Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches by David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari

“…The predictive accuracy of the model was evaluated for four different states of the protein structure: (1) static homology models, (2) enhancing low-frequency vibrational modes during short molecular dynamics (MD) runs, (3) a combination of (2) with a protonation state reassignment, and (4) conventional full-atomistic MD simulations. …”
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How to disseminate the research results on climate change impacts in cities to guide adaptation public policies ? Application to the Paris region (France) by Julie André, Benjamin Le Roy, Aude Lemonsu, Morgane Colombert, Valéry Masson

“…High-resolution climate projections may meet parts of these needs, but two key points require attention: (i) climate models appear to be difficult to apprehend by public stakeholders, thus an effort of pedagogy is necessary, (ii) climate projections often extend to 2100, but stakeholders primarily need short- to medium-term forecasts that align with public policy timelines. …”
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Pharmacotherapies for Obesity: Past, Current, and Future Therapies by Lisa L. Ioannides-Demos, Loretta Piccenna, John J. McNeil

“…This paper reviews the efficacy and safety of pharmacotherapies for obesity focusing on drugs approved for long-term therapy (orlistat), drugs approved for short-term use (amfepramone [diethylpropion], phentermine), recently withdrawn therapies (rimonabant, sibutamine) and drugs evaluated in Phase III studies (taranabant, pramlintide, lorcaserin and tesofensine and combination therapies of topiramate plus phentermine, bupropion plus naltrexone, and bupropion plus zonisamide). …”
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Management of adult patients with alcoholic liver disease: clinical guidelines of the Russian Scientific Liver Society by V. T. Ivashkin, M. V. Mayevskaya, Ch. S. Pavlov, Yu. P. Sivolap, V. D. Lunkov, M. S. Zharkova, R. V. Maslennikov

“…Abstinence from alcohol is the first line and the basic therapeutic procedure for any form and stage of ALD. Short therapeutic interventions practice helps to cope with alcoholic issue at any stage, gives the chance to motivate the patient, including the treatment of addiction to alcohol, intake of drugs. …”
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Nove možnosti organiziranja javne uprave in učinkovitost upravnih sistemov by Gorazd Trpin

“…Prikazujemo in komentiramo tudi dobre rešitve, ki jih je nova ureditev prinesla v upravnem postopku, upravnem sporu in na področju neformalnih oblik varstva pravic posameznikov. …”
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Pneumocystis carinii: A Review of an Important Opportunistic Pathogen in AIDS by M John Gill, Ron Read

“…Serological studies suggest that disease is most often secondary to the reactivation of an asymptomatic infection, usually acquired during childhood. Increasing shortness of breath, a nonproductive cough and hypoxia often preceded by several weeks of lethargy, fever and weight loss are the classical features of P carinii pneumonia in acquired immune deficiency syndrome. …”
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Multi-Sensor Instrument for Aerosol In Situ Measurements by Ilya Bruchkouski, Artur Szkop, Jakub Wink, Justyna Szymkowska, Aleksander Pietruczuk

“…A short comparison campaign took place at the Racibórz measurement site in May 2024 to assess the consistency of the Integrated Aerosol Monitoring Unit (IAMU), which houses three PM aerosol sensors (SPS30, OPC-N3, and OPS 3330) within a single enclosure. …”
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Crossing Virtual Doors: A New Method to Study Gait Impairments and Freezing of Gait in Parkinson’s Disease by Luis I. Gómez-Jordana, James Stafford, C. (Lieke) E. Peper, Cathy M. Craig

“…Our results closely mirrored those obtained with real doors. In short, this methodology provides a safe, personalized yet adequately controlled means to examine FOG in Parkinson’s patients, along with possible interventions.…”
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The Trend Analysis and Forecasting of Extreme Temperature Parameters in southern part of the Caspian Sea by Mostafa Karimi, Fatemeh Sotoudeh, Somayeh Rafati

“…It was predicted extreme temperature to increase about 0.1 to 1.7° C. The short time oscillations and significant positive trend occurred in both the maximum and minimum temperature shows the temperature increase and climate changes in the future. …”
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5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…5-Fluorouracil (5-FU) serves as a first-line therapeutic agent for colorectal cancer, however, its utility is limited by a short half-life and significant cytotoxicity. This study focused on the construction of 5-Fluorouracil-β-Cyclodextrin polymers (5-FUSA-β-CD and 5-FUBA-β-CD) by covalent conjugation using linker strategies to address limitations. …”
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Date pomace polysaccharides-capped selenium nanoparticles: Biosynthesis, optimization, physicochemical characterization, biological activities, stability and gut microbiota modulat... by Gafar Babatunde Bamigbade, Athira Subhash, Mohammed Abdin, Hebah Jarusheh, Basim Abu-Jdayil, Shao-Quan Liu, Giovanni Palmisano, Abdelmoneim Ali, Afaf Kamal Eldin, Mutamed Ayyash

