Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices by Asmaa M. Zahran, Helal F. Hetta, Zeinab Albadry M. Zahran, Alaa Rashad, Amal Rayan, Dalia O. Mohamed, Zeinab Ahmed Abd Elhameed, Salah M. Khallaf, Gaber El-Saber Batiha, Yasir Waheed, Khalid Muhammad, Hanaa Nafady-Hego

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The Protocol for the Multi-Ethnic, multi-centre raNdomised controlled trial of a low-energy Diet for improving functional status in heart failure with Preserved ejection fraction (... by Noelle Robertson, Melanie J Davies, Thomas Yates, Gerry P McCann, Gaurav Singh Gulsin, Emer M Brady, Joanne V Wormleighton, Eylem Levelt, Oliver Rider, Jiliu Pan, Christopher Miller, Iain Squire, Mehak Asad, Fardad Soltani, Michelle Hadjiconstantinou, Rachel L Brown, Joanna M Bilak

“…Randomisation is stratified by sex, ethnicity, and baseline Sodium Glucose Cotransporter-2 inhibitor (SGLT2-i) use, using the electronic database RedCap with allocation concealment. …”
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Clinical Characteristics of COVID-19 in Neonates and Infants Younger Than 3 Months by Fatemeh Varshoei, Mohammad Sadegh Rezai, Roya Farhadi, Azin Hajialibeig, Saeid Mohammadi, Masoud Moradi, Fatemeh Hosseinzadeh

“…Objectives: To better understand COVID-19 in young children, we evaluated the epidemiological, clinical, and outcomes of SARS-CoV-2 infection in neonates and 1-3 months old infants and compared the differences between the two groups. …”
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Cardiovascular Disease Multimorbidity and Decreased Health‐Related Quality of Life in Haiti: A Cross‐Sectional Study by Shalom Sabwa, Vanessa Rouzier, Rodney Sufra, Reichling St. Sauveur, Nour Mourra, Rehana Rasul, Joseph Inddy, Lily D. Yan, Madeline Sterling, Laura Pinheiro, Marie Deschamps, Jean William Pape, Margaret L. McNairy

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Usability Evaluation of Foods with Function Claims Labelling as Health Information in Japan: A User-Testing Study by Yamamoto M, Yamamoto K, Takano-Ohmuro H, Yamamoto R, Saruwatari J

“…It is important to explore ways to evaluate and improve labelling usability from the consumers’ perspective to ensure safe usage.Patients and Methods: We conducted user testing from the consumers’ perspective on labels of five different FFCs, utilizing semi-structured interviews with 50 participants of diverse ages and sexes. Two levels of passing criteria were established for accessibility to correct answers: ≥ 90% of all questions within 1 min and 2 min. …”
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Predicting risk factors for Epstein-Barr virus reactivation using Bayesian network analysis: a population-based study of high-risk areas for nasopharyngeal cancer by Zhiwen Zeng, Kena Lin, Xueqi Li, Xueqi Li, Tong Li, Xiaoman Li, Jiayi Li, Zule Ning, Qinxian Liu, Shanghang Xie, Sumei Cao, Sumei Cao, Jinlin Du

“…The results of multivariable logistic regression showed that only being older than 60 years (OR = 1.718, 95% CI = 1.273,2.322) and being a current smoker (OR = 1.477, 95% CI = 1.167 - 1.872) were the risk factors for EBV reactivation. …”
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Is Intra-articular Platelet-rich Plasma Injection Safe and Effective in Osteoarthritis Knee? A Prospective Study: A Case Series by R Sahaya Jose, N Kattu Bava, M Syed Moosa

“…In total, 30 patients of either sex, between 40 and 70 years of age, suffering from primary knee OA with Kellgren–Lawrence (KL) grades I, II, or III on standing anteroposterior and lateral knee radiographs, with symptoms for >3 months according to the American College of Rheumatology (ACR) clinical classification criteria and pain score of >4 cm on 10 cm visual analog scale (VAS) was included. …”
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What all physicians should know about women’s health: a Delphi study by Susanna Price, Eva Gerdts, Julien Mazières, Alexandra Kautzky-Willer, Fedde Scheele, Chiara Benedetto, Kerry Wilbur, Gertraud Stadler, Marieke Wermer, Jeanine Roeters van Lennep, Merel H de Heer-Koster, Vesna Bjegović-Mikanović, Indre Banaitytė-Baleišienė, Mary Perdiou, Alyson McGregor, Connie Newman, Simona Stankevičiūtė, Iris E Sommer, Florence Thibaut, Karine van 't Land

