Comparing the Prognostic Value of PTEN and Akt Expression with the Mitotic Activity Index in Adjuvant Chemotherapy-Treated Node-Negative Breast Cancer patients aged <55 years by Emiel A. M. Janssen, Håvard Søiland, Ivar Skaland, Einar Gudlaugson, Kjell H. Kjellevold, Arne Nysted, Jon-Arne Søreide, Jan P. A. Baak

“…Cell proliferation, especially the Mitotic Activity Index (MAI), is strongly prognostic in lymph node-negative (LNneg) invasive breast cancer. …”
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Morphological, Physiological and Biochemical Changes in the Grape Variety “Hotan Red” Caused by the Occurrence of Stress Under the Influence of Saline–Alkaline Growing Conditions... by Yan Song, Ruxue Li, Long Zhou, Lili Jiang, Xiong Wang

“…The native Hotan Red grape germplasm from Xinjiang has strong saline–alkali tolerance. To clarify the physiological mechanisms of Hotan Red grapes in response to saline–alkali stress, Hotan Red hydroponic seedlings were used as the research material in this study and were subjected to the combined saline–alkali stress treatments of 0, 40, 80, 120 and 160 mmol·L⁻¹. …”
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Preparation of Zwitterionic Sulfobetaines and Study of Their Thermal Properties and Nanostructured Self-Assembling Features by Yenglik Amrenova, Arshyn Zhengis, Arailym Yergesheva, Munziya Abutalip, Nurxat Nuraje

“…The polymers’ self-assembly behavior was strongly dependent on pH and their surface charge, particularly under varying pH conditions: spherical micelles were observed at neutral pH, while fractal aggregates formed at basic pH. …”
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Methods of security situation prediction for industrial internet fused attention mechanism and BSRU by Xiangdong HU, Zhengguo TIAN

“…The security situation prediction plays an important role in balanced and reliable work for industrial internet.In the face of massive, high-dimensional and time-series data generated in the industrial production process, traditional prediction models are difficult to accurately and efficiently predict the network security situation.Therefore, the methods of security situation prediction for industrial internet fused attention mechanism and bi-directional simple recurrent unit (BSRU) were proposed to meet the real-time and accuracy requirements of industrial production.Each security element was analyzed and processed, so that it could reflect the current network state and facilitate the calculation of the situation value.One-dimensional convolutional network was used to extract the spatial dimension features between each security element and preserve the temporal correlation between features.The BSRU network was used to extract the time dimension features between the data information and reduced the loss of historical information.Meanwhile, with the powerful parallel capability of SRU network, the training time of model was reduced.Attention mechanism was introduced to optimize the correlation weight of BSRU hidden state to highlight strong correlation factors, reduced the influence of weak correlation factors, and realized the prediction of industrial internet security situation combining attention mechanism and BSRU.The comparative experimental results show that the model reduces the training time and training error by 13.1% and 28.5% than the model using bidirectional long short-term memory network and bidirectional gated recurrent unit.Compared with the convolutional and BSRU network fusion model without attention mechanism, the prediction error is reduced by 28.8% despite the training time increased by 2%.The prediction effect under different prediction time is better than other models.Compared with other prediction network models, this model achieves the optimization of time performance and uses the attention mechanism to improve the prediction accuracy of the model under the premise of increasing a small amount of time cost.The proposed model can well fit the trend of network security situation, meanwhile, it has some advantages in multistep prediction.…”
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Research Progress and Prospect of High-Nitrogen Austenitic Stainless Steel by Jiao　Xiaofei, Li　Qun, Wang　Dongjia, Wang　Shuhuan, Ni　Guolong

“…High-nitrogen austenitic stainless steels exhibit high strength and toughness， strong wear and corrosion resistance， and also possess non-magnetic property along with excellent biocompatibility. …”
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Predefined and data-driven CT radiomics predict recurrence-free and overall survival in patients with pulmonary metastases treated with stereotactic body radiotherapy. by Pascal Salazar, Patrick Cheung, Balaji Ganeshan, Anastasia Oikonomou

“…"Clinical indication for SBRT" and "lung primary cancer origin" were strongly associated with RFS and improved the RFS C-index: 0.67 (0.62-0.72) when combined with the best radiomic features. …”
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Temporal and Spatial Evolution Characteristics of Extreme Climate Events in Grand Shangri-La Region from 1961 to 2019 by WU Yang, JIN Hanyu, CHENG Qingping

