Downregulation of Long Noncoding RNA LINC00261 Attenuates Myocardial Infarction through the miR-522-3p/Trinucleotide Repeat-Containing Gene 6a (TNRC6A) Axis by Chaoxin Jiang, Qing Zhao, Chenlong Wang, Minyan Peng, Guoqing Hao, Zhifeng Liu, Wenjin Fu, Kewei Zhao

“…Hypoxic preconditioning in normal cells was used to construct a simulated MI environment to investigate the effect of LINC00261 on apoptosis of cardiac cells. …”
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Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…Additionally, molecular docking simulations performed with AutoDock software confirmed the robust binding interactions between ATBC and these core targets, reinforcing our understanding of their interactions. …”
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Dynamic rationing using agent-based modeling of the assembly process of equipment for nuclear power plants by I. A. Loskutov, D. A. Skvortsova, V. G. Iskandarova

“…The components of programs implemented in the C# language are shown, descriptions of classes are described, their actions to simulate the behavior of agents of a production system. …”
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Economic feasibility assessment and parameter sensitivity analysis of rainwater harvesting systems in different climatic zones of China by Chonghua Xue, Feng Xiong, Junqi Li, Xiaojing Li, Jing Li, Yu Wang, Xiangyu Li, Ziyu Cui

“…Using the Infoworks ICM model, long-term simulations (30 years) were conducted to evaluate the economic advantages of rainwater utilization across these climate zones. …”
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Metal-free production of natural blue colorants through anthocyanin–protein interactions by Wenxin Wang, Peiqing Yang, Fuqing Gao, Yongtao Wang, Zhenzhen Xu, Xiaojun Liao

“…Methods: Using human serum albumin (HSA) as a model protein, we investigated the structural influences of ACNs on their blue color generation using visible absorption spectroscopy, fluorescence quenching, and molecular simulations. Additionally, we examined the bluing effects of six proteins derived from milk and egg and identified the remarkable roles of bovine serum albumin (BSA) and lysozyme (LYS). …”
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Nonhomogeneous Markov chains for degeneration behaviour of RC members’ durability and its Bayesian updating by Ruiqi Guo, Dengguo Li, Guoxin Chen, Yu Jin, Hui Li, Yuanpeng Zhang

“…It provides a new technical approach for dynamically updating the long-term performance degradation time series model of components using state evaluation results. Manuscript uses a simulated case study and a real case study to illustrate the application process of the proposed method and to examine the predictive performance of the model. …”
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Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology by James Johnson, PhD, Ben Gadomski, PhD, Daniel Regan, DVM, PhD, DACVP, Jed Johnson, PhD, Brad Nelson, MS, PhD, DVM, DACVS, Kirk McGilvray, PhD, Kevin Labus, PhD, Anthony Romeo, MD, Jeremiah Easley, DVM, Dipl, ACVS

“…Methods: This study used an ovine model to simulate chronic tendon degeneration with subsequent rotator cuff transection and repair. …”
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ZINQ-L: a zero-inflated quantile approach for differential abundance analysis of longitudinal microbiome data by Shuai Li, Runzhe Li, John R. Lee, John R. Lee, Ni Zhao, Wodan Ling

“…Its comprehensive examination of the abundance distribution enables the identification of heterogeneous associations, improving the testing power.ResultsExtensive simulation studies and an application to a real kidney transplant microbiome study demonstrate the improved power of ZINQ-L in detecting true signals while controlling false discovery rates.ConclusionZINQ-L is a zero-inflated quantile-based approach for detecting individual taxa associated with outcomes or exposures in longitudinal microbiome studies, providing a robust and powerful option to improve and complement the existing methods in the field.…”
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Computational and experimental exploration of morpholine pendent 2-hydrazineyl thiazole: Insights from DFT, ADME profiling, antifungal efficacy and molecular docking analyses by Vishnu A. Adole, I.Antony Danish, J.Jebasingh Kores, J.Winfred Jebaraj, S. Janani, Suresh K. Ghotekar, Rakesh D. Amrutkar

