Therapeutic Potential of Ginger Ethanolic Extract, Ginger-Loaded Chitosan ‎Nanoparticles, and Chitosan Nanoparticles in Induced Type 2 Diabetes Mellitus in Dogss in Induced Type 2... by Rasema M Hameed, Alaa K Mahmood

“…Compared to the diabetic Positive Control, oral GEE, GEE-CNPs, and CNPs ‎treatments significantly (P<0.05) improved ‎fasting glucose levels, insulin sensitivity, lipid profiles (reduced total cholesterol, ‎triglycerides, and LDL-C), liver function markers, and antioxidant status, indicating ‎enhanced metabolic health and reduced oxidative stress. …”
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Detection of atrial fibrillation in primary care with radial pulse palpation, electronic blood pressure measurement and handheld single-lead electrocardiography: a diagnostic accur... by Wim A M Lucassen, Henk C P M van Weert, Bjorn Winkens, Henri E J H Stoffers, J André Knottnerus, Steven B Uittenbogaart, Nicole Verbiest-van Gurp, Petra M G Erkens

“…Exclusion criteria were terminal illness, inability to give informed consent or visit the practice or having a pacemaker or an implantable cardioverter-defibrillator.Outcomes Diagnostic accuracy of individual tests and test combinations to detect unknown AF.Results We included 4339 patients; 0.8% showed new AF. Sensitivity and specificity were 62.8% (range 43.1%–69.7%) and 91.8% (91.7%–91.8%) for radial pulse palpation, 70.0% (49.0%–80.6%) and 96.5% (96.3%–96.7%) for electronic blood pressure measurement and 90.1% (60.8%–100%) and 97.9% (97.8%–97.9%) for handheld ECG, respectively. …”
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Prognostic Utility of Prechemoradiotherapy Albumin-to-Alkaline Phosphatase Ratio in Unresectable Locally Advanced Pancreatic Carcinoma Patients by Veysel Haksoyler, Erkan Topkan

“…The ideal common AAPR cutoff was identified at the rounded 0.46 (area under the curve: 72.3%; sensitivity: 71.2%; specificity: 70.3%) point that dichotomized the patients into two groups: low AAPR (L-AAPR; N=71) and high AAPR (H-AAPR; N=65) groups, respectively. …”
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Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/... by Zhongbao Zhou, Yulong Li, Yumeng Chai, Yong Zhang, Pu Yan

“…Furthermore, PTCD1 expression levels was closely associated with immune infiltrating, immunological checkpoint, EMT, immunotherapy responsiveness, and anti-tumor medication sensitivities. Upregulation of PTCD1 in ccRCC cells resulted in considerably increased cellular invasion and migration. …”
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Rasch Analysis of the Body Function Component of the ICF Rehabilitation Set in Functional Assessment of Orthopedic Patients by WANG Wenxuan, XU Guirong, HE Xinghui, LI Kun, WANG Yingmin

“…The patients performed the worst in the category b280 Pain Sensation and the best in the category b640 Sexual Function.ConclusionAfter deleting the category b130 Energy and Drive Function, the remaining 8 categories of Body Function component in the ICF-RS fit well with the Rasch model, and could be used as a functional assessment instrument for orthopedic patients.…”
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Predictors of cytomegalovirus infection in patients with connective tissue disease treated by pulsed methylprednisolone therapy: a multicenter retrospective cohort study by Haruka Ito, Takahiko Yoshimoto, Akatsuki Kokaze, Kuninobu Wakabayashi, Kazuteru Noguchi, Kiyoshi Matsui, Bunki Natsumoto, Keishi Fujio, Yutaro Hayashi, Yuko Kaneko, Takahisa Gono, Koh Okamoto, Shu Okugawa, Kyoji Moriya, Hirohiko Sueki

“…Receiver operating characteristic curve analysis was used to identify the cut-off values for the factors associated with CMV antigen sensitivity. Results Of the 200 patients included, 87 had antigen positivity. …”
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Qwen-2.5 Outperforms Other Large Language Models in the Chinese National Nursing Licensing Examination: Retrospective Cross-Sectional Comparative Study by Shiben Zhu, Wanqin Hu, Zhi Yang, Jiani Yan, Fang Zhang

