Survey on the Status and Training Demands of Capabilities for Diagnosing and Treating Common Diseases of Primary Care General Practitioners in Hunan Province by LI Lingqi, GAO Yinyan, ZHANG Yuqin, SUN Dingkui, WU Xinyin, ZHANG Weiru

“…Additionally, 77.2% (260/337) of participants lacked sufficient knowledge of clinical practice guidelines; 90.8% (306/337) of participants rarely consulted guidelines when facing decision-making difficulties, mainly because they felt guidelines could not address complex cases[50.0% (153/306) ], were unclear on how to search for guidelines[43.1% (132/306) ]and the resources available for retrieving guidelines[34.3% (105 /306) ]; participants mainly obtain the guidelines through the WeChat official account[72.5% (237/327) ] and databases such as the China National Knowledge Infrastructure [50.2% (164/327) ]. 97.0% (327/337) of participants expressed a demand for training to improve their capabilities, suggesting that training should be tailored to the specific needs of primary care institutions[60.8% (205/337) ]; the preferred approaches are advanced training in higher-level hospitals[71.3% (233/327) ]and primary care institutions with high diagnostic and treatment capabilities[56.3% (184/327) ]; the preferred training programs are on standardized treatment of common diseases[78.0% (263/337) ]and multiple coexisting diseases[69.4% (234/337) ]. …”
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Healthcare utilization and related costs among older people seeking primary care due to back pain: findings from the BACE-N cohort study by Danielle van der Windt, Milada Cvancarova Småstuen, Kjersti Storheim, Margreth Grotle, Zinajda Zolic-Karlsson, Ørjan Nesse Vigdal, Rikke Munk Killingmo, Lise Kretz

“…Objectives To describe healthcare utilization and estimate associated costs during 1 year of follow-up among older people seeking primary care due to a new episode back pain and to describe healthcare utilization across patients with different risk profiles stratified using the StarT Back Screening Tool (SBST).Design Prospective cohort study.Participants and setting A total of 452 people aged ≥55 years seeking Norwegian primary care with a new episode of back pain were included.Outcome measures The primary outcome of this study was total cost of healthcare utilization aggregated for 1 year of follow-up. …”
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Investigating the miRNA-mRNA interactome of human trabecular meshwork cells treated with TGF-β1 provides insights into the pathogenesis of pseudoexfoliation glaucoma. by Anton W Roodnat, Chelsey Doyle, Breedge Callaghan, Karen Lester, Megan Henry, Carl Sheridan, Declan J McKenna, Colin E Willoughby, Sarah D Atkinson

“…For both mRNA and miRNA species, differential expression was determined using a bioinformatics pipeline consisting of FastQC, STAR, FeatureCounts, edgeR (for miRNA) and DESeq2 (for mRNA). …”
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Protocol for assessing and visualizing cell microaggregate formation in whole blood by imaging flow cytometry by Johannes Krell, Komal Kumar Javarappa, Angie Wenedy, Andrew L. Frelinger, III, Laurent Renia, Clarissa Prazeres da Costa, Martin Schlegel, Percy Knolle, Gerhard Schneider, Oliver Hayden

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Protocol for a patient-derived preclinical platform to model tumor-immune interactions and evaluate therapeutic efficacy by Wen-Hsin Chang, Andrew I. Chin, Ching-Hsien Chen

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Protocol for investigating astrocytic mitochondria in neurons of adult mice using two-photon microscopy by Jian Zhou, Fengling Du, Fan Zhang, Xianhui Zhang, Yuanyuan Wu, Lifang Zhang, Ping Liao, Tianqi Tu, Jianhua Peng, Tao Li, Yong Jiang

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Is It the pH That Matters? Challenging the Pathophysiology of Acidemia in a Case of Severe Hypercapnia Secondary to Intraoperative CO2 Insufflation by Evan Merle, Saad Zaatari, Rory Spiegel

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Plaque Rupture-Induced Myocardial Infarction and Mechanical Circulatory Support in Alpha-Gal Allergy by Sohab S. Radwan, Gauravpal Gill, Amre Ghazzal, Awais Malik, Christopher Barnett

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Suspected Sugammadex Hypersensitivity following Repeated Administration in the Setting of Multiple Flap Takebacks in a Brief Timespan by Elizabeth G. Zolper, Alan H. Kim, Kevin G. Kim, Paige K. Dekker, Jenna C. Bekeny, David H. Song, Kenneth L. Fan

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Erratum to “Esophageal Pemphigus Vulgaris: A Rare Etiology of Upper Gastrointestinal Hemorrhage” by Jennifer Rose F. Del Castillo, Muhammad Nadeem Yousaf, Fizah S. Chaudhary, Nahar Saleh, Lawrence Mills

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Magnetic Resonance Enterography: The Test of Choice in Diagnosing Intestinal “Zebras” by Anjali S. Kumar, Jasna Coralic, Reid Vegeler, Kirthi Kolli, John Liang, Allison Estep, Allen P. Chudzinski, James D. McFadden

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The Heart Block Hat-Trick: A Case of Alternating First-, Second-, and Third-Degree Heart Blocks by Nicholas Huerta, Salman Malik, Christopher Haas

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Concurrent Diagnosis of Chronic Myeloid Leukemia and Follicular Lymphoma: An Unreported Presentation by Amy G. Starr, Sushma R. Jonna, Joeffrey J. Chahine, Bhaskar V. Kallakury, Chaitra S. Ujjani

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PL-7 Antisynthetase Syndrome in Association with Sjögren’s, Systemic Lupus Erythematosus, and Rheumatoid Arthritis by Mehrin Jawaid, Yael Ross, Mohammad Kamran

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Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis by Ifeyinwa E. Obiorah, Alexandra Kyrillos, Metin Ozdemirli

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A Mysterious Gram-Positive Rods by Javzandulam Natsag, Zaw Min, Yasir Hamad, Bassel Alkhalil, Atiq Rahman, Richard Williams

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Giant Bilateral Adrenal Myelolipoma with Congenital Adrenal Hyperplasia by S. Al-Bahri, A. Tariq, B. Lowentritt, D. V. Nasrallah

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Cardiac Involvement by HIV-Associated DLBCL by Charles T. Mupamombe, Jude Noel, Derek B. Laskar, Liza Valdivia

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Infective Aortic Valve Endocarditis Causing Embolic Consecutive ST-Elevation Myocardial Infarctions by Kanksha Peddi, Alexander L. Hsu, Tomas H. Ayala

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