Identification of biomarkers for tumor regression grade in esophageal squamous cell carcinoma patients after neoadjuvant chemoradiotherapy by Zhifu Chen, Yan Wang, Jun Chen, Zijun Xu, Tingjuan Zhang, Lu Sun, Lihua Zhu, Liben Xu, Chaoyang Wu, Zhiyuan Qiu, Dianjun Wang, Ting Wu

“…Neoadjuvant chemoradiotherapy not only increases the rate of complete resection but also improves the median survival. However, a sensitive biomarker is urgently needed in clinical practice.Methods60 esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant chemoradiotherapy (NCRT) were enrolled at the People's Hospital Affiliated to Jiangsu University. …”
Get full text

Tumor mutation burden for predicting immune checkpoint blockade response: the more, the better by Ming Zheng

“…In contrast, low TMB (category II) cancer types, for which the prognostic associations were sensitive to TMB cut-off selection, showed markedly limited and distinct ranges of significantly favorable TMB cut-offs. …”
Get full text

Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy by Xin Huang, Yan Tong, Chen-Xing Qi, Han-Dong Dan, Qin-Qin Deng, Yin Shen

“…A ROC curve showed that these specific intranetwork FCs of RSNs discriminated between the two groups with a high degree of sensitivity and specificity. Our study highlighted that DR patients had widespread deficits in both low-level perceptual and higher-order cognitive networks. …”
Get full text

Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU by Chunxia Wang, Yun Cui, Huijie Miao, Xi Xiong, Jiaying Dou, Lujing Shao, Xiaomeng Tang, Yucai Zhang

“…Remarkably, the area under ROC curve (AUC) for serum ApoA5 levels on PICU admission was 0.789 for prediction of PICU mortality with a sensitivity of 75% and a specificity of 84.5% at a threshold value of 822 ng/mL. …”
Get full text

The prevalence of attention-deficit hyperactivity disorder and its associated factors among children in Ethiopia, 2024: a systematic review and meta-analysis by Molla Azmeraw, Dessie Temesgen, Amare Kassaw, Alemu Birara Zemariam, Gashaw Kerebeh, Gebremeskel Kibret Abebe, Addis Wondmagegn Alamaw, Biruk Beletew Abate

“…A Galbraith plot was employed to illustrate outliers. Sensitivity analysis was also applied.ResultThis study included a total of six articles with 4,338 participants. …”
Get full text

Application of the <italic>International Classification of Functioning，Disability and Health Rehabilitation Set</italic> in Rehabilitation of Patients with Knee Osteoarthritis in t... by YAO Dong, HE Yiqi, ZHANG Qin, LIU Changhua, LI Taibiao, YAO Caiming, WANG Xiangfeng, WANG Qinfeng, HU Hongjun

“…ICF-RS was used to evaluate the overall functional level, rehabilitation efficacy and rehabilitation treatment costs of the patients.ResultsThe main physical functional disorders of KOA patients were b280 pain sensation, b455 exercise tolerance, b130 energy and drive function, and b134 sleep function in sequence; the main activity functional disorders were d410 changing basic body postures, d455 moving around, and d415 maintaining a body posture; the main participation functional disorders were d850 paid employment and d920 recreation and leisure. …”
Get full text

Cord Direct Antiglobulin Test for Predicting the Need for Phototherapy in Neonates with ABO Incompatibility: A Prospective Cohort Study by Ranjith Balan, Sakthipriya Balaji, Arun Kumar, Subash Sundar, Shrinidhi Krishnan, Ashok Chandrasekaran

“…The adjusted odds ratio of positive DAT for both methods in predicting the requirement for phototherapy was 3.21 (95% CI 2.1-5.8). The sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of the tube method were 37.5%, 85.16%, 2.53, and 0.73, respectively, while for the gel method they were 37.08%, 86.57%, 2.76, and 0.73, respectively. …”
Get full text