“…The Grand Shangri-La region connects the Qinghai-Tibet Plateau,the Yunnan-Guizhou Plateau,and the Hengduan Mountains and is of great geographical significance.Five rivers flow through the region,and the climate is vulnerable.Therefore,it is necessary to explore extreme climate changes and their response mechanism,so as to assess regional climate risks and achieve disaster warnings.Based on the daily temperature and precipitation data of 56 meteorological stations from 1961 to 2019,this paper analyzes changes in extreme climate indexes and their correlation with large-scale circulation index in the region by using Mann-Kendall,Sen's slope estimation,Pettitt test,and Pearson correlation analysis.The results show that:① The extreme warm index and the extreme precipitation intensity index (RX1day,R95p,R99p,and SDII) increase significantly,while the cold index (CSDI、FD、ID、TN10p、TX10p) and the number of continuous humid days decrease greatly.In terms of different seasons,the warming amplitude of most of the extreme temperature indexes in winter is higher than that in summer,and the precipitation intensity increases gradually in summer and autumn but decreases slightly in winter.② Spatially,the diurnal temperature range in the north of the Qinghai-Tibet Plateau is higher than that in the south,and the frequency of extremely high-temperature rises,with the high temperature appearing mostly in arid valleys in the south and east of the Qinghai-Tibet Plateau.The precipitation intensity is high in the south and west of the Hengduan Mountains,and persistent precipitation is strong in the Yalong River basin and the upper reaches of the Jinsha River in the north.③ Extreme climate indexes and south China sea summer monsoon index (SCSMI) are significantly correlated in the same year.In addition,there is a one-year response lag between the extreme precipitation index and Arctic oscillation (AO),North Atlantic oscillation (NAO),and Pacific decadal oscillation (PDO).The above analysis shows that the Grand Shangri-La region generally shows warming and humid climate characteristics.The frequency of heavy precipitation in flood season and warm winter events increases and is closely related to large-scale circulation.…”
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Intelligent information systems for power grid fault analysis by computer communication technology by Ronglong Xu, Jing Zhang

“…Moreover, the system exhibits strong robustness in complex scenarios, with an average fault prediction error rate of just 1.1% across multiple simulations. …”
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Association of iron status indicators with thyroid hormone concentrations during pregnancy: a systematic review and meta-analysis by Mohammadamin Parsaei, Mohadese Dashtkoohi, Elahe Amirkhalili, Mohammadreza Chashmyazdan, Tim I. M. Korevaar, Tim I. M. Korevaar, Pantea Nazeri

“…Conversely, maternal hemoglobin levels were inversely associated with thyroid-stimulating hormone (P-value = 0.009) and directly associated with free T4 (P-value &lt; 0.001), with no significant link to total T4.ConclusionsMaternal hemoglobin levels are more strongly correlated with thyroid function than serum ferritin levels. …”
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Development of a Human Intestinal Organoid Model for In Vitro Studies on Gut Inflammation and Fibrosis by Leonidas Kandilogiannakis, Eirini Filidou, Ioannis Drygiannakis, Gesthimani Tarapatzi, Stylianos Didaskalou, Maria Koffa, Konstantinos Arvanitidis, Giorgos Bamias, Vassilis Valatas, Vasilis Paspaliaris, George Kolios

“…Similarly, HIOs elicited strong mRNA and protein mesenchymal (CXCL10) and epithelial (CXCL1, CCL2, CXCL8, and CCL20) chemokine responses in early but not late passages. …”
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Deep learning-based skin lesion analysis using hybrid ResUNet++ and modified AlexNet-Random Forest for enhanced segmentation and classification. by Saleem Mustafa, Arfan Jaffar, Muhammad Rashid, Sheeraz Akram, Sohail Masood Bhatti

“…This method takes advantage of ResUNet++ strong classification skill and modified AlexNet-Random Forest robustness for more accurate segmentation. …”
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Nanoconfined Water in Shales and Its Impact on Real Gas Flow by Yudan Li, Shaohua Gu, Cheng Dai

“…Compared with inorganic pores, gas transport in organic pores is greatly enhanced by the water film flow due to the strong water slip. Moreover, the contribution of water film mobility is remarkable in small pores with large contact angles, especially at high pressures. …”
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Studying agronomic characters in new millet accessions from the VIR collection at Yekaterinino Experiment Station of VIR by T. V. Kulemina

“…‘Zapadnoye’, k-10481) and from Chelyabinsk Province (local cultivar, k-888). Medium and strong resistance to bacterial pathogens was observed in k-888, k-10275, k-10473, k-10474, k-10324, and k-10325. …”
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Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells by Adhish S. Walvekar, Marc Warmoes, Dean Cheung, Tim Sikora, Najmesadat Seyedkatouli, Gemma Gomez-Giro, Sebastian Perrone, Lisa Dengler, François Unger, Bruno F. R. Santos, Floriane Gavotto, Xiangyi Dong, Julia Becker-Kettern, Yong-Jun Kwon, Christian Jäger, Jens C. Schwamborn, Nicole J. Van Bergen, John Christodoulou, Carole L. Linster