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Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Ob... by Satoru Kagami, Kimihiko Funahashi, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Heita Ozawa, Fumikazu Koyama, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka

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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

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What was Killing Babies in Ipswich Between 1872 and 1909? by Eilidh Garrett, Alice Reid

“…Our work makes use of the ICD10h coding system being developed to contribute to two projects: Digitising Scotland (University of Edinburgh) and SHiP — Studying the history of Health in Port Cities (Radboud University, Nijmegen). …”
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Prevalence and distribution of hypertension and related risk factors in Jilin Province, China 2015: a cross-sectional study by Bin Liu, Wei Sun, Junduo Wu, Tianyi Li, Xianjing Song, Yangyu Zhang, Yingyu Liu, Longbo Li, Yunpeng Yu, Yihang Liu, Chao Qi

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Prevalence of chronic kidney disease in Western Australia, 2010–2020 by Delia Hendrie, Crystal Man Ying Lee, Suzanne Robinson, Aron Chakera, James Boyd, Elizabeth Thomas, Sean Randall, Madison Frith, Kevin Chai, Kanika Mehta, Mohamed Estai

“…Objective To assess the prevalence and trends of chronic kidney disease (CKD) in Western Australia (WA) from 2010 to 2020 using linked pathology data.Design A retrospective observational cohort study using linked de-identified data from WA pathology providers, hospital morbidity records and mortality records.Setting A Western Australian population-based study.Participants All individuals aged 18 years and older with at least one serum creatinine test.Primary outcome measure CKD status as determined by estimated glomerular filtration rate and urine albumin-creatinine ratio.Results Analysing data from 2 501 188 individuals, there was a significant increase in age-sex standardised CKD prevalence from 4.7% in 2010 to 6.0% in 2020, with annual average percentage change of 3.0% (95% CI: 2.3% to 3.7%). …”
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Multilevel and Spatially Heterogeneous Factors Influencing Poor Households’ Income in a Frontier Minority Area in Northeast China by Binyan Wang, Mark W. Rosenberg, Shijun Wang, Peifeng Yang, Junfeng Tian

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Clinical Characteristics in Patients with Rheumatoid Arthritis: Differences between Genders by M. Intriago, G. Maldonado, J. Cárdenas, C. Ríos

“…Women had higher values of DAS-28 (3.4 vs 2.5), HAQ-DI (1.1 vs 0.4), ESR (33.0 vs 23.2), painful joints (8 vs 3), swollen joints (6 vs 2), and overall physician assessment (3 vs 2). …”
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Global burden of metabolic dysfunction-associated steatotic liver disease, 2010 to 2021 by Gong Feng, Giovanni Targher, Christopher D. Byrne, Yusuf Yilmaz, Vincent Wai-Sun Wong, Cosmas Rinaldi Adithya Lesmana, Leon A. Adams, Jerome Boursier, George Papatheodoridis, Mohamed El-Kassas, Nahum Méndez-Sánchez, Silvia Sookoian, Laurent Castera, Wah-Kheong Chan, Feng Ye, Sombat Treeprasertsuk, Helena Cortez-Pinto, Hon Ho Yu, Won Kim, Manuel Romero-Gómez, Atsushi Nakajima, Khin Maung Win, Seung Up Kim, Adriaan G. Holleboom, Giada Sebastiani, Ponsiano Ocama, John D. Ryan, Monica Lupșor-Platon, Hasmik Ghazinyan, Mamun Al-Mahtab, Saeed Hamid, Nilanka Perera, Khalid A. Alswat, Qiuwei Pan, Michelle T. Long, Vasily Isakov, Man Mi, Marco Arrese, Arun J. Sanyal, Shiv Kumar Sarin, Nathalie Carvalho Leite, Luca Valenti, Philip N. Newsome, Hannes Hagström, Salvatore Petta, Hannele Yki-Järvinen, Jörn M. Schattenberg, Marlen I. Castellanos Fernández, Isabelle A. Leclercq, Gulnara Aghayeva, Abdel-Naser Elzouki, Ali Tumi, Ala I. Sharara, Asma Labidi, Faisal M. Sanai, Khaled Matar, Maen Al-Mattooq, Maisam Waid Akroush, Mustapha Benazzouz, Nabil Debzi, Maryam Alkhatry, Salma Barakat, Said A. Al-Busafi, John Rwegasha, Wah Yang, Agyei Adwoa, Christopher Kenneth Opio, Mohammadjavad Sotoudeheian, Yu Jun Wong, Jacob George, Ming-Hua Zheng

