Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

“…To obtain direct evidence that diabetic sEV promotes cardiomyocyte apoptotic cell death, isolated neonatal rat ventricular cardiomyocytes (NRVMs) were treated with sEV and subjected to simulated ischemia/reperfusion (SI/R). Treatment of cardiomyocytes with sEV from diabetic plasma, diabetic adipocytes, or HGHL-challenged 3T3L1 adipocytes significantly enhanced SI/R-induced apoptosis and reduced cell viability. …”
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Effect of Floating Needle Perfusion Therapy combined with Joint Mobilization on Shoulder Pain of Hemiplegia after Stroke by Xin WANG, Hu LI, Xiuyan LU

“…The control group only received routine rehabilitation training, including normal limb position, prevention of secondary injury, active or auxiliary functional exercise, low-frequency electrical stimulation, and daily living ability simulation training of upper limb, etc., 25 minutes a time, once a day, five days per week, continuous treatment for four weeks. …”
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Dialing the glenosphere eccentricity posteriorly to optimize range of motion in reverse shoulder arthroplasty by Stefan Bauer, MD, Arnaud Meylan, MD, Jaad Mahlouly, MD, Wei Shao, MD, William G. Blakeney, MBBS, MSc, MS, FRACS

“…Methods: In this computer model study, 10 female CTs were analyzed and EXT, ER, IR, and adduction simulated (18 models.) A 135° stem with a +10° liner (145°) was combined with a 25-mm standard/or +3-mm lateralized baseplate (BP) and a 36-mm +2-mm eccentric glenosphere in 4 ECC positions (50° posterior; 30° posterior; 30° anterior; 50° anterior) from the reference position 0° neutral (10 models). …”
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Cooling and Sterile Inflammation in an Oxygen-Glucose-Deprivation/Reperfusion Injury Model in BV-2 Microglia by Jana Lücht, Nele Rolfs, Sylvia J. Wowro, Felix Berger, Katharina R. L. Schmitt, Giang Tong

“…Murine BV-2 microglial cells were exposed to 2 to 6 h OGD (0.2% O2 in glucose- and serum-free medium) followed by up to 19 h of reperfusion, simulated by restoration of oxygen (21% O2) and nutrients. …”
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Fifteen-second bouts of hyperoxia improve 5-minute time-trial performance in acute hypoxic conditions by Martin Faulhaber, Sina Schneider, Linda K. Rausch, Tobias Dünnwald, Verena Menz, Hannes Gatterer, Michael D. Kennedy, Wolfgang Schobersberger

“…TT2 and TT3 were conducted in normobaric hypoxia (15.0 % inspiratory fraction of oxygen, corresponding to about 3200 m simulated altitude). During TT2 and TT3 the participants were breathing through a face mask during five 15-second periods (0:20 to 0:35; 1:20 to 1:35; etc.). …”
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Analyzing power errors in the optical pumping system of atomic spin comagnetometers by Jiale QUAN, Ye LIU, Longyan MA, Wenfeng FAN, Wei QUAN

“…This setup was designed to simulate real-world fluctuations in the pumping power that may occur during the comagnetometer operation. …”
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Theoretical and applied research on hydraulic slit-fracture joint roof control and pressure relief of hard roof in goaf roadway by Yongjiang ZHANG, Fei JI, Tongbin ZHAO, Ke YANG, Wenbin WU, Wangang JIANG

“…In order to improve the rock structure of roof plate, adjust the breaking and transporting law of hard rock layer, and then control the strong mine pressure in the adjacent roadway, this paper analyzes the distribution law of mine pressure in the mine roadway, adopts numerical simulation means to study the distribution of the support pressure in the adjacent roadway under the hard roof plate, investigates the mechanism of the peripheral rock structure transferring loads under the conditions of different roof-cutting parameters, and puts forward a joint method of cutting top plate to remove the pressure by the abrasive jet ultra-high pressure hydraulic cutting - hydraulic fracturing. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…Methods In this study, mice were exposed to a controlled warm and humid environment (25 ± 3 °C with 95% humidity) for 16 days to simulate conditions associated with “Dampness Syndrome.” …”
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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Statistical analysis will include chi-square tests with Monte Carlo simulation for categorical variables, paired t tests or Wilcoxon tests for continuous variables, and multivariate linear mixed models to evaluate the primary outcome, adjusting for confounders. …”
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Analisis Pengembangan Jaringan Komputer UIN Sunan Kalijaga Yogyakarta Menggunakan Perbandingan Protokol Routing Statik dan Routing Dinamis OSPF by Rahmadhan Gatra, Bambang Sugiantoro

“…The study was made based on modeling (simulation) based on EVE-NG applications. The performance resulting from the comparison of routing is measured using QoS parameters including the value of throughput, packet loss, delay, and jitter. …”
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Home Sweet Home: A Program Report on Promoting the Uptake of Home Dialysis by Lucas James Churchill, Frances Reintjes, Robert Pauly, Nikhil Shah, Stephanie Thompson

