A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Despite anecdotal reports linking multiple drugs to PV, corroborating evidence from large datasets is missing.ObjectiveTo examine the extent to which previously reported associations between a comprehensive list of 36 drugs implicated in PV pathogenesis could be replicated using population-level pharmacovigilance data.DesignSeries of observational, retrospective, case-control, pharmacovigilance analyses (one analysis/drug, 36 total).SettingPopulation based.ParticipantsIndividuals who submitted a report of a drug-related adverse event to the FDA from Q4 of 2003 to Q2 of 2023.ExposureCases were identified by the presence of adverse events described by the MedDRA preferred term “pemphigus” (10034280) and then sorted based on exposure to each of the drugs of interest.Main outcomes and measuresReporting Odds Ratios (RORs) quantifying the association between a given drug exposure and reports of pemphigus adverse events.ResultsThe analyses revealed statistically significant associations between reports of pemphigus and exposure to 11/36 previously reported drugs, two of which had particularly high RORs (>200) [gold sodium thiomalate (ROR, 266.0; 95% CI, 202.6-349.3) and hydroxychloroquine (ROR, 282.6; 95% CI, 261.0-306.1)], three had very strong RORs (14-45) [penicillamine (ROR, 30.5; 95% CI, 11.4-81.7), piroxicam (ROR, 14.8; 95% CI, 8.2-26.7), and imiquimod (ROR, 42.3; 95% CI, 26.2-68.3)], and six had modestly strong RORs (2-5) [rifampin (ROR, 2.8; 95% CI, 1.4-5.6), hydrochlorothiazide (ROR, 1.6; 95% CI, 1.2-2.1), irbesartan (ROR, 2.7; 95% CI, 1.6-4.4), lisinopril (ROR, 5.3; 95% CI, 4.5-6.2), nivolumab (ROR, 2.7; 95% CI, 1.8-4.1), and nifedipine (ROR, 3.0; 95% CI, 1.9-5.0)]. …”
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lncRNA ZFAS1 Promotes HMGCR mRNA Stabilization via Binding U2AF2 to Modulate Pancreatic Carcinoma Lipometabolism by Luoluo Wang, Yi Ruan, Xiang Wu, Xinhua Zhou

“…Being one of the most lethal malignant tumors worldwide, pancreatic carcinoma (PC) shows strong invasiveness and high mortality. In tumorigenesis and progression, the role played by long-chain noncoding RNAs (lncRNAs) cannot be ignored. …”
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The Decreased Treg Cells Number Associated with Retinal Lesion Size in Ocular Toxoplasmosis by Ovi Sofia, Muna Amalia, Herryanto Thomassawa, Loeki Enggar Fitri, Seskoati Prayitnaningsih, Hani Susianti

“…The number of Treg cells was significantly related to retinal lesion size (p=0.043), with a correlation coefficient of −0.648, indicating a strong and inverse correlation. There was no significant correlation between serum IL-27 levels and retinal lesion size (p=0.556). …”
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Breeding practices and selection criteria in Gudali cattle breed from Benin: implications for the design of a community-based breeding program by Loukaiya Zorobouragui, Loukaiya Zorobouragui, Isidore Houaga, Isidore Houaga, Alassan S. Assani, Hilaire S. S. Worogo, Lionel Kinkpe, Kathiravan Periasamy, Ibrahim T. Alkoiret

“…While only 3.33% of farmers were aware of community-based breeding programs (CBBP), there was strong interest (95%) in participating. Potential challenges such as access to feed and disease management were reported. …”
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Ki67 Predicts Progression in Early CIN: Validation of a Multivariate Progression-Risk Model by Arnold-Jan Kruse, Jan P. A. Baak, Emiel A. Janssen, Kjell-Henning Kjellevold, Bent Fianec, Kjell Lovslett, Johan Bergh, Stanley Robboy

