Predictive value of systemic immune inflammation index combined with coagulation index in traumatic coagulopathy in patients with severe trauma by Chen Wang, Yongyong Huang, Shiyun Liao, Jiming Song

“…The best cut-off value was 0.65. The sensitivity and specificity were 80.3, 84.2 respectively. …”
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Intraoperative Analgesia with Magnesium Sulfate versus Remifentanil Guided by Plethysmographic Stress Index in Post-Bariatric Dermolipectomy: A Randomized Study by S. E. Silva Filho, S. Dainez, M. A. M. C. Gonzalez, F. Angelis, J. E. Vieira, C. S. Sandes

“…A relatively new algorithm called the plethysmographic stress index has been considered sensitive and relatively specific as a parameter for assessing the need for intraoperative analgesia. …”
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The efficacy of cholecalciferol in the comprehensive treatment of patients with autoimmune diabetes by N.V. Pashkovska, I.O. Tsaryk

“…The study confirms the pleiotropic effects of vitamin D: reducing autoimmune inflammation, impro­ving insulin sensitivity, normalizing lipid profiles, and supporting β-cell function. …”
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Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization by Li X, Wu S, Pan Y, Wu Z, Du Z, Xie W, Zhou Q

“…Furthermore, we performed sensitivity analysis employing the intercept test of MR-Egger, the Cochran’s Q test, the MR-PRESSO approach, and a leave-one-out method.Results: By conducting MR analysis on the KORA FF4 cohort, we identified several skin microbiotas (ASV003 [Staphylococcus (unc).], ASV016 [Enhydrobacter (unc).], and ASV021 [Micrococcus (unc).]) related with an elevated risk of MM. …”
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Elastosonographic Evaluation of Endometrium in Postmenopausal Bleeding by İsmail Burak Gültekin, Orhan Altınboğa, Serap Gültekin, Elif Akkaş Yılmaz, Gökşen İnanç İmamoğlu, Afra Alkan, Tuncay Küçüközkan

“…However, the need for a noninvasive method with high sensitivity and specificity is still under search. Some women who had been offered biopsy but did not accept the intervention because of the invasive nature of the procedure will be eft undiagnosed for a possible malignancy. …”
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Sex Differences in the Prognostic Value of Circulating Biomarkers in Patients Presenting With Acute Chest Pain by Gard Mikael Sæle Myrmel, MD, Nasir Saeed, Ole Thomas Steiro, MD, Hilde Lunde Tjora, MD, PhD, Jørund Langørgen, MD, PhD, Rune Oskar Bjørneklett, MD, PhD, Øyvind Skadberg, MD, Vernon Vijay Singha Bonarjee, MD, PhD, Øistein Rønneberg Mjelva, MD, Eva Ringdal Pedersen, MD, PhD, Kjell Vikenes, MD, PhD, Torbjørn Omland, MD, PhD, Kristin Moberg Aakre, MD, PhD

“…Objectives: This study investigated whether there are sex differences in the long-term prognostic value of biomarkers in patients presenting with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods: High-sensitivity cardiac troponin (hs-cTn), hs-cTnI, N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor (GDF)-15, and C-reactive protein (CRP) concentrations were measured in 1,476 patients admitted with suspected NSTE-ACS. …”
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Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats by Wen Han, Hao Wang, Longxiang Su, Yun Long, Na Cui, Dawei Liu

“…Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; however, there are little data describing its role during sepsis in the heart. …”
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Exploring the role of inflammatory biomarkers in trigeminal neuralgia by Shenglong Lai, Haiyang Li, Yazhou Xing, Du Wu, Lin Wang, Qinghua Liang

“…No significant causal effect of PCT on TN was observed. Sensitivity analyses confirmed the robustness of these findings, showing no evidence of horizontal pleiotropy or heterogeneity. …”
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Patients with chronic heart failure and predominant left atrial versus left ventricular myopathy by Xuanyi Jin, Wan Ting Tay, Dinna Soon, David Sim, Seet Yoong Loh, Sheldon Lee, Fazlur Jaufeerally, Lieng Hsi Ling, A. Mark Richards, Adriaan A. Voors, Carolyn S. P. Lam, Joost P. van Melle

“…Patients with predominant LA myopathy were older, had a higher prevalence of atrial fibrillation (AF), diabetes, higher plasma concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP), Growth differential factor 15(GDF15), high sensitivity Troponin T (hs-TNT) as well as more dilated left and right atria, and worse right atrial function compared to other groups (all p-values < 0.05). …”
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Safety and Efficacy of Bleb Needling with Antimetabolite after Trabeculectomy Failure in Glaucoma Patients: A Systemic Review and Meta-Analysis by Xuhao Chen, Lingge Suo, Ying Hong, Chun Zhang

“…Subgroup analysis, sensitivity analysis, and metaregression were applied to explore the origination of heterogeneity. …”
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Targeted inhibition of Aurora kinase A promotes immune checkpoint inhibition efficacy in human papillomavirus-driven cancers by Pragya Sinha, Faye M Johnson, Soma Ghosh, Jagannadha K Sastry, Madison P O'Hara, Tuhina Mazumdar, Lacin Yapindi