“…XGBoost also achieved an area under the curve of 0.961, sensitivity of 0.905, specificity of 0.978, F1-score of 0.901, positive predictive value of 0.901, and negative predictive value of 0.977. …”
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Identification of biomarkers for the diagnosis of type 2 diabetes mellitus with metabolic associated fatty liver disease by bioinformatics analysis and experimental validation by Guiling Wu, Guiling Wu, Sihui Wu, Sihui Wu, Tian Xiong, Tian Xiong, Tian Xiong, You Yao, You Yao, Yu Qiu, Yu Qiu, Yu Qiu, Liheng Meng, Cuihong Chen, Xi Yang, Xi Yang, Xi Yang, Xinghuan Liang, Yingfen Qin

“…Immune dysregulation was observed in MAFLD, with TNFRSF1A and SERPINB2 strongly linked to immune regulation.ConclusionThe sensitivity and accuracy in diagnosing and predicting T2DM-associated MAFLD can be greatly improved using SERPINB2 and TNFRSF1A. …”
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Logistic Regression Model in a Machine Learning Application to Predict Elderly Kidney Transplant Recipients with Worse Renal Function One Year after Kidney Transplant: Elderly KTbo... by Ubiracé Fernando Elihimas Júnior, Jamila Pinho Couto, Wallace Pereira, Michel Pompeu Barros de Oliveira Sá, Eduardo Eriko Tenório de França, Filipe Carrilho Aguiar, Diogo Buarque Cordeiro Cabral, Saulo Barbosa Vasconcelos Alencar, Saulo José da Costa Feitosa, Thais Oliveira Claizoni dos Santos, Helen Conceição dos Santos Elihimas, Emilly Pereira Alves, Marcio José de Carvalho Lima, Frederico Castelo Branco Cavalcanti, Paulo Adriano Schwingel

“…The model presented goodness-fit in the evaluation of artificial intelligence metrics (precision: 90%; sensitivity: 71%; and F1 score: 0.79). Conclusion. Renal function in elderly KT recipients was lower than in younger KT recipients. …”
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Assessment of salicylic acid and potassium nitrate to mitigate frost stress in autumn-sown potato crop cv. Sutlej by Muhammad Wasim Haider, Syed Mohsin Abbas, Tanveer Hussain, Muhammad Tahir Akram, Umar Farooq, Mona S. Alwahibi, Mohamed S. Elshikh, Zaid Shakeel, Muhammad Nafees, Muhammad Rizwan, Rashid Iqbal

“…Based on the above findings, it can be concluded and recommended that 0.5 mM foliar spray of SA can be utilized on potato crop cv. Sutlej in frost-sensitive regions. However, the application rate of KNO3 needs to be optimized in order to use its maximal frost stress tolerance potential.…”
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Blood Lipid Levels and Their Value as Markers of Disease Activity in Severe Ulcerative Colitis by Zhu L, Tian L, Li S, Huo L

“…The combined detection of TC level and erythrocyte sedimentation rate (ESR) predicted a working characteristic receiver operating characteristic curve area of 0.768 (0.694– 0.841) in patients with severe UC, which had good early predictive value with a sensitivity of 77.0% and specificity of 66.7%.Conclusion: TC, HDL-C, LDL-C, and non-HDL-C levels were decreased in patients with severe UC. …”
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Progress in Treatment of Temporomandibular Joint Disorder by Wei YANG, Minghua XIE, Yu CAI, Zhuoming CHEN

“…In stomatology department, including occlusal plywood training, denture repair, orthodontic, adjustment, crown and bridge repair, occlusal reconstruction and other means are used to relieve the pain; traditional Chinese medicine carries on the syndrome differentiation treatment of internal administration and external application, combined with acupuncture, floating needle, fire needle, warm acupuncture, thunder fire moxibustion, heat sensitive moxibustion, filiform needle, acupoint injection, medicine separated moxibustion, etc., the curative effect is remarkable; He-Ne laser therapy could activate the intracranial morphine peptide system, inhibit the release of pain causing substances; when the conservative treatment is ineffective, minimally invasive surgery under the arthroscope can be selected to release adhesion and improve spasm. …”
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Flowering Characteristics and Expression Patterns of Key Genes in Response to Photoperiod in Different <i>Chrysanthemum</i> Varieties by Qiuling Zhang, Xueru Li, Shuyu Cai, Junzhuo Li, Jiaying Wang, Yanfei Li, Silan Dai

