Unveiling causal immune cell–gene associations in multiple myeloma: insights from systematic reviews and Mendelian randomization analyses by Hui Zhang, Hui Zhang, Ling Zhang, Jing-Xuan Lian, Zhi-Fu Kou, Yu Zhu, Yu Zhu, Li-Tian Ma, Li-Tian Ma, Jin Zheng, Jin Zheng, Can-Jun Zhao, Can-Jun Zhao

“…Post-adjustment for multiple testing, the levels of seven types of immune cells (two types of Treg, two types of TNBK, two types of B cells, and one type of Myeloid cell) were found to be elevated in association with an increased risk of multiple myeloma (MM), while the levels of another eight types of immune cells (one types of Treg, three types of TNBK, one type of MT cells, and two types of Myeloid cell and one type of cDC cells) were demonstrated to be associated with a decreased risk of MM. As supported by sensitivity analysis. SMR analysis pinpointed the risk genes VDR, VHL, POMC, and FANCD2, with VHL and POMC correlating at the methylation level. …”
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Impacts of genomic alterations on the efficacy of HER2-targeted antibody–drug conjugates in patients with metastatic breast cancer by Riqing Huang, Anqi Hu, Qixiang Rong, Ditian Shu, Meiting Chen, Wei Yang, Yue Zhang, Qiufan Zheng, Xin An, Cong Xue, Haifeng Li, Yanxia Shi

“…Hence, this study aims to identify factors predicting sensitivity to HER2 ADC in metastatic breast cancer. …”
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Gully mitigation and rehabilitation measures have varying effects on soil macrofauna abundance and diversity in semi-arid lands by Harrison Churu, Solomon Kamau, Wilson Ng’etich, Keziah Magiroi, Bonface Alkamoi, James Mutio, Syphyline Kebeney, Fred Wamalwa

“…In summary, our study shows that gully mitigation and rehabilitation measures positively affects the most sensitive soil macrofauna groups (earthworms and beetles), which are often used as bioindicators of soil health. …”
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Esophageal lesions at irritable bowel syndrome by M. G. Mnatsakanyan, O. V. Tashchyan, Yu. A. Morozova, A. P. Pogromov, G. M. Dyukova, D. V. Khalyapina

“…Psychometric components were estimated as well: anxiety and depression scores, scores of alexithymia, associated symptoms, quality of life, degree of hyperventilation, index of visceral sensitivity, degree of pain by visual analog scale. …”
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Diagnostic value of dual-layer spectral detector CT parameters for differentiating high- from low-grade bladder cancer by Li Chen, Lili Xu, Xiaoxiao Zhang, Jiahui Zhang, Xin Bai, Qianyu Peng, Erjia Guo, Xiaomei Lu, Shenghui Yu, Zhengyu Jin, Gumuyang Zhang, Yi Xie, Huadan Xue, Hao Sun

“…With AEF higher in high-grade BCa, AEF results were as follows: area under the curve (AUC), 0.924 (95% confidence interval, 0.861–0.988); sensitivity, 95.5%; specificity, 81.0%; and accuracy, 85.9%. …”
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Management of Persistent Epistaxis Using Floseal Hemostatic Matrix vs. traditional nasal packing: a prospective randomized control trial by Scott Murray, Adrian Mendez, Alexander Hopkins, Hamdy El-Hakim, Caroline C. Jeffery, David W. J. Côté

“…Further, trial data was used for a formal cost-effectiveness analysis to determine incremental cost-effectiveness ratio (ICER). Univariate sensitivity analysis and uncertainty analysis were performed. …”
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Predictive value of circulating fibroblast growth factor-23 and Klotho on protein-energy wasting in patients undergoing hemodialysis by Xiaoling Zhou, Yang Luo, Yidan Guo, Meng Jia, Chunxia Zhang, Zhihua Shi, Ye Du

“…When the combination of FGF-23 and Klotho was used to predict PEW, its sensitivity was 81.8%, specificity was 60.5%, and the AUC was 0.746.ConclusionPlasma levels of FGF-23 and Klotho are associated with PEW in hemodialysis patients. …”
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Optimal power flow using recent red-tailed hawk optimization algorithm by Ahmed M Nassef, Mohammad Ali Abdelkareem, Mohamed Louzazni

“…Metaheuristic optimization approaches perform better than classical techniques that rely on sensitivity analysis and gradient-based methods. This is because metaheuristic techniques may avoid becoming stuck in local optima, a limitation of classical techniques. …”
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qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements by Faidra Karkala, Roy B. Simons, Floor Claessens, Vivian Kalamara, Manfred Kayser, Athina Vidaki

“…We optimized qBiCo using synthetic DNA standards and assessed it using standard developmental validation criteria, showcasing that qBiCo is reliable, robust and sensitive down to picogram level. We also evaluated its performance by testing decreasing DNA amounts using several commercial bisulfite conversion kits. …”
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The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum by Alexander A. Morano, Wei Xu, Francesca M. Navarro, Neeta Shadija, Jeffrey D. Dvorin, Hangjun Ke

