Using Targeted Virotherapy to Treat a Resistant Ewing Sarcoma Model: From the Bedside to the Bench and Back by Hesham Abdelbary, Christopher W. Brown, Joel Werier, John Bell

“…The established EWS cell line shared similar molecular and genetic traits to the patient’s original tumor specimen. …”
Get full text

Utilisation of alcohol-related treatment after a first alcohol use disorder diagnosis in Hamburg, Germany by Jakob Manthey, Kilian Huß, Sven Buth, Ludwig Kraus, Anna Schranz, Carolin Kilian, Jürgen Gallinat, Ingo Schäfer, Bernd Schulte

“…Among treatment entrants, nearly half received only brief psychiatric consultation. A similar share of patients utilised standard or intensive inpatient treatment; the latter occasionally followed by rehabilitation treatment. …”
Get full text

Lithological and geochemical characterization of ‘adinole’ artefacts from cave deposits in southwest Wales: A material of choice during the late Middle to Upper Palaeolithic by Richard Bevins, Elizabeth A. Walker, Nick Pearce, Duncan Pirrie, Rob Ixer, Ian Saunders, Matthew Power

“…Some artefacts appear to cluster on geochemical plots, such as a group of eight artefacts from Hoyle’s Mouth Cave which share petrological characteristics and appear to have come from a common source. …”
Get full text

Exploring the rise and diversity of health and societal issues that use a public health approach: A scoping review and narrative synthesis. by Alison Hurst, Nick Shaw, Daniele Carrieri, Ken Stein, Katrina Wyatt

“…There is an increase in calls across diverse issues for a "public health approach" however, it is not clear whether there is any shared understanding in approach in its conceptualisation or implementation. …”
Get full text

Why and how should we simulate platform trials? Learnings from EU-PEARL by Elias Laurin Meyer, Tobias Mielke, Marta Bofill Roig, Michaela Maria Freitag, Peter Jacko, Pavla Krotka, Peter Mesenbrink, Tom Parke, Sonja Zehetmayer, Dario Zocholl, Franz König

“…To give some examples, the newly developed software supports simulating staggered entry of treatments throughout the trial, choosing different options for control data sharing, specifying different platform stopping rules and platform-level operating characteristics. …”
Get full text

Data linkage of German statutory health insurance claims data and care needs assessments preceding a population-based cohort study on nursing home admission by Karin Wolf-Ostermann, Dominik Domhoff, Kathrin Seibert, Susanne Stiefler, Dirk Peschke

“…Linkage rates were lower where more people shared the same attributes. The resulting dataset showed minor differences regarding age, sex and care level compared to the original cohort.Conclusions Data linkage between German SHI claims data and CNA data is feasible. …”
Get full text

Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…This review discusses the development and clinical application of mRNA vaccines in oncology, with a particular focus on recent clinical trials and the computational workflows and methodologies for identifying both shared and individual antigens. While this review centers on therapeutic mRNA vaccines targeting existing tumors, it does not cover preventative vaccines. …”
Get full text

Eating disorders in minority ethnic populations in Australia, Canada, Aotearoa New Zealand and the UK: a scoping review by A. Williams-Ridgway, R. McGowan, S. McNeil, H. Tuomainen

“…The aim of this scoping review, the first of its kind, was to systematically examine research on disordered eating and EDs among minority ethnic populations in Australia, Canada, Aotearoa New Zealand and the United Kingdom (UK), four countries with shared sociocultural and healthcare characteristics. …”
Get full text

Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Transcriptome analysis revealed distinct mechanisms for these two approaches: EA primarily regulates neuroglial plasticity, whereas MA predominantly targets neurotransmitter regulation. Both EA and MA share a common therapeutic target in the integrin family. …”
Get full text

Ecological Drivers of Molt‐Breeding Overlap, an Unusual Life‐History Strategy of Small‐Island Birds? by Christopher C. De Ruyck, Nicola Koper

“…There was also greater diet overlap and wider niche widths of invertebrate resources in the wet season when molt‐breeding overlap occurred, and greater niche partitioning of invertebrate items among species in the dry season suggesting that competitive interactions for invertebrates were stronger in the dry season. Birds also shared more plant food sources in the dry season when invertebrate abundance is low, though seasonal differences in plant diet diversity and niche width varied by species. …”
Get full text

Extrapolating evidence for molecularly targeted therapies from common to rare cancers: a scoping review of methodological guidance by Sarah J Lord, Saskia Cheyne, John Simes, Doah Cho, Chee Khoon Lee

“…Extrapolating existing evidence of targeted therapy from common cancers to rare cancers sharing the same biomarker may reduce evidence requirements for regulatory approval in rare cancers. …”
Get full text

