Pharmacological effects of fibroblast growth factor 21 are sex-specific in mice with the <em>lethal yellow</em> (A^y) mutation by E. N. Makarova, T. V. Yakovleva, N. Yu. Balyibina, K. O. Baranov, E. I. Denisova, A. D. Dubinina, N. A. Feofanova, N. M. Bazhan

“…Food intake (FI), body weight (BW), blood parameters, and gene expression in the liver, muscles, brown adipose tissue, subcutaneous and visceral white adipose tissues, and hypothalamus were measured. FGF21 action strongly depended on the sex of the animals. In the males, FGF21 decreased BW and insulin blood levels without affecting FI. …”
Get full text

DFT and molecular docking analyses of the effects of solvent polarity and temperature on the structural, electronic, and thermodynamic properties of p-coumaric acid: Insights for a... by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tadesse Lemma Wakjira, Dereje Gelanu, Tesfaye Feyise, Jebel Haji Mahamud, Abdulkerim Abdela, Kebede Shankute Gizew

“…Additionally, molecular docking studies indicated that p-CA achieved strong binding affinities with various proteins, notably a maximum of −7.5 eV with the 3rts protein; however, the presence of caffeine reduced this binding affinity, suggesting competitive interactions that could diminish its therapeutic effectiveness. …”
Get full text

Spatio-temporal risk prediction of leptospirosis: A machine-learning-based approach. by Rodrigue Govan, Romane Scherrer, Baptiste Fougeron, Christine Laporte-Magoni, Roman Thibeaux, Pierre Genthon, Philippe Fournier-Viger, Cyrille Goarant, Nazha Selmaoui-Folcher

“…The strategy achieved a concordance metric of 83.29%, indicating a strong ability to predict the presence of contamination risk, with a sensitivity of 83.93%. …”
Get full text

The Role of Rotational Thromboelastometry in Early Detection of the Hemostatic Derangements in Neonates with Systemic Candida Infection by Rozeta Sokou, Alexia Eleftheria Palioura, Aikaterini Konstantinidi, Alexandra Lianou, Maria Lampridou, Martha Theodoraki, Daniele Piovani, Stefanos Bonovas, Konstantina A. Tsante, Petros Ioannou, Nicoletta Iacovidou, Andreas G. Tsantes

“…Specifically, neonates with SCI had significantly prolonged clotting time (CT) and clot formation time (CFT), as well as lower clot amplitude at 10 min (A10) and maximum clot firmness (MCF) when compared to healthy neonates (<i>p</i> values < 0.05), findings that remained consistent after adjusting for confounding factors such as gestational age, birth weight, and sex. In addition, a strong correlation was noted between ROTEM parameters and disease severity based on the modified NEOMOD, nSOFA, and NeoBAT scores. …”
Get full text

Decomposition of skill scores for conditional verification: impact of Atlantic Multidecadal Oscillation phases on the predictability of decadal temperature forecasts by A. Richling, J. Grieger, H. W. Rust

“…Additionally, the decomposition reveals a strong imbalance among the subsets (defined by AMO phases) in terms of reference weighting, allowing for insightful interpretation and conclusions. …”
Get full text

Role of Prothrombin and Methylenetetrahydrofolate Reductase Gene Polymorphisms as well as Thrombophilia Markers, as Risk Factors for Unexplained Recurrent Miscarriage: A Case-Contr... by Zeinab Ahmed Abd Elhameed, Omar M Shaaban, Hanan G Abd Elazeem, Azza Abouelfadle, Tarek Farghaly, Ghada Mahran, Mohamed Ismail Seddik

“…C allele was found in 70.5% of group I and 75% of group II, while T allele was foundin 29.5% of group I and 25% of group II (P=0.269).Conclusion: PT G20210A and MTHFR C677T gene mutations are not correlated with RM in the Egyptian population.However, Egyptian women with RM are strongly associated with hyperhomocysteinemia, PC, PS, and ATIII deficiencies(registration number: NCT03209063).…”
Get full text

Sharia Financial Literacy and Good Corporate Governance for Generation Z: Study in Sharia Banks in Indonesia by Novrida Qudsi Lutfillah Lutfillah, Yeni Agustin Novitasari, Atik Andhayani

“…These findings emphasize the need for Sharia banks and regulators to actively promote financial literacy and enforce strong GCG practices to enhance their competitiveness among Generation Z.   …”
Get full text

Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens by Zhaoyang Wang, Chongyu Tian, Jiahang Zhu, Shiqian Wang, Xiang Ao, Yanjuan He, Huixin Chen, Xiuying Liao, Deming Kong, Yongfei Zhou, Wanbo Tai, Ming Liao, Huiying Fan

“…Results In experiments on BALB/c mice, the vaccine candidate elicited strong humoral and a certain cellular immune responses and protected mice from the heterologous AIV challenge. …”
Get full text

The synergistic effects of recycled polyethylene terephthalate fiber and fly ash on the ductility of one-part geopolymer stabilized soft soil by Zihan Zhou, Guo Hu, Qiang Zhu, Chuanqin Yao, Jun Wu

“…Microstructural analysis revealed that PET fiber can form strong interfacial bonding with geopolymer-soil matrix, generating considerable cohesive and frictional forces. …”
Get full text