“…Seven <i>chrysanthemum</i> varieties, ‘A44’, ‘C60’, ‘183’, ‘A20’, ‘C1’, ‘C27’, and ‘C31’, reached a floral competent state in the L20, L20, L22, L22, L18, L20, and L24 periods, respectively, and were most sensitive to SD induction at this time. The expression patterns of key floral genes in the photoperiod pathway were analyzed and it was found that <i>CmCRY1</i>, <i>CmCRY2</i>, <i>CmGI1</i>, <i>CmGI2</i>, and <i>CmCO</i> were mainly expressed in leaves. …”
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Role of Chest X-Ray in Coronavirus Disease and Correlation of Radiological Features with Clinical Outcomes in Indian Patients by Satyanand Sathi, Richa Tiwari, Savita Verma, Anil Kumar Garg, Virendra Singh Saini, Manoj Kumar Singh, Amit Mittal, Devinder Vohra

“…Baseline chest X-ray showed a sensitivity of 63.3% in diagnosing typical findings of SARS-CoV-2 pneumonia. …”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…Loss of function in the subunits of the GTPase-activating protein (GAP) activity toward Rags-1 (GATOR1) complex, an amino-acid sensitive negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), is implicated in both genetic familial epilepsies and Neurodevelopmental Disorders (NDDs) (Baldassari et al., 2018). …”
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Comprehensive genomic surveillance reveals transmission profiles of extensively drug-resistant tuberculosis cases in Pará, Brazil by Davi Josué Marcon, Davi Josué Marcon, Abhinav Sharma, Alex Brito Souza, Alex Brito Souza, Rafaella Bonfim Barros, Valnete das Graças Dantas Andrade, Ricardo José de Paula Souza Guimarães, Luana Nepomuceno Gondim Lima, Luana Nepomuceno Gondim Lima, Lúcia Helena Martins Tavares Monteiro, Ana Judith Pires Garcia Quaresma, Ana Judith Pires Garcia Quaresma, Layana Rufino Ribeiro, Layana Rufino Ribeiro, Philip Noel Suffys, Robin Mark Warren, Carlos Augusto Abreu Alberio, Karla Valéria Batista Lima, Karla Valéria Batista Lima, Emilyn Costa Conceição

“…The genotypic drug susceptibility profile of TB stains (39/40) was as follows: sensitive (1/2, 5%), rifampicin mono-resistant (RR) (4/10%), isoniazid mono-resistant (1/2%), multidrug-resistant (MDR) (21/52%), extensively drug-resistant (XDR) (3/7%), pre-XDR (8/20%), and other (1/2%). …”
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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…Additionally, we conducted various sensitivity analyses and statistical tests to further illustrate the robustness of the observed associations. …”
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Real-World Clinical Outcomes and Treatment Patterns Among Black and Non-Black Patients With Prostate Cancer Initiated on Apalutamide in a Urology Setting by Benjamin H. Lowentritt, Carmine Rossi, Erik Muser, Frederic Kinkead, Bronwyn Moore, Patrick Lefebvre, Dominic Pilon, Shawn Du

“…**Background:** The use of androgen receptor signaling inhibitors, including apalutamide, in combination with androgen deprivation therapy is recommended for the treatment of metastatic castration-sensitive prostate cancer (mCSPC) and non-metastatic castration-resistant prostate cancer (nmCRPC). …”
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A Study of the Interaction Between Implanted Pacemakers and the Power-Frequency Field Produced by Traction Transformer in High-Speed EMU by Rui Tian, Yu-Long Zhang, Mai Lu, Jian-Fang Deng

“…The <inline-formula> <tex-math notation="LaTeX">$U_{in~max}$ </tex-math></inline-formula> at the unipolar and bipolar electrodes of passengers are 0.409 mV and 0.005 mV, which are smaller than the perception sensitivity. The above results illustrated that the electromagnetic fields generated by the traction transformer are within the recognized accepted limits for passengers with pacemaker, and we recommended that individuals with heart diseases should try to choose a pacemaker with better anti-interference ability in bipolar pacing mode and keep a distance from windows as possible when riding on high-speed trains.…”
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The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status by Jooa Kwon, Melanie R. Neeland, Justine A. Ellis, Jane Munro, Richard Saffery, Boris Novakovic, Toby Mansell

“…We also assessed the extent to which these signatures are due to underlying inflammation as assessed by glycoprotein acetyls (GlycA) and high-sensitivity C-Reactive Protein (hsCRP) levels. Methods Targeted nuclear magnetic resonance (NMR) metabolomic profiles of plasma of 72 children with JIA and 18 controls were assessed cross-sectionally. …”
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