“…UV–Vis, IR, and NMR simulations were used to forecast spectroscopic characteristics. …”
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Attributing heatwave-related mortality to climate change: a case study of the 2009 Victorian heatwave in Australia by Sarah E Perkins-Kirkpatrick, Linda Selvey, Philipp Aglas-Leitner, Nina Lansbury, Samuel Hundessa, Dáithí Stone, Kristie L Ebi, Nicholas John Osborne

“…An epidemiological model derived from well-established methods defining the relationship between observed heatwave temperatures (95th, 97.5th and 99th percentiles) and mortality is applied to heatwaves in simulations that either include or omit anthropogenic climate forcing from eight climate models. …”
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Three-dimensional ultrasound fusion imaging in precise needle placement for thermal ablation of hepatocellular carcinoma by Jiaming Liu, Yuqing Guo, Yueting Sun, Ming Liu, Xiaoer Zhang, Ruiying Zheng, Longfei Cong, Baoxian Liu, Xiaoyan Xie, Guangliang Huang

“…Plan of needle placement was made through a predetermined simulated ablation zone to ensure a 5 mm ablative margin with the coverage rate toward tumor and ablative margin. …”
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Optomechanical Gyroscope Based on Micro-Hemispherical Shell and Optical Ring Resonators by Jamal N. A. Hassan, Wenyi Huang, Maoyuan Wang, Senyu Zhang, Guangjun Wen, Yongjun Huang

“…Overall, the gyroscope design utilizes principles of both mechanical resonators and integrated photonics to address challenges in on-chip light coupling and angular velocity detection for next-generation optomechanical inertial sensors. Numerical simulations demonstrated the optomechanical micro-hemispherical shell resonator gyroscope could attain a calculated scale factor of 77.9 mV/(°/s) and total angle random walk of 0.0662 °/h^1/2 for a micro-hemispherical shell mass of 212 ng at an input laser power of 5 mW. …”
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Variability and Source Characterization of Regional PM of Two Urban Areas Dominated by Biomass Burning and Anthropogenic Emission by Christian Mark G. Salvador, Jhon Robin dR. Yee, Iara Chantrelle V. Coronel, Angel T. Bautista, Raymond J. Sugcang, Mark Anthony M. Lavapiez, Rey Y. Capangpangan, Preciosa Corazon B. Pabroa

“…The surface concentration of PM2.5 was analyzed using simulated and reanalyzed satellite data (MERRAero), complemented, and validated with filter measurements for PM2.5 and black carbon (BC). …”
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Effects of Long-Term Serum Starvation on Autophagy, Metabolism, and Differentiation of Porcine Skeletal Muscle Satellite Cells by Yi Wang, Juan Gao, Bojun Fan, Yuemin Hu, Yuefei Yang, Yajie Wu, Jiaqiao Zhu, Junwei Li, Feng Li, Huiming Ju

“…The SMSCs isolated and preserved in our laboratory were revived and divided into six groups based on the culture medium serum concentration to simulate varying levels of serum starvation: 20% serum (control group), 15% serum (mild serum starvation group), 5% serum (severe serum starvation group), and their autophagy inhibition groups supplemented with 3-methyladenine. …”
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Quantifying the potential value of entomological data collection for programmatic decision-making on malaria control in sub-Saharan African settings by Nora Schmit, Hillary M. Topazian, Matteo Pianella, Giovanni D. Charles, Peter Winskill, Penelope A. Hancock, Ellie Sherrard-Smith, Katharina Hauck, Thomas S. Churcher, Azra C. Ghani

“…The 3-year impact and cost of various intervention packages was simulated in different sub-Saharan African settings, including combinations of scaling-up insecticide-treated nets (ITN), switching to next-generation ITNs, and a treatment and prevention package. …”
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Hydrological-hydraulic modelling to assess Nature-Based Solutions for flood risk mitigation in an urban area of Catania (Sicily, Italy) by L. Sciuto, F. Licciardello, E.R. Giuffrida, S. Barresi, V. Scavera, D. Verde, S. Barbagallo, G.L. Cirelli

