Hepatitis C Infection and Periodontal Disease: Is there a Common Immunological Link? by Dorin Nicolae Gheorghe, Liliana Foia, Vasilica Toma, Amelia Surdu, Elena Herascu, Dora Maria Popescu, Petra Surlin, Cristin Constantin Vere, Ion Rogoveanu

“…HCV infection can determine direct extrahepatic manifestations at the oral and periodontal level including oral lichen planus, Sjögren-like sialadenitis, and oral cancer. The changes caused by the infection in the subjects’ immune system, diet, and lifestyle can facilitate the development of oral conditions such as periodontal disease. …”
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VDR Polymorphisms in Autoimmune Connective Tissue Diseases: Focus on Italian Population by Andrea Latini, Giada De Benedittis, Carlo Perricone, Serena Colafrancesco, Paola Conigliaro, Fulvia Ceccarelli, Maria Sole Chimenti, Lucia Novelli, Roberta Priori, Fabrizio Conti, Cinzia Ciccacci, Paola Borgiani

“…Variants in VDR gene have been associated with susceptibility to many illnesses sensitive to vitamin D administration and to autoimmune disorders, but no data are available regarding autoimmune connective tissue diseases in Italian population. We analyzed three VDR polymorphisms in 695 Italian patients with autoimmune connective tissue diseases (308 with systemic lupus erythematosus (SLE), 195 with primary Sjogren’s syndrome (pSS), and 192 with rheumatoid arthritis (RA)) and in 246 healthy controls with the aim to evaluate a possible association of VDR SNPs with susceptibility to these diseases in the Italian population. …”
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Recognizing Immunoglobulin G4-Related Overlap Syndromes in Patients with Pancreatic and Hepatobiliary Diseases by Aldo J Montano-Loza, Eoin Lalor, Andrew L Mason

“…The first description of autoimmune pancreatitis and elevated serum immunoglobulin-G4 (IgG4) in 2001 heralded further reports of several related autoimmune diseases with raised IgG4 levels. It is now recognized that a spectrum of overlap syndromes associated with increased IgG4 and biopsy evidence of IgG4-producing plasma cells, which has now been convincingly linked with cholangitis, autoimmune hepatitis, Sjögren’s syndrome, nephritis and retroperitoneal fibrosis. …”
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A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases by Radjesh Bisoendial, Erik Lubberts

“…Accumulating evidence now underscores an integral role of IL-17A in driving the pathophysiology and clinical manifestations in three potentially life-threatening autoimmune diseases, namely, systemic lupus erythematosus, Sjögren’s syndrome, and systemic sclerosis. …”
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Comparative Analysis of CXCR5 Circulating DNA Methylation Levels in Autoimmune Rheumatic Diseases by Yiming Shi, Yingying Qin, Yunshen Li, Ping Jiang, Kai Wei, Jianan Zhao, Yu Shan, Yixin Zheng, Fuyu Zhao, Mi Zhou, Li Li, Yu Shen, Xinliang Lv, Yuejuan Zheng, Shicheng Guo, Qin Ding, Cen Chang, Dongyi He

“…ABSTRACT Objective To assess CXC chemokine receptor 5 (CXCR5) circulating DNA methylation differences in autoimmune rheumatic diseases and their relation with clinical features. …”
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Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease by Masaki Fukui, Yoko Ogawa, Shin Mukai, Mizuka Kamoi, Teru Asato, Yutaka Kawakami, Kazuo Tsubota

“…To investigate whether the SNARE protein vesicle-associated membrane protein 8 (VAMP8) was implicated in the development of chronic ocular graft-versus-host disease (GVHD). Methods. Firstly, the chronic GVHD (cGVHD) and Sjögren’s syndrome (SS)-impaired lacrimal gland (LG) tissue sections from humans for diagnostic purpose were evaluated for VAMP8 expression by histopathology and immunohistochemistry. …”
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The autoimmune disease risk variant NCF1-His90 is associated with a reduced risk of tuberculosis in women by Xinjun Hu, Shasha Li, Renliang Huang, Ziwei Fu, Chenyu Ma, Zheng Cheng, Hongjun Hu, Qiaomiao Zhou, Frank Petersen, Xinhua Yu, Xinhua Yu, Junfeng Zheng

“…This casual variant confers an increased risk for multiple autoimmune disorders, including primary Sjögren’s syndrome and systemic lupus erythematosus. …”
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Comparison of Corneal Epitheliotrophic Factors of Undiluted Autologous Platelet-Rich Plasma and Autologous Serum Eye Drops for Dry Eye Disease by Passara Jongkhajornpong, Kaevalin Lekhanont, Sasivimol Rattanasiri, Prapaporn Pisitkun, Ammarin Thakkinstian

“…In the 100% AS group, Sjögren’s syndrome negatively correlated with the concentrations of PDGF-BB (P = 0.028) and VEGF (P = 0.023). …”
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Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention by Fuli Fan, Shubei Liu, Bin Wang, Xiaojian Song, Wei Wang