Magnitude and Predictors of Dietary Diversity among HIV-Infected Adults on Antiretroviral Therapy: The Case of North-Western, Ghana by Louis Nebayeng Mornah, Mahama Saaka, Diana Pireh

“…Having a secured salary paid job, not taking cotrimoxazole prophylaxis, and being a young adult were strong predictors of a high dietary diversity score. …”
Get full text

The Relationship Between the Functional and Physical Condition with Pain and Trauma of Basketball Players in Terms of Gender by Ernestas Barkus, Ligita Šilinė

“…In female players, a moderate inverse relationship was found between functional condition and pain (r = -0.679, p<0.05), and a strong relationship with trauma (r = -0.898, p<0.05) was found. …”
Get full text

Network characteristics of referrals for chronic disease patients: results from hierarchical medical reform in Shenzhen, China by Fangfang Gong, Junxia Luo, Zhihong Wang, Ping Tang, Guangyu Hu, Ying Zhou, Hanqun Lin

“…Primary care facilities (PCFs) were strongly associated with the tertiary hospital (0.51–0.98). …”
Get full text

A Study on Canopy Volume Measurement Model for Fruit Tree Application Based on LiDAR Point Cloud by Na Guo, Ning Xu, Jianming Kang, Guohai Zhang, Qingshan Meng, Mengmeng Niu, Wenxuan Wu, Xingguo Zhang

“…These results demonstrate that the PLSR model exhibits strong generalization ability, minimal prediction bias, and low average prediction error, offering a valuable reference for precision control of canopy spraying in orchards.…”
Get full text

Nutrient Profiling Models in Low- and Middle-Income Countries Considering Local Nutritional Challenges: A Systematic Review by Marie Tassy, Ries van Dijk, Alison L Eldridge, Tsz Ning Mak, Adam Drewnowski, Edith JM Feskens

“…Warning Label schemes are used to strongly discourage the consumption of energy-dense products in countries where overnutrition affects most of the population, such as Latin American LMICs. …”
Get full text

Seasonal and Regional Differences in Extreme Rainfall Events and Their Contribution to the World’s Precipitation: GPM Observations by Shailendra Kumar, Yamina Silva, Aldo S. Moya-Álvarez, Daniel Martínez-Castro

“…EREs based on various parameters are strongly linked over SAsia compared to SA. For example, the largest top 10% EREs have a higher probability to be part of the top 10% deepest and intense EREs over SAsia. …”
Get full text

Scientific breeding of winter bread wheat in the Non-Сhernozem zone of Russia: the history, methods and results by B. I. Sandukhadze, R. Z. Mamedov, M. S. Krakhmalyova, V. V. Bugrova

“…Cultivar Moskovskaya 39 (registration in 1999) was referred to strong wheat, with a stable protein content of 15–16 %, gluten 30–35 %. …”
Get full text

Prediction of coal dust particle size after spraying dust reduction in roadway based on orthogonal experiment and regression analysis by Bingyou JIANG, Yuqian ZHANG, Changfei YU, Ben JI, Haoyu WANG, Zhuang LIU

“…The results show that: the coal dust D90 after spray dust reduction decreases with the increase of the distance from the dust source to the spray frame, increases and then decreases with the increase of wind speed, and increases with the increase of water supply pressure, and there is a strong positive correlation between full dust, exhaled dust reduction efficiency and D90, the better the spray dust reduction effect, the larger the coal dust D90 after spray dust reduction; the weighting-based prediction model of coal dust D90 after dust spraying has higher accuracy and smaller error, and can accurately characterize the quantitative relationship between coal dust D90 after dust spraying and three influencing factors, namely, the distance of the spray frame from the dust source, the wind speed of the roadway, and the water supply pressure of the nozzle.…”
Get full text

Diabetes Treatment with Dapagliflozin and Its Combinations: Insights from Clinical Practice by Akshay Bafna, Ajit Mehta, Rajeev Garg, Jayagopal Pathiyil Balagopalan, Rajesh Rajput, Nitin Zalte, Preethi Naik, Amarnath Sugumaran, Senthilnathan Mohanasundaram

“…The use of a triple-drug FDC of dapagliflozin plus sitagliptin plus metformin was strongly recommended by 74.40% of clinicians. Early initiation and intensification with a combination of SGLT2i and DPP4i in young T2DM patients (30–50 years) inadequately managed on metformin was highly recommended (94.58%). …”
Get full text

A Collision-Free Path-Planning Method for an Articulated Mobile Robot by P. Quintero-Alvarez, G. Ramirez, S. Zeghloul

“…This kind of robot is a strongly constrained system. Even in a free environment, under some circumstances, the robot may be blocked by its trailers in its progression towards the goal. …”
Get full text

Investigating Light and Water Optimization for Early Seedling Establishment in Albizia lebbeck (L.) Benth by Kelechi Godwin Ibeh, Adejoke Olukemi Akinyele

“…However, there was no significant difference between daily watering (W1) and moderate watering frequency (W2). Strong intrinsic synchronization was observed between the collar diameter and plant height growth trajectories over time, reflecting coordinated lateral and vertical stem expansion regulated by developmental processes. …”
Get full text