“…Specifically, five distinct scenarios are formulated by varying the type of NBS and their implementation percentages, considering both public areas and fiscal measures. Model simulations are conducted with return periods (T) of 10, 50, and 200 years. …”
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Multi-observatory Study of Young Stellar Energetic Flares (MORYSEF): No Evidence for Abnormally Strong Stellar Magnetic Fields after Powerful X-Ray Flares by Konstantin V. Getman, Oleg Kochukhov, Joe P. Ninan, Eric D. Feigelson, Vladimir S. Airapetian, Abygail R. Waggoner, L. Ilsedore Cleeves, Jan Forbrich, Sergio A. Dzib, Charles J. Law, Christian Rab, Daniel M. Krolikowski

“…Previous models of large PMS X-ray flares, lacking direct magnetic field measurements, showed discrepancies from this baseline law, which MHD simulations attribute to unusually strong magnetic fields during flares. …”
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Effect of ISPAD Anaerobic Digestion on Ammonia Volatilization from Soil Applied Swine Manure by Susan King, Michael Schwalb, David Giard, Joann Whalen, Suzelle Barrington

“…This research was conducted using laboratory wind tunnels simulating land application. The five experimental soils offered similar pH values but different water holding capacity, cation exchange capacity, cation saturation, and organic matter. …”
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Unraveling the individual and interactive effects of climate and competition on branch growth dynamics in Pinus koraiensis in Northeast China by Xuehan Zhao, Zheng Miao, Zheng Miao, Fengri Li, Fengri Li, Yuanshuo Hao, Yuanshuo Hao, Yumeng Jiang, Lihu Dong, Lihu Dong

“…In the face of the current challenges posed by climate change, accurate information to inform forest management and policy-making is urgently needed.MethodsWe collected 745 branches from 54 sampled trees of Korean pine and, we employed a mixed-effects model to assess the effects of tree variables, competition, climate, and their interactions on branch growth. Furthermore, we simulated branch growth under different combinations of competition and climatic conditions to provide practical and targeted recommendations for Korean pine plantation management.ResultsOur results demonstrate that (1) in addition to branch age, size, and tree height growth, competition, climate, and their interactions significantly improved the branch growth model, with the effects of interactions surpassing the individual effects of climate, which highlights the importance of considering interactive effects; (2) the effects of climate and competition varied depending on the social status of the trees, with dominant and intermediate individuals showing greater sensitivity to competition and climate than suppressed individuals, suggesting that, for future research in this direction, prioritizing sampling of dominant and intermediate individuals would be a cost-effective approach; and (3) owing to the presence of interactions, the influence of climate on branch growth was modulated by competition, suggesting that adjusting competition levels in response to climate stress could lead to desirable branch growth outcomes.DiscussionOur study underscores the importance of understanding the different sources of variation in branch growth is crucial for advancing our understanding of tree growth and crown dynamics, as well as for formulating sustainable management policies amidst the uncertainties of climate change.…”
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Assemblies design and modeling analysis of a new fine mesh neutronics/thermal-hydraulics coupling benchmark for plate-type PWR core by Zhigang Li, Wei Lu, Shanfang Huang, Xiafeng Zhou, Yingwei Wu, Bangyang Xia, Junji Chen, Tao He, Guodong Liu, Yangyu Zhong, Zhiying Yue

“…In order to support the verification of neutronics/thermal-hydraulics coupling calculation method or simulation codes at the fine mesh for plate-type pressurized water reactor (PWR) with high parameters (which the ratio of power to mass flow rate is greater than 235 kW/kg, the core outlet enthalpy exceeds 1500 kJ/kg), a set of coupling calculation of plate-type PWR based on high parameters (COPHP) is design by Nuclear Power Institute of China (NPIC). …”
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