Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…This novel anti-PD-L1/CD40 bispecific antibody holds potential for strong anti-tumor therapeutic efficacy by selectively restricting CD40 stimulation in tumors.…”
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Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit by Guo Tang, Tianshan Zhang, Ping Zhang, Sha Yang, Tao Cheng, Rong Yao

“…The nomogram demonstrated strong predictive performance with an area under the curve (AUC) of 0.858 (95% CI: 0.788–0.927) in the training set and 0.845 (95% CI: 0.757–0.933) in the validation set. …”
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Secondary School Teachers’ Conceptions of Teaching Science Practical Work through Inquiry-Based Instruction by Tomas Shivolo, Hamza Omari Mokiwa

“… Contemporary science teaching pedagogy in Namibia places a strong emphasis on fostering inquiry-based instruction and practical work in secondary school science education. …”
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Daily activity, mood, and quality of life in colorectal cancer patients with chemotherapy‐induced peripheral neuropathy: A mediation effect analysis by Ling‐Chun Lu, Shiow‐Luan Tsay, Sou‐Yi Chang, Chung‐Ming Chen, Chieh‐Yu Liu

“…Although the management of CIPN and RDA can prevent irreversible functional problems, enhancing the adaption of mood disturbance can strongly promote their QoL.…”
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Roles of core nosZ denitrifiers in enhancing denitrification activity under long-term rice straw retention by Shijie Zhang, Shijie Zhang, Mengyao Hou, Mengyao Hou, Bing Li, Bing Li, Panfeng Guan, Panfeng Guan, Qing Chi, Qing Chi, Hao Sun, Hao Sun, Hangbo Xu, Hangbo Xu, Dongjie Cui, Dongjie Cui, Yupan Zhu, Yupan Zhu

“…The denitrification process is known to contribute to soil nitrogen (N) loss, which is strongly affected by fertilization strategies; however, the effects of distinct straw retention modes on soil denitrification activity have rarely been discriminated and the underlying mechanisms remain unclear. …”
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Does muscle fatigue change motor synergies at different levels of neuromotor control? by Michał Pawłowski, Mariusz P. Furmanek, Mariusz P. Furmanek, Grzegorz Juras

“…On the higher level of hierarchy control of synergies, there were non-significant effects of different types of fatigue on movement performance, however, on the lower level we observed a strong effect of fatigue on forming motor synergies. …”
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Comparison of the Influence of the Chinese Lobby and the Israeli Lobby in the United States by D. B. Grafov

“…The influence of China lobby on decision-making process in the United States can be explained through strong economic ties between American corporations and the Chinese market. …”
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Identification of Crotonylation Metabolism Signature Predicting Overall Survival for Clear Cell Renal Cell Carcinoma by Jie Zheng, Yingqing Liu, Kai Wei, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

“…CRS proves to be an accurate predictor of patient outcomes and immune features in ccRCC. KAT2A shows strong associations with clinical factors and the immunosuppressive environment, suggesting potential for innovative immunotherapies in ccRCC treatment.…”
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Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…Di-n-butyl-di-(4-chlorobenzohydroxamato) tin(IV) (DBDCT), a new patent agent, exhibited strong antitumor activity. In some cases, its activity was close to or even higher than cisplatin, a first-line clinical metallic agent. …”
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Radiochemistry and Preclinical PET Imaging of Ga-Desferrioxamine Radiotracers Targeting Prostate-Specific Membrane Antigen by Eleni Gourni PhD, Luigi Del Pozzo BSc, Mark Bartholomä PhD, Yvonne Kiefer BSc, Philipp T. Meyer MD, PhD, Helmut R. Maecke PhD, Jason P. Holland D.Phil

“…Results indicated that the target binding affinity, protein association, blood pool and background organ clearance properties, and uptake in PSMA-positive lesions are strongly dependent on the nature of the chelate, the linker, and the spacer groups. …”
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Association of functional variants in miRNA genes with the risk of coronary heart disease by Taqweem Ul Haq, Muhammad Riaz Khan, Sajjad Ali, Tariq Aziz, Thamer H. Albekairi, Aftab Ali Shah

“…Conclusion Our findings suggest that functional variants rs2858060, rs6505162, and a novel triplet insertion (CAC) in MIR222, MIR423, and MIR4274 respectively are strongly associated with CHD. These results underline the potential of miRNA gene variants as genetic biomarkers for CHD susceptibility.…”
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Researchers and practitioners talk about users and each other: making user and audience studies matter by Brenda Dervin, CarrieLynn Reinhard