“…Surprisingly, the galactose-grown NAXDko cells displayed only subtle signs of mitochondrial impairment, whereas metabolomic analyses revealed a strong inhibition of the cytosolic, de novo serine synthesis pathway in those cells as well as in NAXD patient-derived fibroblasts. …”
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Computational insights into Sitahe (Leuconotis eugenifolia) bioactive compounds: A promising approach for radioprotection through p53 inhibition by Dian Pribadi Perkasa, Iin Kurnia, Taufik Muhammad Fakih, Teja Kisnanto, Dwi Ramadhani, Harry Nugroho Eko Surniyantoro, Boky Jeanne Tuasikal, Alfian Mahardika Forentin, Mukh Syaifudin

“…Molecular docking studies identified strong binding affinities between these compounds and the p53 DNA binding domain, with baurenol demonstrating the highest binding affinity at −6.75 kcal/mol, which is better compared to rhazinilam (−4.55 kcal/mol), leuconolam (−4.36 kcal/mol), leuconoxine (−4.26 kcal/mol), and dehydroleuconoxine (−4.76 kcal/mol). …”
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Multiomics Integrated Analysis Identifies SLC24A2 as a Potential Link between Type 2 Diabetes and Cancer by Qin Bian, Haijun Li, Xiaoyi Wang, Tingting Liang, Kai Zhang

“…SLC24A2 was first identified as a key gene strongly associated with fasting plasma glucose (FPG). …”
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Cinnamic Acid Compounds (<i>p</i>-Coumaric, Ferulic, and <i>p</i>-Methoxycinnamic Acid) as Effective Antibacterial Agents Against Colistin-Resistant <i>Acinetobacter baumannii</i> by Alaaddin Korkut, Serap Özkaya Gül, Esra Aydemir, Hakan Er, Elif Odabaş Köse

“…The compounds showed effective antibiofilm activity against strong and moderate biofilm-producing isolates, inhibiting biofilm formation by 77.5% and 19.7%. …”
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Mineralogical and geochemical characteristics of the third member of Palaeogene Dongying formation in the Nanpu Sag, Bohai Bay Basin: implications for controlling on organic matter... by Shiyan Yin, Shiyan Yin, Aidong Yao, Jianzhong Cheng, Chuang Lei, Zhaosheng Wang, Zhenguo Zhang, Ying Zhang, Yu Wang, Xiaoying Han, Zhigang Ma

“…Introduction and MethodsTo identify the unconventional shale oil exploration potential of the third member of the Palaeogene Dongying Formation (Ed3) in the Nanpu Sag, Bohai Bay Basin, variations in paleoclimate and paleoenvironment and their influence on organic matter accumulation were investigated through analyzing mineralogical and geochemical characteristics of forty-nine mudstone samples.ResultsResults show that the Ed3 mudstones exhibit strong heterogeneity with the organic carbon content ranging from 0.30% to 2.66%, petroleum potential yield ranging from 0.44 to 11.41 mg/g, and hydrogen index ranging from 57 to 466 mg/g TOC, which are dominated by mixed kerogen and low maturity to maturity. …”
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Znaczenie partnerstwa publiczno-prywatnego we wdrażaniu polityki regionalnej Podkarpacia w procesie integracji europejskiej by Jan Cebulak

“…We wdrażaniu zasad PPP należy brać pod uwagę także ryzyko polityczne i legislacyjne, zwłaszcza niestabilność polityczna i częste zmiany personalne, głównie po stronie partnerów publicznych, mogą być zagrożeniem dla realizacji rozpoczętych projektów, transferowania środków finansowych, powodowania zmian obowiązujących obciążeń podatkowych czy też innych uregulowań prawnych. …”
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Heterosis and heritability of traits contributing to select high yielding drought stress tolerance sweetpotato breeding lines by Mahaman Mourtala Issa Zakari, Emeka Benjamin Utobo, Zangui Souley Moussa, Josefina Ndamononghenda Abed, Ifeanyi Maxwell Nwankwo Innocent, Happiness Ogba Oselebe

“…Highly significant (p < 0.01) and strong positive genotypic and phenotypic associations were obtained between chlorophyll content and upper biomass yield (0.87) and between storage root diameter and storage root yield (0.81). …”
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