Network toxicology and molecular docking reveal key mechanisms of domoic acid neurotoxicity with bio-layer interferometry validation by Dongyao Wang, Yiping Liu, Shitao Chen, Diya Lv, Yuxiao Tang, Yan Liu, Wen Yang, Hui Shen, Lianghua Wang, Feng Lu

“…Further refinements via STRING and Cytoscape software highlight the protein-protein interactions. 30 targets were recognized by both the K-means algorithm and topological analysis. …”
Get full text

Bioinformatic and Molecular Docking Study of Zerumbone and Its Derivates against Colorectal Cancer by Riri Fauziyya, Winni Nur Auli, Nisa Yulianti Suprahman, Sarmoko Sarmoko, Arif Ashari, Kalista Alsadila, Lanita Agustin, Safia Fazila, Miralda Zahra, Esteria Christina Pane, Sukrasno Sukrasno

“…Bioinformatic analysis was conducted using STITCH and STRING to identify potential target genes, and molecular docking was used to search for anticancer candidates from 20 zerumbone derivatives. …”
Get full text

Calculation and Experimental Study of the Dynamics of the Track Mover Bypass of a Cross-Country Transport Vehicle by Alexey I. Taratorkin, Sergey V. Abdulov, Viktor B. Derzhanskii, Alexandr A. Volkov, Evgeniy B. Sarach, Alexandr I. Komissarov

“…The article presents an analysis of the methods for studying the dynamics of the branches of the track bypass, substantiates and proposes a research methodology and a simulation spatial model of the track mover of a cross-country transport vehicle, which differs from the common string inertialess and rod inertial models of the branches of the track mover by the ability to take into account a complex set of kinematic and force factors excited during the movement of the tracked vehicle in steady and transient motion modes. …”
Get full text

The hyaluronan-related genes HAS2, HYAL1-4, PH20 and HYALP1 are associated with prognosis, cell viability and spheroid formation capacity in ovarian cancer by Jette Riecks, Arianna Parnigoni, Balázs Győrffy, Ludwig Kiesel, Alberto Passi, Davide Vigetti, Martin Götte

“…By STRING analysis, interactions within the enzymes of the hyaluronic acid system and with binding partners were visualized. …”
Get full text

Mechanism of Sishen Pills-Tongxie Yaofang in the treatment of ulcerative colitis based on network pharmacology and experimental verification by Haifan Liu, Xue Feng, Dunfang Wang, Li Liu, Yaqing Liu, Bin Liu, Lin Zhu, Caijuan Zhang, Weipeng Yang

“…This study elucidated the potential mechanism and active components of SSP-TXYF in the treatment of UC from the perspective of TCM syndrome. Methods. Metascape, STRING, and Cytoscape were used to explore the SSP-TXYF-compound-target-UC network and biological enrichment pathways, so as to screen the active compounds, key targets, and pathways of SSP-TXYF. …”
Get full text

Identification of Aberrantly Expressed Genes during Aging in Rat Nucleus Pulposus Cells by Shi Cheng, Xiaochuan Li, Linghan Lin, Zhiwei Jia, Yachao Zhao, Deli Wang, Dike Ruan, Yu Zhang

“…A protein-protein interaction (PPI) network of the DEGs was constructed using the Search Tool for the Retrieval of Interacting Genes (STRING) database and Cytoscape software. Module analysis was conducted for the PPI network using the MCODE plugin in Cytoscape. …”
Get full text

GFOD1 expression in clear cell renal cell carcinoma and its role in cancer cell proliferation, migration, and invasion by Zhi Liu, Kui Wu, Qian Shu, Xin Chen

“…The transwell assay served to detect variations in the metastatic ability of cells and to uncover important factors in epithelial-mesenchymal transition (EMT). …”
Get full text

The Significance and Diagnostic Potential of CEA and FIB in Colorectal Cancer by Lin Zhu, Jie Feng, Xu Zhang, Xuemei Wei, Cuiling Ming, Yanhong Gao

“…Bioinformatics analysis of FIB‐related differentially expressed genes related to CRC was performed using the String, LinkedOmics, and Gene Expression Omnibus databases. …”
Get full text

CRISPR/Cas9-targeted smpB mutation revealing roles in biofilm formation, motility, and antibiotic susceptibility in Acinetobacter baumannii. by Techit Thavorasak, Sirijan Santajit, Witawat Tunyong, Thida Kong-Ngoen, Onrapak Reamtong, Sumate Ampawong, Nawannaporn Saelim, Thapani Srisai, Pisinee Aiumurai, Pornpan Pumirat, Wanpen Chaicumpa, Nitaya Indrawattana

“…<h4>Background</h4>Acinetobacter baumannii is a multidrug-resistant pathogen and a major cause of hospital-acquired infections worldwide. Its ability to survive in harsh environments and evade antibiotic treatments underscores the urgent need for new therapeutic targets. …”
Get full text

Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment by Giulia Gerini, Alice Traversa, Fabrizio Cece, Matteo Cassandri, Paola Pontecorvi, Simona Camero, Giulia Nannini, Enrico Romano, Francesco Marampon, Mary Anna Venneri, Simona Ceccarelli, Antonio Angeloni, Amedeo Amedei, Cinzia Marchese, Francesca Megiorni