Design and psychometric testing of a moral intelligence instrument for pre-hospital emergency medical services personnel: a sequential-exploratory mixed-method study by Fateme Mohammadi, Rasoul Salimi, Salman Khazaei, Mostafa Bijani

“…This is because moral intelligence is the ability to recognize and be sensitive to moral issues, which contributes to the organization of appropriate behavior in the face of moral issues. …”
Get full text

A High Resolution Melting Analysis (HRM) PCR assay for the detection and identification of Old World Leishmania species. by Yusr Saadi-Ben Aoun, Hejer Souguir, Hamed Chouaieb, Mongia Kraiem, Insaf Bel Hadj Ali, Ahmed S Chakroun, Florian Noguier, Akila Fathallah-Mili, David Piquemal, Ikram Guizani

“…In comparison to DE, the sensitivity and specificity of the HRM PCR assay on human cutaneous samples were 88% and 84.62%, respectively, while the ITS1-PCR assay evaluation parameters were 84% and 92.31%. …”
Get full text

Changes in hematoma volume following aneurysmal subarachnoid hemorrhage and its impact on patient prognosis by Zhenshan Huang, Feng Qian, Kui Ma, Guowei Jiang, Lianfu Zhang, Yongming Zhang, Yongming Zhang

“…An HVpre volume over 22.25 mL and HVpost over 15.67 mL indicated a higher risk of poor prognosis, with sensitivities of 79.3 and 80.7%, and specificities of 67.1 and 69.3%.ConclusionHVpre, HVpost, and (HVpre−HVpost)/HVpre can serve as neuroimaging biomarkers for assessing patients after aSAH and can effectively predict clinical prognosis.…”
Get full text

A novel mitochondrial-related risk model for predicting prognosis and immune checkpoint blockade therapy response in uterine corpus endometrial carcinoma by Ru-Gen Liao, Jin-Hong Wang, Fan Zhang, Yu-Tong Fang, Li Zhou, Yong-Qu Zhang

“…Additionally, further analyses including functional enrichment, immune landscape assessment, prediction of response to ICB therapy, mutation profiling, and drug sensitivity analysis elucidated biological distinctions between the identified risk groups. …”
Get full text

A retrospective record-based study to evaluate the profile of TB patients diagnosed and registered at DOTS center at the tertiary care center and to study the gaps in the implement... by Ruchi Arora Sachdeva, Sahil Singh, MK Sen

“…Conclusion: This study thrusts on intensification of strategies like to improve lab infrastructure, to provide CBNAAT and LPA facilities at all medical colleges and district level, and IEC training to doctors (Interns, Medical officers, specialists), TB health workers and laboratory staff with the latest guidelines, importance of updating Nikshay portal and sensitization of treating physicians and lab personnel to send relevant samples for CBNAAT and LPA testing so as to detect drug-resistant cases on time in order to achieve elimination of disease.…”
Get full text

Factors influencing the unexpected measles outbreak of 2023 in Colombo, Sri Lanka by Kasunee Kalubowila, Chandana Gajanayake

“…To prevent future outbreaks and enhance immunization coverage, targeted catch-up immunization campaigns focusing on high-risk groups, alongside culturally sensitive educational initiatives are urgently required. …”
Get full text

Translation and Validation of the Sinhalese Version of the Brief Medication Questionnaire in Patients with Diabetes Mellitus by P. Ranasinghe, R. Jayawardena, P. Katulanda, G. R. Constantine, V. Ramanayake, P. Galappatthy

“…The overall BMQ score with a cutoff value of 2 presented better equilibrium between sensitivity and specificity for the gold standard. Those with low adherence had a significantly higher percentage of poor glycaemic control (HbA1c ≥ 8.5%). …”
Get full text

The influence of the choice of foreign policy strategies of the Republic of Serbia and Montenegro on the development of their bilateral military relations by Spasojević Čedo D.