“…From the survey free text, participants commonly expressed that they valued the “first-hand information” and a “real life perspective” from HSH facilitators and the simulation helped to ease anxiety about home dialysis. …”
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A FAIR and open geographic data collection for the Massaciuccoli Lake basin wetland in ItalyZenodoZenodo by Gian Luca Vannini, Pasquale Bove, Gianpaolo Coro

“…Future projections are available under the Representative Concentration Pathways (RPC) 2.6, 4.5, and 8.5 to simulate low, medium, and high greenhouse gas concentration scenarios respectively.The present geodata collection is particularly useful for wetland monitoring, management and planning. …”
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Stress responses of transportation on red tilapia which given feed containing chromium by Rakhmawati, Rakhmawati, Muhammad Agus Suprayudi, Mia Setiawati, Widanarni, Widanarni, Muhammad Zairin Junior, Dedi Jusadi

“…After a 60-day feeding experiment, the experimental fishes were fasted and distributed in polyethylene bags (N=60 fish/bag) containing 3 L of water, subjected to condition of transport simulation for 13 hours. Survival rate, levels of plasma cortisol, blood glucose, superoxide dismutase (SOD), and malondialdehyde (MDA) enzyme were observed at before transportation, after transportation, one day, and two days after transportation. …”
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4D Radar Imaging and Camera Fusion for Road Crossing Detection and Classification Using Deep Learning by Liyaana Shahirah Wan Abd Aziz, Farah Nadia Mohd Isa, Faridah Abd Rahman, Arvind Hari Narayanan, Ahmad Reza Alghooneh, George Shaker

“…Two road-crossing scenes were simulated to collect data, generating a point cloud dataset labeled with target classes for neural network training and testing. …”
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Hubungan Risiko Tsunami terhadap Tingkat Ansietas pada Anak-anak di SDN 02 Ulak Karang Selatan (Zona Merah) dan SDN 33 Kalumbuk (Zona Hijau) by Septia Endike, Yaslinda Yaunin2 , Rima Yaunin, Rima Semiarty

“…Additional findings indicate that a variety of simulated earthquake and tsunami were conducted on the red zoned school children decrease the anxiety in the child.…”
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Fracture-seepage characteristic zones of the overburden of extra-thick coal seams: Evolutionary patterns and their engineering applications by Xiangguo KONG, Tianshuo ZHAO, Haifei LIN, Pengxiang ZHAO, Xu WANG, Yuchu CAI, Pengfei JI, Di HE, Ke LI, Chuanyu XU

“…To this end, this study analyzed the evolutionary patterns of the fracture morphology and seepage capacity of the overburden using physical similarity simulation experiments. Accordingly, this study investigated the mechanisms behind the evolution of fracture-seepage characteristic zones of the overburden of extra-thick coal seams and proposed a method for identifying fracture-seepage characteristic zones of the overburden. …”
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Unveiling GPT-4V's hidden challenges behind high accuracy on USMLE questions: Observational Study by Zhichao Yang, Zonghai Yao, Mahbuba Tasmin, Parth Vashisht, Won Seok Jang, Feiyun Ouyang, Beining Wang, David McManus, Dan Berlowitz, Hong Yu

“…GPT-4V accuracy improved with hints, maintaining stable performance across difficulty levels, while medical student performance declined as difficulty increased. In a simulated curbside consultation scenario, GPT-4V required multiple specific prompts to interpret complex case data accurately. …”
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Plateau hypoxia improves tumor immune microenvironment and inhibits subcutaneous tumor growth of colorectal cancer by ZHAO Sijie, WANG Meng, GAO Yuan

“…The mice in the plateau hypoxic group were housed in a low-pressure oxygen （10%） chamber to simulate an altitude of approximately 5 600 m， while the mice of the other group was maintained in SPF-grade normal atmospheric conditions （21% oxygen， at an altitude of about 300 m）. …”
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Exploring the mechanisms of Devonian oceanic anoxia: impact of ocean dynamics, palaeogeography, and orbital forcing by J. Gérard, L. Sablon, J. J. C. Huygh, A.-C. Da Silva, A. Pohl, C. Vérard, M. Crucifix

“…The evolution of continental configuration provides a plausible explanation for the increased frequency of ocean anoxic events identified during the Middle and Late Devonian periods, as it contributed to the expansion of oxygen-depleted zones. Our simulations also show that both the decreased atmospheric <span class="inline-formula"><i>p</i></span><span class="inline-formula">O₂</span> and increased oceanic <span class="inline-formula">PO₄</span> concentration exacerbate ocean anoxia, consistent with established knowledge. …”
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Magnetocaloric Effect for a <i>Q</i>-Clock-Type System by Michel Aguilera, Sergio Pino-Alarcón, Francisco J. Peña, Eugenio E. Vogel, Natalia Cortés, Patricio Vargas

“…We calculate the thermodynamic quantities using Monte Carlo simulations for even <i>Q</i> numbers, ranging from <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>Q</mi><mo>=</mo><mn>2</mn></mrow></semantics></math></inline-formula> to <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>Q</mi><mo>=</mo><mn>8</mn></mrow></semantics></math></inline-formula> spin orientations per site in a lattice. …”
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