PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression by Sen Meng, Hao Liu, Jiayu Xu, Chuyin Deng, Xingyou Qian, Sufang Chu, Wei-Guo Zhu, Jiuling Zhu, Hongmei Yong, Zhongwei Li, Jin Bai

“…Furthermore, we consistently showed a strong association between meR316-ALKBH5 and poor outcomes in patients with CRC. …”
Get full text

Perception of antibiotic use and antibiotic resistance among faculty and staff in a medical school: insights from a mixed mode survey in Bahrain by Ronni Mol Joji, Archana Prabu Kumar, Amer Almarabheh, Ali Al-Mahmeed, Mohd Shadab, Khalid Bindayna, Mohammad Shahid

“…Conclusions Although the study revealed a strong understanding of antibiotics, awareness regarding antibiotic resistance remained low. …”
Get full text

Wide-ranging and Violent Volcanic History of a Quiet Transborder Area: Volcanic Geoheritage of the Novohrad–Nógrád UNESCO Global Geopark by Szabolcs Harangi, Imre Szarvas, Réka Lukács

“…“Ancient world without borders” – its motto reflects both the remarkable geodiversity and the strong link between people living on either side of the state border. …”
Get full text

L'approche écosystémique de la santé des populations : le cas de l’exposition au mercure des communautés riveraines de l’Amazonie et du nord du Québec by Sebastian Weissenberger, Delaine Sampaio da Silva, Roger Schetagne

“…The ecosystem approach, whether implicitly or deliberately adopted, emerges as the best adapted model for this type of environmental issue, especially when paired with a strong implication of the concerned populations. In the absence of any options to reduce the mercury contamination in the affected ecosystems, the emphasis has been put on monitoring and on the management and communication of health risks. …”
Get full text

Blowing Out the Candle: How to Quench Galaxies at High Redshift—An Ensemble of Rapid Starbursts, AGN Feedback, and Environment by Lucas C. Kimmig, Rhea-Silvia Remus, Benjamin Seidel, Lucas M. Valenzuela, Klaus Dolag, Andreas Burkert

“…We predict that relics of such high- z quenched galaxies should best be characterized by a strong alpha enhancement.…”
Get full text

Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases by Caitlyn L. Holmes, Daeun Shim, John Kernien, Chad J. Johnson, Jeniel E. Nett, Miriam A. Shelef

“…Only ionomycin and C. albicans were strong inducers of NETs in mice with ionomycin-induced NETs mostly citrullinated and C. albicans-induced NETs a mix of citrullinated and uncitrullinated. …”
Get full text

Advances in Therapy for Urothelial and Non-Urothelial Subtype Histologies of Advanced Bladder Cancer: From Etiology to Current Development by Whi-An Kwon, Ho Kyung Seo, Geehyun Song, Min-Kyung Lee, Weon Seo Park

“…For advanced-stage diseases, clinical trial participation is strongly recommended to address the lack of robust evidence. …”
Get full text

Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus by Fangyu Li, Rui Li, Hongjun Deng

“…Next, we constructed weighted gene co-expression network (WGCNA) for disease module analysis to screen out shared genes strongly associated with diseases. We also analyzed the enriched pathways of shared genes using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. …”
Get full text

How to Achieve a 50% Reduction in Nutrient Losses From Agricultural Catchments Under Different Climate Trajectories? by Maarten Wynants, Johan Strömqvist, Lukas Hallberg, John Livsey, Göran Lindström, Magdalena Bieroza

“…Target IN load reductions were backcasted with a combination of SM, fertilizer reduction, and CC, wherein the required measures depended strongly on the climatic trajectory. Overall, this study successfully demonstrated a modeling approach for evaluating best‐management practices under diverging climate change trajectories, tailored to the catchment characteristics and specific nutrient reduction targets.…”
Get full text

Limitations of Separating Athletes into High or Low-Risk Groups based on a Cut-Off. A Clinical Commentary by Justin M. Losciale, Linda K. Truong, Patrick Ward, Gary S. Collins, Garrett S. Bullock

“…# Key Results Cut-offs typically lack strong biologic plausibility to support them; and are typically derived in a data-driven manner and thus not generalizable to other samples. …”
Get full text

Methodological advances in seismic noise imaging of the Alpine area by Paul, Anne, Pedersen, Helle A., Bodin, Thomas, Kästle, Emanuel, Soergel, Dorian, Alder, Chloé, Lu, Yang, Nouibat, Ahmed

“…Our findings include detailed mapping of strong and abrupt Moho depth changes under the Western Alps, contrasting orientations of fast velocity directions between the upper and lower Alpine crust, and the absence of significant radial anisotropy everywhere in the European crust and shallow upper mantle, except in the Apenninic lower crust. …”
Get full text

