Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

“…Methods The study enrolled eligible adult patients with a clinical diagnosis of nr-axSpA who met the 2009 Assessment of SpondyloArthritis international Society (ASAS) classification criteria and had objective signs of active inflammation on magnetic resonance imaging (MRI) of sacroiliac joints and/or high-sensitivity C-reactive protein. Patients were randomized 1:1 to receive double-blinded treatment with upadacitinib 15 mg once daily (QD) or placebo for 52 weeks, after which all patients received open-label treatment with upadacitinib 15 mg QD. …”
Get full text

Phosphate-modified CpG oligonucleotides induce in vitro maturation of human myeloid dendritic cells by A. A. Ostanin, O. Y. Leplina, E. A. Burakova, T. V. Tyrinova, A. A. Fokina, A. S. Proskurina, S. S. Bogachev, D. A. Stetsenko, E. R. Chernykh

“…At the same time, IFN-DCs were characterized by greater sensitivity to the action of CpG-ODNs than IL4-DCs. …”
Get full text

Comparative analysis of inflammatory biomarkers for the diagnosis of neonatal sepsis: IL-6, IL-8, SAA, CRP, and PCT by Chen Ying, Yan Aixia, Zhang Li, Hu Xiaoming, Chen Liang, Cui Jun, Fan Zichuan, Li Ying

“…Receiver operating characteristic (ROC) curves were used to determine the sensitivity and specificity of IL-6, IL-8, and SAA alone and in combination with CRP and PCT. …”
Get full text

Confocal Microscopy for Detection of Intracellular Bacteria in Urine Samples of patients Suspected with Urinary Tract Infection: A Cross-sectional Observational Study by Bhagyashri Patil-Takbhate, Nilam Memane, Srikanth Tripathy, Nageswari Gandham, Shahzad Mirza

“…Mean age of women was 36.2±9.5 years and 74 (80.4%) had fever, 19 (20.7%) had burning sensation and 16 (17.4%) had frequent micturition. …”
Get full text

2′-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway by Wang Yinghao, Guan Qiaoli, Liu Guanfu, Wu Xiaoyun, Wang Xuanjun, Sheng Jun

“…Insulin receptor (InsR) sensitizers represent a new type of therapeutic agent for the treatment of diabetes, with 2′-O-methylperlatolic acid (2-O-M) being a potential InsR targeting drug. …”
Get full text

Associations between Age-Related Changes in the Core Vestibular Projection Pathway and Balance Ability: A Diffusion Tensor Imaging Study by Sang Seok Yeo, Jung Won Kwon, In Hee Cho

“…Spatiotemporal parameters during tandem gait and values of sway during one-leg standing using the wearable sensors were measured. All parameters between two groups were analyzed by the Mann-Whitney U test and independent t-test. …”
Get full text

Emergency medicine physician supervision and mortality among patients receiving care from non-physician clinicians in a task-sharing model of emergency care in rural Uganda: a retr... by Rebecca Leff, Brian Rice, Bradley Dreifuss, Heather Hammerstedt, Mark Bisanzo, Stacey Chamberlain, Ashley Pickering, Colleen Laurence, Prisca Mary Kizito, Steven Jonathan Kisingiri, Charles Ndyamwijuka, Serena Nakato, Lema Felix Adriko

“…After controlling for vital sign abnormalities, ‘Direct’ and ‘Indirect’ supervision were both significantly associated with reduced OR for mortality (‘Direct’: 0.57 (0.37 to 0.90), ‘Indirect’: 0.71 (0.55 to 0.92)) when compared with ‘Independent Care’. Sensitivity analysis showed that this mortality benefit was significant for the minority of patients (17.2%) with ≥3 abnormal vitals (‘Direct’: 0.44 (0.22 to 0.85), ‘Indirect’: 0.60 (0.41 to 0.88)), but not for the majority (82.8%) with two or fewer abnormal vitals (‘Direct’: 0.81 (0.44 to 1.49), ‘Indirect’: 0.82 (0.58 to 1.16)).Conclusions Emergency medicine physician supervision of emergency care non-physician clinicians is independently associated with reduced overall mortality. …”
Get full text

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans. by Ashwin Seetharaman, Himani Galagali, Elizabeth Linarte, Mona H X Liu, Jennifer D Cohen, Kashish Chetal, Ruslan Sadreyev, Alex J Tate, Taiowa A Montgomery, Gary Ruvkun

“…Caenorhabditis elegans mutants that disable RNAi are more sensitive to viral infection. Many mutants that enhance RNAi have also been identified; these mutations may reveal genes that are normally down-regulated in antiviral defense. …”
Get full text

Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis by Soojin Jang, Ho-Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Yun-Sik Dho, Kyu-Chang Wang, Byong Chul Yoo

“…However, cerebrospinal fluid (CSF) cytology has low sensitivity, and imaging approaches are ineffective. …”
Get full text

