Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions by Marta Marchini, Greta Keller, Naaz Khan, Rushabh Shah, Adriana Saliceti Galarza, Katherine B. Starr, Alexandra Apostopoulos, Thomas J. Sanger

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Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. by Eric Dessaud, Vanessa Ribes, Nikolaos Balaskas, Lin Lin Yang, Alessandra Pierani, Anna Kicheva, Bennett G Novitch, James Briscoe, Noriaki Sasai

“…Morphogens are secreted signalling molecules that act in a graded manner to control the pattern of cellular differentiation in developing tissues. An example is Sonic hedgehog (Shh), which acts in several developing vertebrate tissues, including the central nervous system, to provide positional information during embryonic patterning. …”
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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 by Yuchen Li, Chaemin Lim, Taylor Dismuke, Daniel S. Malawsky, Sho Oasa, Zara C. Bruce, Carolin Offenhäuser, Ulrich Baumgartner, Rochelle C. J. D’Souza, Stacey L. Edwards, Juliet D. French, Lucy S. H. Ock, Sneha Nair, Haran Sivakumaran, Lachlan Harris, Andrey P. Tikunov, Duhyeong Hwang, Coral Del Mar Alicea Pauneto, Mellissa Maybury, Timothy Hassall, Brandon Wainwright, Santosh Kesari, Gregory Stein, Michael Piper, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojević, Leon F. McSwain, Timothy R. Gershon, Bryan W. Day

“…Abstract OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population. …”
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Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target by Mingxia Wang, Shangling Zhu, Weixiang Peng, Qiuxia Li, Zhaoxia Li, Minqi Luo, Xiaoxue Feng, Zhuofeng Lin, Jianlin Huang

“…Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, and is activated in a number of malignancies. …”
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OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma by Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J. Vanner, Hayden J. Selvadurai, Lilian Lee, Jinchu Vijay, Julia E. Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D. Simons, Xi Huang, Peter B. Dirks

“…Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in a dysregulated developmental hierarchy, the apex of which is defined by characteristically quiescent SOX2+ stem-like cells. …”
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Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway by Maoping Cai, Shengdong Ge, Yaying Hong, Yao Chen, Yang-Zi Ren, Dacai Zhong, Mingkun Chen, Yuan Liu, Zhe-Sheng Chen, Ninghan Feng, Zhanghui Chen, Shan-Chao Zhao

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Corrigendum to “Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health” by Sen Yin, Xuemei Bai, Danqing Xin, Tingting Li, Xili Chu, Hongfei Ke, Min Han, Wenqiang Chen, Xingang Li, Zhen Wang

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Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma by Odessa R Yabut, Jessica Arela, Hector G Gomez, Jesse Garcia Castillo, Thomas Ngo, Samuel J Pleasure

Subjects: “…Sonic Hedgehog…”
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Transplanted Adult Neural Stem Cells Express Sonic Hedgehog In Vivo and Suppress White Matter Neuroinflammation after Experimental Traumatic Brain Injury by Genevieve M. Sullivan, Regina C. Armstrong

“…To test this concept, NSCs isolated from adult mouse subventricular zone (SVZ) were transplanted into the lateral ventricle of adult mice at two weeks post-TBI followed by analysis at four weeks post-TBI. We examined sonic hedgehog (Shh) signaling as a candidate mechanism by which transplanted NSCs may regulate neuroregeneration and/or neuroinflammation responses of endogenous cells. …”
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Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis by Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo

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Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy by Shunqiao Jin, Shunqiao Jin, Xiaojiao Liu, Xiaojiao Liu, Lingqin Cai, Lingqin Cai, Jiayu Yan, Ling Li, Hongjun Dong, Yuxue Gao, Xicong Zhu, Cong Zhang, Xuezhu Xu

“…Furthermore, itraconazole suppressed Hedgehog signaling and counteracted the activation of the Hedgehog agonist recombinant human Sonic Hedgehog (rhShh). …”
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The Assessment of CDX1, IHH, SHH, GATA4, FOXA2, FOXF1 in Congenital Intra-Abdominal Adhesions by Helēna Freijere Pope, Māra Pilmane, Anna Junga, Aigars Pētersons