Ophthalmic products with extracellular matrix components. Their effectiveness in the process of corneal repair in neurotrophic, herpetic, recurrent keratitis and erosions by D.Yu. Maychuk, A.A. Tarkhanova, I.A. Pronkin

“…The cause of this condition in most cases are infectious and inflammatory diseases of the anterior segment of the eye, the outcome of which is a violation of the architectonics of the extracellular matrix (ECM) of the cornea, clinically manifested by edema of the stroma, its fibrosis. Purpose. Comparative analysis of the effectiveness of existing ophthalmic agents based on biomimetics of ECM to stimulate the processes of reparative regeneration in neurotrophic, herpetic, recurrent keratitis and corneal erosions. …”
Get full text

Adaptation of shell morphology to different tidal zones—insights into phenotypic plasticity of Littorina brevicula by Siqi Lai, Ling Shi, Ling Shi, Yida Han, Ying Tian, Ying Tian, Zhenlin Hao

“…Morphological disparities were evident, with high tidal zone specimens showing lower spires and a more spherical shell conformation, while mid tidal zone specimens had elongated spires and a tower-like shell shape. 3D model simulation analyses revealed different stress distributions; the mid-tide zone simulation showed concentrated stress in a circumscribed region, whereas the high-tide zone simulation showed a more expansive stress distribution across the entire shell.DiscussionThe distinct morphological adaptations observed in L. brevicula across tidal zones suggest a strong influence of environmental factors on shell morphology. …”
Get full text

Association of arm circumference with the prevalence of gallstones in United States adults: a retrospective analysis on US National Health and Nutrition Examination Survey by Jianjun Wang, Xi Chen, Wei He, Xintao Zeng, Pei Yang, Jianping Gong, Decai Wang

“…Although a causal relationship between AC and the prevalence of GS could not be established, our study provides strong new support for the potential role of AC in the health assessments of adult populations.…”
Get full text

Analysis on the adjustment of transportation structure and the logistics transformation of railway freight by Chaohe Rong, Xingchan Li, Gaiping Zhang, Xuecheng Wang

“…The study posits that the railway sector must enhance cooperation with other market entities, aligning with the lead enterprises in the logistics chain that are characterized by speed, high value and strong coordination capabilities, in order to better serve the transportation market. …”
Get full text

Sustainable Valorization of Rice Straw into Biochar and Carbon Dots Using a Novel One-Pot Approach for Dual Applications in Detection and Removal of Lead Ions by Jagpreet Singh, Monika Bhattu, Meenakshi Verma, Mikhael Bechelany, Satinder Kaur Brar, Rajendrasinh Jadeja

“…The sensor exhibited a strong linear correlation over a concentration range of 1 µM to 100 µM, with a limit of detection (LOD) of 0.11 µM. …”
Get full text

Abnormal insulin metabolism and decreased levels of mindfulness in type 2 diabetes mellitus by Xue Zhang, Rui Huang, Jiaxin Li, Mingyue Yang, Daowen Zhang, Cancan Liu, Kuanlu Fan

“…Abstract Objective Disorders of insulin metabolism are strongly associated with a variety of psychological problems. …”
Get full text

Acute Toxicity of Xylene on the African Catfish <i>Clarias gariepinus</i> by I.C. Davies, E.S. Erondu, A.I. Hart, L.C. Osuji

“…The median lethal time LT50 recorded was 55.7 hours. There was a strong correlation between (%) mortality in Probits and the Log10 Dose (R²=0.9772). …”
Get full text

Estimation of Rock Burst Grades Using Rock Mass Strength by Yalei Wang, Jinming Xu, Junshuai Xu, Chuanjiang Zhong

“…The results show that σcm calculated by the generalized Hoek–Brown criterion may be considered well in the rock type and strength, construction condition, and structure features of the rock mass; the estimation results of rock burst using the ratio of σc to σmax are quite different from the actual situation, while those using the ratio of the σcm to σmax coincided relatively with the actual rock bursts; the ratios of σcm to σmax, which are greater than 0.167, 0.066 to 0.167, 0.012 to 0.066, and less than 0.012, are corresponded to the slight, medium, strong, and violent grades of the rock bursts, respectively; the randomness of data selection has certain influence on the rock burst estimation criterion, but the variation range is small; the modified estimation criterion of rock burst proposed in this work has a good reliability. …”
Get full text

Achieving Sustainable Development Goals (SDGs) In Africa: Challenges and Prospects by Kennedy Mahlatsi

“…However, due to their strong inclusivity focus, the SDGs present a better opportunity to involve more effectively different stakeholders. …”
Get full text