“…This combination enhanced CD8 T-cell infiltration and decreased the frequencies of MDSCs, whereas neither alisertib nor ICIs (anti-PD-1/anti-CTLA-4) alone showed such effects.Conclusion Our study establishes the potential of Aurora A inhibition to sensitize HPV-positive tumors to ICIs, specifically anti-CTLA-4 treatment. …”
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Association between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study by Natalia Stepanova, Victoria Driianska, Lesya Korol, Lyudmyla Snisar

“…Serum tIS levels ≥ 50 µmol/L predicted PD technique failure with 70.4% sensitivity and 87.9% specificity (p < 0.0001). The association between high tIS levels and PD technique failure remained significant after adjusting for confounders identified in logistic regression, including peritoneal weekly creatinine clearance, the D/P creatinine ratio, high peritoneal transport status, and PDE IL-6 and MCP-1 concentrations (HR 2.9, 95% CI 1.13; 8.21). …”
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A nomogram model based on albumin-bilirubin score for predicting 90-day prognosis in patients with acute-on-chronic liver failure by Wei Ding, Wei Ding, Jiandong Shen, Li Zhang, Li Zhang, Jianguo Shao, Zhaolian Bian, Hong Xue

“…The area under the curve (AUC) was 0.804 (95% CI: 0.741–0.866), with a specificity of 85.0% and a sensitivity of 65.7% at a cut-off of 0.425. The AUC of the validation set was 0.811 (95% CI: 0.697–0.926). …”
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Health and Characteristics of Australian Apple Growing Soils by Marcus Hardie, Garth Oliver, William Cotching, Brianna Walker, Rachel Lancaster, Nigel Swarts

“…This study indicates that apple growing soils require careful management to improve topsoil structure, and to maintain or increase soil carbon, as well as use of soil moisture sensors to schedule irrigation. In addition, some sites also require improved subsoil drainage and care to ensure fertigation and irrigation do not result in leaching of nutrients beneath the root zone.…”
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Integrating Two-Tier Optimization Algorithm With Convolutional Bi-LSTM Model for Robust Anomaly Detection in Autonomous Vehicles by Moneerah Alotaibi, Manal Abdullah Alohali, Khalid Mahmood, Asma A. Alhashmi, Jehad Saad Alqurni, Sultan Refa Alotaibi, Ahmad A. Alzahrani, Imene Issaoui

“…In contrast with traditional vehicles, which are fully coordinated and functioned by humans, AVs gather information regarding the exterior environment utilizing sensors to guarantee secure navigation. AVs decrease environmental effects since they regularly employ electricity to function rather than fossil fuel, thus diminishing greenhouse gasses. …”
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Does high body mass index increase the risk of shoulder instability surgery? The LUXE prospective cohort study on 227 recurrent anterior shoulder instability by Vincent Roy, MD, MSc, Claire Bastard, MD, MSc, Emilie Sandman, MD, MSc, FRCSC, Alexis Rousseau-Saine, MD, FRCSC, Marie-Lyne Nault, MD, PhD, FRCSC, Dominique M. Rouleau, MD, MSc, FRCSC

“…Background: The aim of this study was to determine whether body mass index (BMI) plays a role in overall morbidity following shoulder instability surgery and whether some surgical techniques are BMI-sensitive. Methods: A prospective, multicenter database was created that included the following three surgical techniques: arthroscopic Bankart (AB), arthroscopic Bankart with remplissage (ABR), and Open Latarjet (OL). …”
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Side effects of psychotropic drugs on eye by A.A. Petukhova, A.A. Panov, Ya.V. Malygin, M.A. Kazanfarova

“…The association between phenothiazines and anticonvulsants and retinopathy, chlorpromazine and cataract, anticonvulsants and poor color vision and reduced contrast sensitivity is also important. Psychiatrists and ophthalmologists should consider potenti al ocular side effects in patients receiving psychotropic drugs. …”
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Plasma CXCL3 Levels Are Associated with Tumor Progression and an Unfavorable Colorectal Cancer Prognosis by Can Cui, Rui Zhang, Feng Gu, Yunfeng Pei, Li Sun, Yueyang Huang, Guoping Niu, Jian Li

“…The area under the curve was 0.81 with a sensitivity of 0.71 and specificity of 0.82, distinguishing CRC from other tumor types. …”
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Analysis of Air Pollution Data in India between 2015 and 2019 by Disha Sharma, Denise Mauzerall

“…Our reanalyzed dataset is useful for evaluation of Indian air quality from satellite data, atmospheric models, and low-cost sensors. Our dataset also provides a baseline to evaluate the future success of National Clean Air Programme as well as aids in assessment of existing and future air pollution mitigation policies.…”
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Atherogenic Index in Type 2 Diabetes and Its Relationship with Chronic Microvascular Complications by Zhen Li, Qi Huang, Li Sun, Tengfei Bao, Zhe Dai

“…Standard 75 g oral glucose tolerance testing was performed to measure 0 and 2 hr plasma levels of glucose and insulin. Insulin sensitivity was assessed with HOMA-IR. Results. Increase in AIP was associated with an increased risk for hypertension (P<0.05), HbA1c (P<0.05), HOMA-IR (P<0.05), UA (P<0.05), and decreased eGFR levels (P<0.05). …”
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