Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…Furthermore, to clarify the mechanism of successful tumor growth inhibition for a long duration in vivo, we investigated whether short-term high radiation exposure enhances radiation sensitivity. Initially, a 4 h induction treatment with 5 and 10 kBq/mL of ²²⁵Ac-DOTA-RGD₂ enhanced both cytotoxicity and γH2AX expression with 0.5 kBq/mL of ²²⁵Ac-DOTA-RGD₂ compared to a treatment with only 0.5 kBq/mL of ²²⁵Ac-DOTA-RGD₂. …”
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Innovative Deep Learning Architecture for the Classification of Lung and Colon Cancer From Histopathology Images by Menatalla M. R. Said, Md. Sakib Bin Islam, Md. Shaheenur Islam Sumon, Semir Vranic, Rafif Mahmood Al Saady, Abdulrahman Alqahtani, Muhammad E. H. Chowdhury, Shona Pedersen

“…The proposed model demonstrated exceptional overall accuracy, precision, sensitivity, F1 score, and specificity, achieving 99.74%, 99.74%, 99.74%, 99.74%, and 99.94%, respectively. …”
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Mirvetuximab Soravtansine in solid tumors: A systematic review and meta-analysis. by Shamsnur Rehim, Shuang Yuan, Hongjing Wang

“…The pooled ORRs of the platinum-sensitive, platinum-resistant groups were 59% (95% CI 36%-81%, I2 = 61.88%), 33% (95% CI 25%-40%, I2 = 69.73%), respectively. …”
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Krebs von den Lungen-6 surveillance in immune checkpoint inhibitor-induced pneumonitis by Isamu Okamoto, Kazuya Tsubouchi, Ryosuke Matsukane, Shoji Nakamura, Haruna Minami, Yasuto Yoneshima, Kojiro Hata, Sai Yasukochi, Kimitaka Suetsugu, Takeshi Hirota

“…Receiver operating characteristic curve analysis showed an area under the curve (AUC) of 0.903 (sensitivity 81.1%, specificity 91.6%) with a cut-off value 1.52 times pre-KL-6 levels, indicating that KL-6 is a reliable biomarker for pneumonitis. …”
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Resilience Informatics in Public Health: Qualitative Analysis of Conference Proceedings by Maiya G Block Ngaybe, Lidia Azurdia Sierra, Andrew McNair, Myla Gonzalez, Mona Arora, Kacey Ernst, Enrique Noriega-Atala, M Sriram Iyengar

“…The workshop’s conclusions provide a road map for future public health resilience, highlighting the need for scalable, culturally sensitive, community-driven interventions. Future directions include focused discussions to yield concrete outputs such as implementation guidelines and tool designs, reshaping public health strategies in the face of emerging threats.…”
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E-HEART score: A novel scoring system for undifferentiated chest pain in the emergency department by V. Yuvaraj, Sachin Sujir Nayak, S. Vimal Krishnan

“…At a cutoff of E-HEART score >6, it accurately predicted ACS with a sensitivity of 92% and a specificity of 99% with a diagnostic accuracy of 97%. …”
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Comprehensive investigation of matrix metalloproteinases in skin cutaneous melanoma: diagnostic, prognostic, and therapeutic insights by Lingxia Wu, Chenxiaoxiao Liu, Weicai Hu

“…Our findings also revealed associations between MMP expression and immune modulation, drug sensitivity, and functional states of SKCM cells. Lastly, MMP7 knockdown in A375 cells significantly significant (p-value < 0.05) impacted several characteristics, including cell proliferation, colony formation, and wound healing. …”
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Relationship Between Serum HMGB1 and RAGE Levels and Restenosis in Type 2 Diabetes Mellitus Patients Complicated With Lower Extremity Vascular Disease: A Retrospective Study by Jia T, Zhang X, Li L, Jiang X, Wang M

“…Pre-surgery demographics and serum levels of HMGB1, RAGE, glycated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were analyzed. …”
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Omentin-1, a Protective Adipokine for Irritable Bowel Syndrome by Gao Y, Chen C, Huang X, Liu Y, Zhou Z, Pan Y

“…The somatic symptoms of IBS were determined by the 5-item IBS symptoms severity score (IBS-SSS), quality of life (QOL) by 34-item IBS-QOL questionnaire, and psychological disorders by Patient Health Questionnaire (PHQ-9), Hospital Anxiety and Depression Scale (HADS), Visceral Sensitivity Index (VSI). Therapeutic effect of omentin-1 for IBS was investigated in a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced IBS mouse model.Results: We found that serum levels of omentin-1 were significantly decreased in patients with the diarrhea-predominant IBS (IBS-D) subtype (not the constipation or alternating subtype) compared to those in healthy subjects. …”
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Estudio volumétrico de las canteras romanas de Rodadero de los Lobos – cortijo Piquín (sierra de Córdoba) mediante UAV LiDAR by Juan Carlos Moreno Escribano, Antonio Monterroso Checa, Massimo Gasparini, María Luisa Loza Azuaga, Esther Ontiveros Ortega, José Beltrán Fortes, Daniel Becerra Fernández

