Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration by Liang Xin, Haoxiang Zhu, Haoxiang Zhu, Suping Niu, Xie Han, Hongxian Pang, Jiangfan Li, Ye Hu, Xuhong Wang, Lujin Li, Lujin Li, Yi Fang

“…Moreover, the study found that tapentadol was significantly more effective in treating lower back pain compared to non-lower back pain.ConclusionThis research successfully developed a pharmacodynamic model for dose-titrated tapentadol administration, which can simulate the temporal changes in analgesic effects of tapentadol across different clinical scenarios. …”
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Eicosapentaenoic Acid and Docosahexaenoic Acid as an Antimicrobial Agent in Orthopedics—An In Vitro Study About the Race for Surface by Christopher Spiegel, Burak Ünalan, Andreas Kaserbacher, Rohit Arora, Débora C. Coraça-Huber

“…The co-culture setup helped to examine the influence of omega-3 fatty acids on the race for surface to simulate prosthetic joint infections. Methods: In this study, we tested <i>Staphylococcus aureus</i> ATCC 29213 co-cultured with human fetal osteoblasts <i>hFOB 1.19</i> in the presence of sub-MIC and MIC concentrations of docosahexaenoic acid (1.25 mg/L, 2.5 mg/L) and eicosapentaenoic acid (0.15 mg/L, 0.3 mg/L) after 1, 6 and 24 h of incubation. …”
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Seasonal Mathematical Model of Salmonellosis Transmission and the Role of Contaminated Environments and Food Products by Mohammed H. Alharbi, Fawaz K. Alalhareth, Mahmoud A. Ibrahim

“…Predictions indicate a gradual decline in the number of new cases, with stabilization anticipated at approximately 40,000 cumulative cases. Further simulations examined the dynamics of disease extinction and persistence based on <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi mathvariant="script">R</mi><mn>0</mn></msub></semantics></math></inline-formula>. …”
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NH3 release during the snow evaporation process in typical cities in Northeast China by Xiaoteng Liu, Hongsheng Jia, Yunze Zhao, Yachao Zhang, Haodong Hou, Yingying Xu

“…This study collected snow samples from five notable snowfall events in Changchun, Jilin Province that occurred from November 2023 to March 2024, to conduct indoor simulated evaporation experiments (among them, the actual phase changes of two snowfall events consisted mainly of evaporation, whereas those of the other three events consisted mainly of sublimation). …”
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CO2 geological storage in sedimentary basins: An update on the potential and suitability evaluation and a field test by Yujie Diao, Xin Ma, Chenglong Zhang, Xiaolin Jin, Xufeng Li, Chao Zhang

“…The CGS has also characterized historical CO2 plume migration in reservoirs at the storage site of the Shenhua CCS demonstration project and conducted numerical simulations of CO2 plume migration for periods of 10 and 20 years following the shutdown of the injection well. …”
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Spartina alterniflora invasion significantly alters the assembly and structure of soil bacterial communities in the Yellow River Delta by Pengyuan Sun, Yuxin Wu, Pengcheng Zhu, Jingfeng Wang, Jingfeng Wang, Xiaona Yu, Weihua Guo

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Enhancing CO₂ selectivity in MOFs through a dual-ligand strategy: Experimental and theoretical insights by Amir Kazemi, Akram Karbalaee Hosseini, Mahyar Ashourzadeh Pordsari, Mohsen Tamtaji, Saber Keshavarz, Faranak Manteghi, Azadeh Tadjarodi, Ahad Ghaemi, Sohrab Rohani, William A. Goddard

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The influence of scapular orientation on the medial scapula corpus angle in snapping scapula syndrome by Brittany Percin, BS, MS4, Joseph Featherall, MD, Robert Z. Tashjian, MD, Peter N. Chalmers, MD, Christopher D. Joyce, MD, Alexander J. Mortensen, MD, Heath B. Henninger, PhD

“…The scapula type and MSCA were measured on a controlled reference imaging plane, and ones translated and rotated below the supraspinatus fossa to create 19 planes simulating variations due to scapulothoracic orientation. …”
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The European summer heatwave of 2019 – a regional storyline perspective by T. Klimiuk, P. Ludwig, A. Sanchez-Benitez, H. F. Goessling, P. Braesicke, P. Braesicke, J. G. Pinto

“…The magnitude of the heatwave temperature response significantly exceeds the globally modelled background warming, with distinct spatial and temporal variations in the regional increments. Our simulations indicate a general linear dependence of the 2 m temperature response on global-warming levels: during the July 2019 heatwave, warming rates ranged between factors of 2 and 3 in central Europe, resulting in anthropogenic warming of 8 to 12 °C in the <span class="inline-formula">+4</span> K climate. …”
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Potentially inappropriate prescribing in hospitalised children: a retrospective, cross-sectional study at a tertiary children’s hospital in China by Linan Zeng, Lingli Zhang, Dan Yu, Huiqing Wang, Liang Huang, Siyu Li, Guo Cheng, Zhi-Jun Jia

