Prospective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor by Ben-Max de Ruiter, Jan E. Freund, C. Dilara Savci-Heijink, Jons W. van Hattum, Marinka J. Remmelink, Theo M. de Reijke, Joyce Baard, Guido M. Kamphuis, D. Martijn de Bruin, Jorg R. Oddens

“…CLE was able to correctly predict rT in two of the four cases (50%) identified on histopathology. The sensitivity, specificity, positive predictive value, and negative predictive value were 0.5 (95% confidence interval [CI] 0.07–0.93), 0.83 (95% CI 0.59–0.96), 0.4 (95% CI 0.05–0.85), and 0.88 (95% CI 0.64–0.99) for CLE prediction of rT, and 0.69 (95% CI 0.39–0.91), 0.33 (95% CI 0.07–0.7), 0.6 (95% CI 0.32–0.84), and 0.43 (95% CI 0.1–0.82) for prediction of DM, respectively. …”
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Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

“…The two-component CovRS system, comprising the sensor kinase CovS and transcription factor CovR, is a central regulator of GAS virulence genes. …”
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Psychosocial, physical, cognitive and quality of life aspects in primary restless legs syndrome by I. Jarašiūnaitė, R. Kaladytė-Lokominienė

“…Restless Legs Syndrome (RLS) is a chronic neurological disorder manifesting with unpleasant sensations in the legs and/or other parts of the body and uncontrollable urge to move in order to reduce sensory discomfort. …”
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Analysis of Fatigue Crack Propagation of an Orthotropic Bridge Deck Based on the Extended Finite Element Method by Ying Wang, Zhen Wang, Yuqian Zheng

“…As one of the most fatigue-sensitive parts of an orthotropic steel bridge deck, the weld between the U-rib and the top deck is prone to fatigue cracking under the actions of the stress concentration, welding residual stress, and vehicle load. …”
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Relationships between the Planetary Health Diet Index, its food groups, and polygenic risk of obesity in the CARTaGENE cohort by Guiomar Masip, Daiva E. Nielsen

“…We constructed a primary polygenic risk score (PRS-Khera) for body mass index (BMI) comprised of ~ 2 million SNPs and utilized a secondary 97 SNPs polygenic risk score (PRS-Locke) for sensitivity analyses. The PHDI was based on 16 food groups. …”
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Extended-spectrum beta-lactamase and carbapenemase-producing Gram-negative bacteria in urinary tract infections in Ethiopia: a systematic review and meta-analysis by Mitkie Tigabie, Getnet Ayalew, Lidetu Demoze, Kebebe Tadesse, Yalewayker Gashaw, Muluneh Assefa

“…To determine the possible sources of heterogeneity, a subgroup analysis was performed. Additionally, a sensitivity analysis was conducted to determine the influence of single studies on the pooled estimates. …”
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Identifying the barriers and facilitators to culturally responsive HIV and PrEP screening for racial, ethnic, sexual, and gender minoritized patients: A scoping review protocol. by Julia Xavier, Maranda C Ward, Patrick G Corr, Nikhil Kalita, Paige McDonald

“…The results of this scoping review will inform a practitioner-level intervention that will support culturally sensitive quality improvement of HIV-related prevention and care for patients from minoritized groups. …”
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Clinical Features, Risk Factors, and Therapy of Epithelial Keratitis after Cataract Surgery by Yani Wang, Dongfang Li, Wenjie Su, Yunhai Dai

“…In vivo confocal microscopy showed absence of subbasal never fibers in eyes with epithelial defects, and central corneal sensation was also significantly depressed in those eyes, but there was no significant difference between the two groups (P=0.227). …”
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Actualización de la cartografía eólica en el centro y sur de Neuquén by Samuel D. Troncoso Schenker, Lidia Ferreyra, Claudia Palese

“…Se utilizaron datos de sensores remotos para caracterizar el relieve y la rugosidad superficial. …”
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Advancing Horticultural Crop Loss Reduction Through Robotic and AI Technologies: Innovations, Applications, and Practical Implications by H. W. Gammanpila, M. A. Nethmini Sashika, S. V. G. N. Priyadarshani

“…Robotic systems have been devised to automate labor-intensive tasks involved in horticulture, such as harvesting, pruning, and weeding. Equipped with sensors, cameras, and intelligent algorithms, these robots are capable of identifying ripe fruits, detecting and removing weeds, and performing precise pruning operations. …”
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Longitudinal genetic studies of cognitive characteristics by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova

“…Transposons representing stress-sensitive DNA elements appeared to mediate the environmental influence on epigenetic modifications. …”
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A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…Altogether, these results suggest that the glucose pathway may be an essential target for therapeutic intervention to sensitize tumor cells to the cell death process by inhibition of glucose transporters. …”
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Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti... by Arndt Borkhardt, Nan Qin, Stephen T Keir, Darell D Bigner, Allison Cole, Matthias Wölfl, Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Lena Blümel, Mara Maue, Jasmin Bartl, Ulvi Ahmadov, Maike Langini, Frauke-Dorothee Meyer, Joselyn Cruz-Cruz, Claus M Graef, Till Milde, Olaf Witt, Anat Erdreich-Epstein, Gabriel Leprivier, Ulf Kahlert, Anja Stefanski, Kai Stühler, Julia Hauer, Thomas Beez, Christiane B Knobbe-Thomsen, Ute Fischer, Jörg Felsberg, Finn K Hansen, Rajeev Vibhakar, Sujatha Venkatraman, Samuel H Cheshier, Guido Reifenberger, Thomas Kurz, Marc Remke, Siddhartha Mitra