“…During fecal fermentation, they boosted short-chain fatty acid (SCFA) production and the abundance of SCFA-producing bacteria, including Gemmiger formicilis and Bifidobacterium species. …”
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The Effect of Flood Exposure on Insurance Adoption Among US Households by June Choi, Noah S. Diffenbaugh, Marshall Burke

“…We find that a flood disaster declaration in a given year increases the take‐up rate of insurance by 7% in the following year, but that the effect diminishes in subsequent years and is gone after 5 years. This effect is more short‐lived in counties in inland states that do not border the Gulf and Atlantic coasts. …”
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Hugo Chavez : le renouveau du populisme vénézuélien ? by Olivier Folz

“…First in order to apprehend the principal characteristics of this charismatic leader, and, after a short study of the Venezuelan’s populism of the Fifties, we will concentrate on the character, then, through his declarations and his writings, we will examine the diagnosis which it carries on the crisis that Venezuela crosses, the nature of its electoral program and, finally, his report/ratio with the people. …”
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Efficiency of a macroroughness block ramp in reducing the impact of low-head dams on riverine fish dispersion by Tomanova Sylvie, Courret Dominique, Richard Sylvain, Mercier Olivier, Guillemin Axel, Labedan Mathilde, Sagnes Pierre

“…Fish between 70 and 451 mm in total length were detected crossing the ramp, usually within a short time. In comparison with the efficiency results available for other types of fishways, the macroroughness ramp studied here ranks among the most efficient devices for fish movement restoration.…”
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Sensitivity Analysis of Biosensor-Based SiGe Source Dual Gate Tunnel FET Having Negative Capacitance by Dipshika Das, Rudra Sankar Dhar, Pradip Kumar Ghosh, Yash Sharma, Amit Banerjee

“…Dual gate architecture with laterally split dielectric is used to overcome the short channel impact and to enhance the current ratio. …”
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Predicting and synthesizing terahertz spoof surface plasmon polariton devices with a convolutional neural network model by Vahid Najafy, Bijan Abbasi-Arand, Maryam Hesari-Shermeh

“…In addition to the speed of dataset generation, the simple framework of this network has also facilitated the training of the network in a short time. By comparing the network in this study with previous works, it is apparent that in addition to structural and geometrical changes in the unit cell, the designer is afforded greater freedom in determining the material of the incident medium and, for the first time, specifying the angle of incidence of the source. …”
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Psychosocial Effect of COVID-19 Phobia in Health Workers in the Pandemic Service and Intensive Care by Merve Bülbül, Ayşe Nur İnci Kenar, Gonca Ayşe Ünal

“…It has been thought that reducing the working time in the service and/or intensive care unit during the pandemic, performing short-term rotations, may reduce the level of psychosocial impact and even be protective in terms of mental health of medical staff.…”
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Genetic analysis of Pinna rudis L 1758 (Mollusca, Bivalvia, Pinnidae) in the Northwest Cabo Verde Islands (Central-East Atlantic) by Evandro P. Lopes, Sarah Santos, Raquel Xavier, Joana L. Santos, M. Pilar Cabezas, Fernando Sequeira, António M. Santos

“…The high genetic structure found for P. rudis could be influenced by hydrodynamic barriers, local currents and hydrographic isolation, in association with the short larval duration (planktotrophic) reported for this species. …”
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Role of myositis-specific autoantibodies in personalized therapy by Anand N Malaviya, Sanjiv Kapoor

“…These are exciting times for clinicians, for research scientists, and for the patients with inflammatory myositis with reasons to be optimistic about a bright future. This short review provides a summary of the present knowledge with emphasis on its clinical implications.…”
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Assessment of Aerosol Radiative Impact over Oceanic Regions Adjacent to Indian Subcontinent Using Multisatellite Analysis by S. K. Satheesh, V. Vinoj, K. Krishnamoorthy

“…Consequently we provide improved assessment of short wave aerosol radiative forcing (ARF) (on both regional and seasonal scales) estimates over this region. …”
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