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Exogenous diethyl aminoethyl hexanoate alleviates the damage caused by low-temperature stress in Phaseolus vulgaris L. seedlings through photosynthetic and antioxidant systems by Yu Bai, Qiya Dai, Yanheng He, Li Yan, Jianpo Niu, Xuan Wang, Yongdong Xie, Xuena Yu, Wen Tang, Huanxiu Li, Zhi Huang, Bo Sun, Guochao Sun, Xun Wang, Yi Tang

“…This study aimed to investigate the impact DA-6 has on the growth, photosynthesis, antioxidant system, and gene expression in cold-tolerant (YJ009763) and cold-sensitive (Baibulao) P. vulgaris seedlings under low-temperature stress. Results To simulate low-temperature stress, P. vulgaris seedlings were exposed to 5 °C, and 25 mg/L DA-6 solution applied to their leaves. …”
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Response of Soil Respiration to Snowfall in a Kubuqi Salix Plantation Forest of During Freeze-thaw Period by WANG Jixuan, LAN Xiaozhen, PEI Zhiyong, ZHANG Junyao, WANG Xinping, LI Ying, WANG Haichao, SUN Xiaotian, SUN Kai

“…The two-factor composite model of soil temperature and moisture explained soil respiration better than the single factor model, and it explained 81% of the variation in soil respiration. The simulation results of the structural equation modelling (SEM) showed that all factors could jointly explain 70% of the variation in soil respiration rate, snowfall and stubble levelling directly affected soil respiration, and land preparation affected soil respiration indirectly by affecting soil temperature and moisture. …”
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Influence of land cover change on atmospheric organic gases, aerosols, and radiative effects by R. Vella, R. Vella, M. Forrest, A. Pozzer, A. Pozzer, A. P. Tsimpidi, T. Hickler, T. Hickler, J. Lelieveld, J. Lelieveld, H. Tost

“…Two scenarios were evaluated: (1) one comparing present-day land cover, which includes areas deforested for crops and grazing land, with potential natural vegetation (PNV) cover simulated by the model, and (2) an extreme reforestation scenario in which present-day grazing land is restored to natural vegetation levels. …”
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Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma by Hua Dai, Xin Tao, Yuansen Shu, Fanrong Liu, Xiaoping Cheng, Xiushen Li, Bairui Shu, Hongcheng Luo, XuXiang Chen, Zhaorui Cheng

“…The functional role of PTGES3 was further corroborated through molecular docking simulations and in vitro experimental assays. We identified 27 genes associated with lipid metabolism, 18 of which exhibited significant correlation with overall survival in HCC patients. …”
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Systematic review and quantitative meta-analysis of age-dependent human T-lymphocyte homeostasis by Victoria Kulesh, Victoria Kulesh, Kirill Peskov, Kirill Peskov, Kirill Peskov, Gabriel Helmlinger, Gennady Bocharov, Gennady Bocharov, Gennady Bocharov

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VECTOR: Velocity-Enhanced GRU Neural Network for Real-Time 3D UAV Trajectory Prediction by Omer Nacar, Mohamed Abdelkader, Lahouari Ghouti, Kahled Gabr, Abdulrahman Al-Batati, Anis Koubaa

“…Synthetic data are generated using the Gazebo robotics simulator and PX4 Autopilot, while real-world data are sourced from the UZH-FPV and Mid-Air drone racing datasets. …”
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Dispersion modelling of particulate matter concentrations of sand product plants in a mineral complex by Y. Zehtab Yazdi, N. Mansouri, F. Atabi, H. Aghamohammadi

“…Next, a Gaussian model was used to estimate the particulate matter concentrations in the surrounding residential areas. Finally, the simulated concentrations were compared with the United States Environmental Protect Agency and World Health Organization standards.FINDINGS: Results showed that hauling operations, with producing 70%, 86%, and 90% of total PM2.5, PM10 and total suspended particulates, respectively, were the major sources of dust emission in the sand and gravel product plants. …”
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Stochastic Modeling of Adaptive Trait Evolution in Phylogenetics: A Polynomial Regression and Approximate Bayesian Computation Approach by Dwueng-Chwuan Jhwueng, Chia-Hua Chang

“…As analytical representations for the likelihood of the models are not feasible, we implement an approximate Bayesian computation (ABC) technique to assess the performance through simulation. We also plan to apply models to the empirical study using the two datasets: the longevity vs. fecundity in the Mediterranean nekton group, and the trophic niche breadth vs. body mass in carnivores in a European forest region.…”
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Temporal segmentation method for 30-meter long-term mapping of abandoned and reclaimed croplands in Inner Mongolia, China by Deji Wuyun, Liang Sun, Zhongxin Chen, Luís Guilherme Teixeira Crusiol, Jinwei Dong, Nitu Wu, Junwei Bao, Ruiqing Chen, Zheng Sun, Hasituya, Hongwei Zhao

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Impacts of Recent Climate Trends and Human Activity on the Land Cover Change of the Abbay River Basin in Ethiopia by Asaminew Abiyu Cherinet, Denghua Yan, Hao Wang, Xinshan Song, Tianlin Qin, Mulualem T. Kassa, Abel Girma, Batsuren Dorjsuren, Mohammed Gedefaw, Hejia Wang, Otgonbayar Yadamjav

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