“…In conclusion, the results confirm that quantitative Ki67 features have strong prognostic value for progression in early CIN lesions.…”
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In Vitro Experimental Assessment of Ethanolic Extract of Moringa oleifera Leaves as an α-Amylase and α-Lipase Inhibitor by Adebanke Ogundipe, Babatunde Adetuyi, Franklyn Iheagwam, Keleko Adefoyeke, Joseph Olugbuyiro, Oluseyi Ogunlana, Olubanke Ogunlana

“…Diphenyl-2-picrylhydrazyl (DPPH), ABTS (2,2′-azino-bis (ethylbenzothiazoline-6-sulfonic acid)), and nitric oxide (NO) assays showed the extract to have a strong free radical scavenging activity. The 50% inhibitory concentration (IC50) values of the lipase and amylase activities of the extract are 1.0877 mg/mL and 0.1802 mg/mL, respectively. …”
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HET-CAM test in evaluation of irritating action of adhesives used in shoe making industry by U.B. Lototska-Dudyk, B.P. Kuzminov, N.Ye. Chemodurova, V.A. Turkina

“…According to the irritating index, polyurethane (one- and two-component) and styrene-butadiene adhesives were estimated to be strong irritants, while rubber and polychloroprene ones cause moderate irritating action. …”
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Crude Oil Foulant Deposition Studies on a Heated Surface Using a Novel Batch Stirred Coupon Test Rig by Pragya Singh, Srinivas Krishnaswamy, Krishnaswamy Ponnani, Ankur Verma, Jaya Rawat

“…The foulant deposits obtained were found to have a strong (hard) and weakly (soft) adhering component. …”
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Biological characteristics, immune infiltration and drug prediction of PANoptosis related genes and possible regulatory mechanisms in inflammatory bowel disease by Minglin Zhang, Tong Liu, Lijun Luo, Yuxin Xie, Fen Wang

“…The nomogram model, calibration curves, ROC and DCA curves have strong predictive value. Immuno-infiltration analysis revealed that immune cell infiltration was increased in patients with IBD, and the model genes were closely related to the infiltration of various immune cells. …”
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Enhancing the Therapeutic Effect and Bioavailability of Irradiated Silver Nanoparticle-Capped Chitosan-Coated Rosuvastatin Calcium Nanovesicles for the Treatment of Liver Cancer by Tamer Mohamed Mahmoud, Mohamed Mahmoud Abdelfatah, Mahmoud Mohamed Omar, Omiya Ali Hasan, Saad M. Wali, Mohamed S. El-Mofty, Mohamed G. Ewees, Amel E. Salem, Tarek I. Abd-El-Galil, Dina Mohamed Mahmoud

“…CS.Nop has displayed a strong in vitro–in vivo correlation with R² 0.9887. …”
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Enlarged airspaces in the distal lung in adolescents born very preterm as measured by aerosol by Per Wollmer, Cecilia Hagman, Madeleine Petersson Sjögren, Jakob Löndahl, Ellen Tufvesson, Hugo Öhrneman, Frida Lindström, Jenny Rissler

“…The adolescents diagnosed with BPD had a mean rAiDA of 313±54 µm. There was a strong negative correlation between gestational age and distal airspace radius (p<0.0001). …”
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Land Suitability Assessment for Apple (Malus domestica) Production in Sentele Watershed in Hadiya Zone, Southern Ethiopia by Getachew Beyene, Nigussie Dechassa, Alemayehu Regasa, Lemma Wogi

“…The methodology was based on the land evaluation developed by FAO (1976) that suggests biophysical diagnostic factors, which most strongly influenced the cultivation of apples. Criteria were defined, background information was gathered, and a raster surface was created. …”
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First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status by Magdalena Materniak-Kornas, Katarzyna Piórkowska, Katarzyna Ropka-Molik, Adrianna Dominika Musiał, Joanna Kowalik, Anna Kycko, Jacek Kuźmak