“…La prospección mediante el sensor LiDAR ha permitido la captura de datos de la superficie del terreno, hasta este momento inéditos, debido a lo escarpado del mismo y la frondosidad de la vegetación, que dificultan la prospección superficial. …”
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Perinatal interventions to prevent Adverse Childhood Experiences (ACEs): A scoping review. by Jane Kinsey, Jaime La Charite, Shirley Russ, Adam Schickedanz

“…<h4>Background</h4>Preventing Adverse Childhood Experiences (ACEs) is a public health priority, and the perinatal period is a sensitive life stage when preventive interventions could be particularly effective. …”
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Association between penicillin allergy labels and serious adverse events in hospitalized patients: a systematic review and meta-analysis by Shipeng Zhang, Shipeng Zhang, Tianyi Dong, Jiawen Xian, Jiawen Xian, Xinyue Xiao, Xinyue Xiao, Jiaqing Yuan, Jiaqing Yuan, Tong Zeng, Tong Zeng, Kuan Deng, Kuan Deng, Rui Fu, Hanyu Wang, Hanyu Wang, Yanjie Jiang, Xueying Li, Xueying Li

“…Data from the included studies, including relative risk (RR) and 95% confidence intervals (CI), were extracted and analyzed using Stata 16.0. Sensitivity analyses were conducted to validate the results. …”
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Genetic characteristics of influenza A and B viruses circulating in Russia in 2019–2023 by Svetlana B. Yatsyshina, Anna A. Artamonova, Maria A. Elkina, Anna V. Valdokhina, Victoria P. Bulanenko, Aleksandra A. Berseneva, Vasily G. Akimkin

“…The vast majority of currently circulating viruses remain sensitive to NA inhibitors.…”
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The predictive value of the serum creatinine-to-albumin ratio (sCAR) and lactate dehydrogenase-to-albumin ratio (LAR) in sepsis-related persistent severe acute kidney injury by Xiaoxiao Luo, Dongyang Liu, Cuicui Li, Jia Liao, Wuyang Lv, Yuchen Wang, Ruxue Diao, Yingyu Jin

“…The model's predictive ability for secondary outcomes, such as renal replacement therapy (RRT), also improved with the addition of the Log(sCAR)_Log(LAR) score. The sensitivity analysis further corroborated the stability of the Log(sCAR)_Log(LAR) score in predicting persistent severe SA-AKI and secondary outcomes, such as RRT. …”
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Association between spasticity and neuropathic pain in patients with multiple sclerosis by B. Afanasjeva, R. Balnytė

“…Patients usually experienced burning pain, in some cases sensation of painful freezing and electrical shock. …”
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Identification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development by Yanong Li, Yixuan He, Yawei Liu, Bingchen Wang, Bo Li, Xiaoguang Qiu

“…Performance metrics included area under the curve (AUC), accuracy, sensitivity, and specificity. ResultsOn the independent validation dataset, GVisageNet achieved an AUC of 0.938 (P<.01) in distinguishing midline brain tumors from NCs. …”
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AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can... by Hong Wang, Chunli Cui, Weiyi Li, Hui Wu, Jianjun Sha, Jiahua Pan, Wei Xue

“…Downregulating AGD1 enhanced the sensitivity of CRPC to docetaxel treatment by inhibiting their stemness, with the reverse also being true. …”
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Growth response of <i>Emiliania huxleyi</i> to ocean alkalinity enhancement by G. Faucher, M. Haunost, A. J. Paul, A. U. C. Tietz, U. Riebesell

“…In this context, we studied the sensitivity of <i>Emiliania huxleyi</i>, the most widespread coccolithophore species, to ocean alkalinity enhancement in a culture experiment. …”
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The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national by Xiaodi Tang, Kexin Zhang, Rong He

“…Multivariate Cox proportional hazards models, restricted cubic spline (RCS), Kaplan-Meier (KM) curves, subgroup analysis and sensitivity analysis were used to analyze the associations between TyG, TyG related indices and the risk of heart disease in national participants and in type 2 diabetes (T2D) or non-T2D patients respectively. …”
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Performance evaluation model of the narrators of Rahian Noor camps. by Abbas Alwardi, Mohammad Mahdi Mohtadi, Mohammadjavad Pahlevanzadeh, Amirhossein Saffarinia, Mohammad Reza Fathi

“…Also, for the research to be more practical, providing a performance evaluation model for other people related to Rahian Noor camps and using other performance evaluation methods for goal management, behavioral rating evaluation method, sensitive event recording method, and psychological evaluation method. …”
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