“…This research examines the expression of Caudal Type Homeobox 1 (CDX1), Indian Hedgehog (IHH), Sonic Hedgehog (SHH), GATA Binding Protein 4 (GATA4), Forkhead Box A2 (FOXA2) and Forkhead Box F1 (FOXF1) gene expression in human abdominal congenital adhesion fibroblast and endothelium cells by chromogenic in situ hybridization, with the aim of elucidating their potential association with the etiology of congenital intra-abdominal adhesion band development. …”
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Cortisol regulates neonatal lung development via Smoothened by Shanshan Lu, Yifei Chen, Jiawen Song, Liangliang Ren, Jun Du, Donglai Shen, Jiayin Peng, Yao Yin, Xia Li, Yuqing Wang, Yan Gao, Siman Han, Yichang Jia, Yun Zhao, Yizheng Wang

“…Methods In this study, the simulation of the molecular docking by Autodock, in vitro binding experiments, and Sonic Hedgehog (SHH) pathway examination in cells were performed to study the directly binding of cortisol to Smoothened (SMO). …”
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Astragaloside IV Treats Parkinson’s Disease by Regulating the Proliferation and Differentiation of NSCs through the SHH–Nurr1 Pathway by Zicong Wu, Jianing Zhang, Han Gao, Wentao Li

“…Recently, there has been a surge of interest in enhancing the differentiation of neural stem cells (NSCs) and supplementing dopamine neurons as a potential treatment for Parkinson’s disease, the second most prevalent neurodegenerative disorder. Two factors, sonic hedgehog (SHH) and nuclear receptor–related 1 protein (Nurr1), have been identified as influential in NSCs differentiation. …”
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Small Molecules Greatly Improve Conversion of Human-Induced Pluripotent Stem Cells to the Neuronal Lineage by Sally K. Mak, Y. Anne Huang, Shifteh Iranmanesh, Malini Vangipuram, Ramya Sundararajan, Loan Nguyen, J. William Langston, Birgitt Schüle

“…This protocol generates neural precursors using Dorsomorphin and SB431542 and further maturation into dopaminergic neurons by replacing sonic hedgehog with purmorphamine or smoothened agonist. …”
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The Regenerative Potential of Facial Nerve Motoneurons following Chronic Axotomy in Rats by Yusu Ni, Diyan Chen, Yi Jiang, Danhong Qiu, Wen Li, Huawei Li

“…The rats were housed in the animal facility of the Eye and ENT Hospital of Shanghai Medical School, Fudan University (Shanghai, China). Expression of Shh (sonic hedgehog) and growth-associated protein 43 (GAP43, a neuronal marker) was detected in bilateral facial nuclei using reverse transcriptase PCR, western blotting analysis, and immunohistochemistry. …”
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Human Neonatal Thymus Mesenchymal Stem Cells Promote Neovascularization and Cardiac Regeneration by Shuyun Wang, Shan Huang, Lianghui Gong, Zhize Yuan, Joshua Wong, Jeffrey Lee, Ming-Sing Si

“…We found that ntMSCs expressed and secreted the proangiogenic and cardiac regenerative morphogen sonic hedgehog (Shh) in vitro more than patient-matched bone-derived MSCs. …”
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Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair by Xin Shen, Hang Zhang, Zesheng Song, Yangjiele Dong, Xiao Ge, Shenghao Jin, Songsong Guo, Ping Zhang, Yu Fu, Yuchi Zhu, Na Xiao, Dongmiao Wang, Jie Cheng, Rongyao Xu, Hongbing Jiang

“…Importantly, our data demonstrated that the Sonic hedgehog (Shh) signaling was responsible for the transition process initiation, which was strongly activated by c-Jun/SIRT6/BAF170 complex-driven Shh enhancers. …”
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Shh Signaling from the Injured Lung Microenvironment Drives BMSCs Differentiation into Alveolar Type II Cells for Acute Lung Injury Treatment in Mice by Mengyu Wu, Jing Liu, Shu Zhang, Yi Jian, Ling Guo, Huacai Zhang, Junwei Mi, Guoxin Qu, Yaojun Liu, Chu Gao, Qingli Cai, Dalin Wen, Di Liu, Jianhui Sun, Jianxin Jiang, Hong Huang

“…The mechanisms of BMSC differentiation into AT2 cells have not been determined. The Sonic Hedgehog (Shh) pathway is involved in regulating multiple differentiation of MSCs. …”
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Differentiation of Rat Adipose-Derived Stem Cells into Parathyroid-Like Cells by Ping Zhang, Hao Zhang, Wenwu Dong, Zhihong Wang, Yuan Qin, Changhao Wu, Qi Dong

“…The adipose-derived stem cells were stimulated by sonic hedgehog (SHH) and activin A. The differentiation of the adipose-derived stem cells to parathyroid-like cells was confirmed by the detection of parathyroid hormone and the related parathyroid markers. …”
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