Challenges and Controversies in Human Mesenchymal Stem Cell Therapy by Barbara Lukomska, Luiza Stanaszek, Ewa Zuba-Surma, Pawel Legosz, Sylwia Sarzynska, Katarzyna Drela

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The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals by Zezheng Pan, Mengli Sun, Xia Liang, Jia Li, Fangyue Zhou, Zhisheng Zhong, Yuehui Zheng

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Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation by Xiao-Hua Luo, Ying-Jun Chang, Xiao-Jun Huang

“…Stem cell source and donor age are other important factors. …”
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Gene Editing in Pluripotent Stem Cells and Their Derived Organoids by Hang Zhou, Yun Wang, Li-Ping Liu, Yu-Mei Li, Yun-Wen Zheng

“…With the rapid rise in gene-editing technology, pluripotent stem cells (PSCs) and their derived organoids have increasingly broader and practical applications in regenerative medicine. …”
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Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy by Quan Zhuang, Ruoyu Ma, Yanshuang Yin, Tianhao Lan, Meng Yu, Yingzi Ming

“…MSCs are pluripotent adult stem cells that can differentiate into various types of tissue lineages, such as the cartilage (chondrocytes), bone (osteoblasts), fat (adipocytes), and muscle (myocytes). …”
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Mesenchymal Stem Cell Transplantation for Liver Cell Failure: A New Direction and Option by Yantian Cao, Bangjie Zhang, Rong Lin, Qingzhi Wang, Jie Wang, Fangfang Shen

“…Background and Aims. Mesenchymal stem cell transplantation (MSCT) became available with liver failure (LF), while the advantages of MSCs remain controversial. …”
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Human Placental Mesenchymal Stem Cells for the Treatment of ARDS in Rat by Zurab Kakabadze, Nicholas Kipshidze, Teona Paresishvili, Nodar Kipshidze, Zurab Vadachkoria, David Chakhunashvili

“…Currently, there have been reports of efficient use of mesenchymal stem cells (MSCs) for the treatment of ARDS caused by COVID-19. …”
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Stem Cell Hierarchy and Clonal Evolution in Acute Lymphoblastic Leukemia by Fabian Lang, Bartosch Wojcik, Michael A. Rieger

“…Cancer is characterized by a remarkable intertumoral, intratumoral, and cellular heterogeneity that might be explained by the cancer stem cell (CSC) and/or the clonal evolution models. …”
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The aging hematopoietic stem cell niche: a mini review by Xin Gao, Jing Zhang, Jing Zhang, Owen J. Tamplin

“…Hematopoietic stem cells (HSCs) undergo a functional decline during aging. …”
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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application by Mengyuan Wang, Quan Yuan, Liang Xie

“…Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. …”
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Eradication of HIV by Transplantation of CCR5-Deficient Hematopoietic Stem Cells by Gero Hütter, Susanne Ganepola

“…Our report raises the hope for further targeted treatment strategies against HIV and represents a successful personalized treatment with allogeneic stem cells carrying a beneficial gene. However, this case has ignited a controversy regarding the question of whether this patient has achieved complete eradication of HIV or not. …”
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Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells by Yeri Alice Rim, Yoojun Nam, Narae Park, Hyerin Jung, Yeonsue Jang, Jennifer Lee, Ji Hyeon Ju

“…Scientists have tried to reprogram various origins of primary cells into human induced pluripotent stem cells (hiPSCs). …”
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Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges by Yangjie Gao, Zhe Ji, Jingyu Zhao, Julin Gu

“…As a particularly serious condition in immunocompromised patients, fungal infections (FIs) have increasingly become a public health problem worldwide. Mesenchymal stem cells (MSCs), characterized by multilineage differentiation potential and immunomodulatory properties, are considered an emerging strategy for the treatment of FIs. …”
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Vascular Transdifferentiation in the CNS: A Focus on Neural and Glioblastoma Stem-Like Cells by Sophie Guelfi, Hugues Duffau, Luc Bauchet, Bernard Rothhut, Jean-Philippe Hugnot

“…Glioblastomas are devastating and extensively vascularized brain tumors from which glioblastoma stem-like cells (GSCs) have been isolated by many groups. …”
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Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted? A Systematic Review and Meta-Analyses by Zhantao Deng, Jiewen Jin, Jianning Zhao, Haidong Xu

“…In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). …”
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CD9 in acute myeloid leukemia: Prognostic role and usefulness to target leukemic stem cells by Lucas Touzet, Florent Dumezy, Christophe Roumier, Céline Berthon, Claire Bories, Bruno Quesnel, Claude Preudhomme, Thomas Boyer

“…Interestingly, CD9 expression was different between the more immature physiologic and AML cells (CD34+CD38−) as it was also expressed in AML on putative leukemic stem cells (LSCs) but not on hematopoietic stem cells (HSCs). …”
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Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis by Fang Cheng, Zhong Huang, Zhi Li

“…Complex perianal fistula is a highly debilitating and difficult to treat condition. Local mesenchymal stem cell (MSC) therapy for perianal fistula has shown considerable promise but still remains controversial. …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for stem cell therapy in clinical trials. …”
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Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Minyi Chen, Runkai Hu, Weichao Han, Shaobo Ding

“…In recent years, human mesenchymal stem cell (hMSC) transplantation has become a promising therapeutic strategy for CP. …”
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Real-world prognostic factors in autotransplanted multiple myeloma patients with severe renal impairment: study of the Polish Myeloma Study Group by Anna Waszczuk-Gajda, David H. Vesole, Jolanta Małyszko, Artur Jurczyszyn, Tomasz Wróbel, Joanna Drozd-Sokołowska, Piotr Boguradzki, Krzysztof Mądry, Agnieszka Tomaszewska, Jarosław Biliński, Maria Król, Longin Niemczyk, Magdalena Olszewska-Szopa, Wieslaw W. Jedrzejczak, Grzegorz W. Basak

“…Introduction The prognostic factors in autotransplanted multiple myeloma (MM) patients with concomitant advanced chronic kidney disease (CKD) are poorly understood, limited, and controversial. Material and methods We retrospectively analysed 44 patients with MM and CKD (eGFR < 40 ml/min), present both at diagnosis and at autologous stem cell transplantation (ASCT), with no improvement of renal function in-between. …”
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