“…However, when the relationship between SNPs and SRLV proviral load was analyzed, five had a strong association, considering the whole population of tested sheep. …”
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Determination of the Hydration Damage Instability Period in a Shale Borehole Wall and Its Application to a Fuling Shale Gas Reservoir in China by Haicheng She, Zaiqiang Hu, Zhan Qu, Yao Zhang, Hu Guo

“…During the process of drilling in shale, the complex stress and fluid-structure interactions result in the wall rock generating a strong hydration diffusion and swelling effect, which alters the stress distribution in the rock wall and deteriorates the mechanical parameters of the rock. …”
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Pentraxin 3 Levels in Young Women with and without Polycystic Ovary Syndrome (PCOS) in relation to the Nutritional Status and Systemic Inflammation by Katarzyna Wyskida, Grzegorz Franik, Piotr Choręza, Natalia Pohl, Leszek Markuszewski, Aleksander Owczarek, Paweł Madej, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz

“…Our results show that the decrease in PTX3 levels observed in obese is distorted in PCOS by microinflammation, and possibly, dysfunction of stroma adipose tissue and liver steatosis is reflected by enhanced insulin resistance.…”
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Does energy-consuming right trading policy achieve a low-carbon transition of the energy structure? A quasi-natural experiment from China by Ye Chen, Bin Zhong, Bingnan Guo

“…The transmission mechanism of industrial structure upgrading and the new-quality productive forces in the impact process was discussed, and the regulatory role of environmental regulations was tested.ResultsThe findings indicate: 1) ECRT has a strong driving effect on the low-carbon transition of the energy structure. 2) ECRT can promote low-carbon transition of the energy structure through the dual channel of promoting industrial structure upgrading and new quality productive forces. 3) The influence of ECRT on the low-carbon transition of the energy structure is different in different regions, and the higher degree of industrial agglomeration and renewable energy-rich regions are more significantly promoted by new quality productivity. 4) Environmental regulation has a significant positive moderating effect on the relationship between ECRT and low-carbon transition of the energy structure. 5) Furthermore, the exploratory analysis reveals that the positive impacts of ECRT policies on the low-carbon Transition of the energy structure translates into higher green total factor productivity and lower environmental pollution, which promotes the sustainable development of the low-carbon Transition of the energy structure.DiscussionThis paper responds to the basic question of whether energy use rights policies can promote the low-carbon Transition of the energy structure, and provides empirical evidence and policy reference not only for the development of China’s environmental policy and the direction of energy consumption but also for the international community’s efforts in sustainable energy and environmental governance.…”
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Response mechanism of heat-sensitive neurons under combined noise stimulation by Yunhai Wang, Guodong Huang, Rui Zhu, Shu Zhou, Yuan Chai

“…When exposed to Chua's circuit stimulus, chaotic emission patterns reveal significant shifts in attractor contour, indicating a strong response to spike, r-clonic, and periodic stimuli. …”
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3D Web Application of Wind Prediction Under Typhoon on Coastal Cities Based on Ensemble k-NN and OpenFOAM by Mamad Tamamadin, Seong-Hoon Kee, Jurng-Jae Yee

“…Coastal cities are vulnerable areas to the impacts of strong wind under typhoon events. To anticipate the impact, this study proposes a novel approach to integrate the typhoon track predictions generated by an ensemble k-Nearest Neighbors (k-NN) as the reference locations of the typhoon center. …”
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Information and communication technology-based health interventions for transgender people: A scoping review. by Horas T H Wong, Sujith Kumar Prankumar, Jialiang Cui, Christopher Tumwine, Isaac Yeboah Addo, Wansang Kan, Muhammad Naveed Noor

“…In the recent past, there has been a strong interest in the use of information and communication technology (ICT) to deliver healthcare to 'hard-to-reach' populations. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

“…Clinical diagnosis of syndromes benefits strongly from objective facial phenotyping. This study introduces a novel approach to enhance clinical diagnosis through the development and exploration of a low-dimensional metric space referred to as the clinical face phenotypic space (CFPS). …”
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