“…Background: Atypical memory B (AMB) is a novel subset of B lymphocytes, but its immune features and pathogenetic roles in systemic rheumatic diseases are still largely elusive. This study aimed to characterize transcriptomic features, immune phenotypes and potential signaling pathways of AMB, and also to confirm its alternations in systemic rheumatic diseases via combined transcriptome analyses. …”
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TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review by Juan Montejo-Hernández, Jorge Rico-Fontalvo, Jose Cabrales, Shuchi Anand, María Cristina Martínez-Ávila, Claudia Duran-Merino, Luis Arias-Restrepo, Camilo Andrés Gómez Duran

“…TINU is a rare disorder that needs to be distinguished from sarcoidosis, Sjogren’s disease, and tuberculosis. Treatment is indicated in patients with progressive renal insufficiency, consisting of steroid therapy. …”
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Clinical Characteristics of Concomitant Systemic Lupus Erythematosus and Primary Biliary Cirrhosis: A Literature Review by Toru Shizuma

“…Of the 34 reported concomitant cases of SLE and PBC, 97.1% (33/34) were females, and PBC was diagnosed initially in 69.0% (20/29), except for five cases in which both SLE and PBC were simultaneously diagnosed. Sjögren’s syndrome was the most common autoimmune disease complicating concomitant SLE and PBC (23.5%, 8/34). …”
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Clinical Correlations of Novel Autoantibodies in Patients with Dry Eye by Sezen Karakus, Alan N. Baer, Esen K. Akpek

“…Diagnostic criteria for Sjögren’s syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. …”
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Attenuation of Autoimmune Phenomena in a Patient with Autoimmune Polyglandular Syndrome Type 1 by Jill D. Jacobson, Julia R. Broussard, Courtney Marsh, Brandon Newell

“…We report on a girl whose disease was progressing rapidly until she began on immunosuppressive agents. …”
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Severe Maternal Morbidity Associated with Systemic Lupus Erythematosus Flare in the Second Trimester of Pregnancy by Matthew J. Blitz, Adiel Fleischer

“…Here, we present a case of severe maternal morbidity in a 23-year-old primigravida with SLE and secondary Sjögren’s syndrome who experienced a life-threatening multisystem flare at 17 weeks of gestational age. …”
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Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results by Edyta Dziadkowiak, Agata Sebastian, Małgorzata Wieczorek, Elżbieta Kusińska, Marta Waliszewska-Prosół, Piotr Wiland, Maria Ejma

“…Primary Sjogren’s syndrome (pSS) is a chronic autoimmune disease. …”
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Contraceptives or Hormone Replacement Therapy and Associations with Autoimmune Conditions: Exploring Effects of Estrogen Analog Supplementation by Irakli Tskhakaia, Yurilu Gonzalez Moret, Anna‐Kay Palmer, Diego Lema, M. Carolina Musri, Nanuka Tsibadze, Arthur Lau

“…Prematching, the group who received combined therapy showed increased risks for Sjögren disease (risk ratio [RR] 1.46), rheumatoid arthritis (RR 1.1), and other autoimmune conditions. …”
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Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives by Giuseppe Lopalco, Luca Cantarini, Antonio Vitale, Florenzo Iannone, Maria Grazia Anelli, Laura Andreozzi, Giovanni Lapadula, Mauro Galeazzi, Donato Rigante

“…An overview of monogenic autoinflammatory disorders, PFAPA syndrome, rheumatoid arthritis, type 2 diabetes mellitus, uveitis, pericarditis, Behçet’s disease, gout, Sjögren’s syndrome, interstitial lung diseases, and Still’s disease is presented to highlight the fundamental points that interleukin-1 displays in the cryptic interplay between innate and adaptive immune systems.…”
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Enteropathic Spondyloarthritis: From Diagnosis to Treatment by Rosario Peluso, Matteo Nicola Dario Di Minno, Salvatore Iervolino, Francesco Manguso, Giuseppina Tramontano, Pasquale Ambrosino, Carmela Esposito, Antonella Scalera, Fabiana Castiglione, Raffaele Scarpa

“…Rheumatic manifestations are the most frequent extraintestinal findings of IBD with a prevalence between 17% and 39%, and IBD is associated, less frequently, with other rheumatic disease such as rheumatoid arthritis, Sjogren syndrome, Takayasu arteritis, and fibromyalgia. …”
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Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value by Xavier Mariette, Gaetane Nocturne, Pascale Chretien, Claire Goulvestre, Paul Cioni, Eric Ballot, Dounia Khelifi-Touhami

“…Objective Anti-SS-B antibodies are often associated with anti-SS-A in Sjögren’s disease. Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. …”
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Clinical and Pathological Roles of Ro/SSA Autoantibody System by Ryusuke Yoshimi, Atsuhisa Ueda, Keiko Ozato, Yoshiaki Ishigatsubo

“…Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. …”
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