“…Adipose-derived mesenchymal stem cells (ASCs) are commonly employed in clinical treatment for various diseases due to their ability to differentiate into multi-lineage and anti-inflammatory/immunomodulatory properties. …”
Get full text

Biofilm Formation, Antibiotic Resistance, and Virulence Analysis of Human and Avian Origin <i>Klebsiella pneumoniae</i> from Jiangsu, China by Yulu Xue, Fangyu Shi, Bangyue Zhou, Yi Shi, Wenqing Luo, Jing Zhu, Yang Yang, Sujuan Chen, Tao Qin, Daxin Peng, Yinyan Yin

“…In addition, hypervirulent <i>Klebsiella pneumoniae</i> (hvKP) phenotypes confirmed by string test were exclusive to two human isolates (<i>KP</i>15, <i>KP</i>20). …”
Get full text

Pembelajaran Membaca dan Menulis Melalui Penggunaan Bahasa Ibu di SDN 153 Rejang Lebong by Yeni Kartika, Maria Botifar, Muksal Mina Putra

“…Need for learning to read and write to students. are two abilities that must be taught. Lower grade students who learn in their native language usually show better learning outcomes. …”
Get full text

Emergence and characterization of IncFII/IncR plasmids with multiple 5,692 bp- blaKPC−2-bearing tandem repeats in ceftazidime/avibactam non-susceptible Klebsiella pneumoniae strain... by Hongmao Liu, Hongmao Liu, Mei Zhu, Junwan Lu, Junwan Lu, Shan Wu, Rujian Ye, Wei Pan, Yirong Li, Qiyu Bao, Qiyu Bao, Dawei Huang

“…Virulence phenotypes were confirmed using the string test and a Galleria mellonella larvae infection model. …”
Get full text

CYFIP2: potential pancreatic cancer biomarker and immunotherapeutic target by Cong Xiao, Xiaojuan Zhang, Bobo Hou, Ping Wan, Zhenjun Cao, Xuefeng Rao

“…Data were analyzed using a variety of web-based platforms and software such as R (4.3.2), UCSC, MethSurv, Cytoscape (v3.10.2), UALAND, STRING, TISIDB, Harmonizome 3.0, TIMER 2.0, TCIA and TIDE. …”
Get full text

Integrative profiling of lung cancer biomarkers EGFR, ALK, KRAS, and PD-1 with emphasis on nanomaterials-assisted immunomodulation and targeted therapy by Li Peng, Hongmei Li, Wencai Yan, Yingjie Liu, Haihao Zhu, Yingcai Hong

“…Protein–protein interaction (PPI) networks were constructed via STRING to explore functional associations and signaling networks. …”
Get full text

Clustering Zwitterionic Amino Acids at the Upper Rim of Cone Calix[4]arene Triggers the Selective Recognition of Gram‐Negative Bacterial Envelope by Francesco Rispoli, Luca Moretti, Carlo Alberto Vezzoni, Eloisa Tosi, Linda Molteni, Carlotta Ciaramelli, Luciano Marchiò, Stefano Volpi, Laura Baldini, Francesco Sansone, Alessandro Palmioli, Cristina Airoldi, Alessandro Casnati

“…In this study, for the first time, the ability of synthetic macrocycles to selectively recognize the envelope of Gram‐negative bacteria is highlighted, and the way to the chemical modifications of the ligand structure is paved to develop devices for the detection or treatment of bacterial infections, thus allowing to add another string to the bow for the fight against antimicrobial resistance.…”
Get full text

Application of bioinformatics analysis and molecular docking to study the mechanism of Qingying decoction in treating psoriasis by Cuicui Shen, Xuewei Liu, Huangchao Jia, Wenhe Wang, Xiaomeng Wang, Haiyan Wang, Dan Wang, Jianwei Li

“…Protein-protein interaction (PPI) network was constructed using STRING platform. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed using the DAVID database and the clusterProfiler package of R software. …”
Get full text

Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora by Qianqian Liu, Kexin Jiang, Shipeng Duan, Na Zhao, Yanmei Shen, Lirong Zhu, Ke-Qin Zhang, Jinkui Yang

“…Introduction: Arthrobotrys oligospora has been utilized as a model strain to study the interaction between fungi and nematodes owing to its ability to capture nematodes by developing specialized traps. …”
Get full text

Network pharmacology and experimental study of Angelica sinensis and Astragalus membranaceus capsules in treating heart failure by Xue Wu, Ai Liu, Xinfang Lv, Xiaodong Zhi, Xiangting Zeng, Kai Liu, Xinke Zhao, Bing Jiang, HuGang Jiang, Yingdong Li

“…Methods: The “active component-target” network and the “drug-disease target” protein interaction network were constructed using Cytoscape 3.9.0 and STRING Database. GO and KEGG enrichment analysis was performed using DAVID database. …”
Get full text

Vampire Motif in O. Mirtov’s Novel Dead Swell: Gender Aspect by Ekaterina V. Kuznetsova

“…Recognizable clichés associated with the appearance and abilities of vampires manifest themselves at different levels of the novel: at the level of subtext in ambiguous conversations about blood, in the description of the appearance of the characters (red lips, a string of red coral beads around the neck, pallor, haggardness), in the characteristics of their actions (the physical attraction of a man to a woman is compared with the craving of a vampire to fresh blood, it is realized in the form of sadistic pleasure associated with violence: forced intimacy, neck bites, beatings, tickling). …”
Get full text