Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

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An Innovative Drug Delivery System Loaded with a Modified Combination of Triple Antibiotics for Use in Endodontic Applications by Ardavan Parhizkar, Hanieh Nojehdehian, Fahimeh Tabatabaei, Saeed Asgary

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The dual-function of bioactive peptides derived from oyster (Crassostrea gigas) proteins hydrolysates by Dongyang Zhu, Zhen Yuan, Di Wu, Chao Wu, Hesham R. El-Seedi, Ming Du

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The effect of healthy eating index-2015 in the associations of biological aging and non-alcoholic fatty liver disease: an interaction and mediation analysis by Xiang Zhang, Zhijie Ding, Yong Yan, Weiming Yang, Xiaoming Ai, Yongping Zhou

“…Weighted multivariable logistic regression analysis, restricted cubic spline (RCS), and subgroup analysis were performed to analyze the association of BA and HEI-2015 with prevalence of NAFLD and the mediation effect of HEI-2015 was also discussed. …”
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High-density lipoprotein cholesterol as a prognostic marker for 90-day transplant-free mortality in hepatitis B virus-related acute-on-chronic liver failure by Ke Shi, Yi Zhang, Yanqiu Li, Xiaojing Wang, Ying Feng, Xianbo Wang

“…The prognostic accuracy of lipid profile parameters was evaluated by the area under the receiver operating characteristic curve (AUC), and the association between HDL-C levels and mortality was assessed using a restricted cubic spline analysis. Correlations between lipid profile parameters and inflammatory factors were analyzed. …”
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Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice by Zhe-Zhe Zhang, Li-Ping Zeng, Jing Chen, Yong-Fang Wu, Ya-Tao Wang, Lan Xia, Qi-Gang Yang, Fang Wang, Gui-Hai Chen

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Ultrasound-guided Hydrostatic Reduction of Acute Intussusception in Children at a Tertiary Care Center: An Observational Study by Ajay Kumar Yadav, Neha Yadav, Binit Dev, Sonia Dahal, Rohit Prasad Yadav, Sushil Taparia, Hiramani Pathak

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Association between C-reactive protein and chronic pain in US adults: A nationwide cross-sectional study. by Chunsheng Huang, Qizhen Tong, Qiaoling Tong

“…To explore the non-linear relationship, weighted restricted cubic spline (RCS) with three knots coupled with a weighted logistic regression model to assess the dose-response relationship between CRP (continuous variables) and chronic pain.…”
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Comparative Evaluation of Salt Tolerance in Four Self-Rooted Hazelnut (<i>Corylus avellana</i> L. and <i>Corylus americana</i> Walter) Cultivars by Xavier Rius-Garcia, María Videgain-Marco, José Casanova-Gascón, Luis Acuña-Rello, Pablo Martín-Ramos

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Optimization of a Rabbit Dry Eye Model Induced by Topical Instillation of Benzalkonium Chloride by Carlos Carpena-Torres, Jesús Pintor, María Jesús Pérez de Lara, Fernando Huete-Toral, Almudena Crooke, Cristina Pastrana, Gonzalo Carracedo

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Association between prognostic nutritional index and all-cause mortality and cardiovascular disease mortality in American adults with non-alcoholic fatty liver disease by Yuqing Lei, Shaohong Tao, Yubo Yang, Fang Xie, Weining Xie

“…The non-linear association between PNI and mortality was addressed through penalized spline smoothing. Subgroup analyses were conducted to examine the potential influence of relevant clinical variables on the relationship between PNI and mortality. …”
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Dose-response relationship between the fatty liver index and asthma risk: NHANES 2001~2018 by Tengfei Sun, Kexin Fan, Zhuoxiao Han, Hua Qiao

“…We assessed their dose-response relationship using a restricted cubic spline (RCS) model. The threshold effect was analyzed to identify the FLI threshold point. …”
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Ultrasonic characteristics of inserted central catheter related fibroblastic sleeve by Zhifei Ben, Jue Wang, Jinyong Zhan, Kaiying Xu

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Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF-κB/NLRP3 Pathway by Ling Yang, Yan Guo, Xin Fan, Ye Chen, Bo Yang, Ke-Xuan Liu, Jun Zhou

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Notch Signaling Pathway Is Involved in bFGF-Induced Corneal Lymphangiogenesis and Hemangiogenesis by Fang Xie, Xue Zhang, Wenting Luo, Hongyan Ge, Dawei Sun, Ping Liu

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Nonlinear association between depressive symptoms and homeostasis model assessment of insulin resistance: a cross-sectional analysis in the American population by Chunqi Jiang, Bo Wang, Yinuo Qu, Jun Wang, Xin Zhang

“…However, a significant discrepancy between trend tests and regression analyses suggests a potential non-linear relationship between depressive symptom and the assessment of insulin resistance using the Homeostasis Model. Constrained cubic spline analysis confirmed this non-linear relationship, identifying an inflection point at 10.47. …”
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Association between a body shape index and colorectal cancer in US population: a cross-sectional study based on NHANES by Hui Liu, Jialu Kang, Wei Liu, Yongqing Shen

“…In addition, restricted cubic spline curves (RCS) were utilized, and subgroup analyses along with interaction tests were also carried out. …”
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Prioritization of biological processes based on the reconstruction and analysis of associative gene networks describing the response of plants to adverse environmental factors by P. S. Demenkov, E. A. Oshchepkova, T. V. Ivanisenko, V. A. Ivanisenko

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Seasonal Changes in Climate Variables in Rainfed Crop Areas in the Lerma-Chapala-Santiago Basin, Mexico by Raymundo Ordoñez-Sierra, Miguel A. Gómez-Albores, Carlos Díaz-Delgado, Luis Ricardo Manzano-Solís, Angel Rolando Endara-Agramont, Carlos Alberto Mastachi-Loza

“…Climate surfaces were generated by interpolation using the thin-plate smoothing spline algorithm in the software ANUSPLIN. Climate data were Fourier-transformed and fitted to a sinusoidal curve model, and changes in amplitude (increase) and phase were analyzed. …”
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RETRACTED ARTICLE: Associations of composite dietary antioxidant index with cardiovascular disease mortality among patients with type 2 diabetes by Chan Yang, Qiangfei Yang, Xi Peng, Xinqiong Li, Guocheng Rao

“…Three multivariable models were built. Restricted cubic spline analyses were utilized to explore the nonlinear association of CDAI with CVD mortality, and nonlinearity was tested by the likelihood ratio test. …”
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