Integrated transcriptomic hypothalamic-pituitary-ovarian axis network analysis reveals the role of energy availability on egg production in layers by Jianling Peng, Yong Cui, Haiping Liang, Shenyijun Xu, Linjian Weng, Meng Ru, Ramlat Ali, Qing Wei, Jiming Ruan, Jianzhen Huang

“…The hypothalamic-pituitary-ovarian (HPO) axis is an energy-sensitive functional axis for follicle development, synthesis, and secretion of reproductive hormones, and plays a key role in modulating sustained ovulation in layers. …”
Get full text

Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…Abstract Background Hemorrhagic fever with renal syndrome (HFRS) is a climate-sensitive zoonotic disease that poses a significant public health burden worldwide. …”
Get full text

Application of Video Processing Technology Based on Diffusion Equation Model in Basketball Analysis by Yafeng Feng, Xianguo Liu

“…In the basketball segmentation research of the perspective shot, the commonly used object segmentation method based on the change area detection is very sensitive to noise and requires the object not to move too fast. …”
Get full text

Fecal propionate is a signature of insulin resistance in polycystic ovary syndrome by Sitong Dong, Sitong Dong, Xinrui Yao, Xinrui Yao, Jiao Jiao, Jiao Jiao, Bei Lin, Bei Lin, Bei Lin, Fujie Yan, Xiuxia Wang, Xiuxia Wang, Xiuxia Wang

“…The area under the curve (AUC) for propionate and the combined presence of P. copri and M. funiformis in predicting PCOS was 78.0%, with a sensitivity of 78.5% and a specificity of 72.4%. Pathways related to carbohydrate metabolism were significantly enriched in the microbiota of the PCOS-IR population but not in the control IR group.ConclusionsHigher fecal propionate levels correlate with PCOS-related insulin resistance. …”
Get full text

Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-... by Joan Khoo, Christoph E Hagemeyer, Darren C Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo

“…Hyperbaric oxygenation therapy, which was shown to improve insulin sensitivity, is impractical for regular use. We evaluated the effects of water which is stably-enriched with oxygen (ELO water) to increase arterial blood oxygen levels, on mitochondrial function in the presence of normal- or high-glucose environments, and as glucose-lowering therapy in humans.…”
Get full text

Explainable Predictive Model for Suicidal Ideation During COVID-19: Social Media Discourse Study by Salah Bouktif, Akib Mohi Ud Din Khanday, Ali Ouni

“…Despite easy expression via social media, suicidal thoughts remain sensitive and complex to comprehend and detect. Suicidal ideation captures the new suicidal statements used during the COVID-19 pandemic that represents a different context of expressions. …”
Get full text

The impact of precipitation, temperature, and soil moisture on wheat yield gap quantification: evidence from Morocco by Lahcen Ousayd, Terence Epule Epule, Salwa Belaqziz, Victor Ongoma, Abdelhakim Amazirh, Abdelghani Chehbouni

“…It analyzes the historical sensitivity of wheat yield to temperature, precipitation, and soil moisture, which are important factors affecting agricultural productivity. …”
Get full text

Significance of the Lesion–Pleura Relationship in Differentiating Peripheral Inflammatory Lesions and Lung Cancers by Tao Y, Zhang WT, Ding C, Fu BJ, Lv FJ, Chu ZG

“…Among the 296 lesions with a lesion-pleura distance ≤ 16 mm, the optimal cutoff value of distance was ≤ 8.9 mm (area under curve [AUC], 0.733; sensitivity: 0.770; specificity: 0.623; P < 0.001) for predicting PLCs. …”
Get full text

Assessing the acute effect of compression socks on improving arterial compliance in young volunteers by Kosuke Morinaga, Masako Nakahara, Kotaro Matsuura, Shigekazu Ishihara, Yasuhiro Idobata, Takafumi Kobata, Toshio Tsuji

“…Mean arterial blood pressures (MAPs) were measured at the upper arms and ankles on both sides. Sensor cuffs were attached over socks to estimate pressures exerted on arterial walls by the socks in the condition of wearing socks. …”
Get full text

Serum Soluble Interleukin-2 Receptor Does Not Differentiate Complex Regional Pain Syndrome from Other Pain Conditions in a Tertiary Referral Setting by K. D. Bharwani, M. Dirckx, D. L. Stronks, W. A. Dik, F. J. P. M. Huygen

“…Additionally, sIL-2R levels discriminated well between CRPS and healthy controls with a high sensitivity (90%) and specificity (89.5%), suggesting a possible role for sIL-2R in the diagnosis of CRPS. …”
Get full text

Cardiometabolic index as a predictor of gallstone incidence in U.S. adults: insights from NHANES 2017–2020 by Ji Li, Shou-jun Bai

“…Receiver Operating Characteristic (ROC) curves evaluated and compared the predictive performance of CMI, Body Mass Index (BMI), and Waist Circumference (WC), establishing optimal cutoff values along with their sensitivity and specificity. Results This study included 3,706 participants, of whom 10.6% (392) had GSD. …”
Get full text