Russia-China Relations: An Asymmetrical Partnership? by Sergei Lukonin

“…China accounts for around 20% of the total foreign trade volume of the Russian Federation, while Russia's share in Chinese foreign trade turnover is about 3%. …”
Get full text

Peer-based Retention Of people who Use Drugs in Rural Research (PROUD-R2): a multisite, randomised, 12-month trial to compare efficacy of standard versus peer-based approaches to r... by Morgan Brown, Miriam R Elman, Jodi Lapidus, April M Young, Kathryn E Lancaster, Sarann Bielavitz, Ryan R Cook, Gillian Leichtling, Edward Freeman, Angela T Estadt, Rhonda Alexander, Caiti Barrie, Kandi Conn, Rhody Elzaghal, Lisa Maybrier, Renee McDowell, Cathy Neal, Elizabeth N Waddell, P Todd Korthuis

“…Introduction Rural communities bear a disproportionate share of the opioid and methamphetamine use disorder epidemics. …”
Get full text

Evaluation of Mast Cells in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma by Ashish Shrestha, Shashi Keshwar, Toniya Raut

“…Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) are epithelial-derived pathologies which share inflammation as a common initial pathogenic-inducing state. …”
Get full text

Examining the Role of Preserving Medical Records at Kamuganguzi HCIV. by Mugabirwe, Gift

“…Kamuganguzi HCIV in respect of the centralization and sharing of medical records, the preservation of patients’ records, access to patient records and archiving technology. …”
Get full text

ICT Usage and Implementation of Competence-Based Curriculum in Selected Secondary Schools in Kabale Municipality. by Mugabe, Samuel

“…The study recommended that schools need to have adequate and up-to-date ICT infrastructure, including hardware, software, and connectivity; Teachers need to be trained in how to effectively integrate ICT into their teaching practices; Encourage collaboration and sharing of best practices; ICT should be integrated into all subject areas, not just in computer studies or ICT classes; Schools should regularly evaluate the impact of ICT integration on student learning outcomes and Schools need to provide ongoing support to teachers and students to ensure that they are able to use technology effectively. …”
Get full text

Factors Influencing the Uptake and Sustainable Use of Soil and Water Conservation Measures in Bubaare Micro-Catchment, Kabale District, South Western Uganda by Willbroad, Byamukama, Ssemakula, E, Kalibwani, R

“…In this regard, several key recommendations were made which involved extending financial services to the farmers, communication and information access, training and experience sharing, strengthening research and development, education and awareness, providing technical and financial support.…”
Get full text

Experiences of HIV Positive Serostatus Disclosure to Sexual Partner Among Individuals in Discordant Couples in Mbarara City, Southwestern Uganda. by Atwijukiire, Humphrey, Nakidd, Gladys, Tweheyo, Otwine Anne, Kabami, Jane

“…Key emerging themes as experienced benefits of HIV serostatus disclosure included: 1) social support and care; 2) decisions regarding health, fertility, and childbearing; 3) sharing information on HIV prevention and protection measures; 4) positive living; and 5) ease of HIV serostatus disclosure. …”
Get full text

The Role of Community-Based Organisations in Compating HIV/AIDS in Kanungu District, Uganda. by Denis, Karugaba

“…First they have the intended beneficiaries, specifically the people living with HIV/AIDS who share their own experiences and pioneer preventive activities within the communities in which they live. …”
Get full text

Corneal Epithelial Thickness Mapping in Healthy Population Corneas Using MS-39 Anterior Segment Optical Coherence Tomography by AlTurki HS, Alsubhi SS, Alhazmi A, Alhadlag A, Albalawi NS, Alzoman MA, Aljasir M, Alsubaie M, Aljindan M, Alsomali A

“…Hissah Saleh AlTurki,1 Shahad Salah Alsubhi,1 Asma Alhazmi,1 Abdulrahman Alhadlag,2 Nada Saleh Albalawi,3 Musab Abdulaziz Alzoman,1 Mohammed Aljasir,1 Majed Alsubaie,1 Mohanna Aljindan,4 Abdulaziz Alsomali5 1Ophthalmology Department, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia; 2Surgery Department, College of Medicine, Shaqra University, Riyadh, Saudi Arabia; 3Ophthalmology Department, King Salman Armed Forces Hospital, Tabuk, Saudi Arabia; 4Ophthalmology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 5Ophthalmology Department, College of Medicine, King Faisal University, Alahsa, Saudi ArabiaCorrespondence: Shahad Salah Alsubhi, Ophthalmology Department, Dhahran Eye Specialist Hospital, 32413, Hassan Alaslami, Ash Shati Ash Sharqi District, Dhahran, Saudi Arabia, Email Shahadsalah@hotmail.comPurpose: The corneal epithelium is the outermost layer of the cornea. …”
Get full text