Exploring the exoproteome of the parasitic nematode Anisakis simplex (s. s.) and its impact on the human host – an in vitro cross-talk proteomic approach by Robert Stryiński, Robert Stryiński, Ewa Fiedorowicz, Jesús Mateos, Aneta Andronowska, Elżbieta Łopieńska-Biernat, Mónica Carrera

Get full text

Burden of Illness in Prostate Cancer Patients with a Low-to-Moderate Risk of Progression: A One-Year, Pan-European Observational Study by Cesare Selli, Anders Bjartell, Javier Burgos, Matthew Somerville, Juan-Manuel Palacios, Laure Benjamin, Libby Black, Ramiro Castro

“…The score was lower at 12 months than at 3 months, but it was still significantly higher than at baseline (P<0.001). Hormonal treatment-related symptoms, sexual functioning, and sexual activity scores significantly worsened at 3 and 12 months (all P<0.001). …”
Get full text

Prevention of Cardiovascular Disease: Screening for Magnesium Deficiency by Paolo Severino, Lucrezia Netti, Marco Valerio Mariani, Annalisa Maraone, Andrea D’Amato, Rossana Scarpati, Fabio Infusino, Mariateresa Pucci, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele

Get full text

Síndrome de Sheehan: marcador de subdesarrollo by Alfredo Jácome Roca

“…El diagnóstico a menudo se hace tardíamente y los pacientes tienen deficiencia hormonal sintomática, por lo que se les debe dar terapia de suplencia, con el fin de mejorar la calidad de vida y evitar un potencial riesgo de muerte. …”
Get full text

The potential role of differentially expressed tRNA-derived fragments in high glucose-induced podocytes by Zhenxing Zhang, Yunyang Qiao, Jialing Ji, Chan Huang, Huimin Shi, Weihua Gan, Aiqing Zhang

“…KEGG pathway analysis revealed that tRFs may be involved in signaling pathways related to growth hormones, phospholipase D, the regulation of stem cell pluripotency, and T-/B-cell receptors. …”
Get full text

Evaluation of Individual Cardiovascular Risk in Pre-Dialysis CKD Patients by Using the Ratio of Calcium–Phosphorus Product to Estimated Glomerular Filtration Rate (Ca × P/eGFR) by Krasimir Kostov, Tatyana Simeonova, Borislav Ignatov, Tsvetelina Eftimova

“…Biochemical parameters, including serum creatinine (SCr), blood urea nitrogen (BUN), calcium (Ca), inorganic phosphate (Pi), parathyroid hormone (PTH), alkaline phosphatase (ALP), Ca × P, eGFR, and the Ca × P/eGFR ratio, were measured and calculated. …”
Get full text

Lower Kinetic Chain, Meet the Thinking Brain: A Scoping Review of Cognitive Function and Lower Extremity Injury Risk by Michaela A. Reyes, Mark O. Probasco, Trina N. Worby, Dylan E. Loertscher, Lyndsey K. Soderbeck, Wendy E. Huddleston

“…The classic model of non-contact ACL injury includes environmental, anatomical, hormonal and biomechanical risk factors which directly impact either the amount of stress placed on the ligament or the relative capacity of ligament to withstand the forces placed on it. …”
Get full text

Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis by Xiaohui Meng, Xiaohui Meng, Li Sheng, Yongqing You, Yongqing You, Huibo Dai, Manshu Yu, Funing Wang, Funing Wang, Ziren Zhou, Ziren Zhou, Yun Shan, Meixiao Sheng

“…Integrated data analysis indicated that steroid hormone biosynthesis, the Ras signaling pathway, apoptosis, and estrogen signaling contributed to the effects of QXHZF. …”
Get full text

Nitrate–Nitrite–Nitric Oxide Pathway, Oxidative Stress, and Fertility Outcomes in Morbidly Obese Women Following Bariatric Surgery: A Systematic Review by Charalampos Voros, Despoina Mavrogianni, Aspasia Minaoglou, Alexios Karakasis, Anthi-Maria Papahliou, Vasileios Topalis, Antonia Varthaliti, Raphail Mantzioros, Panagiota Kondili, Menelaos Darlas, Regina Sotiropoulou, Diamantis Athanasiou, Dimitrios Loutradis, Georgios Daskalakis

“…A systematic review employing PRISMA criteria included articles published between 2000 and 2024 from PubMed, Scopus, and Embase that investigated NO₃-NO₂ pathways, oxidative stress markers, hormonal alterations, and reproductive outcomes in morbidly obese women following bariatric surgery. …”
Get full text

Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study by Juanjuan Zhang, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Zhixia Cao, Jun Dong, Xiaoxi Zheng, Xu Zhang, Xinrong Dong, Xing Wang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu

“…SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine. Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD. …”
Get full text