“…</b> All informants showed strong commitment to improving user studies and making them matter more to design, practice and society. …”
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Experimental Study of the Flow Mechanism of Deep Lacustrine Carbonate Reservoirs in the Yingxi Area of the Qaidam Basin by Xiangrong Luo, Yongxian Zheng, Penggang Huang, Li’an Yang, Xiaodong Chen, Xiaojuan Ren, Guo Wang, Yanzhi Wang, Zhiguo Wang, Xiaoxiao Li

“…The experimental results demonstrate that the cores, especially the fractured cores, have a strong stress sensitivity. The oil phase flow in the core has the characteristics of non-Darcy flow, and the threshold pressure gradient is 0.01–0.003 MPa/m. …”
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Estimation of stress tolerance indices for identification of heat tolerant genotypes in barley by Yogender Kumar*, Suman Devi, Divya Phougat and Harsh Chaurasia

“…PCA study considered second principal component (PC 2) as heat tolerant component based on strong correlation with STI, YI, YSI, MP, GMP, HM, MRP and Ys under stress condition. …”
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The effect of a comprehensive intervention on anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight by Fatemeh Sadat Hashemi Javaheri, Zahra Mousavi, Saeideh Mohammadi, Arezoo Amjadi, Khadijeh Abbasi Mobarakeh, Seyedeh Hayedeh Mousavi Shalmani, Mahdieh Torkaman, Masoomeh Alsadat Mirshafaei, Sara Khoshdooz, Zahra Saeedirad, Naser Kalantari, Parmis Mirzaei, Saeid Doaei, Nastaran Keshavarz Mohammadi, Maryam Gholamalizadeh

“…Abstract Background Non-communicable diseases in adulthood are reported to be strongly associated with adolescent obesity. The present study aimed to assess the effect of a comprehensive lifestyle modification intervention on the anthropometric indices, dietary intake, and physical activity of adolescent boys with overweight. …”
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A multidimensional Bayesian IRT method for discovering misconceptions from concept test data by Martin Segado, Aaron Adair, John Stewart, Yunfei Ma, Byron Drury, David Pritchard

“…In addition to a broad first dimension strongly correlated with overall test score, we discover thirteen additional dimensions which load on smaller sets of distractors; we discuss two as examples, showing that these are consistent with already-known misconceptions in Newtonian mechanics. …”
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Suretyship in the Teaching of Ben Sira (Sir 29:14–20) by Andrzej Piwowar

“…First, the way of functioning of suretyship in Israel and the approach to it is discussed, mainly based on the Book of Proverbs, which quite strongly and emphatically forbids that practice. This is followed by a delimitation of the pericope in the work of Ben Sira devoted to that issue and the presentation of its structure. …”
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Stability on 3D Boussinesq system with mixed partial dissipation by Lin Hongxia, Liu Sen, Guo Xiaochuan, You Ruiqi

“…This enables us to establish the strong Poincaré-type inequalities on u˜\widetilde{u}, u3,θ{u}_{3},\theta and some anisotropic inequalities, which ensure the establishment of the closed priori estimates. …”
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Protective Role of Glutathione and Nitric Oxide Production in the Pathogenesis of Pterygium by Fidelina Parra, Alexander Kormanovski, Gustavo Guevara-Balcazar, María del Carmen Castillo-Hernández, Antonio Franco-Vadillo, Mireille Toledo-Blas, Rosa Adriana Jarillo-Luna, Eleazar Lara-Padilla

“…GSH and CAT were enhanced in recurrent pterygium and systemic-treated primary pterygium but were unchanged for topical-treated primary pterygium. There was a strong positive correlation of eNOS with NO and 3NT, GSSG% with NO and 3NT, and GSH with GSSG and CAT. …”
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A high-throughput ResNet CNN approach for automated grapevine leaf hair quantification by Nagarjun Malagol, Tanuj Rao, Anna Werner, Reinhard Töpfer, Ludger Hausmann

“…ResNet CNN-based phenotypic results compared to ground truth data received by two experts revealed a strong correlation with R values of 0.98 and 0.92 and root-mean-square error values of 8.20% and 14.18%, indicating that the model performance is consistent with expert evaluations and outperforms the traditional manual rating. …”
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