“…This particularly refers to the development of bilateral relations in sensitive foreign policy segments of small states, such as defence and security. …”
Get full text

Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China by Keyi Wu, Weidong Fan, Jing Wei, Jianyun Lu, Xiaowei Ma, Zelin Yuan, Zhiwei Huang, Qi Zhong, Yining Huang, Fei Zou, Xianbo Wu

“…Subgroup analyses indicated that individuals aged 5–14 and 15–24 years may exhibit higher sensitivity to BC and Cl− exposure than other individuals. …”
Get full text

A conceptual model for advanced/metastatic gastric or gastroesophageal junction cancer: a review of qualitative studies and results from patient interviews by France Ginchereau Sowell, Thom de Milliano, Keri J. S. Brady, Ginamarie Foglia, Medha Sasane, Samira Bensfia, Matthew Reaney

“…The 12 most important symptoms (mentioned by ≥ 50% of patients; average disturbance ratings: ≥5, scale: 0 'not disturbing' to 10 'extremely disturbing') were: nausea, fatigue, temperature sensitivity, indigestion, weakness, diarrhea, vomiting, early satiety, swallowing difficulties, taste alterations, abdominal pain, general pain. …”
Get full text

Clinical validation of an artificial intelligence-based decision support system for diagnosis and risk stratification of heart failure (STRATIFYHF): a protocol for a prospective, m... by Prithwish Banerjee, Guy A MacGowan, Frans H Rutten, Iacopo Olivotto, Petar M Seferović, Jonathan Mant, Djordje G Jakovljevic, Oscar Fernandez, Josep Darbà, Nduka C Okwose, Jose Zamorano, Duncan Edwards, David Sinclair, Lazar Velicki, Amy Groenewegen, Lars S Maier, Dimitris Fotiadis, Sarah Jane Charman, Annamaria Del Franco, Maria Tafelmeier, Andrej Preveden, Cristina Garcia Sebastian, Amy S Fuller, Anne Pauline Nelissen, Petros Malitas, Aikaterini Zisaki, Zoran Bosnic, Petar Vracar, Fausto Barlocco, Marta Jiménez-Blanco Bravo, Nenad Filipovic, Bano Fatima, Williams Kate, Fornaro Alessandra, Milovancev Aleksandra, Ascanio Meritxell, Aguera Ainoa, Pičulin Matej, Flis Borut, Boucharas Dimitrios, Manousos Dimitris, Tsiknakis Manolis, Kassiotis Thomas, Sustersic Tijana, Milicevic Bogdan, Hobbs FD Richard, Kaagman Onno

“…The primary aim of the present study is to collect prospective clinical data to validate the STRATIFYHF DSS (in terms of diagnostic accuracy, sensitivity and specificity) as a tool to predict the risk, diagnosis and progression of HF. …”
Get full text

Characteristics of base materials and acrylates used in removable prosthetics in dental practice (review) by Yu.I. Poliukhovych, A.Ye. Demkovych, Yu.I. Bondarenko, V.V. Shcherba, O.I. Lebid, K.M. Duda

“…The main unsatisfactory quality of acrylic prostheses is their negative impact on the tissues of the prosthetic bed, which is reflected in the sensitivity of the mucous membrane and the phenomena of inflammation. …”
Get full text

Efficacy of brain stimulation therapies across psychiatric, movement, and cognitive disorders: an umbrella review synthesizing meta-analyses of randomized controlled trialsResearch... by Zhenyue Zu, Fenglan Chen, Linxi Yang, Wenzhuo Wei, Mi Zhang, Limin Huang, Ni Li, Zihan Lv, He Du, Xinrong Xue, Lijun Ma, Huixue Wang, Kai Wang, Xiaoming Li

“…We calculated pooled effect estimates for core symptoms based on the largest meta-analyses, then conducted sensitivity and subgroup analyses, and assessed heterogeneity, publication bias, and small-study effects. …”
Get full text