Improving the Utility, Safety, and Ethical Use of a Passive Mood-Tracking App for People With Bipolar Disorder Using Coproduction: Qualitative Focus Group Study by Laurence Astill Wright, Matthew Moore, Stuart Reeves, Elvira Perez Vallejos, Richard Morriss

“…Results were cross-checked by someone with lived experience of BD. ResultsFocus groups were transcribed and analyzed using thematic analysis. …”
Get full text

Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…In-depth Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses, conducted within the Metascape database, revealed that the core targets of ATBC’s influence on bone metabolism are predominantly concentrated within vital signaling cascades, including thyroid hormone signaling, FOXO signaling, glucagon signaling, AMPK signaling, insulin signaling, adipocytokine signaling, and Notch signaling pathways. …”
Get full text

Dissection of the genetic basis and molecular mechanism of ovule number per ovary in oilseed rape (Brassica napus L.) by Muslim Qadir, Muslim Qadir, Muslim Qadir, Xinyi Lin, Farhan Nabi, Kishore Kumar Ashok, Xue-Rong Zhou, Qingbin Sun, Peiman Shi, Xinfa Wang, Jiaqin Shi, Hanzhong Wang

“…Transcriptomic analysis identified 7689 differentially expressed genes (DEGs) between the two pools, of which nearly half were enriched into functional categories of reported genes regulating ONPO, including protein, RNA, signalling, miscellaneous, development, hormone metabolism, and tetrapyrrole synthesis. Integration of linkage QTL mapping, transcriptome sequencing and BLAST analysis identified 15 homologues of reported ovule number genes and 327 DEGs in the QTL regions, which were considered as direct and potential candidate genes. …”
Get full text

Editorial by Dmitry A. Medvedev

“…Even though the color perception may not impress someone, we will definitely change the coloristics in next year. …”
Get full text

Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients by Li Sun, Dongliang Zhang, Jiawen Liu, Xiang Gao, Chuanjian Suo, Shuang Fei, Zhengkai Huang, Zijie Wang, Hao Chen, Jun Tao, Zhijian Han, Xiaobing Ju, Zengjun Wang, Min Gu, Ruoyun Tan

“…LVH was positively associated with postoperative intact parathyroid hormone (iPTH) and iPTH nonnormalization. ΔLVMI was positively associated with preoperative type-I collagen N-terminal peptide and postoperative iPTH. …”
Get full text

The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

“…After a median follow-up of seven years, no significant differences were observed in biochemical recurrence, overall mortality, or initiation of hormonal therapy. However, the atorvastatin arm had a lower risk of major acute cardiovascular events (HR 0.11, 95% CI 0.01–1.01). …”
Get full text

Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial by Xiaomeng Zhang, Xiaofang Wang, Zhuohua Xu, Yajuan Chu, Xingxing Chen, Li Zhang, Jin Meng, Wei Shi, Zhaozhi Yang, Xin Mei, Xiaoli Yu, Zhen Zhang, Xiaomao Guo, Miao Mo, Guangyu Liu, Jiong Wu, Zhimin Shao, Jinli Ma

“…Patients aged ≥ 50 years who underwent breast-conserving surgery for unifocal non-lobular invasive breast cancer, with pathological T1 disease, clear margins, negative axillary nodes, and positive hormonal receptors, were recruited. The primary endpoint was 3-year cosmetic deterioration, and secondary endpoints included adverse events, ipsilateral breast tumor recurrence (IBTR), regional recurrence, and survivals. …”
Get full text

Incidence and temporal patterns of true recurrences and second primaries in women with breast cancer: A 10-year competing risk-adjusted analysis by Silvia Mancini, Lauro Bucchi, Annibale Biggeri, Orietta Giuliani, Flavia Baldacchini, Alessandra Ravaioli, Federica Zamagni, Fabio Falcini, Rosa Vattiato

“…Prognostic factors for TRs (tumour stage and grade, lymph node status and residual disease) and SBCs (patient age and –inverse association– hormone therapy) were different. In the 9th-10th year of follow-up, the excess incidence of total BC episodes as compared with the expected incidence of BC was no longer significant (standardised incidence ratio, 1.15; 95 % CI, 0.86–1.53). …”
Get full text

Satisfacción con la vida y bienestar psicológico como predictores del florecimiento durante la adolescencia by Nicole Waigel, Viviana Noemí Lemos

“…Metodología: A partir de un muestreo no probabilístico participaron 421 adolescentes argentinos (Medad = 14,9; DE = 1,75), quienes respondieron la Escala Perfil PERMA (Waigel & Lemos, 2023), la Escala de Bienestar Psicológico de Ryff (Meier & Oros, 2019) y la Escala de Satisfacción con la vida (Castro Solano, 2000). Los datos se analizaron mediante análisis de regresión jerárquica y análisis multivariados de variancia (MANOVAs). …”
Get full text

Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…The promoter region of these genes was found to contain multiple cis-acting elements related to hormone responses, defence, and stress, indicating that they may respond to a variety of developmental and environmental stimuli. …”
Get full text