“…ABSTRACT Dynamins, or dynamin-related proteins (DRPs), are large mechano-sensitive GTPases that mediate membrane dynamics or organellar fission/fusion events. …”
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The e-STROKE Study: The Design of a Prospective Observational Multicentral Study by Kateřina Dvorníková, Veronika Kunešová, Svatopluk Ostrý, Robert Mikulík, Michal Bar

“…Additionally, this study seeks to assess the specificity and sensitivity of multimodal CT in distinguishing stroke mimics from actual strokes. …”
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Injection Rate-Dependent Deflecting Propagation Rule of Hydraulic Fracture: Insights from the Rate-Dependent Fracture Process Zone of Mixed-Mode (I-II) Fracturing by Yuekun Xing, Bingxiang Huang

“…The ordinal response of Fiber Bragg grating sensors embedded along the fracture propagation path, and the continuous fluctuant injecting pressures validate the step-by-step propagation of the hydraulic fracture. …”
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Reticulocyte hemoglobin content: a new frontier in iron deficiency diagnostics for major surgical patients by Suma Choorapoikayil, Mischa J. Kotlyar, Lisa Kawohl, Paul P. Pratz, Denana Mehic, Peter Kranke, Florian Rumpf, Lea V. Blum, Jan A. Kloka, Kai Zacharowski, Vanessa Neef, Patrick Meybohm

“…The ROC curve analysis revealed an AUC of 0.842 (95% CI (0.82–0.87)) at Ret-He cutoff 33.5 pg, by which IDA was discriminated with 69.7% (95% CI (65.3–74.0%)) sensitivity and 85.7% (95% CI (82.3-86.1%)) specificity. …”
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The value of MRI in differentiating ovarian clear cell carcinoma from other adnexal masses with O-RADS MRI scores of 4–5 by Lingling Lin, Le Fu, Huawei Wu, Saiming Cheng, Guangquan Chen, Lei Chen, Jun Zhu, Yu Wang, Jiejun Cheng

“…Critical relevance statement CCC has a high incidence rate in Asians and has limited sensitivity to platinum chemotherapy. This comprehensive model improves CCC prediction ability and clinical applicability for facilitating individualised clinical decision-making. …”
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Integrated Analysis of Cell-Free DNA and Novel Protein Biomarkers for Stratification and Therapy Monitoring in Stage IV Pancreatic Cancer: A Preliminary Study by Saskia Hussung, Maria E. Hess, Elham Bavafaye Haghighi, Uwe A. Wittel, Melanie Boerries, Ralph M. Fritsch

“…<b>Methods:</b> We prospectively collected 160 plasma samples from 47 patients with mPDAC at our institution. Highly sensitive single-target ddPCR assays were employed to detect and quantify <i>KRAS</i>^mut cfDNA. …”
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Impedance mapping with high-density microelectrode array chips reveals dynamic heterogeneity of in vitro epithelial barriers by Alessandra Venz, Bastien Duckert, Liesbet Lagae, Saeedeh Ebrahimi Takalloo, Dries Braeken

“…Epithelial barrier function assays benefit from using HD-MEA impedance sensors due to their increased informativity and resolution, which will be of great value in future organ-on-chip platforms.…”
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Atherosclerotic Risk Factors in Children with Celiac Disease by Anna Rybak, Aldona Wierzbicka, Piotr Socha, Anna Stolarczyk, Bożena Cukrowska, Łukasz Obrycki, Zbigniew Wawer, Roman Janas, Beata Oralewska, Anna Szaflarska-Popławska, Barbara Iwańczak, Elżbieta Cyrta-Jarocka, Urszula Grzybowska-Chlebowczyk, Wojciech Cichy, Grażyna Czaja-Bulsa, Jerzy Socha

“…We obtained selected clinical data, and we assessed lipid profile, apolipoproteins (A1, B, and E), lipoprotein (a), homocysteine, as well as antioxidants (folic and uric acid), and high-sensitivity CRP (hsCRP) for all patients. The compliance to GFD was verified using anti-transglutaminase antibodies and deamidated gliadin peptide antibodies. …”
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Comparison of positive BioFire FilmArray meningitis/encephalitis (ME) panels, CSF cultures, CSF parameters, clinical presentation and in-patient mortality among patients with bacte... by Thein Myint, Jaime Soria, Yuanzheng Gao, Marice Ruiz Conejo Castillo, Vaneet Arora, Julie A. Ribes

“…This panel has shown variable performance with some institutions showing high sensitivity and specificity for many pathogens but others seeing false positives during clinical use. …”
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USING ARTIFICIAL INTELLIGENCE (AI) AND DEEP LEARNING TECHNIQUES IN FINANCIAL RISK MANAGEMENT by Joseph Olorunfemi AKANDE

“…Moreover, federated learning systems present a promising solution for ensuring privacy and security when dealing with sensitive financial data. This approach allows for collaborative learning without compromising the confidentiality of data, an essential factor in financial risk management. …”
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Seroprevalence of anti-ToxoplasmaIgG among the human population in Indonesia: a systematic review and meta-analysis by Taufik Mulya Perdana, Alfin Harjuno Dwiputro, Stefanie Kusuma, Artha Maressa Theodora Simanjuntak, Frengki Prabowo Saputro Wijayanto

“…We performed subgroup analysis, meta-regression, and sensitivity analysis to explore source heterogeneity and the robustness of the pooled estimates. …”
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