiome strongly influences host metabolism by fermenting dietary components into metabolites that signal to the host. …”
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Health-Related Quality of Life Subdomains in Patients with Parkinson’s Disease: The Role of Gender by Anja Ophey, Carsten Eggers, Richard Dano, Lars Timmermann, Elke Kalbe

“…Disease-related HrQoL determinants (UPDRS-III, H&Y stage, and LEDD) were less strong and consistent HrQoL determinants than nonmotor symptoms. …”
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Regional irreversibility of mean and extreme surface air temperature and precipitation in CMIP6 overshoot scenarios associated with interhemispheric temperature asymmetries by P. J. Roldán-Gómez, P. De Luca, R. Bernardello, M. G. Donat, M. G. Donat

“…These analyses show that in scenarios with strong forcing changes like SSP5-3.4OS, the post-overshoot state is characterized by a temperature asymmetry between the Northern Hemisphere and Southern Hemisphere associated with shifts in the Intertropical Convergence Zone (ITCZ). …”
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The safety of cyclosporine and tacrolimus in pediatric nephrotic syndrome patients: a disproportionate analysis based on the FAERS database by Yu Liu, Chong Yan, Yaowang Zhao, Sui Deng, Jiancheng Zu

“…Sensitivity analysis indicated that gender influenced the occurrence of AEs, with CsA showing higher nephrotoxicity in male patients, while TAC was more strongly associated with metabolic disorders and neurological AEs in female patients.ConclusionIn pediatric NS patients, CsA primarily induces nephrotoxicity and neurological complications, whereas TAC is more likely to cause kidney fibrosis and metabolic disorders. …”
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Oral glucose tolerance testing as a complement to fasting plasma glucose in screening for type 2 diabetes: population-based cross-sectional analyses of 146 000 health examinations... by Patrik Wennberg, Mattias Brunström, Anna Rosén, Julia Otten, Andreas Stomby, Simon Vallin

“…The numbers needed to screen (NNS) to prevent one case of T2D through detection and treatment of IGT was estimated, combining prevalence numbers with average progression rates and intervention effects from previous meta-analyses.Results The prevalence of IGT ranged from 0.9% (95% CI 0.7% to 1.1%) to 29.6% (95% CI 27.4% to 31.7%), and the prevalence of T2D ranged from 0.06% (95% CI 0.02% to 0.11%) to 7.0% (95% CI 5.9% to 8.3%), depending strongly on age, sex and risk factor burden. The estimated NNS to prevent one case of T2D through detection and lifestyle treatment of IGT ranged from 1332 among 40-year-old men without risk factors, to 39 among 60-year-old women with all risk factors combined.Conclusions The prevalence of hyperglycaemia on OGTT is highly dependent on age, sex and risk factor burden; OGTT should be applied selectively to high-risk groups to avoid unnecessary testing in the general population.…”
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Perceptions of sexual assault perpetrators, victims, and event depend on system justification beliefs and perpetrator atonement. by Brianna C Delker, Kira K Means, Allison Schwam, Aubrie L Patterson, Camille A Fogel, Amelita Brown, Alex M Czopp, Kate C McLean

“…Findings underscore the strong influences that perpetrator stories and psychological investment in an unequal status quo have on perceptions of sexual violence.…”
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Correlation between the white blood cell/platelet ratio and 28-day all-cause mortality in cardiac arrest patients: a retrospective cohort study based on machine learning by Huai Huang, Guangqin Ren, Shanghui Sun, Zhi Li, Yongtian Zheng, Lijuan Dong, Shaoliang Zhu, Xiaosheng Zhu, Wenyu Jiang

“…Subgroup analyses stratified the prognostic value of WPR by demographic and clinical factors.ResultsWPR demonstrated the highest prognostic significance among the variables studied, showing a strong association with 28-day all-cause mortality. …”
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Isolation, characterization and control of Botrytis spp. pathogenic on strawberry in Iran by Fatemeh Maghsoodi, Parissa Taheri, Saeed Tarighi

“…Also, the EO at all concentrations tested strongly inhibited spore germination of B. cinerea and B. pelargonii. …”
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Malaria and Helminth Coinfection among Children at the Douala Gyneco-Obstetric and Pediatric Hospital by Ashungafack Flavio, Yamssi Cedric, Noumedem Anangmo Christelle Nadia, Vincent Khan Payne

“…Blood samples were collected from the children and thick blood smears were prepared and examined microscopically for malaria parasites. Stool samples were also collected and examined through the Kato-Katz technique for the identification of helminth eggs. …”
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Gaps in our understanding of ice-nucleating particle sources exposed by global simulation of the UK Earth System Model by R. J. Herbert, A. Sanchez-Marroquin, A. Sanchez-Marroquin, D. P. Grosvenor, D. P. Grosvenor, K. J. Pringle, S. R. Arnold, B. J. Murray, K. S. Carslaw

“…The model captures the overall spatial and temporal distribution of measured INP concentrations, which is strongly influenced by the world's major mineral dust source regions. …”
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Assessing the impact of antimicrobial resistance policies on antibiotic use and antimicrobial resistance-associated mortality in children and adults in low and middle-income countr... by Günther Fink, Jay Patel, Kyaw Zay Ya

“…Outcomes included the proportion of children receiving antibiotics for lower respiratory tract infections and diarrhoea (specific to paediatric populations), along with total antibiotic consumption and AMR-associated mortality in general populations.Results Our analysis of 138 LMICs found wide variation in antibiotic use between countries and regions. We observed strong evidence of negative association (mean difference MD=−0.150, 95% CI (−0.2593 to –0.0407)) between the presence of regulatory or legislative policies that ban over-the-counter sales of antibiotics and the proportion of children receiving antibiotic drugs for lower respiratory tract infection. …”
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Creative Marketing and Financial Performance of Small Medium Enterprises in Rwanda: A Case Study of Selected Businesses in Nyamata Town. by Tenywa, Bashir

“…On the determinants of creative marketing and financial performance of small medium enterprises, majority the participants 20 (30%) strongly agreed, 19 (28%) agreed, 4 (6%) that market selection was one of the determinants of creative marketing and financial performance of small medium enterprises. …”
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Corporate Financing and Risk Management in the Banking Sector in Uganda During and Post Covid-19. Evidence from Kabale District by Semusu, Alex, Byamukama , Eliab Mpora

“…There is a need to set up strong structures for the management of corporate financing in order to enhance risk management in the banking sector.…”
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