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The Association of Weight Status with Physical Fitness among Chinese Children by Xianwen Shang, Ailing Liu, Yanping Li, Xiaoqi Hu, Lin Du, Jun Ma, Guifa Xu, Ying Li, Hongwei Guo, Guansheng Ma

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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Overall test sensitivity and specificity reported below [95% confidence interval (CI) shown in brackets] are not directly comparable across different MCED tests, owing to differences in the number of cancer types each test can detect: Galleri (three studies) Sensitivity: 20.8% (14.0% to 29.2%) to 66.3% (61.2% to 71.1%) Specificity: 98.4% (98.1% to 98.8%) to 99.5% (99.0% to 99.8%) CancerSEEK (two studies) Sensitivity: 27.1% (18.5% to 37.1%) to 62.3% (59.3% to 65.3%) Specificity: 98.9% (98.7% to 99.1%) to 99.1% (98.5% to 99.8%) SPOT-MAS (two studies) Sensitivity: 72.4% (66.3% to 78.0%) to 100% (54.1% to 100%) Specificity: 97.0% (95.1% to 98.4%) to 99.9% (99.6% to 100%) Trucheck (one study) Sensitivity: 90.0% (55.5% to 99.7%) Specificity: 96.4% (95.9% to 96.8%) CDA (one study) Sensitivity: 40.0% (12.2% to 73.8%) Specificity: 97.6% (96.8% to 98.2%) AminoIndex Cancer Screenings for individual cancers separately; sensitivity ranged from 16.7% (3.0% to 56.4%) for ovary/uterus cancer to 51.7% (34.4% to 68.6%) for gastric cancer. …”
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Access Differentials in Primary Healthcare among Vulnerable Populations in a Health Insurance Setting in Kumasi Metropolis, Ghana: A Cross-Sectional Study by Gertrude Acquah-Hagan, Daniel Boateng, Emmanuel Appiah-Brempong, Peter Twum, Joseph Amankwa Atta, Peter Agyei-Baffour

“…This study was a descriptive cross-sectional study conducted among multilevel participants of vulnerable groups in Kumasi Metropolis: 710 vulnerable people constituting elderly/aged (n = 359), pregnant women (n = 117), head poters (teenage girls who migrated from the northern Ghana mainly to the capital cities of the Ashanti and Greater Accra region to help in carrying of goods for their livelihood) (n = 86), sex workers (n = 75), and other vulnerable groups (people with disabilities and street participants) (n = 73). …”
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The Effects of MyChoices and LYNX Mobile Apps on HIV Testing and Pre-Exposure Prophylaxis Use by Young US Sexual Minority Men: Results From a National Randomized Controlled Trial by Katie B Biello, Kenneth H Mayer, Hyman Scott, Pablo K Valente, Jonathan Hill-Rorie, Susan Buchbinder, Lucinda Ackah-Toffey, Patrick S Sullivan, Lisa Hightow-Weidman, Albert Y Liu

“…MethodsBetween October 2019 and May 2022, we implemented a 3-arm, parallel randomized controlled trial in 9 US cities to test the efficacy of the LYNX and MyChoices apps against standard of care (SOC) among young sexual minority men (aged 15-29 years) reporting anal sex with cisgender male or transgender female in the last 12 months. …”
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