“…Here, we report a cross-entity, epigenetic drug screen to evaluate therapeutic vulnerabilities in MYC amplified MB, which sensitizes them to macrophage-mediated phagocytosis by targeting the CD47-signal regulatory protein α (SIRPα) innate checkpoint pathway.Methods We performed a primary screen including 78 epigenetic inhibitors and a secondary screen including 20 histone deacetylase inhibitors (HDACi) to compare response profiles in atypical teratoid/rhabdoid tumor (AT/RT, n=11), MB (n=14), and glioblastoma (n=14). …”
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Sistem Isyarat Bahasa Indonesia (SIBI) Metode Convolutional Neural Network Sequential secara Real Time by Oky Dwi Nurhayati, Dania Eridani, Muhammad Hafiz Tsalavin

“…Experimental results show that the CNN method on the hand signal image could provide an accuracy of 97.2%, precision of 91.96%, sensitivity of 91.9%, specificity of 91.96%, and F1 score of 91.9%, respectively. …”
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Carbono azul almacenado en los bosques de manglar del Pacífico Norte de Nicaragua by Oscar González-Quiroz, Manuel Vanegas, Eugenia Cerda, Melvin Lezama, Claudia Dolmus, Issamar Quiroz, María Paz, Carlos Solís, Eleazar Blanco, Marling Pérez

“…Se descargaron imágenes satelitales del sensor Sentinel 2B (15 m x 15 m) para calcular el índice de vegetación de diferencia normalizada. …”
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In Vivo Functional Assessment of Sodium-Glucose Cotransporters (SGLTs) Using [18F]Me4FDG PET in Rats by Yohji Matsusaka, Xinyu Chen, Paula Arias-Loza, Rudolf A. Werner, Naoko Nose, Takanori Sasaki, Steven P. Rowe, Martin G. Pomper, Constantin Lapa, Takahiro Higuchi

“…In the kidneys, radiotracer was also sensitive to SGLT inhibition. After IV injection, [18F]Me4FDG reabsorption in the renal cortex was significantly suppressed by phlorizin when compared to untreated animals (%ID/g at 60 min, 0.42±0.10 vs. untreated controls, 1.20±0.03; P<0.0001). …”
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Four-year clinical update and treatment switching-adjusted outcomes with first-line nivolumab plus ipilimumab with chemotherapy for metastatic non-small cell lung cancer in the Che... by Enriqueta Felip, David P. Carbone, Martin Reck, Luis Paz-Ares, Yong Yuan, Nan Hu, Niels Reinmuth, Xiaoqing Zhang, Thomas John, Ying Cheng, Shun Lu, Manuel Cobo, Michael Schenker, Tudor-Eliade Ciuleanu, Stéphanie Bordenave, Oscar Juan-Vidal, Juliana Menezes, Eduardo Richardet, Hideaki Mizutani, Bogdan Zurawski, Aurelia Alexandru, Javed Mahmood, Tuli De, Irene Santi, John R. Penrod, Adam Lee

“…We report updated efficacy and safety in all randomized patients with a minimum 4-year follow-up and an exploratory treatment-switching adjustment analysis in all treated patients who received chemotherapy and subsequent immunotherapy.Methods Adults with stage IV/recurrent non-small cell lung cancer (NSCLC), no sensitizing EGFR/ALK alterations, and ECOG performance status ≤1 were randomized 1:1 to nivolumab 360 mg every 3 weeks plus ipilimumab 1 mg/kg every 6 weeks with chemotherapy (two cycles) or chemotherapy (four cycles, with optional maintenance pemetrexed for the nonsquamous population). …”
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Jovens e os Stories do Instagram: estudo netnográfico durante a pandemia da Covid-19 by Alan César Belo Angeluci, Brasilina Passarelli, Carolina Gois Falandes, Milena Possar Garcia

“…In Dix, everyday posts, humour, and sensitive topics prevailed, with less image editing, anticipating the photo dump phenomenon. …”
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Relationship between chlorophyll-a, sea surface temperature, and sea surface salinity by M. Hidayat, R. Wafdan, M. Ramli, Z. Muchlisin, S. Rizal

“…This indicates that station positions are very sensitive to changes in chlorohophyll-a values. When the southwest monsoon occurred, it reached the maximum. …”
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Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B or C by Contrast-Enhanced Magnetic Resonance Imaging by René Hako, Pavol Kristian, Peter Jarčuška, Ivana Haková, Ivana Hockicková, Ivan Schréter, Martin Janičko

“…Spearman's rank correlation coefficient (r = 0,86, P < .001) confirmed high agreement of biopsy and MR Triple test. MR Triple test’s sensitivity was 96.30% (95%CI 81.03% to 99.91%), specificity 90.62% (95%CI 74.98% to 98.02%), positive predictive value 89.66% (95%CI 74.64% to 96.23%), and negative predictive value 96.67% (95%CI 80.86% to 99.50%) for discrimination between F3-4 and F1-2 fibrosis on liver biopsy. …”
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